JPS57112367A - Preparation of stable aqueous solution of compound having thiol group - Google Patents
Preparation of stable aqueous solution of compound having thiol groupInfo
- Publication number
- JPS57112367A JPS57112367A JP18861780A JP18861780A JPS57112367A JP S57112367 A JPS57112367 A JP S57112367A JP 18861780 A JP18861780 A JP 18861780A JP 18861780 A JP18861780 A JP 18861780A JP S57112367 A JPS57112367 A JP S57112367A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- thiol group
- aqueous solution
- amino acid
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 125000003396 thiol group Chemical group [H]S* 0.000 title abstract 4
- 239000007864 aqueous solution Substances 0.000 title abstract 3
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 108010008488 Glycylglycine Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 abstract 1
- 229960000830 captopril Drugs 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 229960003180 glutathione Drugs 0.000 abstract 1
- 229940043257 glycylglycine Drugs 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- -1 thiol compound Chemical class 0.000 abstract 1
- 150000003573 thiols Chemical group 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18861780A JPS57112367A (en) | 1980-12-29 | 1980-12-29 | Preparation of stable aqueous solution of compound having thiol group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18861780A JPS57112367A (en) | 1980-12-29 | 1980-12-29 | Preparation of stable aqueous solution of compound having thiol group |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57112367A true JPS57112367A (en) | 1982-07-13 |
| JPS647983B2 JPS647983B2 (enrdf_load_stackoverflow) | 1989-02-10 |
Family
ID=16226806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18861780A Granted JPS57112367A (en) | 1980-12-29 | 1980-12-29 | Preparation of stable aqueous solution of compound having thiol group |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57112367A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5147803A (en) * | 1988-09-12 | 1992-09-15 | Nippon Shoji Kabushiki Kaisha | Method and composition for stabilizing blood coagulation factors and blood control plasmas containing the composition |
| JP2001011441A (ja) * | 1999-05-28 | 2001-01-16 | Johnson & Johnson Consumer Co Inc | 酸素不安定種を安定化する組成物および方法 |
| CN100356912C (zh) * | 2005-07-08 | 2007-12-26 | 王建标 | 一种硫普罗宁冻干制剂及其制备方法 |
| JP2007537988A (ja) * | 2003-10-10 | 2007-12-27 | バクスター・インターナショナル・インコーポレイテッド | 低分子ペプチドを含む薬学的タンパク質処方物の安定化 |
| US8859807B2 (en) * | 2006-10-04 | 2014-10-14 | Kyowa Hakko Bio Co., Ltd. | Glutathione preparation and method for production thereof |
| JP2021066722A (ja) * | 2018-10-18 | 2021-04-30 | バイオ・アクセラレーター株式会社 | ポリスルフィドの安定化 |
-
1980
- 1980-12-29 JP JP18861780A patent/JPS57112367A/ja active Granted
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5147803A (en) * | 1988-09-12 | 1992-09-15 | Nippon Shoji Kabushiki Kaisha | Method and composition for stabilizing blood coagulation factors and blood control plasmas containing the composition |
| EP0359201B1 (en) * | 1988-09-12 | 1993-03-03 | Nippon Shoji Kabushiki Kaisha | Method for stabilizing blood coagulation factors |
| JP2001011441A (ja) * | 1999-05-28 | 2001-01-16 | Johnson & Johnson Consumer Co Inc | 酸素不安定種を安定化する組成物および方法 |
| JP2007537988A (ja) * | 2003-10-10 | 2007-12-27 | バクスター・インターナショナル・インコーポレイテッド | 低分子ペプチドを含む薬学的タンパク質処方物の安定化 |
| CN100356912C (zh) * | 2005-07-08 | 2007-12-26 | 王建标 | 一种硫普罗宁冻干制剂及其制备方法 |
| US8859807B2 (en) * | 2006-10-04 | 2014-10-14 | Kyowa Hakko Bio Co., Ltd. | Glutathione preparation and method for production thereof |
| JP2021066722A (ja) * | 2018-10-18 | 2021-04-30 | バイオ・アクセラレーター株式会社 | ポリスルフィドの安定化 |
| US11866752B2 (en) | 2018-10-18 | 2024-01-09 | Bio-Xcelerator, Inc. | Cysteine polysulfidation and mitochondrial bioenergetics regulated by cysteinyl-tRNA synthetase |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS647983B2 (enrdf_load_stackoverflow) | 1989-02-10 |
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