JPS5547678A - Novel 2-pyridyl-1-phthalazone derivative - Google Patents

Novel 2-pyridyl-1-phthalazone derivative

Info

Publication number
JPS5547678A
JPS5547678A JP12038778A JP12038778A JPS5547678A JP S5547678 A JPS5547678 A JP S5547678A JP 12038778 A JP12038778 A JP 12038778A JP 12038778 A JP12038778 A JP 12038778A JP S5547678 A JPS5547678 A JP S5547678A
Authority
JP
Japan
Prior art keywords
formula
derivative
pyridyl
phthalazone
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12038778A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP12038778A priority Critical patent/JPS5547678A/en
Priority to US06/064,368 priority patent/US4293553A/en
Priority to AU49712/79A priority patent/AU4971279A/en
Priority to CA000333350A priority patent/CA1135697A/en
Priority to SE7906681A priority patent/SE7906681L/en
Priority to DE19792932259 priority patent/DE2932259A1/en
Priority to FR7920485A priority patent/FR2433017A1/en
Priority to NL7906138A priority patent/NL7906138A/en
Priority to GB7927986A priority patent/GB2030136B/en
Priority to IT25069/79A priority patent/IT1163698B/en
Publication of JPS5547678A publication Critical patent/JPS5547678A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 2-pyridyl-1-phthalazone derivative of formula I (R1 and R2 are lower alkyl groups; R3 is alkyl group; R4 is H or lower alkyl group).
EXAMPLE: 7-Ethoxycarbonyl-6,8-dimethyl-2-(2-pyridyl)-1-phthalazone.
USE: Preventives and remedies for ischemic cerebral blood vessel trouble or heart diseases, and thrombotic diseases having anti-thromboxane and blood vessel smooth muscle relaxing actions useful as vasodilators and brochodilators.
PROCESS: A phthalonic acid derivative of formula II is reacted with a pyridylhydrazine derivative of formula III at 20W150°C, preferably 50W80°C, in a solvent, e.g. ethanol, to give the compound of formula I. The compound of formula II is obtained by oxidizing a 3-hydroxy-3-methylphthalide derivative with potassium permanganate.
COPYRIGHT: (C)1980,JPO&Japio
JP12038778A 1978-08-11 1978-10-02 Novel 2-pyridyl-1-phthalazone derivative Pending JPS5547678A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP12038778A JPS5547678A (en) 1978-10-02 1978-10-02 Novel 2-pyridyl-1-phthalazone derivative
US06/064,368 US4293553A (en) 1978-08-11 1979-08-07 1-Phthalazone derivatives, and use thereof
AU49712/79A AU4971279A (en) 1978-08-11 1979-08-08 1-phthalazone derivatives
CA000333350A CA1135697A (en) 1978-08-11 1979-08-08 1-phthalazone derivatives, process for preparation thereof, and use thereof
SE7906681A SE7906681L (en) 1978-08-11 1979-08-09 FTALAZONDERIVAT
DE19792932259 DE2932259A1 (en) 1978-08-11 1979-08-09 1-PHTHALAZONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
FR7920485A FR2433017A1 (en) 1978-08-11 1979-08-10 PHTALAZONE-1 DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
NL7906138A NL7906138A (en) 1978-08-11 1979-08-10 1-PHTHALA DERIVATIVES, METHODS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATIONS CONTAINING THIS COMPOUND AS AN ACTIVE COMPONENT.
GB7927986A GB2030136B (en) 1978-08-11 1979-08-10 1-phthalazone derivatives and acid addition salts their preparation and compositions containing them
IT25069/79A IT1163698B (en) 1978-08-11 1979-08-10 DERIVATIVES OF 1-FTALAZONE, PROCEDURE FOR THEIR PREPARATION, AND THEIR USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12038778A JPS5547678A (en) 1978-10-02 1978-10-02 Novel 2-pyridyl-1-phthalazone derivative

Publications (1)

Publication Number Publication Date
JPS5547678A true JPS5547678A (en) 1980-04-04

Family

ID=14784942

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12038778A Pending JPS5547678A (en) 1978-08-11 1978-10-02 Novel 2-pyridyl-1-phthalazone derivative

Country Status (1)

Country Link
JP (1) JPS5547678A (en)

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