JPS5545693A - Bis*imidazole* compound*its manufacture and its use - Google Patents

Bis*imidazole* compound*its manufacture and its use

Info

Publication number
JPS5545693A
JPS5545693A JP12250679A JP12250679A JPS5545693A JP S5545693 A JPS5545693 A JP S5545693A JP 12250679 A JP12250679 A JP 12250679A JP 12250679 A JP12250679 A JP 12250679A JP S5545693 A JPS5545693 A JP S5545693A
Authority
JP
Japan
Prior art keywords
imidazole
bis
manufacture
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12250679A
Other languages
English (en)
Other versions
JPS6350353B2 (ja
Inventor
Tairaa Hiru Deibitsudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of JPS5545693A publication Critical patent/JPS5545693A/ja
Publication of JPS6350353B2 publication Critical patent/JPS6350353B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP12250679A 1978-09-22 1979-09-21 Bis*imidazole* compound*its manufacture and its use Granted JPS5545693A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/944,672 US4188397A (en) 1978-09-22 1978-09-22 2,2-Alkyldiylbis(thio)bis(imidazoles)

Publications (2)

Publication Number Publication Date
JPS5545693A true JPS5545693A (en) 1980-03-31
JPS6350353B2 JPS6350353B2 (ja) 1988-10-07

Family

ID=25481849

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12250679A Granted JPS5545693A (en) 1978-09-22 1979-09-21 Bis*imidazole* compound*its manufacture and its use

Country Status (6)

Country Link
US (1) US4188397A (ja)
EP (1) EP0010361B1 (ja)
JP (1) JPS5545693A (ja)
DE (1) DE2965287D1 (ja)
IE (1) IE49461B1 (ja)
IT (1) IT1119165B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5837255A (ja) * 1981-08-26 1983-03-04 住金鋼材工業株式会社 合成床板
JPH03128360A (ja) * 1989-07-31 1991-05-31 Merck & Co Inc イミダゾール化合物およびトランスグルタミナーゼ阻害剤としてのその使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126012B1 (fr) * 1983-05-17 1988-01-13 Sanofi S.A. Compositions pharmaceutiques à base de disulfures symétriques
US4847270A (en) * 1985-12-12 1989-07-11 Smithkline Beckman Corporation Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-alkyldiyl bis(thio)bis-imidazoles and derivatives
US4728656A (en) * 1985-12-12 1988-03-01 Smithkline Beckman Corporation 2,2-alkyldiylbis(thio)bis(imidazoles) useful for inhibition of the 5-lipoxygenase pathway
JPH0680057B2 (ja) * 1986-04-28 1994-10-12 保土谷化学工業株式会社 トリフエニルイミダゾ−ル及びその二量体
US4778806A (en) * 1986-08-19 1988-10-18 Smithkline Beckman Corporation Inhibition of interleukin-1 production by monocytes and/or macrophages
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
IE904450A1 (en) * 1989-12-11 1991-06-19 Rhone Poulenc Sante Imidazoles
IT1265209B1 (it) * 1993-11-22 1996-10-31 Pierrel Spa Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US6426360B1 (en) 1994-07-28 2002-07-30 G D Searle & Co. 4,5-substituted imidazolyl compounds for the treatment of inflammation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3070599A (en) * 1962-12-25 Method fos preparing secondary amino-
DE960279C (de) * 1954-09-29 1957-03-21 Asta Werke Ag Chem Fab Verfahren zur Herstellung von Bis-[imidazyl-(2)]-disulfid und dessen Abkoemmlingen
US3086018A (en) * 1957-12-24 1963-04-16 Goodyear Tire & Rubber Manufacture of amino thiazole disulfides
DE1797027C3 (de) * 1968-08-06 1980-03-13 Agfa-Gevaert Ag, 5090 Leverkusen Lichtempfindliches photographisches Aufzeichnungsmaterial
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5837255A (ja) * 1981-08-26 1983-03-04 住金鋼材工業株式会社 合成床板
JPH03128360A (ja) * 1989-07-31 1991-05-31 Merck & Co Inc イミダゾール化合物およびトランスグルタミナーゼ阻害剤としてのその使用

Also Published As

Publication number Publication date
EP0010361A1 (en) 1980-04-30
EP0010361B1 (en) 1983-04-27
IE791744L (en) 1980-03-22
IT7968840A0 (it) 1979-09-19
IT1119165B (it) 1986-03-03
IE49461B1 (en) 1985-10-16
DE2965287D1 (en) 1983-06-01
JPS6350353B2 (ja) 1988-10-07
US4188397A (en) 1980-02-12

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