JPS56152440A - Preparation of farnesylmalonic acid diester - Google Patents

Preparation of farnesylmalonic acid diester

Info

Publication number
JPS56152440A
JPS56152440A JP5429980A JP5429980A JPS56152440A JP S56152440 A JPS56152440 A JP S56152440A JP 5429980 A JP5429980 A JP 5429980A JP 5429980 A JP5429980 A JP 5429980A JP S56152440 A JPS56152440 A JP S56152440A
Authority
JP
Japan
Prior art keywords
compound
formula
reaction
acid diester
farnesylmalonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5429980A
Other languages
Japanese (ja)
Inventor
Shoichi Kinoshita
Yoshitomo Yonehara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kawamura Institute of Chemical Research
DIC Corp
Original Assignee
Kawamura Institute of Chemical Research
Dainippon Ink and Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawamura Institute of Chemical Research, Dainippon Ink and Chemicals Co Ltd filed Critical Kawamura Institute of Chemical Research
Priority to JP5429980A priority Critical patent/JPS56152440A/en
Publication of JPS56152440A publication Critical patent/JPS56152440A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the high purity titled compound in high yield, by the reaction of a malonic acid diester and a halogenated farnesyl in a nonpolar solvent in the presence of hexamethylphosphoric triamide and a condensation agent under efficient agitation.
CONSTITUTION: A compound of formula IV is obtained by reaction of a compound of formula I (R1 and R2 are alkyl or alkenyl) with a compound of formula II (R is group of formula III, X is halogen) in a nonpolar solvent in the presence of hexamethylphosphoric triamide (HMPT) and a condensation agent (e.g. Na). HMPT is used in an amount of 0.02W1mol/1mol of the compound of formula I. The reaction is carried out at 70W100°C for about 5hr.
USE: Useful as an intermediate of pharmaceuticals, esp. geranyl farnesylacetate having strong antiulcerative activity.
COPYRIGHT: (C)1981,JPO&Japio
JP5429980A 1980-04-25 1980-04-25 Preparation of farnesylmalonic acid diester Pending JPS56152440A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5429980A JPS56152440A (en) 1980-04-25 1980-04-25 Preparation of farnesylmalonic acid diester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5429980A JPS56152440A (en) 1980-04-25 1980-04-25 Preparation of farnesylmalonic acid diester

Publications (1)

Publication Number Publication Date
JPS56152440A true JPS56152440A (en) 1981-11-26

Family

ID=12966682

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5429980A Pending JPS56152440A (en) 1980-04-25 1980-04-25 Preparation of farnesylmalonic acid diester

Country Status (1)

Country Link
JP (1) JPS56152440A (en)

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