JPS5610134A - Preparation of di-n-propylmalonic acid - Google Patents

Preparation of di-n-propylmalonic acid

Info

Publication number
JPS5610134A
JPS5610134A JP8525479A JP8525479A JPS5610134A JP S5610134 A JPS5610134 A JP S5610134A JP 8525479 A JP8525479 A JP 8525479A JP 8525479 A JP8525479 A JP 8525479A JP S5610134 A JPS5610134 A JP S5610134A
Authority
JP
Japan
Prior art keywords
equivalent weight
give
high yields
malonate
dialkyl malonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8525479A
Other languages
Japanese (ja)
Inventor
Hiroshi Otaka
Yoshiaki Fujimoto
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP8525479A priority Critical patent/JPS5610134A/en
Publication of JPS5610134A publication Critical patent/JPS5610134A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain readily the titled compound in high yields useful as an intermediate for a remedy of epilepsy, by reacting a dialkyl malonate with a specific amount of an n-propyl halide and sodium alcoholate to give an intermediate in high yields, which is not isolated and hydrolyzed with water.
CONSTITUTION: A dialkyl malonate shown by the formula I (R is lower alkyl) is reacted with at least double equivalent weight, preferably 2.2W2.5 time equivalent weight based on the dialkyl malonate of a n-propyl halide and at least 4 times equivalent weight, preferably not less than 5 times equivalent weight of sodium alcoholate in a reaction medium, preferably ethanol or propanol, to give an di-n- propyldialkyl malonate, which is not isolated and hydrolyzed by adding water to the reaction system to give di-n-propylmalonic acid shown by the formula II.
EFFECT: Alkylation process is carried out in high yields and complicated the removal process of impurities becomes unnecessary.
COPYRIGHT: (C)1981,JPO&Japio
JP8525479A 1979-07-04 1979-07-04 Preparation of di-n-propylmalonic acid Pending JPS5610134A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8525479A JPS5610134A (en) 1979-07-04 1979-07-04 Preparation of di-n-propylmalonic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8525479A JPS5610134A (en) 1979-07-04 1979-07-04 Preparation of di-n-propylmalonic acid

Publications (1)

Publication Number Publication Date
JPS5610134A true JPS5610134A (en) 1981-02-02

Family

ID=13853430

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8525479A Pending JPS5610134A (en) 1979-07-04 1979-07-04 Preparation of di-n-propylmalonic acid

Country Status (1)

Country Link
JP (1) JPS5610134A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62195419U (en) * 1986-05-30 1987-12-12

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62195419U (en) * 1986-05-30 1987-12-12

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