JPS5540658A - 1,4-thiazan-3-carboxylic ester derivative and its preparation - Google Patents

1,4-thiazan-3-carboxylic ester derivative and its preparation

Info

Publication number
JPS5540658A
JPS5540658A JP11523978A JP11523978A JPS5540658A JP S5540658 A JPS5540658 A JP S5540658A JP 11523978 A JP11523978 A JP 11523978A JP 11523978 A JP11523978 A JP 11523978A JP S5540658 A JPS5540658 A JP S5540658A
Authority
JP
Japan
Prior art keywords
compound
formula
thiazan
methyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11523978A
Other languages
Japanese (ja)
Inventor
Naoto Yoneda
Kazuo Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP11523978A priority Critical patent/JPS5540658A/en
Publication of JPS5540658A publication Critical patent/JPS5540658A/en
Pending legal-status Critical Current

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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 and R2 are lower alkyl groups).
EXAMPLE: Methyl 5-methyl-1,4-thiazan-3-carboxylate.
USE: An intermediate for the synthesis of cycloalliin[5-(S)-methyl-1,4-thiazan-3(R)- carboxylic acid-1(S)-oxide] and its fomolog, which is an antithrombotic and a remedy for arteriosclerosis, having a fibrinolytic action.
PROCESS: A compound of formula II is reacted with a compound of formula III: (X is halogen) in the presence of a base, and preferably a dehydrating agent, in a solvent, e.g. methanol, at room temperature, preferably 0W5°C, to give a compound of formula V. The C=N bond of the compound thus obtained is reduced. With an agent, e.g. sodium borohydride, to give the objective compound of formula I having the C-N bond.
COPYRIGHT: (C)1980,JPO&Japio
JP11523978A 1978-09-19 1978-09-19 1,4-thiazan-3-carboxylic ester derivative and its preparation Pending JPS5540658A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11523978A JPS5540658A (en) 1978-09-19 1978-09-19 1,4-thiazan-3-carboxylic ester derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11523978A JPS5540658A (en) 1978-09-19 1978-09-19 1,4-thiazan-3-carboxylic ester derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5540658A true JPS5540658A (en) 1980-03-22

Family

ID=14657781

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11523978A Pending JPS5540658A (en) 1978-09-19 1978-09-19 1,4-thiazan-3-carboxylic ester derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5540658A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003860A1 (en) * 1981-04-29 1982-11-11 Gillet Claude Derivatives of 1,4-thiazane-carboxylic acid,preparation and utilization thereof and compositions containing same
US4992535A (en) * 1988-10-26 1991-02-12 G. D. Searle & Co. Methods of making novel R and S diastereomers of N6 -[(2-hydroxypropyl)aryl]adenosines

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003860A1 (en) * 1981-04-29 1982-11-11 Gillet Claude Derivatives of 1,4-thiazane-carboxylic acid,preparation and utilization thereof and compositions containing same
FR2509303A1 (en) * 1981-04-29 1983-01-14 Midit Ste Fiduciaire Enregistr 1.4-THIAZANE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE, AND THE COMPOSITIONS CONTAINING THESE DERIVATIVES
JPS58500713A (en) * 1981-04-29 1983-05-06 コンチネンタル　フアルマ　インコ−ポレイテツド 1,4-thiazanecarboxylic acid derivatives, methods for producing the same, and pharmaceutical compositions containing the derivatives
US4992535A (en) * 1988-10-26 1991-02-12 G. D. Searle & Co. Methods of making novel R and S diastereomers of N6 -[(2-hydroxypropyl)aryl]adenosines

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