JPS567784A - Imidazoquinolone derivative - Google Patents
Imidazoquinolone derivativeInfo
- Publication number
- JPS567784A JPS567784A JP8221479A JP8221479A JPS567784A JP S567784 A JPS567784 A JP S567784A JP 8221479 A JP8221479 A JP 8221479A JP 8221479 A JP8221479 A JP 8221479A JP S567784 A JPS567784 A JP S567784A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- lower alkyl
- aryl
- imidazoquinolone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound shown by the formula I (R1 and R2 are lower alkyl; R3 is OH, amino, etc.; Z is OH hydroxyamino, etc.,) and its pharmaceutically acceptable salt.
EXAMPLE: 1,2,5,8-Tetrohydro-1,3-dimethyl-2,8-dioxo-5-( 2-propynyl )imidazo[ 4,5- g]quinoline-7-carboxylic acid ethyl ester.
USE: An antimicrobial agent and a carcinostatic agent. Effective against mouse leukemia (L-1210), Yosida-sarcoma, Ehrlich ascites carcinoma, etc.
PROCESS: For example, in the formula I, when R3 is lower alkyl, aryl lower alkenyl, OH, mono- or di-lower alkylamino, etc. and Z is lower alkoxy, a compound shown by the formula II (R6 is lower alkyl) is reacted with a compound shown by the formula R7-X (R7 is lower alkynyl, aryl lower alkenyl, etc.) to give a compound shown by the formula I. The reaction is carried out advantageously in the presence of an deoxidizer in a solvent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8221479A JPS567784A (en) | 1979-06-28 | 1979-06-28 | Imidazoquinolone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8221479A JPS567784A (en) | 1979-06-28 | 1979-06-28 | Imidazoquinolone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS567784A true JPS567784A (en) | 1981-01-27 |
Family
ID=13768161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8221479A Pending JPS567784A (en) | 1979-06-28 | 1979-06-28 | Imidazoquinolone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS567784A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002145A2 (en) * | 1992-07-22 | 1994-02-03 | Genelabs Technologies, Inc. | 2-aryl-4-quinolones as antitumor compounds |
US5571822A (en) * | 1994-09-30 | 1996-11-05 | The University Of North Carolina At Chapel Hill | Antitumor compounds |
-
1979
- 1979-06-28 JP JP8221479A patent/JPS567784A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002145A2 (en) * | 1992-07-22 | 1994-02-03 | Genelabs Technologies, Inc. | 2-aryl-4-quinolones as antitumor compounds |
WO1994002145A3 (en) * | 1992-07-22 | 1994-04-28 | Genelabs Tech Inc | 2-aryl-4-quinolones as antitumor compounds |
US5571822A (en) * | 1994-09-30 | 1996-11-05 | The University Of North Carolina At Chapel Hill | Antitumor compounds |
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