JPS5592385A - 1-vinyl-1,8-naphthylidine derivative and its salt - Google Patents
1-vinyl-1,8-naphthylidine derivative and its saltInfo
- Publication number
- JPS5592385A JPS5592385A JP16209578A JP16209578A JPS5592385A JP S5592385 A JPS5592385 A JP S5592385A JP 16209578 A JP16209578 A JP 16209578A JP 16209578 A JP16209578 A JP 16209578A JP S5592385 A JPS5592385 A JP S5592385A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- vinyl
- salt
- protecting group
- naphthylidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000005452 food preservative Substances 0.000 abstract 1
- 235000019249 food preservative Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:1-Vinyl- 6 -fluoro-1, 4-dihydro- 4 -oxo- 7 -(1-piperazinyl)-1, 8- naphthylidine-3-carboxylic acid and its salt.
USE: Antibacterial agent especially effective to gram-negative bacteria including Pseudomonas aeruginosa. Useful as medicine for man, animal, and fish, and a food preservative. Characterized by the 6-position fluorine atom.
PROCESS: The compound I is prepared either by simply heating a compound II (R1 is H or protecting group; R2 is H, lower alkyl; X, Y are H, halogen, lower alkoxy, etc.), or by heating the compound II in the presence of a catalyst such as acidic substance, acid anhydride, base, etc., usually at 50W270°C, and if necessary, hydrolyzing the product to eliminate the protecting group or the ester residue.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (30)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16209578A JPS5592385A (en) | 1978-12-29 | 1978-12-29 | 1-vinyl-1,8-naphthylidine derivative and its salt |
AR277659A AR223983A1 (en) | 1978-08-25 | 1979-08-09 | A PROCEDURE FOR PREPARING 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-3-CARBOXYLIC ACID DERIVATIVES |
AU50049/79A AU530052B2 (en) | 1978-08-25 | 1979-08-17 | Naphthyridine derivatives |
YU2032/79A YU42193B (en) | 1978-08-25 | 1979-08-20 | Process for preparing 1,8-naphthydrine compound |
DD79215122A DD145753A5 (en) | 1978-08-25 | 1979-08-22 | PROCESS FOR THE PREPARATION OF NAPHTHYRIDINE DERIVATIVES |
MX10123879U MX6111E (en) | 1978-08-25 | 1979-08-23 | PROCEDURE FOR THE PREPARATION OF 1,8 NAFTIRIDINE DERIVATIVES |
US06/068,966 US4359578A (en) | 1978-08-25 | 1979-08-23 | Naphthyridine derivatives and salts thereof useful as antibacterial agents |
HU79BE1361A HU179927B (en) | 1978-08-25 | 1979-08-23 | Process for preparing naphthyridine derivatives |
ES483629A ES483629A1 (en) | 1978-08-25 | 1979-08-24 | Novel naphtyridine derivatives and pharmaceutical compositions containing them. |
PL1979217926A PL120114B1 (en) | 1978-08-25 | 1979-08-24 | Process for preparing novel derivatives of 1,8-naphtiridine |
DE7979400587T DE2961979D1 (en) | 1978-08-25 | 1979-08-24 | Novel naphtyridine derivatives and pharmaceutical compositions containing them |
DK355679A DK153552C (en) | 1978-08-25 | 1979-08-24 | ANALOGY PROCEDURE FOR PREPARING 1,8-NAPHTHYRIDE INGREDIATES |
FI792645A FI66379C (en) | 1978-08-25 | 1979-08-24 | ANALOGIFICATION OF THERAPEUTIC ANALYSIS OF 6-HALOGEN-1,4-DIHYDRO-4-OXO-7- (1-PIPERAZINYL) -1-SUBSTITUTES 1,8-NAPHTHYRIDINE-3-CARBOXYL SYROR |
NO792760A NO153136C (en) | 1978-08-25 | 1979-08-24 | ANALOGY PROCEDURE FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE NAFTYRIDINE DERIVATIVES. |
CS795770A CS235502B2 (en) | 1978-08-25 | 1979-08-24 | Method of 1-ethyl or vinyl-6-halogen-1-4-dihydro-4-oxo-7- (1-piperazinyl)-1,8-naphtyridin-3-carboxyl acid production |
CA000334439A CA1168241A (en) | 1978-08-25 | 1979-08-24 | Naphthyridine derivatives, intermediates thereof and processes for preparation thereof |
EP79400587A EP0009425B1 (en) | 1978-08-25 | 1979-08-24 | Novel naphtyridine derivatives and pharmaceutical compositions containing them |
PH22967A PH14287A (en) | 1978-08-25 | 1979-08-27 | Naphthyridine derivatives,pharmaceutical compositions containing same and method of treatment thereof |
RO79103694A RO81942A (en) | 1978-12-20 | 1979-09-13 | PROCESS FOR THE PREPARATION OF NAPHTIRIDINE DERIVATIVES |
RO79103692A RO81940A (en) | 1978-12-20 | 1979-09-13 | PROCESS FOR THE PREPARATION OF 6-HALO-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDINE |
RO7998656A RO77558A (en) | 1978-12-20 | 1979-09-13 | PROCESS FOR THE PREPARATION OF NAPHTIRIDINE DERIVATIVES |
RO79103693A RO81939A (en) | 1978-12-20 | 1979-09-13 | PROCESS FOR THE PREPARATION OF 6-HALO-4-OXO-7- (1-PYPERAZINYL) -1,8-NAPHTHYRIDINE DERIVATIVES |
AR283027A AR227529A1 (en) | 1978-08-25 | 1980-10-28 | A PROCEDURE FOR PREPARING A 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAFTIRIDIN-CARBOXYLIC ACID DERIVATIVE |
AR283026A AR225195A1 (en) | 1978-08-25 | 1980-10-28 | A PROCEDURE FOR PREPARING A DERIVATIVE OF 6-HALOGEN-4-OXO-7- (1-PIPERAZINYL) -1,8-NAPHTIRIDINE AND INTERMEDIARIES USED THEREOF |
US06/264,824 US4352803A (en) | 1978-08-25 | 1981-05-18 | Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof |
IN1487/CAL/82A IN154878B (en) | 1978-08-25 | 1982-12-17 | |
CS835364A CS235545B2 (en) | 1978-08-25 | 1983-07-15 | Method of 1-ethyl or vinyl-6-halogen-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine derivatives preparation |
YU318/85A YU42614B (en) | 1978-08-25 | 1985-02-28 | Process for preparing 1,8-naphthydrine compound |
YU317/85A YU42637B (en) | 1978-08-25 | 1985-02-28 | Process for preparing 1,8-naphthydrine compound |
YU319/85A YU42615B (en) | 1978-08-25 | 1985-02-28 | Process for preparing 1,8-naphthydrine compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16209578A JPS5592385A (en) | 1978-12-29 | 1978-12-29 | 1-vinyl-1,8-naphthylidine derivative and its salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5592385A true JPS5592385A (en) | 1980-07-12 |
JPS6130675B2 JPS6130675B2 (en) | 1986-07-15 |
Family
ID=15747970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16209578A Granted JPS5592385A (en) | 1978-08-25 | 1978-12-29 | 1-vinyl-1,8-naphthylidine derivative and its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5592385A (en) |
-
1978
- 1978-12-29 JP JP16209578A patent/JPS5592385A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6130675B2 (en) | 1986-07-15 |
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