JPS57108039A - Ml-236b derivative - Google Patents

Ml-236b derivative

Info

Publication number
JPS57108039A
JPS57108039A JP11548380A JP11548380A JPS57108039A JP S57108039 A JPS57108039 A JP S57108039A JP 11548380 A JP11548380 A JP 11548380A JP 11548380 A JP11548380 A JP 11548380A JP S57108039 A JPS57108039 A JP S57108039A
Authority
JP
Japan
Prior art keywords
derivative
absidia
microorganism
formula
netabolite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11548380A
Other languages
Japanese (ja)
Other versions
JPS6348858B2 (en
Inventor
Akira Terahara
Minoru Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP11548380A priority Critical patent/JPS57108039A/en
Priority to MX819478U priority patent/MX7065E/en
Priority to DK247081A priority patent/DK149080C/en
Priority to ES502827A priority patent/ES8300353A1/en
Priority to AU71376/81A priority patent/AU549988B2/en
Priority to IE1257/81A priority patent/IE51270B1/en
Priority to US06/270,846 priority patent/US4346227A/en
Priority to CH3722/81A priority patent/CH655090A5/en
Priority to DE19813122499 priority patent/DE3122499A1/en
Priority to FR8111190A priority patent/FR2483912B1/en
Priority to NL8102737A priority patent/NL191738C/en
Priority to FI811762A priority patent/FI71168C/en
Priority to KR1019810002023A priority patent/KR840001055B1/en
Priority to SE8103560A priority patent/SE453389B/en
Priority to IT67777/81A priority patent/IT1144598B/en
Priority to CA000379232A priority patent/CA1150170A/en
Priority to GB8117450A priority patent/GB2077264B/en
Priority to BE0/205046A priority patent/BE889150A/en
Priority to AT0256781A priority patent/AT374495B/en
Priority to US06/351,974 priority patent/US4410629A/en
Priority to US06/351,975 priority patent/US4448979A/en
Publication of JPS57108039A publication Critical patent/JPS57108039A/en
Publication of JPS6348858B2 publication Critical patent/JPS6348858B2/ja
Priority to MX9203563A priority patent/MX9203563A/en
Priority to NL960028C priority patent/NL960028I2/en
Granted legal-status Critical Current

Links

Landscapes

  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

NEW MATERIAL:An ML-236B derivative of formulaI(R is H, lower alkyl or alkaline metal) or formula II.
USE: With the inhibitory activity against cholesterol and useful as a remedy for hyperlipemia.
PROCESS: ML-236B of formula III separated and purified from a netabolite of Penicillium citrinum which is a kind of blue mold is converted into a derivative of formulaIor II by the action of a microorganism. Any strain capable of producing a hydroxylase, e.g. of the genuses Absidia, Cunninghamella or Syncephalastrum, may be cited as the microorganism to be used. Preferably, Absidia. coerulea IFO 4423 is suitable.
COPYRIGHT: (C)1982,JPO&Japio
JP11548380A 1980-06-06 1980-08-22 Ml-236b derivative Granted JPS57108039A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP11548380A JPS57108039A (en) 1980-08-22 1980-08-22 Ml-236b derivative
MX819478U MX7065E (en) 1980-06-06 1981-06-04 A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
DK247081A DK149080C (en) 1980-06-06 1981-06-04 METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
FI811762A FI71168C (en) 1980-06-06 1981-06-05 FOERFARANDE FOER FRAMSTAELLNING AV ML-236B-DERIVAT VILKA ANVAENDS SOM CEEEMEDELEL
IT67777/81A IT1144598B (en) 1980-06-06 1981-06-05 PHARMACEUTICAL COMPOUNDS SUITABLE TO INHIBIT THE BIOSYNTHESIS OF CHOLESTEROL AND PROCEDURE FOR THEIR PREPARATION
IE1257/81A IE51270B1 (en) 1980-06-06 1981-06-05 Ml-236b derivatives and their preparation
US06/270,846 US4346227A (en) 1980-06-06 1981-06-05 ML-236B Derivatives and their preparation
CH3722/81A CH655090A5 (en) 1980-06-06 1981-06-05 HEXAHYDRONAPHTHALINE DERIVATIVES AND THEIR PRODUCTION.
DE19813122499 DE3122499A1 (en) 1980-06-06 1981-06-05 NEW DERIVATIVES OF ML-236B, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT PREPARATIONS CONTAINING THESE DERIVATIVES
FR8111190A FR2483912B1 (en) 1980-06-06 1981-06-05 HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
NL8102737A NL191738C (en) 1980-06-06 1981-06-05 ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives.
ES502827A ES8300353A1 (en) 1980-06-06 1981-06-05 ML-236B Derivatives and their preparation
KR1019810002023A KR840001055B1 (en) 1980-06-06 1981-06-05 Process for preparing ml-236 b decivatives
SE8103560A SE453389B (en) 1980-06-06 1981-06-05 HYDROXICARBOXYLIC ACIDS, CIRCULATED LAKTONES, SALTS AND ESTERS THEREOF, AND PROCEDURE FOR THE PREPARATION OF THESE COMPOUNDS
AU71376/81A AU549988B2 (en) 1980-06-06 1981-06-05 Hydroxy esters
CA000379232A CA1150170A (en) 1980-06-06 1981-06-08 Ml-236b derivatives and their preparation
GB8117450A GB2077264B (en) 1980-06-06 1981-06-08 Ml-236b derivatives and their preparation
BE0/205046A BE889150A (en) 1980-06-06 1981-06-09 HYDROXYCARBOXYL DERIVATIVES OF THE COMPOUND ML-236B, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
AT0256781A AT374495B (en) 1980-06-06 1981-06-09 METHOD FOR PRODUCING NEW DERIVATIVES OF ML-236B
US06/351,974 US4410629A (en) 1980-06-06 1982-02-24 ML-236B Derivatives and their preparation
US06/351,975 US4448979A (en) 1980-06-06 1982-02-24 ML-236B Derivatives
MX9203563A MX9203563A (en) 1980-06-06 1992-06-26 DERIVATIVES OF ML-236B AND ITS PREPARATION.
NL960028C NL960028I2 (en) 1980-06-06 1996-11-18 ML-236B derivatives, process for their preparation and pharmaceutical preparations containing these derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11548380A JPS57108039A (en) 1980-08-22 1980-08-22 Ml-236b derivative

Publications (2)

Publication Number Publication Date
JPS57108039A true JPS57108039A (en) 1982-07-05
JPS6348858B2 JPS6348858B2 (en) 1988-09-30

Family

ID=14663630

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11548380A Granted JPS57108039A (en) 1980-06-06 1980-08-22 Ml-236b derivative

Country Status (1)

Country Link
JP (1) JPS57108039A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100450562B1 (en) * 2001-09-29 2004-09-30 코바이오텍 (주) Process for preparing pravastatin precursor and its derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0613455Y2 (en) * 1989-03-17 1994-04-06 矢崎総業株式会社 Gas meter with integrated entrance and exit

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100450562B1 (en) * 2001-09-29 2004-09-30 코바이오텍 (주) Process for preparing pravastatin precursor and its derivatives

Also Published As

Publication number Publication date
JPS6348858B2 (en) 1988-09-30

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