ZA821534B - Rapid solid phase synthesis of olignucleotides using phosphorus oxychloride activation - Google Patents

Rapid solid phase synthesis of olignucleotides using phosphorus oxychloride activation

Info

Publication number
ZA821534B
ZA821534B ZA821534A ZA821534A ZA821534B ZA 821534 B ZA821534 B ZA 821534B ZA 821534 A ZA821534 A ZA 821534A ZA 821534 A ZA821534 A ZA 821534A ZA 821534 B ZA821534 B ZA 821534B
Authority
ZA
South Africa
Prior art keywords
olignucleotides
activation
solid phase
phase synthesis
phosphorus oxychloride
Prior art date
Application number
ZA821534A
Inventor
Michael S Verlander
William Dean Fuller
Murray Goodman
Original Assignee
Bioresearch Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Inc filed Critical Bioresearch Inc
Publication of ZA821534B publication Critical patent/ZA821534B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
ZA821534A 1981-03-10 1982-03-09 Rapid solid phase synthesis of olignucleotides using phosphorus oxychloride activation ZA821534B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24223181A 1981-03-10 1981-03-10

Publications (1)

Publication Number Publication Date
ZA821534B true ZA821534B (en) 1984-04-25

Family

ID=22913966

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA821534A ZA821534B (en) 1981-03-10 1982-03-09 Rapid solid phase synthesis of olignucleotides using phosphorus oxychloride activation

Country Status (3)

Country Link
EP (1) EP0073826A1 (en)
WO (1) WO1982003079A1 (en)
ZA (1) ZA821534B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539097A (en) * 1983-09-02 1996-07-23 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
US4507433A (en) * 1983-10-07 1985-03-26 The Johns Hopkins University Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates
JPS62265299A (en) * 1985-12-18 1987-11-18 Senjiyu Seiyaku Kk Production of alpha-tocopherol, uridinephosphoric acid diester and halogen-substituted compound thereof or their salt
US5047524A (en) * 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5262530A (en) * 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
WO1994001446A2 (en) * 1992-07-09 1994-01-20 Beckman Instruments, Inc. Derivatized organic solid support for nucleic acid synthesis
FR2714061B1 (en) * 1993-12-16 1996-03-08 Genset Sa Process for the preparation of polynucleotides on solid support and apparatus allowing its implementation.
US6469157B1 (en) 1993-12-16 2002-10-22 Proligo Llc Process for preparing polynucleotides on a solid support

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288780A (en) * 1962-01-30 1966-11-29 Ajinomoto Kk Process for preparing 5'-ribonucleotides
GB1157275A (en) * 1965-07-27 1969-07-02 Takeda Chemical Industries Ltd A Method for the Production of 5'-Ribonucleotide
US3466273A (en) * 1966-12-16 1969-09-09 Asahi Chemical Ind Process for producing nucleotide by a selective phosphorylation
CA1159052A (en) * 1980-02-29 1983-12-20 University Patents, Inc. Process for making oligonucleotides

Also Published As

Publication number Publication date
WO1982003079A1 (en) 1982-09-16
EP0073826A1 (en) 1983-03-16

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