JPS56133299A - Manufacture of oligonucleotide - Google Patents

Manufacture of oligonucleotide

Info

Publication number
JPS56133299A
JPS56133299A JP2927281A JP2927281A JPS56133299A JP S56133299 A JPS56133299 A JP S56133299A JP 2927281 A JP2927281 A JP 2927281A JP 2927281 A JP2927281 A JP 2927281A JP S56133299 A JPS56133299 A JP S56133299A
Authority
JP
Japan
Prior art keywords
nucleoside
polymer
modified
inorganic polymer
inorganic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2927281A
Other languages
English (en)
Inventor
Eichi Karuzaasu Maabin
Deii Mateutsuchi Maaku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Patents Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of JPS56133299A publication Critical patent/JPS56133299A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
JP2927281A 1980-02-29 1981-02-28 Manufacture of oligonucleotide Pending JPS56133299A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12602580A 1980-02-29 1980-02-29

Publications (1)

Publication Number Publication Date
JPS56133299A true JPS56133299A (en) 1981-10-19

Family

ID=22422602

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2927381A Granted JPS56138199A (en) 1980-02-29 1981-02-28 Polynucleotide synthesizing supporter and method of manufacturing and using same
JP2927281A Pending JPS56133299A (en) 1980-02-29 1981-02-28 Manufacture of oligonucleotide
JP63009782A Granted JPS63225395A (ja) 1980-02-29 1988-01-21 ポリヌクレオチド合成用支持体
JP1310496A Pending JPH0327395A (ja) 1980-02-29 1989-11-29 ポリヌクレオチド合成用支持体の製造方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2927381A Granted JPS56138199A (en) 1980-02-29 1981-02-28 Polynucleotide synthesizing supporter and method of manufacturing and using same

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP63009782A Granted JPS63225395A (ja) 1980-02-29 1988-01-21 ポリヌクレオチド合成用支持体
JP1310496A Pending JPH0327395A (ja) 1980-02-29 1989-11-29 ポリヌクレオチド合成用支持体の製造方法

Country Status (7)

Country Link
EP (4) EP0035255B1 (ja)
JP (4) JPS56138199A (ja)
AT (2) ATE7702T1 (ja)
AU (2) AU542967B2 (ja)
CA (2) CA1159052A (ja)
DE (2) DE3163811D1 (ja)
MX (1) MX158743A (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA821534B (en) * 1981-03-10 1984-04-25 Bioresearch Inc Rapid solid phase synthesis of olignucleotides using phosphorus oxychloride activation
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
JPS58148896A (ja) * 1982-02-26 1983-09-05 Shimadzu Corp Ｄｎａ等微量自動合成装置
DE3208565A1 (de) * 1982-03-10 1983-11-10 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur abspaltung von tritylschutzgruppen
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
US4474948A (en) * 1982-04-08 1984-10-02 Biosearch Benzazolides and their employment in phosphite ester oligonucleotide synthesis processes
IL69196A0 (en) * 1982-08-20 1983-11-30 Genex Corp Solid phase synthesis of oligonucleotides
WO1984002526A1 (en) * 1982-12-29 1984-07-05 Univ Southern Illinois Process for producing polynucleotides
FR2544720B1 (fr) * 1983-04-19 1987-11-27 California Inst Of Techn Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
DE3329892A1 (de) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US5539097A (en) * 1983-09-02 1996-07-23 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
JPS61152695A (ja) * 1984-12-26 1986-07-11 Nippon Shinyaku Co Ltd 長鎖ｄｎａの合成法
US4818681A (en) * 1985-02-22 1989-04-04 Molecular Diagnostics, Inc. Fast and specific immobilization of nucleic acids to solid supports
EP0229053A1 (en) * 1985-06-14 1987-07-22 University Patents, Inc. Method for synthesizing deoxyoligonucleotides
FR2596761B1 (fr) * 1986-04-08 1988-05-20 Commissariat Energie Atomique Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
US5071974A (en) * 1986-10-31 1991-12-10 Amoco Corporation Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
DE3801987A1 (de) * 1988-01-23 1989-07-27 Boehringer Mannheim Gmbh Traeger zur chemischen oder/und enzymatischen umsetzung von nukleinsaeuren oder nukleinsaeurefragmenten an festphasen
SE9003743D0 (sv) * 1990-11-26 1990-11-26 Pharmacia Ab Method and means for oligonucleotide synthesis
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5503816A (en) * 1993-09-27 1996-04-02 Becton Dickinson And Company Silicate compounds for DNA purification
FR2714061B1 (fr) 1993-12-16 1996-03-08 Genset Sa Procédé de préparation de polynucléotides sur support solide et appareil permettant sa mise en Óoeuvre.
US5874554A (en) * 1996-12-13 1999-02-23 Incyte Pharmaceuticals, Inc. Methods and solvent vehicles for reagent delivery in oligonucleotide synthesis using automated pulse jetting devices
DE69825722T2 (de) * 1998-02-04 2005-08-25 Corning Inc. Substrat zum Drucken einer Matrize
US6399765B1 (en) * 1999-03-17 2002-06-04 Isis Pharmaceuticals, Inc. Methods for removing dimethoxytrityl groups from oligonucleotides
EP1303529B1 (de) * 1999-11-10 2005-10-26 Merckle Gmbh Verfahren und vorrichtung zur herstellung von oligomeren und arrays von oligomeren sowie die verwendung der vorrichtung
JP2004508379A (ja) * 2000-09-07 2004-03-18 アベシア・バイオテクノロジー・インコーポレーテッド オリゴヌクレオチド合成用のシントン
KR101137736B1 (ko) 2004-09-30 2012-04-24 각코호진 와세다다이가쿠 반도체 센싱용 전계 효과형 트랜지스터, 반도체 센싱디바이스, 반도체 센서 칩 및 반도체 센싱 장치
US7396676B2 (en) 2005-05-31 2008-07-08 Agilent Technologies, Inc. Evanescent wave sensor with attached ligand
EP1896455A2 (en) * 2005-06-06 2008-03-12 Medichem, S.A. Process for the preparation of tetrazolyl compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1113937B (de) * 1959-11-13 1961-09-21 Shell Int Research Verfahren zur Herstellung von heterocyclischen Amiden der Phosphorsaeure
US3557077A (en) * 1967-09-18 1971-01-19 Kay Brunfeldt Reactions system
US3531258A (en) * 1967-11-16 1970-09-29 Us Health Education & Welfare Apparatus for the automated synthesis of peptides
IL62834A0 (en) * 1980-05-14 1981-07-31 Ens Bio Logicals Inc Polynucleotide synthesis
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes

Also Published As

Publication number Publication date
EP0173356B1 (en) 1990-09-19
ATE7702T1 (de) 1984-06-15
DE3163811D1 (en) 1984-07-05
JPH0327395A (ja) 1991-02-05
EP0035255A1 (en) 1981-09-09
EP0035719B1 (en) 1989-09-20
JPS56138199A (en) 1981-10-28
EP0035719A2 (en) 1981-09-16
EP0097805A2 (en) 1984-01-11
AU550148B2 (en) 1986-03-06
EP0173356A3 (en) 1987-01-14
JPS63225395A (ja) 1988-09-20
CA1159052A (en) 1983-12-20
MX158743A (es) 1989-03-10
AU6794281A (en) 1981-09-03
EP0097805A3 (en) 1984-02-22
EP0173356A2 (en) 1986-03-05
EP0035719A3 (en) 1981-11-18
AU542967B2 (en) 1985-03-28
AU6794381A (en) 1981-09-03
EP0035255B1 (en) 1984-05-30
DE3177215D1 (de) 1990-10-25
ATE56723T1 (de) 1990-10-15
JPH0259158B2 (ja) 1990-12-11
CA1168229A (en) 1984-05-29
JPS6330316B2 (ja) 1988-06-17

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