JPS5536419A - 2-substituted adenosine derivative and its preparation - Google Patents
2-substituted adenosine derivative and its preparationInfo
- Publication number
- JPS5536419A JPS5536419A JP10965578A JP10965578A JPS5536419A JP S5536419 A JPS5536419 A JP S5536419A JP 10965578 A JP10965578 A JP 10965578A JP 10965578 A JP10965578 A JP 10965578A JP S5536419 A JPS5536419 A JP S5536419A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkoxy
- preparation
- antiviral activity
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2-substituted adenosine Chemical class 0.000 title 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- IQZWKGWOBPJWMX-UHFFFAOYSA-N 2-Methyladenosine Natural products C12=NC(C)=NC(N)=C2N=CN1C1OC(CO)C(O)C1O IQZWKGWOBPJWMX-UHFFFAOYSA-N 0.000 abstract 1
- IQZWKGWOBPJWMX-IOSLPCCCSA-N 2-methyladenosine Chemical compound C12=NC(C)=NC(N)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O IQZWKGWOBPJWMX-IOSLPCCCSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10965578A JPS5536419A (en) | 1978-09-08 | 1978-09-08 | 2-substituted adenosine derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10965578A JPS5536419A (en) | 1978-09-08 | 1978-09-08 | 2-substituted adenosine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5536419A true JPS5536419A (en) | 1980-03-14 |
| JPS633875B2 JPS633875B2 (enrdf_load_stackoverflow) | 1988-01-26 |
Family
ID=14515785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10965578A Granted JPS5536419A (en) | 1978-09-08 | 1978-09-08 | 2-substituted adenosine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5536419A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5852223A (ja) * | 1981-09-21 | 1983-03-28 | Ajinomoto Co Inc | アデニンアラビノシドの抗ウィルス活性低下防止剤 |
| WO2001027130A1 (en) * | 1999-10-14 | 2001-04-19 | Pfizer Limited | Purine derivatives |
| WO2001027131A1 (en) * | 1999-10-14 | 2001-04-19 | Pfizer Limited | Purine derivatives |
| WO2000077018A3 (en) * | 1999-06-15 | 2001-12-06 | Pfizer Ltd | Purine derivatives |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11635923B2 (en) | 2018-12-28 | 2023-04-25 | Kyocera Document Solutions Inc. | Monitoring system, monitoring method, and monitoring program |
-
1978
- 1978-09-08 JP JP10965578A patent/JPS5536419A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5852223A (ja) * | 1981-09-21 | 1983-03-28 | Ajinomoto Co Inc | アデニンアラビノシドの抗ウィルス活性低下防止剤 |
| WO2000077018A3 (en) * | 1999-06-15 | 2001-12-06 | Pfizer Ltd | Purine derivatives |
| US6900309B1 (en) | 1999-06-15 | 2005-05-31 | Pfizer Inc | Purine derivatives |
| WO2001027130A1 (en) * | 1999-10-14 | 2001-04-19 | Pfizer Limited | Purine derivatives |
| WO2001027131A1 (en) * | 1999-10-14 | 2001-04-19 | Pfizer Limited | Purine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS633875B2 (enrdf_load_stackoverflow) | 1988-01-26 |
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