JPS5592385A - 1-vinyl-1,8-naphthylidine derivative and its salt - Google Patents

1-vinyl-1,8-naphthylidine derivative and its salt

Info

Publication number
JPS5592385A
JPS5592385A JP16209578A JP16209578A JPS5592385A JP S5592385 A JPS5592385 A JP S5592385A JP 16209578 A JP16209578 A JP 16209578A JP 16209578 A JP16209578 A JP 16209578A JP S5592385 A JPS5592385 A JP S5592385A
Authority
JP
Japan
Prior art keywords
compound
vinyl
salt
protecting group
naphthylidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16209578A
Other languages
Japanese (ja)
Other versions
JPS6130675B2 (en
Inventor
Junichi Matsumoto
Yoshiyuki Takase
Yoshio Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP16209578A priority Critical patent/JPS5592385A/en
Priority to AR277659A priority patent/AR223983A1/en
Priority to AU50049/79A priority patent/AU530052B2/en
Priority to YU2032/79A priority patent/YU42193B/en
Priority to DD79215122A priority patent/DD145753A5/en
Priority to US06/068,966 priority patent/US4359578A/en
Priority to MX10123879U priority patent/MX6111E/en
Priority to HU79BE1361A priority patent/HU179927B/en
Priority to EP79400587A priority patent/EP0009425B1/en
Priority to DK355679A priority patent/DK153552C/en
Priority to CA000334439A priority patent/CA1168241A/en
Priority to ES483629A priority patent/ES483629A1/en
Priority to CS795770A priority patent/CS235502B2/en
Priority to DE7979400587T priority patent/DE2961979D1/en
Priority to PL1979217926A priority patent/PL120114B1/en
Priority to NO792760A priority patent/NO153136C/en
Priority to FI792645A priority patent/FI66379C/en
Priority to PH22967A priority patent/PH14287A/en
Priority to RO79103693A priority patent/RO81939A/en
Priority to RO79103692A priority patent/RO81940A/en
Priority to RO7998656A priority patent/RO77558A/en
Priority to RO79103694A priority patent/RO81942A/en
Publication of JPS5592385A publication Critical patent/JPS5592385A/en
Priority to AR283027A priority patent/AR227529A1/en
Priority to AR283026A priority patent/AR225195A1/en
Priority to US06/264,824 priority patent/US4352803A/en
Priority to IN1487/CAL/82A priority patent/IN154878B/en
Priority to CS835364A priority patent/CS235545B2/en
Priority to YU319/85A priority patent/YU42615B/en
Priority to YU317/85A priority patent/YU42637B/en
Priority to YU318/85A priority patent/YU42614B/en
Publication of JPS6130675B2 publication Critical patent/JPS6130675B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:1-Vinyl- 6 -fluoro-1, 4-dihydro- 4 -oxo- 7 -(1-piperazinyl)-1, 8- naphthylidine-3-carboxylic acid and its salt.
USE: Antibacterial agent especially effective to gram-negative bacteria including Pseudomonas aeruginosa. Useful as medicine for man, animal, and fish, and a food preservative. Characterized by the 6-position fluorine atom.
PROCESS: The compound I is prepared either by simply heating a compound II (R1 is H or protecting group; R2 is H, lower alkyl; X, Y are H, halogen, lower alkoxy, etc.), or by heating the compound II in the presence of a catalyst such as acidic substance, acid anhydride, base, etc., usually at 50W270°C, and if necessary, hydrolyzing the product to eliminate the protecting group or the ester residue.
COPYRIGHT: (C)1980,JPO&Japio
JP16209578A 1978-08-25 1978-12-29 1-vinyl-1,8-naphthylidine derivative and its salt Granted JPS5592385A (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
JP16209578A JPS5592385A (en) 1978-12-29 1978-12-29 1-vinyl-1,8-naphthylidine derivative and its salt
AR277659A AR223983A1 (en) 1978-08-25 1979-08-09 A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES
AU50049/79A AU530052B2 (en) 1978-08-25 1979-08-17 Naphthyridine derivatives
YU2032/79A YU42193B (en) 1978-08-25 1979-08-20 Process for preparing 1,8-naphthydrine compound
DD79215122A DD145753A5 (en) 1978-08-25 1979-08-22 PROCESS FOR THE PREPARATION OF NAPHTHYRIDINE DERIVATIVES
US06/068,966 US4359578A (en) 1978-08-25 1979-08-23 Naphthyridine derivatives and salts thereof useful as antibacterial agents
MX10123879U MX6111E (en) 1978-08-25 1979-08-23 PROCEDURE FOR THE PREPARATION OF 1,8 NAFTIRIDINE DERIVATIVES
HU79BE1361A HU179927B (en) 1978-08-25 1979-08-23 Process for preparing naphthyridine derivatives
NO792760A NO153136C (en) 1978-08-25 1979-08-24 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE NAFTYRIDINE DERIVATIVES.
DK355679A DK153552C (en) 1978-08-25 1979-08-24 ANALOGY PROCEDURE FOR PREPARING 1,8-NAPHTHYRIDE INGREDIATES
CA000334439A CA1168241A (en) 1978-08-25 1979-08-24 Naphthyridine derivatives, intermediates thereof and processes for preparation thereof
ES483629A ES483629A1 (en) 1978-08-25 1979-08-24 Novel naphtyridine derivatives and pharmaceutical compositions containing them.
CS795770A CS235502B2 (en) 1978-08-25 1979-08-24 Method of 1-ethyl or vinyl-6-halogen-1-4-dihydro-4-oxo-7- (1-piperazinyl)-1,8-naphtyridin-3-carboxyl acid production
DE7979400587T DE2961979D1 (en) 1978-08-25 1979-08-24 Novel naphtyridine derivatives and pharmaceutical compositions containing them
PL1979217926A PL120114B1 (en) 1978-08-25 1979-08-24 Process for preparing novel derivatives of 1,8-naphtiridine
EP79400587A EP0009425B1 (en) 1978-08-25 1979-08-24 Novel naphtyridine derivatives and pharmaceutical compositions containing them
FI792645A FI66379C (en) 1978-08-25 1979-08-24 ANALOGIFICATION OF THERAPEUTIC ANALYSIS OF 6-HALOGEN-1,4-DIHYDRO-4-OXO-7- (1-PIPERAZINYL) -1-SUBSTITUTES 1,8-NAPHTHYRIDINE-3-CARBOXYL SYROR
PH22967A PH14287A (en) 1978-08-25 1979-08-27 Naphthyridine derivatives,pharmaceutical compositions containing same and method of treatment thereof
RO7998656A RO77558A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF NAPHTIRIDINE DERIVATIVES
RO79103694A RO81942A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF NAPHTIRIDINE DERIVATIVES
RO79103692A RO81940A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF 6-HALO-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDINE
RO79103693A RO81939A (en) 1978-12-20 1979-09-13 PROCESS FOR THE PREPARATION OF 6-HALO-4-OXO-7- (1-PYPERAZINYL) -1,8-NAPHTHYRIDINE DERIVATIVES
AR283027A AR227529A1 (en) 1978-08-25 1980-10-28 A PROCEDURE FOR PREPARING A 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-CARBOXYLIC ACID DERIVATIVE
AR283026A AR225195A1 (en) 1978-08-25 1980-10-28 A PROCEDURE FOR PREPARING A DERIVATIVE OF 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAPHTIRIDINE AND INTERMEDIARIES USED THEREOF
US06/264,824 US4352803A (en) 1978-08-25 1981-05-18 Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof
IN1487/CAL/82A IN154878B (en) 1978-08-25 1982-12-17
CS835364A CS235545B2 (en) 1978-08-25 1983-07-15 Method of 1-ethyl or vinyl-6-halogen-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine derivatives preparation
YU319/85A YU42615B (en) 1978-08-25 1985-02-28 Process for preparing 1,8-naphthydrine compound
YU317/85A YU42637B (en) 1978-08-25 1985-02-28 Process for preparing 1,8-naphthydrine compound
YU318/85A YU42614B (en) 1978-08-25 1985-02-28 Process for preparing 1,8-naphthydrine compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16209578A JPS5592385A (en) 1978-12-29 1978-12-29 1-vinyl-1,8-naphthylidine derivative and its salt

Publications (2)

Publication Number Publication Date
JPS5592385A true JPS5592385A (en) 1980-07-12
JPS6130675B2 JPS6130675B2 (en) 1986-07-15

Family

ID=15747970

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16209578A Granted JPS5592385A (en) 1978-08-25 1978-12-29 1-vinyl-1,8-naphthylidine derivative and its salt

Country Status (1)

Country Link
JP (1) JPS5592385A (en)

Also Published As

Publication number Publication date
JPS6130675B2 (en) 1986-07-15

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