JPS5612391A - Novel camptothecin derivative and its preparaion - Google Patents
Novel camptothecin derivative and its preparaionInfo
- Publication number
- JPS5612391A JPS5612391A JP8641079A JP8641079A JPS5612391A JP S5612391 A JPS5612391 A JP S5612391A JP 8641079 A JP8641079 A JP 8641079A JP 8641079 A JP8641079 A JP 8641079A JP S5612391 A JPS5612391 A JP S5612391A
- Authority
- JP
- Japan
- Prior art keywords
- preparaion
- camptothecin derivative
- peroxide
- formula
- novel camptothecin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- -1 potassium persulfate Chemical compound 0.000 abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 150000002978 peroxides Chemical class 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- HPDRGGNSEBLDKL-NRFANRHFSA-N ac1l3zgz Chemical compound C1=CC=C2C(CO)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HPDRGGNSEBLDKL-NRFANRHFSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003999 initiator Substances 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000001455 metallic ions Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 abstract 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 abstract 1
- 238000007348 radical reaction Methods 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8641079A JPS5612391A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparaion |
| US06/166,953 US4399282A (en) | 1979-07-10 | 1980-07-08 | Camptothecin derivatives |
| GB8022438A GB2056973B (en) | 1979-07-10 | 1980-07-09 | Camptothecin derivatives useful as antitumour agents |
| CH5265/80A CH648316A5 (de) | 1979-07-10 | 1980-07-09 | Camptothecinderivate und verfahren zu ihrer herstellung. |
| IT23348/80A IT1199976B (it) | 1979-07-10 | 1980-07-09 | Derivati della camptotecima e processi per la loro preparazione |
| AU60273/80A AU536181B2 (en) | 1979-07-10 | 1980-07-09 | Derivatives of camptothecin |
| DE19803026172 DE3026172A1 (de) | 1979-07-10 | 1980-07-10 | Camptothecinderivate und ihre herstellung |
| FR8015418A FR2462437A1 (fr) | 1979-07-10 | 1980-07-10 | Nouveaux derives de la camptothecine doues d'activite antitumorale et leur procede de preparation |
| ES493287A ES493287A0 (es) | 1979-07-10 | 1980-07-10 | Un procedimiento para la preparacion de derivados de campto tecina. |
| NLAANVRAGE8003988,A NL188219C (nl) | 1979-07-10 | 1980-07-10 | Camptothecinederivaten, werkwijze voor het bereiden daarvan, farmaceutische preparaten met anti-tumorwerking, werkwijze voor het bereiden daarvan. |
| AR281720A AR228575A1 (es) | 1979-07-10 | 1980-07-10 | Procedimiento para obtener derivados de 7-hidroximetil o 7-carboxicamptotecina y sus sales |
| ES499987A ES8202012A1 (es) | 1979-07-10 | 1981-03-02 | Un procedimiento para la preparacion de derivados de campto-tecina |
| ES499986A ES8202011A1 (es) | 1979-07-10 | 1981-03-02 | Un procedimiento para la preparacion de derivados de campto-tecina |
| US06/676,248 USRE32518E (en) | 1979-07-10 | 1984-11-29 | Camptothecin derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8641079A JPS5612391A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparaion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5612391A true JPS5612391A (en) | 1981-02-06 |
| JPS6242911B2 JPS6242911B2 (enrdf_load_stackoverflow) | 1987-09-10 |
Family
ID=13886088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8641079A Granted JPS5612391A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparaion |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5612391A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59227884A (ja) * | 1983-06-09 | 1984-12-21 | Yakult Honsha Co Ltd | 新規な７−ヒドロキシアルキルカンプトテシン誘導体 |
-
1979
- 1979-07-10 JP JP8641079A patent/JPS5612391A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59227884A (ja) * | 1983-06-09 | 1984-12-21 | Yakult Honsha Co Ltd | 新規な７−ヒドロキシアルキルカンプトテシン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6242911B2 (enrdf_load_stackoverflow) | 1987-09-10 |
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