JPS5616463A - Alpha-thio-alpha-aryl substituted alkanonitrile - Google Patents
Alpha-thio-alpha-aryl substituted alkanonitrileInfo
- Publication number
- JPS5616463A JPS5616463A JP9095979A JP9095979A JPS5616463A JP S5616463 A JPS5616463 A JP S5616463A JP 9095979 A JP9095979 A JP 9095979A JP 9095979 A JP9095979 A JP 9095979A JP S5616463 A JPS5616463 A JP S5616463A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alpha
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Compounds of formula I and II (Ar is aromatic group; R3 is alkyl; R1 is alkyl, aryl; Y is O, carbonyl).
EXAMPLE: α-(p-tolylthio)(m-phenoxyphenyl)acetonitrile.
USE: Synthetic intermediates of compounds having anti-inflammatory, analgesic and antipyretic activities.
PREPARATION: An alkali cyanide such as potassium cyanide and a sulfonic acid chloride of formula R2SO2Cl (R2 is lower alkyl, aryl) such as p-toluenesulfonyl chloride are made to act on a compound of formula III to give a compound of formula IV where equimolar amounts of starting materials are used and water is employed as a solvent. The reaction temperature is -15°C to room temperature. Then, the compound of formula IV is made to react with a thiol of R1SH in the presence of an equimolar amount of a base such as sodium hydroxide at -20°C to room temperature to form the compound of formula I. An alkylating agent is made to act on the compound of formula I in the presence of a base to give the compound of formula II.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9095979A JPS6059906B2 (en) | 1979-07-19 | 1979-07-19 | α-thio-α-aryl group-substituted alkanonitrile |
US06/169,193 US4340740A (en) | 1979-07-16 | 1980-07-15 | Alpha-thio-alpha-aryl-substituted alkanonitrile and process for preparing alpha-aryl-substituted alkanonitrile therefrom |
AT80302375T ATE4895T1 (en) | 1979-07-16 | 1980-07-15 | ALPHA-THIO-ALPHA-ARYL-SUBSTITUTED ALKANNITRILES, PROCESS FOR THEIR PREPARATION, PROCESS FOR THE PREPARATION OF ALPHA-ARYL-SUBSTITUTED ALKONENITRILES AND THEIR CORRESPONDING CARBONIC ACIDS, AND PROCESS FOR THE PREPARATION OF INTERMEDIATE PRODUCTS. |
EP80302375A EP0025262B1 (en) | 1979-07-16 | 1980-07-15 | Alpha-thio-alpha-aryl-substituted alkanonitriles, process for their preparation, process for preparing alpha-aryl-substituted alkanonitriles and the corresponding carboxylic acids therefrom and process for preparing intermediates |
DE8080302375T DE3065155D1 (en) | 1979-07-16 | 1980-07-15 | Alpha-thio-alpha-aryl-substituted alkanonitriles, process for their preparation, process for preparing alpha-aryl-substituted alkanonitriles and the corresponding carboxylic acids therefrom and process for preparing intermediates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9095979A JPS6059906B2 (en) | 1979-07-19 | 1979-07-19 | α-thio-α-aryl group-substituted alkanonitrile |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5616463A true JPS5616463A (en) | 1981-02-17 |
JPS6059906B2 JPS6059906B2 (en) | 1985-12-27 |
Family
ID=14013022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9095979A Expired JPS6059906B2 (en) | 1979-07-16 | 1979-07-19 | α-thio-α-aryl group-substituted alkanonitrile |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6059906B2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0453528Y2 (en) * | 1985-11-22 | 1992-12-16 | ||
JPH0514168Y2 (en) * | 1986-02-26 | 1993-04-15 | ||
EP0339046B1 (en) * | 1986-12-29 | 1995-02-15 | The Upjohn Company | Leukotriene b 4 analogs |
JPS6443714A (en) * | 1987-08-10 | 1989-02-16 | Furuno Electric Co | Inclinometer |
JPH0453529Y2 (en) * | 1987-10-26 | 1992-12-16 | ||
JPH0511453Y2 (en) * | 1987-12-04 | 1993-03-22 |
-
1979
- 1979-07-19 JP JP9095979A patent/JPS6059906B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6059906B2 (en) | 1985-12-27 |
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