JPS5543026A - Novel 2-phenyl-1-phthalazone derivative - Google Patents
Novel 2-phenyl-1-phthalazone derivativeInfo
- Publication number
- JPS5543026A JPS5543026A JP11600778A JP11600778A JPS5543026A JP S5543026 A JPS5543026 A JP S5543026A JP 11600778 A JP11600778 A JP 11600778A JP 11600778 A JP11600778 A JP 11600778A JP S5543026 A JPS5543026 A JP S5543026A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- phenyl
- phthalazone
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-phenyl-1-phthalazone derivative of formula I: (R1 and R2 are lower alkyl groups; R3 is alkyl group; R4,R5 and R6 are H, halogen, alkyl, or alkoxy groups).
EXAMPLE: 7-Ethoxycarbonyl-6,8-dimethyl-2-phenyl-1-phthalazone.
USE: Preventives and remedies for ischemic cerebral vascular trouble, ischemic heart, and thrombotic diseases, having anti-thromboxane and vascular smooth muscle relaxing actions, and useful as bronchodilators and vasodilators.
PROCESS: One mole of a phthalonic acid derivative of formula II is reacted with 1W3mol of a phenylhydrazine derivative of formula III in a solvent at 20W150°C, preferably 50W80°C, to give the compound of formula I. The compound of formula II can be obtained by oxidizing 3-hydroxy-3-methylphthalide derivative of formula IV.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11600778A JPS5543026A (en) | 1978-09-22 | 1978-09-22 | Novel 2-phenyl-1-phthalazone derivative |
US06/064,368 US4293553A (en) | 1978-08-11 | 1979-08-07 | 1-Phthalazone derivatives, and use thereof |
AU49712/79A AU4971279A (en) | 1978-08-11 | 1979-08-08 | 1-phthalazone derivatives |
CA000333350A CA1135697A (en) | 1978-08-11 | 1979-08-08 | 1-phthalazone derivatives, process for preparation thereof, and use thereof |
SE7906681A SE7906681L (en) | 1978-08-11 | 1979-08-09 | FTALAZONDERIVAT |
DE19792932259 DE2932259A1 (en) | 1978-08-11 | 1979-08-09 | 1-PHTHALAZONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
GB7927986A GB2030136B (en) | 1978-08-11 | 1979-08-10 | 1-phthalazone derivatives and acid addition salts their preparation and compositions containing them |
IT25069/79A IT1163698B (en) | 1978-08-11 | 1979-08-10 | DERIVATIVES OF 1-FTALAZONE, PROCEDURE FOR THEIR PREPARATION, AND THEIR USE |
ES483317A ES483317A1 (en) | 1978-08-11 | 1979-08-10 | A procedure for obtaining 1-ftalazone derivatives (Machine-translation by Google Translate, not legally binding) |
FR7920485A FR2433017A1 (en) | 1978-08-11 | 1979-08-10 | PHTALAZONE-1 DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM |
NL7906138A NL7906138A (en) | 1978-08-11 | 1979-08-10 | 1-PHTHALA DERIVATIVES, METHODS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATIONS CONTAINING THIS COMPOUND AS AN ACTIVE COMPONENT. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11600778A JPS5543026A (en) | 1978-09-22 | 1978-09-22 | Novel 2-phenyl-1-phthalazone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5543026A true JPS5543026A (en) | 1980-03-26 |
Family
ID=14676514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11600778A Pending JPS5543026A (en) | 1978-08-11 | 1978-09-22 | Novel 2-phenyl-1-phthalazone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5543026A (en) |
-
1978
- 1978-09-22 JP JP11600778A patent/JPS5543026A/en active Pending
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