JPS5668397A - Production of l-hystidine - Google Patents
Production of l-hystidineInfo
- Publication number
- JPS5668397A JPS5668397A JP14326979A JP14326979A JPS5668397A JP S5668397 A JPS5668397 A JP S5668397A JP 14326979 A JP14326979 A JP 14326979A JP 14326979 A JP14326979 A JP 14326979A JP S5668397 A JPS5668397 A JP S5668397A
- Authority
- JP
- Japan
- Prior art keywords
- hystidine
- medium
- cultivation
- gluconic acid
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: In the cultivation of an L-hystidine-producing bacterium in a liquid medium, gluconic acid is added to a concentration level higher than a prescribed to increase the yield of L-hystidine.
CONSTITUTION: A mutant resisting 2-thiazolealanine or sulfadiazine that originates from a microorgansim is Brevibacterium is cultured in a usual liquid culture medium to form L-hystidine in the medium wherein more than 0.05g/dl of gluconic acid is added to the medium. The cultivation of effected at 24W37°C and a pH 5W9 for 2W7 days. The amount of accumulated L-hystindine is increased by more than 20% compared with no addition of gluconic acid. After completion of cultivation, the centrifuged supernatant is passed throgh a strong-acid type ion exchange resin, the adsorbed L-hystidine is eluted with 3% aqueous ammonia, cocentrated under reduced pressure and cooled to given the crystals in high yield.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14326979A JPS5668397A (en) | 1979-11-07 | 1979-11-07 | Production of l-hystidine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14326979A JPS5668397A (en) | 1979-11-07 | 1979-11-07 | Production of l-hystidine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5668397A true JPS5668397A (en) | 1981-06-09 |
JPS6141554B2 JPS6141554B2 (en) | 1986-09-16 |
Family
ID=15334814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14326979A Granted JPS5668397A (en) | 1979-11-07 | 1979-11-07 | Production of l-hystidine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5668397A (en) |
-
1979
- 1979-11-07 JP JP14326979A patent/JPS5668397A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6141554B2 (en) | 1986-09-16 |
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