JPS5765192A - Preparation of (+)-beta-hydroxyisobutyric acid - Google Patents

Preparation of (+)-beta-hydroxyisobutyric acid

Info

Publication number
JPS5765192A
JPS5765192A JP14145380A JP14145380A JPS5765192A JP S5765192 A JPS5765192 A JP S5765192A JP 14145380 A JP14145380 A JP 14145380A JP 14145380 A JP14145380 A JP 14145380A JP S5765192 A JPS5765192 A JP S5765192A
Authority
JP
Japan
Prior art keywords
acid
genus
isobutyric
methacrylic acid
hydroxyisobutyric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14145380A
Other languages
Japanese (ja)
Other versions
JPS6112678B2 (en
Inventor
Junzo Hasegawa
Shigeki Hamaguchi
Masahiro Ogura
Hajime Kawarada
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP14145380A priority Critical patent/JPS5765192A/en
Publication of JPS5765192A publication Critical patent/JPS5765192A/en
Publication of JPS6112678B2 publication Critical patent/JPS6112678B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare the optically active L-isomer of the titled compound, in high efficiency, by treating isobutyric acid or methacrylic acid with microorganisms capable of converting said acid to L(+)-β-hydroxyisobutyric acid.
CONSTITUTION: Isobutyric acid or methacrylic acid is converted to L(+)-β-hy- droxyisobutyric acid by culturing microorganisms in a conventional medium con- taining isobutyric acid or methacrylic acid at 4.0W9.5 pH and 20W40°C, or by culturing in a conventional medium and containing the obtained microbial cells with the raw material acid in the presence of a small amount of glucose. The resultant L(+)-β-hydroxyisobutyric acid can by separated by adjusting the pH of the liquid to 2.5, saturating the liquid with ammonium sulfate, extracting the objective com- pound with ethylacetate, and distilling in vacuum. The microorganism is selected from yeasts such as Bullera genus, Candida genus, etc., actinomycetes such as Streptomyces genus, molds such as Mucor genus, bacteria such as Bacillus genus.
COPYRIGHT: (C)1982,JPO&Japio
JP14145380A 1980-10-08 1980-10-08 Preparation of (+)-beta-hydroxyisobutyric acid Granted JPS5765192A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14145380A JPS5765192A (en) 1980-10-08 1980-10-08 Preparation of (+)-beta-hydroxyisobutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14145380A JPS5765192A (en) 1980-10-08 1980-10-08 Preparation of (+)-beta-hydroxyisobutyric acid

Publications (2)

Publication Number Publication Date
JPS5765192A true JPS5765192A (en) 1982-04-20
JPS6112678B2 JPS6112678B2 (en) 1986-04-09

Family

ID=15292255

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14145380A Granted JPS5765192A (en) 1980-10-08 1980-10-08 Preparation of (+)-beta-hydroxyisobutyric acid

Country Status (1)

Country Link
JP (1) JPS5765192A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618583A (en) * 1984-11-19 1986-10-21 E. R. Squibb & Sons, Inc. Method of preparing L-(+)-β-hydroxyisobutyric acid by fermentation
GB2596641A (en) * 2019-04-27 2022-01-05 William Belding Roger An anchor assist device

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6247779U (en) * 1985-09-11 1987-03-24

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4618583A (en) * 1984-11-19 1986-10-21 E. R. Squibb & Sons, Inc. Method of preparing L-(+)-β-hydroxyisobutyric acid by fermentation
GB2596641A (en) * 2019-04-27 2022-01-05 William Belding Roger An anchor assist device

Also Published As

Publication number Publication date
JPS6112678B2 (en) 1986-04-09

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