JPS5557551A - Tetralin derivative - Google Patents

Tetralin derivative

Info

Publication number
JPS5557551A
JPS5557551A JP468479A JP468479A JPS5557551A JP S5557551 A JPS5557551 A JP S5557551A JP 468479 A JP468479 A JP 468479A JP 468479 A JP468479 A JP 468479A JP S5557551 A JPS5557551 A JP S5557551A
Authority
JP
Japan
Prior art keywords
derivative
guanidinotetralin
tetralin derivative
carbamoylmethoxycarbonyl
nhcoch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP468479A
Other languages
Japanese (ja)
Other versions
JPS6331462B2 (en
Inventor
Setsuo Fujii
Yojiro Sakurai
Toyoo Nakayama
Ryoji Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii Pharmaceutical Co Ltd
Original Assignee
Torii Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii Pharmaceutical Co Ltd filed Critical Torii Pharmaceutical Co Ltd
Publication of JPS5557551A publication Critical patent/JPS5557551A/en
Publication of JPS6331462B2 publication Critical patent/JPS6331462B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A guanidinotetralin derivative of formula I (R1 is II or III; R2 is -NHCOCH3, -CN, -NR3R3, etc.; R3 is lower alkyl).
EXAMPLE: p-Carbamoylmethoxycarbonyl 7-guanidinotetralin-1-carboxylate.
USE: Effective to inhibit the activity of proteinase (trypsin, thrombin, C1 esterase, kallikrein, plasmin, etc.), and useful for the remedy of the diseases caused by the above enzymes.
PROCESS: The compound I is prepared by reacting an aminotetralin derivative IV with cyanamide, and optionally neutralizing the product to form a salt.
COPYRIGHT: (C)1980,JPO&Japio
JP468479A 1978-10-23 1979-01-19 Tetralin derivative Granted JPS5557551A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95373578A 1978-10-23 1978-10-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP31366987A Division JPS63165358A (en) 1978-10-23 1987-12-11 Guanidinotetralin derivative

Publications (2)

Publication Number Publication Date
JPS5557551A true JPS5557551A (en) 1980-04-28
JPS6331462B2 JPS6331462B2 (en) 1988-06-23

Family

ID=25494458

Family Applications (3)

Application Number Title Priority Date Filing Date
JP468479A Granted JPS5557551A (en) 1978-10-23 1979-01-19 Tetralin derivative
JP468379A Granted JPS5557546A (en) 1978-10-23 1979-01-19 Derivative of tetralin
JP31366987A Granted JPS63165358A (en) 1978-10-23 1987-12-11 Guanidinotetralin derivative

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP468379A Granted JPS5557546A (en) 1978-10-23 1979-01-19 Derivative of tetralin
JP31366987A Granted JPS63165358A (en) 1978-10-23 1987-12-11 Guanidinotetralin derivative

Country Status (1)

Country Link
JP (3) JPS5557551A (en)

Also Published As

Publication number Publication date
JPS5557546A (en) 1980-04-28
JPS63165358A (en) 1988-07-08
JPS6326103B2 (en) 1988-05-27
JPH0146502B2 (en) 1989-10-09
JPS6331462B2 (en) 1988-06-23

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