JPS5616463A - Alpha-thio-alpha-aryl substituted alkanonitrile - Google Patents

Alpha-thio-alpha-aryl substituted alkanonitrile

Info

Publication number
JPS5616463A
JPS5616463A JP9095979A JP9095979A JPS5616463A JP S5616463 A JPS5616463 A JP S5616463A JP 9095979 A JP9095979 A JP 9095979A JP 9095979 A JP9095979 A JP 9095979A JP S5616463 A JPS5616463 A JP S5616463A
Authority
JP
Japan
Prior art keywords
formula
compound
alpha
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9095979A
Other languages
Japanese (ja)
Other versions
JPS6059906B2 (en
Inventor
Genichi Dobashi
Shuichi Mitamura
Katsuyuki Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP9095979A priority Critical patent/JPS6059906B2/en
Priority to US06/169,193 priority patent/US4340740A/en
Priority to AT80302375T priority patent/ATE4895T1/en
Priority to EP80302375A priority patent/EP0025262B1/en
Priority to DE8080302375T priority patent/DE3065155D1/en
Publication of JPS5616463A publication Critical patent/JPS5616463A/en
Publication of JPS6059906B2 publication Critical patent/JPS6059906B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:Compounds of formula I and II (Ar is aromatic group; R3 is alkyl; R1 is alkyl, aryl; Y is O, carbonyl).
EXAMPLE: α-(p-tolylthio)(m-phenoxyphenyl)acetonitrile.
USE: Synthetic intermediates of compounds having anti-inflammatory, analgesic and antipyretic activities.
PREPARATION: An alkali cyanide such as potassium cyanide and a sulfonic acid chloride of formula R2SO2Cl (R2 is lower alkyl, aryl) such as p-toluenesulfonyl chloride are made to act on a compound of formula III to give a compound of formula IV where equimolar amounts of starting materials are used and water is employed as a solvent. The reaction temperature is -15°C to room temperature. Then, the compound of formula IV is made to react with a thiol of R1SH in the presence of an equimolar amount of a base such as sodium hydroxide at -20°C to room temperature to form the compound of formula I. An alkylating agent is made to act on the compound of formula I in the presence of a base to give the compound of formula II.
COPYRIGHT: (C)1981,JPO&Japio
JP9095979A 1979-07-16 1979-07-19 α-thio-α-aryl group-substituted alkanonitrile Expired JPS6059906B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP9095979A JPS6059906B2 (en) 1979-07-19 1979-07-19 α-thio-α-aryl group-substituted alkanonitrile
US06/169,193 US4340740A (en) 1979-07-16 1980-07-15 Alpha-thio-alpha-aryl-substituted alkanonitrile and process for preparing alpha-aryl-substituted alkanonitrile therefrom
AT80302375T ATE4895T1 (en) 1979-07-16 1980-07-15 ALPHA-THIO-ALPHA-ARYL-SUBSTITUTED ALKANNITRILES, PROCESS FOR THEIR PREPARATION, PROCESS FOR THE PREPARATION OF ALPHA-ARYL-SUBSTITUTED ALKONENITRILES AND THEIR CORRESPONDING CARBONIC ACIDS, AND PROCESS FOR THE PREPARATION OF INTERMEDIATE PRODUCTS.
EP80302375A EP0025262B1 (en) 1979-07-16 1980-07-15 Alpha-thio-alpha-aryl-substituted alkanonitriles, process for their preparation, process for preparing alpha-aryl-substituted alkanonitriles and the corresponding carboxylic acids therefrom and process for preparing intermediates
DE8080302375T DE3065155D1 (en) 1979-07-16 1980-07-15 Alpha-thio-alpha-aryl-substituted alkanonitriles, process for their preparation, process for preparing alpha-aryl-substituted alkanonitriles and the corresponding carboxylic acids therefrom and process for preparing intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9095979A JPS6059906B2 (en) 1979-07-19 1979-07-19 α-thio-α-aryl group-substituted alkanonitrile

Publications (2)

Publication Number Publication Date
JPS5616463A true JPS5616463A (en) 1981-02-17
JPS6059906B2 JPS6059906B2 (en) 1985-12-27

Family

ID=14013022

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9095979A Expired JPS6059906B2 (en) 1979-07-16 1979-07-19 α-thio-α-aryl group-substituted alkanonitrile

Country Status (1)

Country Link
JP (1) JPS6059906B2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0453528Y2 (en) * 1985-11-22 1992-12-16
JPH0514168Y2 (en) * 1986-02-26 1993-04-15
EP0339046B1 (en) * 1986-12-29 1995-02-15 The Upjohn Company Leukotriene b 4 analogs
JPS6443714A (en) * 1987-08-10 1989-02-16 Furuno Electric Co Inclinometer
JPH0453529Y2 (en) * 1987-10-26 1992-12-16
JPH0511453Y2 (en) * 1987-12-04 1993-03-22

Also Published As

Publication number Publication date
JPS6059906B2 (en) 1985-12-27

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