JPS54125670A - Lonomycin derivative - Google Patents
Lonomycin derivativeInfo
- Publication number
- JPS54125670A JPS54125670A JP3018778A JP3018778A JPS54125670A JP S54125670 A JPS54125670 A JP S54125670A JP 3018778 A JP3018778 A JP 3018778A JP 3018778 A JP3018778 A JP 3018778A JP S54125670 A JPS54125670 A JP S54125670A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- lonomycin
- metal salt
- formula
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BKZOUCVNTCLNFF-IGXZVFLKSA-N (2s)-2-[(2r,3r,4s,5r,6s)-2-hydroxy-6-[(1s)-1-[(2s,5r,7s,8r,9s)-2-[(2r,5s)-5-[(2r,3s,4r,5r)-5-[(2s,3s,4s,5r,6s)-6-hydroxy-4-methoxy-3,5,6-trimethyloxan-2-yl]-4-methoxy-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,8-dimethyl-1,10-dioxaspiro[4.5]dec Chemical class O([C@@H]1[C@@H]2O[C@H]([C@@H](C)[C@H]2OC)[C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](OC)C3)[C@@H](C)[C@@H]3[C@@H]([C@H](OC)[C@@H](C)[C@](O)([C@H](C)C(O)=O)O3)C)CC2)[C@](C)(O)[C@H](C)[C@@H](OC)[C@@H]1C BKZOUCVNTCLNFF-IGXZVFLKSA-N 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- -1 alkali metal salt Chemical class 0.000 abstract 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- BKZOUCVNTCLNFF-UHFFFAOYSA-N Lonomycin Natural products COC1C(C)C(C2(C)OC(CC2)C2(C)OC3(OC(C(C)C(OC)C3)C(C)C3C(C(OC)C(C)C(O)(C(C)C(O)=O)O3)C)CC2)OC1C1OC(C)(O)C(C)C(OC)C1C BKZOUCVNTCLNFF-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Lonomycin derivative of formula, or its salt.
USE: Medicine effective to protozoa such as coccidium, bacteria, virus, etc. Extremely low toxicity compared with lonomycin and its salts.
PROCESS: An alkali metal salt of the objective compound of formula I is prepared by dissolving lonomycin or its salt in a ketone compound such as acetone, methyl ethyl ketone, adjusting the pH of the solution above 11 by adding an alkaline aqueous solution thereto, and leaving the solution to stand at room temperature. If necessary, the alkali metal salt of the objective compound is converted into the free acid or other salt (e.g. alkaline earth metal salt, or ammonium salt which is commonly used salt in medicine). The lonomycin which is called as TM-481 substance, is a polyether-type antibiotic substance produced by culturing Streptomyces ribocidificus TM-481 (FERM-P No.2267).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3018778A JPS54125670A (en) | 1978-03-16 | 1978-03-16 | Lonomycin derivative |
| GB7905483A GB2024806B (en) | 1978-03-16 | 1979-02-16 | Onomycin derivatives |
| DE19792907976 DE2907976A1 (en) | 1978-03-16 | 1979-03-01 | NEW LONOMYCIN DERIVATIVES |
| CH219679A CH637963A5 (en) | 1978-03-16 | 1979-03-07 | LONOMYCIN DERIVATIVES WITH ANTI-BACTERIAL, ANTI-VIRAL AND ANTI-PROTOZOA ACTIVITIES. |
| BE0/193897A BE874687A (en) | 1978-03-16 | 1979-03-08 | LONOMYCIN DERIVATIVES WITH ANTI-BACTERIAL, ANTI-VIRAL AND ANTI-PROTOZOA ACTIVITIES |
| US06/018,935 US4199515A (en) | 1978-03-16 | 1979-03-09 | Novel lonomycin derivatives |
| FR7906172A FR2419945A1 (en) | 1978-03-16 | 1979-03-09 | LONOMYCIN DERIVATIVES WITH ANTI-BACTERIAL, ANTI-VIRAL AND ANTI-PROTOZOA ACTIVITIES |
| CA323,617A CA1111419A (en) | 1978-03-16 | 1979-03-15 | Lonomycin derivatives |
| IT48363/79A IT1114711B (en) | 1978-03-16 | 1979-03-15 | LONOMYCIN DERIVATIVES WITH ANTIVIRAL AND ANTIPROTOZOIC ANTIBACTERIAL ACTIVITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3018778A JPS54125670A (en) | 1978-03-16 | 1978-03-16 | Lonomycin derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54125670A true JPS54125670A (en) | 1979-09-29 |
Family
ID=12296742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3018778A Pending JPS54125670A (en) | 1978-03-16 | 1978-03-16 | Lonomycin derivative |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS54125670A (en) |
| BE (1) | BE874687A (en) |
-
1978
- 1978-03-16 JP JP3018778A patent/JPS54125670A/en active Pending
-
1979
- 1979-03-08 BE BE0/193897A patent/BE874687A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE874687A (en) | 1979-09-10 |
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