JPS5765191A - Preparation of (+)-alpha-hydroxymethylbutyric acid - Google Patents
Preparation of (+)-alpha-hydroxymethylbutyric acidInfo
- Publication number
- JPS5765191A JPS5765191A JP14025980A JP14025980A JPS5765191A JP S5765191 A JPS5765191 A JP S5765191A JP 14025980 A JP14025980 A JP 14025980A JP 14025980 A JP14025980 A JP 14025980A JP S5765191 A JPS5765191 A JP S5765191A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- microorganisms
- trichosporon
- alpha
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare (+)-α-hydroxymethylbutyric acid by treating(±)-α-methyl- butyric acid with microorganisms belonging to Trichosporon genus.
CONSTITUTION: (±)-α-Methylbutyric acid is converted to (+)-α-hydroxymethyl- butyric acid by the aerobic cultivation of microorganisms belonging to Trichosporon genus, e.g. Trichosporon fermentans CBS2529 strain, in a medium containing ±- α-methylbutyic acid at 4.0W9.5pH. As an alternative method, (+)-α-hydroxy- methylbutyric acid is prepared by culturing the above microorganisms in a nutrient medium at 4.0W9.5pH, adding (±)-a-methylbutyric acid to the cultivation liquid or the suspension of the microorganisms obtained from the liquid, and reacting under aerobic conditions keeping the pH at 6.0W9.0.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14025980A JPS5765191A (en) | 1980-10-06 | 1980-10-06 | Preparation of (+)-alpha-hydroxymethylbutyric acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14025980A JPS5765191A (en) | 1980-10-06 | 1980-10-06 | Preparation of (+)-alpha-hydroxymethylbutyric acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5765191A true JPS5765191A (en) | 1982-04-20 |
JPS6112677B2 JPS6112677B2 (en) | 1986-04-09 |
Family
ID=15264616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14025980A Granted JPS5765191A (en) | 1980-10-06 | 1980-10-06 | Preparation of (+)-alpha-hydroxymethylbutyric acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5765191A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0151419A2 (en) * | 1984-01-27 | 1985-08-14 | E.R. Squibb & Sons, Inc. | Method of preparing D(-)-beta-hydroxyisobutyric acid by fermentation |
-
1980
- 1980-10-06 JP JP14025980A patent/JPS5765191A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0151419A2 (en) * | 1984-01-27 | 1985-08-14 | E.R. Squibb & Sons, Inc. | Method of preparing D(-)-beta-hydroxyisobutyric acid by fermentation |
Also Published As
Publication number | Publication date |
---|---|
JPS6112677B2 (en) | 1986-04-09 |
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