JPS5661395A - Piperazinylalkylphosphonic acid derivative - Google Patents
Piperazinylalkylphosphonic acid derivativeInfo
- Publication number
- JPS5661395A JPS5661395A JP13707079A JP13707079A JPS5661395A JP S5661395 A JPS5661395 A JP S5661395A JP 13707079 A JP13707079 A JP 13707079A JP 13707079 A JP13707079 A JP 13707079A JP S5661395 A JPS5661395 A JP S5661395A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- solvent
- piperazinylalkylphosphonic
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled derivative expressed by formula I [B is 1W4C lower alkylene when A is alanyl group expressed by formula II, and B is lower α-propionylaminoalkylene expressed by formula III (Y is 1W4C lower alkylene) when A is H or lower alkyl].
EXAMPLE: 4-Alanylpiperazinylmethylphosphonic acid.
USE: A raw material for a medicine having an antimicrobial action.
PROCESS: A piperazine derivative, e.g. alanylpiperazine, is reacted with a phosphonic ester, e.g. dibenzyl phosphite, and an aldehyde or ketone, e.g. formalin, under heating in a solvent, e.g. benzene. After the reaction, the solvent is distilled off, and the residue is purified by gel column chromatography to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13707079A JPS5661395A (en) | 1979-10-25 | 1979-10-25 | Piperazinylalkylphosphonic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13707079A JPS5661395A (en) | 1979-10-25 | 1979-10-25 | Piperazinylalkylphosphonic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5661395A true JPS5661395A (en) | 1981-05-26 |
Family
ID=15190190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13707079A Pending JPS5661395A (en) | 1979-10-25 | 1979-10-25 | Piperazinylalkylphosphonic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5661395A (en) |
-
1979
- 1979-10-25 JP JP13707079A patent/JPS5661395A/en active Pending
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