JPS5547678A - Novel 2-pyridyl-1-phthalazone derivative - Google Patents
Novel 2-pyridyl-1-phthalazone derivativeInfo
- Publication number
- JPS5547678A JPS5547678A JP12038778A JP12038778A JPS5547678A JP S5547678 A JPS5547678 A JP S5547678A JP 12038778 A JP12038778 A JP 12038778A JP 12038778 A JP12038778 A JP 12038778A JP S5547678 A JPS5547678 A JP S5547678A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- pyridyl
- phthalazone
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-pyridyl-1-phthalazone derivative of formula I (R1 and R2 are lower alkyl groups; R3 is alkyl group; R4 is H or lower alkyl group).
EXAMPLE: 7-Ethoxycarbonyl-6,8-dimethyl-2-(2-pyridyl)-1-phthalazone.
USE: Preventives and remedies for ischemic cerebral blood vessel trouble or heart diseases, and thrombotic diseases having anti-thromboxane and blood vessel smooth muscle relaxing actions useful as vasodilators and brochodilators.
PROCESS: A phthalonic acid derivative of formula II is reacted with a pyridylhydrazine derivative of formula III at 20W150°C, preferably 50W80°C, in a solvent, e.g. ethanol, to give the compound of formula I. The compound of formula II is obtained by oxidizing a 3-hydroxy-3-methylphthalide derivative with potassium permanganate.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12038778A JPS5547678A (en) | 1978-10-02 | 1978-10-02 | Novel 2-pyridyl-1-phthalazone derivative |
US06/064,368 US4293553A (en) | 1978-08-11 | 1979-08-07 | 1-Phthalazone derivatives, and use thereof |
AU49712/79A AU4971279A (en) | 1978-08-11 | 1979-08-08 | 1-phthalazone derivatives |
CA000333350A CA1135697A (en) | 1978-08-11 | 1979-08-08 | 1-phthalazone derivatives, process for preparation thereof, and use thereof |
SE7906681A SE7906681L (en) | 1978-08-11 | 1979-08-09 | FTALAZONDERIVAT |
DE19792932259 DE2932259A1 (en) | 1978-08-11 | 1979-08-09 | 1-PHTHALAZONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
FR7920485A FR2433017A1 (en) | 1978-08-11 | 1979-08-10 | PHTALAZONE-1 DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM |
NL7906138A NL7906138A (en) | 1978-08-11 | 1979-08-10 | 1-PHTHALA DERIVATIVES, METHODS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATIONS CONTAINING THIS COMPOUND AS AN ACTIVE COMPONENT. |
GB7927986A GB2030136B (en) | 1978-08-11 | 1979-08-10 | 1-phthalazone derivatives and acid addition salts their preparation and compositions containing them |
IT25069/79A IT1163698B (en) | 1978-08-11 | 1979-08-10 | DERIVATIVES OF 1-FTALAZONE, PROCEDURE FOR THEIR PREPARATION, AND THEIR USE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12038778A JPS5547678A (en) | 1978-10-02 | 1978-10-02 | Novel 2-pyridyl-1-phthalazone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5547678A true JPS5547678A (en) | 1980-04-04 |
Family
ID=14784942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12038778A Pending JPS5547678A (en) | 1978-08-11 | 1978-10-02 | Novel 2-pyridyl-1-phthalazone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5547678A (en) |
-
1978
- 1978-10-02 JP JP12038778A patent/JPS5547678A/en active Pending
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