JPS57108039A - Ml-236b derivative - Google Patents
Ml-236b derivativeInfo
- Publication number
- JPS57108039A JPS57108039A JP11548380A JP11548380A JPS57108039A JP S57108039 A JPS57108039 A JP S57108039A JP 11548380 A JP11548380 A JP 11548380A JP 11548380 A JP11548380 A JP 11548380A JP S57108039 A JPS57108039 A JP S57108039A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- absidia
- microorganism
- formula
- netabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000235389 Absidia Species 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical class C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 241000235555 Cunninghamella Species 0.000 abstract 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 abstract 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 abstract 1
- 241000228153 Penicillium citrinum Species 0.000 abstract 1
- 235000002233 Penicillium roqueforti Nutrition 0.000 abstract 1
- 241000736854 Syncephalastrum Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11548380A JPS57108039A (en) | 1980-08-22 | 1980-08-22 | Ml-236b derivative |
MX819478U MX7065E (es) | 1980-06-06 | 1981-06-04 | Un procedimiento microbiologico para preparar derivados de ml-236b |
DK247081A DK149080C (da) | 1980-06-06 | 1981-06-04 | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
DE19813122499 DE3122499A1 (de) | 1980-06-06 | 1981-06-05 | Neue derivate von ml-236b, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittelzubereitungen |
FI811762A FI71168C (fi) | 1980-06-06 | 1981-06-05 | Foerfarande foer framstaellning av ml-236b-derivat vilka anvaends som laekemedel |
KR1019810002023A KR840001055B1 (ko) | 1980-06-06 | 1981-06-05 | Ml-236b 유도체의 제조방법 |
CH3722/81A CH655090A5 (de) | 1980-06-06 | 1981-06-05 | Hexahydronaphthalinderivate und ihre herstellung. |
AU71376/81A AU549988B2 (en) | 1980-06-06 | 1981-06-05 | Hydroxy esters |
US06/270,846 US4346227A (en) | 1980-06-06 | 1981-06-05 | ML-236B Derivatives and their preparation |
NL8102737A NL191738C (nl) | 1980-06-06 | 1981-06-05 | ML-236B-derivaten, werkwijze voor hun bereiding en farmaceutische preparaten, die deze derivaten bevatten. |
IE1257/81A IE51270B1 (en) | 1980-06-06 | 1981-06-05 | Ml-236b derivatives and their preparation |
FR8111190A FR2483912B1 (fr) | 1980-06-06 | 1981-06-05 | Derives hydroxycarboxyles du compose ml-236b, leur procede de preparation et leur application therapeutique |
SE8103560A SE453389B (sv) | 1980-06-06 | 1981-06-05 | Hydroxikarboxylsyror, ringslutna laktoner, salter och estrar derav samt forfarande for framstellning av nemnda foreningar |
IT67777/81A IT1144598B (it) | 1980-06-06 | 1981-06-05 | Composti farmaceutici atti ad inibire la biosintesi del colesterolo e procedimento per la loro preparazione |
ES502827A ES502827A0 (es) | 1980-06-06 | 1981-06-05 | Procedimiento de preparar acidos hidroxicarboxilicos y sus derivados. |
CA000379232A CA1150170A (en) | 1980-06-06 | 1981-06-08 | Ml-236b derivatives and their preparation |
GB8117450A GB2077264B (en) | 1980-06-06 | 1981-06-08 | Ml-236b derivatives and their preparation |
BE0/205046A BE889150A (fr) | 1980-06-06 | 1981-06-09 | Derives hydroxycarboxyles du compose ml-236b, leur procede de preparation et leur application therapeutique |
AT0256781A AT374495B (de) | 1980-06-06 | 1981-06-09 | Verfahren zur herstellung neuer derivate der verbindung ml-236b |
US06/351,974 US4410629A (en) | 1980-06-06 | 1982-02-24 | ML-236B Derivatives and their preparation |
US06/351,975 US4448979A (en) | 1980-06-06 | 1982-02-24 | ML-236B Derivatives |
MX9203563A MX9203563A (es) | 1980-06-06 | 1992-06-26 | Derivados de ml-236b y su preparacion. |
NL960028C NL960028I2 (nl) | 1980-06-06 | 1996-11-18 | ML-236B-derivaten, werkwijze voor hun bereiding enfarmaceutische preparaten, die deze derivaten bevatten. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11548380A JPS57108039A (en) | 1980-08-22 | 1980-08-22 | Ml-236b derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57108039A true JPS57108039A (en) | 1982-07-05 |
JPS6348858B2 JPS6348858B2 (enrdf_load_stackoverflow) | 1988-09-30 |
Family
ID=14663630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11548380A Granted JPS57108039A (en) | 1980-06-06 | 1980-08-22 | Ml-236b derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57108039A (enrdf_load_stackoverflow) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100450562B1 (ko) * | 2001-09-29 | 2004-09-30 | 코바이오텍 (주) | 프라바스타틴의 전구체 및 그 유도체의 생산 방법 |
-
1980
- 1980-08-22 JP JP11548380A patent/JPS57108039A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100450562B1 (ko) * | 2001-09-29 | 2004-09-30 | 코바이오텍 (주) | 프라바스타틴의 전구체 및 그 유도체의 생산 방법 |
Also Published As
Publication number | Publication date |
---|---|
JPS6348858B2 (enrdf_load_stackoverflow) | 1988-09-30 |
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