JPS5610134A - Preparation of di-n-propylmalonic acid - Google Patents
Preparation of di-n-propylmalonic acidInfo
- Publication number
- JPS5610134A JPS5610134A JP8525479A JP8525479A JPS5610134A JP S5610134 A JPS5610134 A JP S5610134A JP 8525479 A JP8525479 A JP 8525479A JP 8525479 A JP8525479 A JP 8525479A JP S5610134 A JPS5610134 A JP S5610134A
- Authority
- JP
- Japan
- Prior art keywords
- equivalent weight
- give
- high yields
- malonate
- dialkyl malonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain readily the titled compound in high yields useful as an intermediate for a remedy of epilepsy, by reacting a dialkyl malonate with a specific amount of an n-propyl halide and sodium alcoholate to give an intermediate in high yields, which is not isolated and hydrolyzed with water.
CONSTITUTION: A dialkyl malonate shown by the formula I (R is lower alkyl) is reacted with at least double equivalent weight, preferably 2.2W2.5 time equivalent weight based on the dialkyl malonate of a n-propyl halide and at least 4 times equivalent weight, preferably not less than 5 times equivalent weight of sodium alcoholate in a reaction medium, preferably ethanol or propanol, to give an di-n- propyldialkyl malonate, which is not isolated and hydrolyzed by adding water to the reaction system to give di-n-propylmalonic acid shown by the formula II.
EFFECT: Alkylation process is carried out in high yields and complicated the removal process of impurities becomes unnecessary.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8525479A JPS5610134A (en) | 1979-07-04 | 1979-07-04 | Preparation of di-n-propylmalonic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8525479A JPS5610134A (en) | 1979-07-04 | 1979-07-04 | Preparation of di-n-propylmalonic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5610134A true JPS5610134A (en) | 1981-02-02 |
Family
ID=13853430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8525479A Pending JPS5610134A (en) | 1979-07-04 | 1979-07-04 | Preparation of di-n-propylmalonic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5610134A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62195419U (en) * | 1986-05-30 | 1987-12-12 |
-
1979
- 1979-07-04 JP JP8525479A patent/JPS5610134A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62195419U (en) * | 1986-05-30 | 1987-12-12 |
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