JPS568327A - Acylation method - Google Patents
Acylation methodInfo
- Publication number
- JPS568327A JPS568327A JP8521279A JP8521279A JPS568327A JP S568327 A JPS568327 A JP S568327A JP 8521279 A JP8521279 A JP 8521279A JP 8521279 A JP8521279 A JP 8521279A JP S568327 A JPS568327 A JP S568327A
- Authority
- JP
- Japan
- Prior art keywords
- organic solvent
- active
- compound
- condensing agent
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare a highly pure acylated product, economically, with simple post-treatment, by acylating a reactive derivative of carboxylic acid and a compound having an active methylene group or methyne group in a hydrous organic solvent, using a safely handleable base as a condensing agent.
CONSTITUTION: A reactive derivative of a carboxylic acid, e.g. acid halide, active acid amide, etc., and a compound having an active methylene group or active methyne group, e.g. dimethyl malonate, ethyl acetoacetate, etc., are acylated in a hydrous organic solvent in the presence of a base such as potassium carbonate, at room temperature or an elevated temperature, to obtain an acylated product useful as an intermediate of medicines, etc. The organic solvent is pref. methyl isobutyl ketone, tetrahydrofuran, etc.
EFFECT: The reaction proceeds without using a dangerous metal compound condensing agent such as metallic sodium, or a highly toxic crown ether catalyst.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8521279A JPS568327A (en) | 1979-07-03 | 1979-07-03 | Acylation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8521279A JPS568327A (en) | 1979-07-03 | 1979-07-03 | Acylation method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS568327A true JPS568327A (en) | 1981-01-28 |
JPS636530B2 JPS636530B2 (en) | 1988-02-10 |
Family
ID=13852266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8521279A Granted JPS568327A (en) | 1979-07-03 | 1979-07-03 | Acylation method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS568327A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179943B2 (en) | 2004-06-14 | 2007-02-20 | Wyeth | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof |
-
1979
- 1979-07-03 JP JP8521279A patent/JPS568327A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179943B2 (en) | 2004-06-14 | 2007-02-20 | Wyeth | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS636530B2 (en) | 1988-02-10 |
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