JPS567784A - Imidazoquinolone derivative - Google Patents

Imidazoquinolone derivative

Info

Publication number
JPS567784A
JPS567784A JP8221479A JP8221479A JPS567784A JP S567784 A JPS567784 A JP S567784A JP 8221479 A JP8221479 A JP 8221479A JP 8221479 A JP8221479 A JP 8221479A JP S567784 A JPS567784 A JP S567784A
Authority
JP
Japan
Prior art keywords
formula
compound shown
lower alkyl
aryl
imidazoquinolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8221479A
Other languages
Japanese (ja)
Inventor
Yoichi Naka
Hiroshi Yuki
Takeki Okumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Priority to JP8221479A priority Critical patent/JPS567784A/en
Publication of JPS567784A publication Critical patent/JPS567784A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound shown by the formula I (R1 and R2 are lower alkyl; R3 is OH, amino, etc.; Z is OH hydroxyamino, etc.,) and its pharmaceutically acceptable salt.
EXAMPLE: 1,2,5,8-Tetrohydro-1,3-dimethyl-2,8-dioxo-5-( 2-propynyl )imidazo[ 4,5- g]quinoline-7-carboxylic acid ethyl ester.
USE: An antimicrobial agent and a carcinostatic agent. Effective against mouse leukemia (L-1210), Yosida-sarcoma, Ehrlich ascites carcinoma, etc.
PROCESS: For example, in the formula I, when R3 is lower alkyl, aryl lower alkenyl, OH, mono- or di-lower alkylamino, etc. and Z is lower alkoxy, a compound shown by the formula II (R6 is lower alkyl) is reacted with a compound shown by the formula R7-X (R7 is lower alkynyl, aryl lower alkenyl, etc.) to give a compound shown by the formula I. The reaction is carried out advantageously in the presence of an deoxidizer in a solvent.
COPYRIGHT: (C)1981,JPO&Japio
JP8221479A 1979-06-28 1979-06-28 Imidazoquinolone derivative Pending JPS567784A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8221479A JPS567784A (en) 1979-06-28 1979-06-28 Imidazoquinolone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8221479A JPS567784A (en) 1979-06-28 1979-06-28 Imidazoquinolone derivative

Publications (1)

Publication Number Publication Date
JPS567784A true JPS567784A (en) 1981-01-27

Family

ID=13768161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8221479A Pending JPS567784A (en) 1979-06-28 1979-06-28 Imidazoquinolone derivative

Country Status (1)

Country Link
JP (1) JPS567784A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002145A2 (en) * 1992-07-22 1994-02-03 Genelabs Technologies, Inc. 2-aryl-4-quinolones as antitumor compounds
US5571822A (en) * 1994-09-30 1996-11-05 The University Of North Carolina At Chapel Hill Antitumor compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002145A2 (en) * 1992-07-22 1994-02-03 Genelabs Technologies, Inc. 2-aryl-4-quinolones as antitumor compounds
WO1994002145A3 (en) * 1992-07-22 1994-04-28 Genelabs Tech Inc 2-aryl-4-quinolones as antitumor compounds
US5571822A (en) * 1994-09-30 1996-11-05 The University Of North Carolina At Chapel Hill Antitumor compounds

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