JPS5572151A - Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation - Google Patents
Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparationInfo
- Publication number
- JPS5572151A JPS5572151A JP14550978A JP14550978A JPS5572151A JP S5572151 A JPS5572151 A JP S5572151A JP 14550978 A JP14550978 A JP 14550978A JP 14550978 A JP14550978 A JP 14550978A JP S5572151 A JPS5572151 A JP S5572151A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- oxo
- hydroxy
- ester
- threo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002148 esters Chemical class 0.000 title abstract 4
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 abstract 2
- LDSJMFGYNFIFRK-BDAKNGLRSA-N (2s,3r)-3-azaniumyl-2-hydroxy-4-phenylbutanoate Chemical compound OC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1 LDSJMFGYNFIFRK-BDAKNGLRSA-N 0.000 abstract 1
- HEQOJEGTZCTHCF-UHFFFAOYSA-N 2-amino-1-phenylethanone Chemical class NCC(=O)C1=CC=CC=C1 HEQOJEGTZCTHCF-UHFFFAOYSA-N 0.000 abstract 1
- VGGGPCQERPFHOB-MCIONIFRSA-N Bestatin Chemical compound CC(C)C[C@H](C(O)=O)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1 VGGGPCQERPFHOB-MCIONIFRSA-N 0.000 abstract 1
- VGGGPCQERPFHOB-UHFFFAOYSA-N Bestatin Natural products CC(C)CC(C(O)=O)NC(=O)C(O)C(N)CC1=CC=CC=C1 VGGGPCQERPFHOB-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229950009811 ubenimex Drugs 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Priority Applications (30)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14550978A JPS5572151A (en) | 1978-11-25 | 1978-11-25 | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation |
| CH5649/81A CH653687A5 (de) | 1978-11-25 | 1979-11-22 | Threo-3-amino-2-hydroxy-butanoylaminoessigsaeure-derivate. |
| DE19792947140 DE2947140A1 (de) | 1978-11-25 | 1979-11-22 | Verfahren zur herstellung von threo-3-amino-2-hydroxybutanoyl- aminoessigsaeure |
| GB8200496A GB2090595B (en) | 1978-11-25 | 1979-11-22 | Threo-3-amino-2-hydroxybutanoylacetice acid derivatives |
| FR7928830A FR2442227A1 (fr) | 1978-11-25 | 1979-11-22 | Procede de production d'acides threo-3-amino-2-hydroxybutanoylaminoacetiques |
| GB7940413A GB2037754B (en) | 1978-11-25 | 1979-11-22 | Threo - 3 -protected amino - 2 - hydroxy-4oxobutanoic acids or esters, their preparation and their use in the preparation of threo - 3 - amino - 2 - hydroxy-butanoylaminoacetic acids |
| SE7909655A SE452888B (sv) | 1978-11-25 | 1979-11-22 | Sett att framstella treo-3-amino-2-hydroxibutanoylaminoettiksyror |
| DK496379A DK162288C (da) | 1978-11-25 | 1979-11-22 | Fremgangsmaade til fremstilling af threo-3-amino-2-hydroxybutanoyl-aminoeddikesyrer |
| NLAANVRAGE7908510,A NL188162C (nl) | 1978-11-25 | 1979-11-22 | Werkwijze voor het bereiden van een bestatinederivaat. |
| CH6192/83A CH653669A5 (de) | 1978-11-25 | 1979-11-22 | Threo-3-geschuetzte amino-2-hydroxy-4-oxobutansaeure oder deren ester und verfahren zu ihrer herstellung. |
| IT27487/79A IT1194593B (it) | 1978-11-25 | 1979-11-22 | Procedimento per la produzione di acidi treo-3-ammino-2-idrossibutanoilamminoacetici nonche' di loro intermedi |
| CS480581A CS221954B2 (en) | 1978-11-25 | 1979-11-22 | Method of making the threo-3-amino-2-hydroxy-4-oxobutane acids with protected aminogroup and esters thereof |
| CH10433/79A CH650265A5 (de) | 1978-11-25 | 1979-11-22 | Verfahren zur herstellung von substituierten threo-3-amino-2-hydroxybutanoylaminoessigsaeuren. |
| DE2954076A DE2954076C2 (cs) | 1978-11-25 | 1979-11-22 | |
| ES486572A ES486572A1 (es) | 1978-11-25 | 1979-11-22 | Procedimiento para la fabricacion de acidos treo-3-amino-2- hidroxibutanoil amonoaceticos. |
| AR278992A AR227636A1 (es) | 1978-11-25 | 1979-11-22 | Procedimiento para producir acido treo-3-amino-2-hidroxibutanoil aminoacetico intermediarios para prepararlo y procedimiento para preparar los intermediarios |
| CA000340428A CA1182125A (en) | 1978-11-25 | 1979-11-22 | Process for producing threo-3-amino-2- hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them |
| HU247179A HU186097B (en) | 1978-11-25 | 1979-11-22 | Process for the production of treo-3-amino-2-hydroxy-4-oxobutyric acids |
| AU53115/79A AU530362B2 (en) | 1978-11-25 | 1979-11-22 | Threo-3-amino-2-hydroxy-butanoyl-aminoacetic acids |
| US06/096,693 US4281180A (en) | 1978-11-25 | 1979-11-23 | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them |
| FR8010563A FR2449078A1 (fr) | 1978-11-25 | 1980-05-12 | Procede de production d'acide threo-3-amino protege 2-hydroxy-4-oxobutanoique ou de ses esters et application a la production d'acide threo-3-amino-2-hydroxybutanoique |
| US06/211,035 US4391986A (en) | 1978-11-25 | 1980-11-28 | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them |
| FR8113611A FR2483409B1 (fr) | 1978-11-25 | 1981-07-10 | Derives de l'acide 3-amino-2-hydroxy butanoylaminoacetique et leur procede de preparation |
| NL8104545A NL8104545A (nl) | 1978-11-25 | 1981-10-06 | "nieuwe threo-3-amino-2-hydroxybutanoylamino-azijnzuur- derivaten en daaruit verkregen geneesmiddelen. |
| SE8106084A SE453748B (sv) | 1978-11-25 | 1981-10-14 | (2s,3r)-3-amino-2-hydroxi-4-(4-metoxifenyl)-butanoyl-(s)-leucin |
| IT8125614A IT1211147B (it) | 1978-11-25 | 1981-12-15 | Acidi treo-3-ammino-2-idrossibutanoilammi no-acetici utili come farmaci. |
| US06/336,492 US4453003A (en) | 1978-11-25 | 1981-12-31 | Process for producing threo-3-amino-2-hydroxy-butanoyl-aminoacetic acids as well as novel intermediates therefor and process for producing them |
| CA000405157A CA1170667A (en) | 1978-11-25 | 1982-06-14 | Process for producing threo-3-amino-2-hydroxybutanoyl- aminoacetic acids, as well as novel intermediates therefor and process for producing them |
| CA000410051A CA1167464A (en) | 1978-11-25 | 1982-08-24 | Process for producing threo-3-amino-2-hydroxybutanoyl- aminoacetic acids, as well as novel intermediates therefor and process for producing them |
| SE8403931A SE466200B (sv) | 1978-11-25 | 1984-07-31 | Treo-3-skyddad amino-2-hydroxi-4-oxosmoersyra eller dess ester samt ett saett foer framstaellning daerav |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14550978A JPS5572151A (en) | 1978-11-25 | 1978-11-25 | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5572151A true JPS5572151A (en) | 1980-05-30 |
| JPS6154015B2 JPS6154015B2 (cs) | 1986-11-20 |
Family
ID=15386885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14550978A Granted JPS5572151A (en) | 1978-11-25 | 1978-11-25 | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5572151A (cs) |
| CS (1) | CS221954B2 (cs) |
| HU (1) | HU186097B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998007421A1 (fr) * | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
-
1978
- 1978-11-25 JP JP14550978A patent/JPS5572151A/ja active Granted
-
1979
- 1979-11-22 CS CS480581A patent/CS221954B2/cs unknown
- 1979-11-22 HU HU247179A patent/HU186097B/hu not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998007421A1 (fr) * | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
| US6429212B1 (en) * | 1996-08-16 | 2002-08-06 | Ishihara Sangyo Kaisha Ltd. | Medicinal composition |
| US6515129B1 (en) | 1996-08-16 | 2003-02-04 | Ishihara Sangyo Kaisha Ltd. | Pharmaceutical composition |
Also Published As
| Publication number | Publication date |
|---|---|
| HU186097B (en) | 1985-05-28 |
| JPS6154015B2 (cs) | 1986-11-20 |
| CS221954B2 (en) | 1983-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5690031A (en) | Preparation of aromatic aldehyde | |
| JPS5576829A (en) | Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it | |
| JPS57118555A (en) | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component | |
| JPS5572151A (en) | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation | |
| JPS54125633A (en) | 4-chloro-3,5-diaminophenyl acetate, its preparation, and hardeners for preparing polyurethane elastomers | |
| JPS56125333A (en) | Phenylacetic acid derivative and its preparation | |
| JPS56108743A (en) | 3-nitro-2-hydroxy-4-phenylbutyric acid derivative, its ester and preparation thereof | |
| JPS55108898A (en) | 25-hydroxy-24-oxocholesterol derivative and its preparation | |
| JPS5618971A (en) | Alpha-halogeno-beta-benzosulfimidopropionitrile and its preparation | |
| JPS5742643A (en) | 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraene-2-ol | |
| JPS55108883A (en) | Ethyl-(gamma-acetamino-gamma-ethoxycarbonyl-gamma-cyanopropyl- methyl) phosphinate and its preparation | |
| JPS579749A (en) | Acyl derivative and its preparation | |
| JPS5572142A (en) | 2-acetoxy-4-aryl-3-oxobutanoic acid derivative and its preparation | |
| JPS51143645A (en) | Process for preparation of 3,3-dimethyl- 2-(2,2-dihalo)cyclopropanecar boxylic acid ester | |
| JPS5422363A (en) | Preparation of thiophene-substituted fatty acid halide | |
| JPS51113817A (en) | Preparation of 2-or non substituted terpene carboxylic esters ortheir esters | |
| JPS5738773A (en) | Pyrazoline compound and its preparation | |
| JPS5312830A (en) | Preparation of dinitrodiphenyl ether | |
| JPS55120591A (en) | Phosphinoethylmalonic acid derivative, and preparation thereof | |
| JPS5217447A (en) | Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester | |
| JPS55143936A (en) | Reparation of 3-pentenoic acid ester | |
| JPS5466652A (en) | O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acid | |
| JPS5772963A (en) | Alpha-(2-pyridyl)arylacetaldehyde | |
| JPS5344691A (en) | Preparation of l-menthol from menthol racemate | |
| JPS5718679A (en) | Preparation of oxoalkylxanthine |