JPS5569587A - Novel antibiotic neothramycin derivative and its preparation - Google Patents
Novel antibiotic neothramycin derivative and its preparationInfo
- Publication number
- JPS5569587A JPS5569587A JP14110078A JP14110078A JPS5569587A JP S5569587 A JPS5569587 A JP S5569587A JP 14110078 A JP14110078 A JP 14110078A JP 14110078 A JP14110078 A JP 14110078A JP S5569587 A JPS5569587 A JP S5569587A
- Authority
- JP
- Japan
- Prior art keywords
- neothramycin
- formula
- derivative
- compound
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FXMOIYLVKOALHC-UHFFFAOYSA-N 3,9-dihydroxy-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical class N1=CC2CCC(O)N2C(=O)C2=C1C=C(O)C(OC)=C2 FXMOIYLVKOALHC-UHFFFAOYSA-N 0.000 title abstract 4
- 230000003115 biocidal effect Effects 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- FXMOIYLVKOALHC-JVXZTZIISA-N (6as,9r)-3,9-dihydroxy-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound N1=C[C@@H]2CC[C@@H](O)N2C(=O)C2=C1C=C(O)C(OC)=C2 FXMOIYLVKOALHC-JVXZTZIISA-N 0.000 abstract 1
- FXMOIYLVKOALHC-MADCSZMMSA-N (6as,9s)-3,9-dihydroxy-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound N1=C[C@@H]2CC[C@H](O)N2C(=O)C2=C1C=C(O)C(OC)=C2 FXMOIYLVKOALHC-MADCSZMMSA-N 0.000 abstract 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- -1 NaHSO3 Chemical compound 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229930188317 neothramycin Natural products 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14110078A JPS5569587A (en) | 1978-11-17 | 1978-11-17 | Novel antibiotic neothramycin derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14110078A JPS5569587A (en) | 1978-11-17 | 1978-11-17 | Novel antibiotic neothramycin derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5569587A true JPS5569587A (en) | 1980-05-26 |
| JPS6221795B2 JPS6221795B2 (enrdf_load_stackoverflow) | 1987-05-14 |
Family
ID=15284181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14110078A Granted JPS5569587A (en) | 1978-11-17 | 1978-11-17 | Novel antibiotic neothramycin derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5569587A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536905A (ja) * | 2005-04-21 | 2008-09-11 | スピロゲン リミティッド | ピロロベンゾジアゼピン |
| US8501934B2 (en) | 2008-07-22 | 2013-08-06 | Spirogen Sarl | Pyrrolobenzodiazepines |
| US8637664B2 (en) | 2005-10-05 | 2014-01-28 | Spirogen Sarl | Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease |
| US9321774B2 (en) | 2012-04-30 | 2016-04-26 | Medimmune Limited | Pyrrolobenzodiazepines |
| US9376440B2 (en) | 2012-04-30 | 2016-06-28 | Medimmune Limited | Pyrrolobenzodiazepines as antiproliferative agents |
-
1978
- 1978-11-17 JP JP14110078A patent/JPS5569587A/ja active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008536905A (ja) * | 2005-04-21 | 2008-09-11 | スピロゲン リミティッド | ピロロベンゾジアゼピン |
| US8633185B2 (en) | 2005-04-21 | 2014-01-21 | Spirogen Sarl | Pyrrolobenzodiazepines |
| KR101396095B1 (ko) * | 2005-04-21 | 2014-05-15 | 스피로즌 살 | 피롤로벤조디아제핀 |
| US8637664B2 (en) | 2005-10-05 | 2014-01-28 | Spirogen Sarl | Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease |
| US8501934B2 (en) | 2008-07-22 | 2013-08-06 | Spirogen Sarl | Pyrrolobenzodiazepines |
| US9321774B2 (en) | 2012-04-30 | 2016-04-26 | Medimmune Limited | Pyrrolobenzodiazepines |
| US9376440B2 (en) | 2012-04-30 | 2016-06-28 | Medimmune Limited | Pyrrolobenzodiazepines as antiproliferative agents |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6221795B2 (enrdf_load_stackoverflow) | 1987-05-14 |
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