JPS56166180A - Dibenzoxazepine derivative and its preparation - Google Patents

Dibenzoxazepine derivative and its preparation

Info

Publication number
JPS56166180A
JPS56166180A JP7017680A JP7017680A JPS56166180A JP S56166180 A JPS56166180 A JP S56166180A JP 7017680 A JP7017680 A JP 7017680A JP 7017680 A JP7017680 A JP 7017680A JP S56166180 A JPS56166180 A JP S56166180A
Authority
JP
Japan
Prior art keywords
formula
lower alkyl
compound shown
actions
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7017680A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0223550B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Kazuo Sasahara
Narimitsu Honda
Masuo Koizumi
Yasushi Murakami
Tomohiro Neichi
Hiroshi Nakakimura
Yukifumi Noda
Koji Matsushita
Shunichi Hata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP7017680A priority Critical patent/JPS56166180A/ja
Priority to IL62894A priority patent/IL62894A/xx
Priority to ZA00813385A priority patent/ZA813385B/xx
Priority to KR1019810001793A priority patent/KR850000212B1/ko
Priority to DE8181104100T priority patent/DE3162614D1/de
Priority to HU811589A priority patent/HU183456B/hu
Priority to AT81104100T priority patent/ATE6645T1/de
Priority to CA000378457A priority patent/CA1162189A/en
Priority to EP81104100A priority patent/EP0040860B1/en
Priority to MX187533A priority patent/MX157054A/es
Publication of JPS56166180A publication Critical patent/JPS56166180A/ja
Priority to US06/354,651 priority patent/US4435391A/en
Publication of JPH0223550B2 publication Critical patent/JPH0223550B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP7017680A 1980-05-28 1980-05-28 Dibenzoxazepine derivative and its preparation Granted JPS56166180A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP7017680A JPS56166180A (en) 1980-05-28 1980-05-28 Dibenzoxazepine derivative and its preparation
IL62894A IL62894A (en) 1980-05-28 1981-05-18 Dibenzoxazepine derivatives,process for preparing the same and pharmaceutical compositions comprising the same
ZA00813385A ZA813385B (en) 1980-05-28 1981-05-20 Dibenzoxazepine derivative,process for preparing the same,and pharmaceutical composition comprising the same
KR1019810001793A KR850000212B1 (ko) 1980-05-28 1981-05-23 디벤조옥사제핀 유도체의 제법
HU811589A HU183456B (en) 1980-05-28 1981-05-27 Process for preparing dibenzoxazepines and pharmaceutical compositions containing thereof
DE8181104100T DE3162614D1 (en) 1980-05-28 1981-05-27 Dibenzoxazepine derivative, process for preparing the same and pharmaceutical composition comprising the same
AT81104100T ATE6645T1 (de) 1980-05-28 1981-05-27 Dibenzoxazepin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
CA000378457A CA1162189A (en) 1980-05-28 1981-05-27 Dibenzoxazepine derivative, process for preparing the same, and pharmaceutical composition comprising the same
EP81104100A EP0040860B1 (en) 1980-05-28 1981-05-27 Dibenzoxazepine derivative, process for preparing the same and pharmaceutical composition comprising the same
MX187533A MX157054A (es) 1980-05-28 1981-05-28 Procedimiento para preparar derivados de disenzoxazepina
US06/354,651 US4435391A (en) 1980-05-28 1982-03-04 Dibenzoxazepine derivative, and pharmaceutical composition comprising the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7017680A JPS56166180A (en) 1980-05-28 1980-05-28 Dibenzoxazepine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56166180A true JPS56166180A (en) 1981-12-21
JPH0223550B2 JPH0223550B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-05-24

Family

ID=13423954

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7017680A Granted JPS56166180A (en) 1980-05-28 1980-05-28 Dibenzoxazepine derivative and its preparation

Country Status (11)

Country Link
US (1) US4435391A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0040860B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS56166180A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR850000212B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE6645T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1162189A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3162614D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU183456B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL62894A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX157054A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA813385B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033983A1 (fr) * 1995-04-25 1996-10-31 Daiichi Radioisotope Laboratories, Ltd. Derives n-oxyde de dibenzoxazepine et medicament les contenant en tant que principe actif
JP2001072659A (ja) * 1998-11-30 2001-03-21 Toray Ind Inc ピロリジン誘導体の製造法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240721A3 (en) * 1986-03-12 1991-01-02 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for the treatment of peripheral circulatory disorders
JP3328673B2 (ja) * 1994-09-28 2002-09-30 日本水産株式会社 抗酸化性新規三環性縮合複素環化合物
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AU2006206611A1 (en) * 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
US7714002B2 (en) * 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
ATE485269T1 (de) * 2005-06-27 2010-11-15 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
ATE502924T1 (de) * 2005-06-27 2011-04-15 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden
MX2007016501A (es) * 2005-06-27 2008-03-06 Squibb Bristol Myers Co Antagonistas heterociclicos n-enlazados del receptor de p2y1, utiles en el tratamiento de condiciones tromboticas.
US20080090805A1 (en) * 2005-10-17 2008-04-17 Acadia Pharmaceuticals Inc. Cb-1 modulating compounds and their use
CA2625423A1 (en) * 2005-10-17 2007-04-26 Acadia Pharmaceuticals Inc. Cb-1 modulating compounds and their use
US7960569B2 (en) * 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
KR101598558B1 (ko) * 2007-12-05 2016-02-29 얀센 파마슈티카 엔.브이. 디벤조아제핀 및 디벤조옥사제핀 ｔｒｐａ1 효능제
US11649218B2 (en) * 2018-03-09 2023-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH473141A (de) 1965-12-30 1969-05-31 Wander Ag Dr A Verfahren zur Herstellung 11-aminoalkylierter Dibenz(b,f)-1,4-oxazepine und Dibenzo(b,f)-1,4-thiazepine
US3646009A (en) 1967-03-15 1972-02-29 Boehringer & Soehne Gmbh Anti-diabetically active sulfonyl-semicarbazides
US3458516A (en) 1968-02-16 1969-07-29 American Cyanamid Co 11-(piperazinyl)dibenz(b,f)(1,4)oxazepines and analogous thiazepines
DE2014223A1 (de) 1969-03-28 1970-10-01 Sumitomo Chemical Company Ltd., Osaka (Japan) Benzoxazepin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JPS5576869A (en) 1978-12-06 1980-06-10 Chugai Pharmaceut Co Ltd Dibenzoxazepine derivative and its preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033983A1 (fr) * 1995-04-25 1996-10-31 Daiichi Radioisotope Laboratories, Ltd. Derives n-oxyde de dibenzoxazepine et medicament les contenant en tant que principe actif
JP2001072659A (ja) * 1998-11-30 2001-03-21 Toray Ind Inc ピロリジン誘導体の製造法

Also Published As

Publication number Publication date
ATE6645T1 (de) 1984-03-15
CA1162189A (en) 1984-02-14
KR830006249A (ko) 1983-09-20
ZA813385B (en) 1982-06-30
EP0040860A1 (en) 1981-12-02
HU183456B (en) 1984-05-28
EP0040860B1 (en) 1984-03-14
IL62894A0 (en) 1981-07-31
DE3162614D1 (en) 1984-04-19
KR850000212B1 (ko) 1985-03-06
IL62894A (en) 1984-10-31
MX157054A (es) 1988-10-24
US4435391A (en) 1984-03-06
JPH0223550B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-05-24

Similar Documents

Publication Publication Date Title
JPS56166180A (en) Dibenzoxazepine derivative and its preparation
FR2360587A1 (fr) Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments
FR2378521A1 (fr) Derives du carbostyrile, utiles notamment comme stimulants des centres b- adrenorecepteurs, et leur procede de preparation
FR2374301A1 (fr) Nouveaux acides phenylalkylcarbohydroxamiques substitues sur le noyau phenyle, utiles comme medicaments inhibant l'agglutination des plaquettes sanguines
FR2393793A1 (fr) Derives de dichloro-3,3 azetidinones-2 a substituants basiques, leur procede de preparation et leur utilisation comme medicaments anti-inflammatoires
IE38763B1 (en) (54)nitrile-substituted o-ethyl-s-n-propyl-o-vinyl-thionothiolsphosphoric acid esters, a process for their preparation and their use as insecticides or acaricides
FR2377382A1 (fr) Nouveaux phenylazacycloalcanes utiles comme medicaments
JPS5735576A (en) 4,1-benzoxazepin-3-acetic derivative and its production
JPS5246095A (en) Preparation of novel thienopyrimidine derivatives
JPS57188587A (en) Thienyloxazolylacetic acid derivative and its preparation
FR2373541A1 (fr) Nouveaux derives sulfamoyl de la 8b-aminomethylergoline utiles notamment comme antagonistes de la serotonine et leur procede de preparation
JPS572279A (en) Dibenzoxazepin derivative
JPS54125660A (en) Oxazole- and thiazolealkanoic acid derivative, its salt and their preparation
JPS5711981A (en) Theobromine derivative and its preparation
JPS57212188A (en) Imidazobenzoxazine derivative and its preparation
JPS5527142A (en) Novel 1-phthalazone derivative
JPS54125659A (en) Oxazolealkanoic acid derivative, its salt and their preparation
JPS5412348A (en) Cyclopropane carboxylic acid esters, their preparation, and insecticides and acaricides comprising them as active constituents
JPS5679668A (en) 1,4-dihydro-4-oxonicotinic acid derivatice and its preparation
FR2360588A1 (fr) Nouveaux composes 1,2-alkyleneoxy-benzemiques, leur preparation et leur application comme medicaments
JPS54144398A (en) Imidazoquinoline derivative and antibacterial agent containing the same
JPS5583786A (en) Diazepine derivative and its preparation
JPS5657783A (en) Gamma-valerolactone derivative
JPS5432437A (en) 2-thio-2-(3-phenoxyphenyl)alkane-carboxylic acid derivatives and their preparation
JPS5283457A (en) Preparation of gamma-lactone derivative