JPS5557551A - Tetralin derivative - Google Patents
Tetralin derivativeInfo
- Publication number
- JPS5557551A JPS5557551A JP468479A JP468479A JPS5557551A JP S5557551 A JPS5557551 A JP S5557551A JP 468479 A JP468479 A JP 468479A JP 468479 A JP468479 A JP 468479A JP S5557551 A JPS5557551 A JP S5557551A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- guanidinotetralin
- tetralin derivative
- carbamoylmethoxycarbonyl
- nhcoch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A guanidinotetralin derivative of formula I (R1 is II or III; R2 is -NHCOCH3, -CN, -NR3R3, etc.; R3 is lower alkyl).
EXAMPLE: p-Carbamoylmethoxycarbonyl 7-guanidinotetralin-1-carboxylate.
USE: Effective to inhibit the activity of proteinase (trypsin, thrombin, C1 esterase, kallikrein, plasmin, etc.), and useful for the remedy of the diseases caused by the above enzymes.
PROCESS: The compound I is prepared by reacting an aminotetralin derivative IV with cyanamide, and optionally neutralizing the product to form a salt.
COPYRIGHT: (C)1980,JPO&Japio
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95373578A | 1978-10-23 | 1978-10-23 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP31366987A Division JPS63165358A (en) | 1978-10-23 | 1987-12-11 | Guanidinotetralin derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5557551A true JPS5557551A (en) | 1980-04-28 |
JPS6331462B2 JPS6331462B2 (en) | 1988-06-23 |
Family
ID=25494458
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP468479A Granted JPS5557551A (en) | 1978-10-23 | 1979-01-19 | Tetralin derivative |
JP468379A Granted JPS5557546A (en) | 1978-10-23 | 1979-01-19 | Derivative of tetralin |
JP31366987A Granted JPS63165358A (en) | 1978-10-23 | 1987-12-11 | Guanidinotetralin derivative |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP468379A Granted JPS5557546A (en) | 1978-10-23 | 1979-01-19 | Derivative of tetralin |
JP31366987A Granted JPS63165358A (en) | 1978-10-23 | 1987-12-11 | Guanidinotetralin derivative |
Country Status (1)
Country | Link |
---|---|
JP (3) | JPS5557551A (en) |
-
1979
- 1979-01-19 JP JP468479A patent/JPS5557551A/en active Granted
- 1979-01-19 JP JP468379A patent/JPS5557546A/en active Granted
-
1987
- 1987-12-11 JP JP31366987A patent/JPS63165358A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5557546A (en) | 1980-04-28 |
JPS63165358A (en) | 1988-07-08 |
JPS6326103B2 (en) | 1988-05-27 |
JPH0146502B2 (en) | 1989-10-09 |
JPS6331462B2 (en) | 1988-06-23 |
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