JPS57108039A - Ml-236b derivative - Google Patents
Ml-236b derivativeInfo
- Publication number
- JPS57108039A JPS57108039A JP11548380A JP11548380A JPS57108039A JP S57108039 A JPS57108039 A JP S57108039A JP 11548380 A JP11548380 A JP 11548380A JP 11548380 A JP11548380 A JP 11548380A JP S57108039 A JPS57108039 A JP S57108039A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- absidia
- microorganism
- formula
- netabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An ML-236B derivative of formulaI(R is H, lower alkyl or alkaline metal) or formula II.
USE: With the inhibitory activity against cholesterol and useful as a remedy for hyperlipemia.
PROCESS: ML-236B of formula III separated and purified from a netabolite of Penicillium citrinum which is a kind of blue mold is converted into a derivative of formulaIor II by the action of a microorganism. Any strain capable of producing a hydroxylase, e.g. of the genuses Absidia, Cunninghamella or Syncephalastrum, may be cited as the microorganism to be used. Preferably, Absidia. coerulea IFO 4423 is suitable.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11548380A JPS57108039A (en) | 1980-08-22 | 1980-08-22 | Ml-236b derivative |
DK247081A DK149080C (en) | 1980-06-06 | 1981-06-04 | METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES |
MX819478U MX7065E (en) | 1980-06-06 | 1981-06-04 | A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B |
US06/270,846 US4346227A (en) | 1980-06-06 | 1981-06-05 | ML-236B Derivatives and their preparation |
NL8102737A NL191738C (en) | 1980-06-06 | 1981-06-05 | ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives. |
CH3722/81A CH655090A5 (en) | 1980-06-06 | 1981-06-05 | HEXAHYDRONAPHTHALINE DERIVATIVES AND THEIR PRODUCTION. |
SE8103560A SE453389B (en) | 1980-06-06 | 1981-06-05 | HYDROXICARBOXYLIC ACIDS, CIRCULATED LAKTONES, SALTS AND ESTERS THEREOF, AND PROCEDURE FOR THE PREPARATION OF THESE COMPOUNDS |
KR1019810002023A KR840001055B1 (en) | 1980-06-06 | 1981-06-05 | Process for preparing ml-236 b decivatives |
IT67777/81A IT1144598B (en) | 1980-06-06 | 1981-06-05 | PHARMACEUTICAL COMPOUNDS SUITABLE TO INHIBIT THE BIOSYNTHESIS OF CHOLESTEROL AND PROCEDURE FOR THEIR PREPARATION |
DE19813122499 DE3122499A1 (en) | 1980-06-06 | 1981-06-05 | NEW DERIVATIVES OF ML-236B, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT PREPARATIONS CONTAINING THESE DERIVATIVES |
FR8111190A FR2483912B1 (en) | 1980-06-06 | 1981-06-05 | HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
FI811762A FI71168C (en) | 1980-06-06 | 1981-06-05 | FOERFARANDE FOER FRAMSTAELLNING AV ML-236B-DERIVAT VILKA ANVAENDS SOM CEEEMEDELEL |
IE1257/81A IE51270B1 (en) | 1980-06-06 | 1981-06-05 | Ml-236b derivatives and their preparation |
AU71376/81A AU549988B2 (en) | 1980-06-06 | 1981-06-05 | Hydroxy esters |
ES502827A ES8300353A1 (en) | 1980-06-06 | 1981-06-05 | ML-236B Derivatives and their preparation |
CA000379232A CA1150170A (en) | 1980-06-06 | 1981-06-08 | Ml-236b derivatives and their preparation |
GB8117450A GB2077264B (en) | 1980-06-06 | 1981-06-08 | Ml-236b derivatives and their preparation |
BE0/205046A BE889150A (en) | 1980-06-06 | 1981-06-09 | HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
AT0256781A AT374495B (en) | 1980-06-06 | 1981-06-09 | METHOD FOR PRODUCING NEW DERIVATIVES OF ML-236B |
US06/351,975 US4448979A (en) | 1980-06-06 | 1982-02-24 | ML-236B Derivatives |
US06/351,974 US4410629A (en) | 1980-06-06 | 1982-02-24 | ML-236B Derivatives and their preparation |
MX9203563A MX9203563A (en) | 1980-06-06 | 1992-06-26 | DERIVATIVES OF ML-236B AND ITS PREPARATION. |
NL960028C NL960028I2 (en) | 1980-06-06 | 1996-11-18 | ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11548380A JPS57108039A (en) | 1980-08-22 | 1980-08-22 | Ml-236b derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57108039A true JPS57108039A (en) | 1982-07-05 |
JPS6348858B2 JPS6348858B2 (en) | 1988-09-30 |
Family
ID=14663630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11548380A Granted JPS57108039A (en) | 1980-06-06 | 1980-08-22 | Ml-236b derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57108039A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100450562B1 (en) * | 2001-09-29 | 2004-09-30 | 코바이오텍 (주) | Process for preparing pravastatin precursor and its derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0613455Y2 (en) * | 1989-03-17 | 1994-04-06 | 矢崎総業株式会社 | Gas meter with integrated entrance and exit |
-
1980
- 1980-08-22 JP JP11548380A patent/JPS57108039A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100450562B1 (en) * | 2001-09-29 | 2004-09-30 | 코바이오텍 (주) | Process for preparing pravastatin precursor and its derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS6348858B2 (en) | 1988-09-30 |
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