JPS56152440A - Preparation of farnesylmalonic acid diester - Google Patents
Preparation of farnesylmalonic acid diesterInfo
- Publication number
- JPS56152440A JPS56152440A JP5429980A JP5429980A JPS56152440A JP S56152440 A JPS56152440 A JP S56152440A JP 5429980 A JP5429980 A JP 5429980A JP 5429980 A JP5429980 A JP 5429980A JP S56152440 A JPS56152440 A JP S56152440A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reaction
- acid diester
- farnesylmalonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the high purity titled compound in high yield, by the reaction of a malonic acid diester and a halogenated farnesyl in a nonpolar solvent in the presence of hexamethylphosphoric triamide and a condensation agent under efficient agitation.
CONSTITUTION: A compound of formula IV is obtained by reaction of a compound of formula I (R1 and R2 are alkyl or alkenyl) with a compound of formula II (R is group of formula III, X is halogen) in a nonpolar solvent in the presence of hexamethylphosphoric triamide (HMPT) and a condensation agent (e.g. Na). HMPT is used in an amount of 0.02W1mol/1mol of the compound of formula I. The reaction is carried out at 70W100°C for about 5hr.
USE: Useful as an intermediate of pharmaceuticals, esp. geranyl farnesylacetate having strong antiulcerative activity.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5429980A JPS56152440A (en) | 1980-04-25 | 1980-04-25 | Preparation of farnesylmalonic acid diester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5429980A JPS56152440A (en) | 1980-04-25 | 1980-04-25 | Preparation of farnesylmalonic acid diester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56152440A true JPS56152440A (en) | 1981-11-26 |
Family
ID=12966682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5429980A Pending JPS56152440A (en) | 1980-04-25 | 1980-04-25 | Preparation of farnesylmalonic acid diester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56152440A (en) |
-
1980
- 1980-04-25 JP JP5429980A patent/JPS56152440A/en active Pending
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