JPS5543026A - Novel 2-phenyl-1-phthalazone derivative - Google Patents

Novel 2-phenyl-1-phthalazone derivative

Info

Publication number
JPS5543026A
JPS5543026A JP11600778A JP11600778A JPS5543026A JP S5543026 A JPS5543026 A JP S5543026A JP 11600778 A JP11600778 A JP 11600778A JP 11600778 A JP11600778 A JP 11600778A JP S5543026 A JPS5543026 A JP S5543026A
Authority
JP
Japan
Prior art keywords
formula
derivative
phenyl
phthalazone
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11600778A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP11600778A priority Critical patent/JPS5543026A/en
Priority to US06/064,368 priority patent/US4293553A/en
Priority to AU49712/79A priority patent/AU4971279A/en
Priority to CA000333350A priority patent/CA1135697A/en
Priority to SE7906681A priority patent/SE7906681L/en
Priority to DE19792932259 priority patent/DE2932259A1/en
Priority to GB7927986A priority patent/GB2030136B/en
Priority to IT25069/79A priority patent/IT1163698B/en
Priority to ES483317A priority patent/ES483317A1/en
Priority to FR7920485A priority patent/FR2433017A1/en
Priority to NL7906138A priority patent/NL7906138A/en
Publication of JPS5543026A publication Critical patent/JPS5543026A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:A 2-phenyl-1-phthalazone derivative of formula I: (R1 and R2 are lower alkyl groups; R3 is alkyl group; R4,R5 and R6 are H, halogen, alkyl, or alkoxy groups).
EXAMPLE: 7-Ethoxycarbonyl-6,8-dimethyl-2-phenyl-1-phthalazone.
USE: Preventives and remedies for ischemic cerebral vascular trouble, ischemic heart, and thrombotic diseases, having anti-thromboxane and vascular smooth muscle relaxing actions, and useful as bronchodilators and vasodilators.
PROCESS: One mole of a phthalonic acid derivative of formula II is reacted with 1W3mol of a phenylhydrazine derivative of formula III in a solvent at 20W150°C, preferably 50W80°C, to give the compound of formula I. The compound of formula II can be obtained by oxidizing 3-hydroxy-3-methylphthalide derivative of formula IV.
COPYRIGHT: (C)1980,JPO&Japio
JP11600778A 1978-08-11 1978-09-22 Novel 2-phenyl-1-phthalazone derivative Pending JPS5543026A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP11600778A JPS5543026A (en) 1978-09-22 1978-09-22 Novel 2-phenyl-1-phthalazone derivative
US06/064,368 US4293553A (en) 1978-08-11 1979-08-07 1-Phthalazone derivatives, and use thereof
AU49712/79A AU4971279A (en) 1978-08-11 1979-08-08 1-phthalazone derivatives
CA000333350A CA1135697A (en) 1978-08-11 1979-08-08 1-phthalazone derivatives, process for preparation thereof, and use thereof
SE7906681A SE7906681L (en) 1978-08-11 1979-08-09 FTALAZONDERIVAT
DE19792932259 DE2932259A1 (en) 1978-08-11 1979-08-09 1-PHTHALAZONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
GB7927986A GB2030136B (en) 1978-08-11 1979-08-10 1-phthalazone derivatives and acid addition salts their preparation and compositions containing them
IT25069/79A IT1163698B (en) 1978-08-11 1979-08-10 DERIVATIVES OF 1-FTALAZONE, PROCEDURE FOR THEIR PREPARATION, AND THEIR USE
ES483317A ES483317A1 (en) 1978-08-11 1979-08-10 A procedure for obtaining 1-ftalazone derivatives (Machine-translation by Google Translate, not legally binding)
FR7920485A FR2433017A1 (en) 1978-08-11 1979-08-10 PHTALAZONE-1 DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
NL7906138A NL7906138A (en) 1978-08-11 1979-08-10 1-PHTHALA DERIVATIVES, METHODS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATIONS CONTAINING THIS COMPOUND AS AN ACTIVE COMPONENT.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11600778A JPS5543026A (en) 1978-09-22 1978-09-22 Novel 2-phenyl-1-phthalazone derivative

Publications (1)

Publication Number Publication Date
JPS5543026A true JPS5543026A (en) 1980-03-26

Family

ID=14676514

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11600778A Pending JPS5543026A (en) 1978-08-11 1978-09-22 Novel 2-phenyl-1-phthalazone derivative

Country Status (1)

Country Link
JP (1) JPS5543026A (en)

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