JPS5517342A - Cephalosporin composition for rectal administaration - Google Patents
Cephalosporin composition for rectal administarationInfo
- Publication number
- JPS5517342A JPS5517342A JP9000178A JP9000178A JPS5517342A JP S5517342 A JPS5517342 A JP S5517342A JP 9000178 A JP9000178 A JP 9000178A JP 9000178 A JP9000178 A JP 9000178A JP S5517342 A JPS5517342 A JP S5517342A
- Authority
- JP
- Japan
- Prior art keywords
- active agent
- salt
- surface active
- composition
- rectal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE: A composition for rectal administration that contains a specific cephalosporin derivative, an oil base and a surface active agent, thus having improved absorption from rectum.
CONSTITUTION: One of cephalosporin derivatives, which is developed by the present inventor, that is, 7-[D(-)-α-(4-ethyl-1-2,3-dioxo-1-piperazinyl carboxamide)- p-hydroxyphenylacetamide]-3-[5-(1-methyl-1-1, 2, 3, 4-tetrazolyl)thiomethyl]-Δ3- cephem-4-carboxylic acid of the formula, or its nontoxic salt is incorporated with a nonionic surface active agent as polyoxyethylene higher alcohol ether, an anionic surface active agent as sulfate ester salt or sulfonate salt and/or bile acid salt to form said composition, which can give high concentration in blood without injection.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9000178A JPS5517342A (en) | 1978-07-25 | 1978-07-25 | Cephalosporin composition for rectal administaration |
GB7924710A GB2028655B (en) | 1978-07-25 | 1979-07-16 | Compositions for rectal administration |
CA332,022A CA1123738A (en) | 1978-07-25 | 1979-07-18 | Pharmaceutical composition for rectal administration of cephalosporin |
NZ191053A NZ191053A (en) | 1978-07-25 | 1979-07-18 | Rectal pharmaceutical composition containing a cephalosporin compound |
IN747/CAL/79A IN151264B (en) | 1978-07-25 | 1979-07-20 | |
IL57846A IL57846A (en) | 1978-07-25 | 1979-07-20 | Pharmaceutical composition for rectal administration of cephalosporin |
ZA00793734A ZA793734B (en) | 1978-07-25 | 1979-07-20 | Pharmaceutical composition for rectal administration of cephalosporin |
EG439/79A EG15790A (en) | 1978-07-25 | 1979-07-21 | Pharmaceutical composition for rectal administration of cephalosporin |
CH680379A CH641351A5 (en) | 1978-07-25 | 1979-07-23 | RECTALLY ADMINISTRABLE PHARMACEUTICAL PRODUCT. |
HU79TO1112A HU180965B (en) | 1978-07-25 | 1979-07-23 | Process for preparing a pharmaceutical composition containing 7-/d/-/-alpha/4-ethyl-2,3-dioxy-1-piperazinyl-/carboxamido/-/p-hydroxy-phenyl/-acetamido-3-/5-/1-methyl-1,2,3,4-tetrazolyl/-thio-methyl/-delta up 3 -cephem-4-carboxylic acid |
DK310079A DK159136C (en) | 1978-07-25 | 1979-07-23 | PROCEDURE FOR PREPARING A PHARMACEUTICAL PREPARATION FOR RECTAL ADMINISTRATION |
FI792303A FI792303A (en) | 1978-07-25 | 1979-07-23 | PHARMACEUTICAL COMPOSITION FOR THE ADMINISTRATION OF KEFALOSPORIN |
FR7918926A FR2433945A1 (en) | 1978-07-25 | 1979-07-23 | PHARMACEUTICAL COMPOSITION FOR RECTAL ADMINISTRATION OF CEPHALOSPORIN |
GR59674A GR69652B (en) | 1978-07-25 | 1979-07-23 | |
DE19792929840 DE2929840A1 (en) | 1978-07-25 | 1979-07-23 | RECTALLY ADMINISTRABLE PHARMACEUTICAL PRODUCT |
LU81546A LU81546A1 (en) | 1978-07-25 | 1979-07-24 | PHARMACEUTICAL COMPOSITION FOR RECTAL ADMINISTRATION OF CEPHALOSPORIN |
AU49191/79A AU529031B2 (en) | 1978-07-25 | 1979-07-24 | Cephalosporin composition |
PH22810A PH16496A (en) | 1978-07-25 | 1979-07-24 | Pharmaceutical composition for rectal administration of cephalosporin |
NL7905708A NL7905708A (en) | 1978-07-25 | 1979-07-24 | PHARMACEUTICAL PREPARATION. |
NO792443A NO792443L (en) | 1978-07-25 | 1979-07-24 | PROCEDURE FOR THE PREPARATION OF A CEPHALOSPOR PREPARATION |
CS795161A CS268651B2 (en) | 1978-07-25 | 1979-07-24 | Method of pharmaceutical production for rectal dosage |
SE7906340A SE7906340L (en) | 1978-07-25 | 1979-07-24 | PHARMACEUTICAL COMPOSITION FOR RECTAL ADMINISTRATION OF CEPHALOSPORIN |
ES482818A ES482818A1 (en) | 1978-07-25 | 1979-07-24 | Compositions for rectal administration |
IT49844/79A IT1118900B (en) | 1978-07-25 | 1979-07-24 | PHARMACEUTICAL COMPOSITION CONTAINING CEPHALOSPORIN FOR RECTAL ADMINISTRATION |
PT69969A PT69969A (en) | 1978-07-25 | 1979-07-24 | Process for preparing pharmaceutical compositions for rectal administration of cephalosporin |
BE0/196403A BE877831A (en) | 1978-07-25 | 1979-07-27 | PHARMACEUTICAL COMPOSITION FOR RECTAL ADMINISTRATION OF CEPHALOSPORIN |
IE1411/79A IE48602B1 (en) | 1978-07-25 | 1979-08-08 | Pharmaceutical composition for rectal administration of 7-(d(-)-alpha-(4-ethyl-2,3-dioxo-1-piperazinylcarboxamide)-p-hydroxyphenyl acetamido)-3-(5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl)-delta3-cephem-4-carboxylic acid or salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9000178A JPS5517342A (en) | 1978-07-25 | 1978-07-25 | Cephalosporin composition for rectal administaration |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5517342A true JPS5517342A (en) | 1980-02-06 |
Family
ID=13986352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9000178A Pending JPS5517342A (en) | 1978-07-25 | 1978-07-25 | Cephalosporin composition for rectal administaration |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS5517342A (en) |
AU (1) | AU529031B2 (en) |
BE (1) | BE877831A (en) |
CA (1) | CA1123738A (en) |
CH (1) | CH641351A5 (en) |
CS (1) | CS268651B2 (en) |
DE (1) | DE2929840A1 (en) |
DK (1) | DK159136C (en) |
EG (1) | EG15790A (en) |
ES (1) | ES482818A1 (en) |
FI (1) | FI792303A (en) |
FR (1) | FR2433945A1 (en) |
GB (1) | GB2028655B (en) |
GR (1) | GR69652B (en) |
HU (1) | HU180965B (en) |
IE (1) | IE48602B1 (en) |
IL (1) | IL57846A (en) |
IN (1) | IN151264B (en) |
IT (1) | IT1118900B (en) |
LU (1) | LU81546A1 (en) |
NL (1) | NL7905708A (en) |
NO (1) | NO792443L (en) |
NZ (1) | NZ191053A (en) |
PH (1) | PH16496A (en) |
PT (1) | PT69969A (en) |
SE (1) | SE7906340L (en) |
ZA (1) | ZA793734B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100739830B1 (en) * | 2001-03-23 | 2007-07-13 | 주식회사 하원제약 | Process for preparing Cephalosporin derivative |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4760059A (en) * | 1985-08-05 | 1988-07-26 | Hoffmann-La Roche Inc. | Rectal dosage form |
AT392906B (en) * | 1987-10-08 | 1991-07-10 | Hoffmann La Roche | Pharmaceutical products for oral administration |
US5190748A (en) * | 1988-11-22 | 1993-03-02 | Hoffmann-La Roche Inc. | Absorption enhancement of antibiotics |
US8075910B2 (en) | 2004-05-20 | 2011-12-13 | Pbm Pharmaceuticals, Inc. | Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions |
CN113637026A (en) * | 2020-05-11 | 2021-11-12 | 承德医学院 | Cefoperazone magnesium compound, and preparation method and application thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5082221A (en) * | 1973-11-08 | 1975-07-03 | ||
JPS5244222A (en) * | 1975-09-30 | 1977-04-07 | Yamanouchi Pharmaceut Co Ltd | Method of making insulin preparations for rectal application |
JPS5272812A (en) * | 1975-12-12 | 1977-06-17 | Banyu Pharmaceut Co Ltd | Preparation of cephatridin pharmaceuticals for rectal infusion |
JPS52105220A (en) * | 1976-02-28 | 1977-09-03 | Toyama Chem Co Ltd | Composition for rectal administration comprising beta-lactam ring containing substance and method of making same |
JPS5619847A (en) * | 1979-07-25 | 1981-02-24 | Hitachi Ltd | Manufacturing process for discharge lamp |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4950119A (en) * | 1972-09-21 | 1974-05-15 | ||
GB1508071A (en) * | 1976-01-19 | 1978-04-19 | Toyama Chemical Co Ltd | Cephalosporins and process for producing the same |
JPS52156918A (en) * | 1976-06-21 | 1977-12-27 | Sumitomo Chem Co Ltd | Preparation of penicillin pharmaceuticals for rectal infusion |
-
1978
- 1978-07-25 JP JP9000178A patent/JPS5517342A/en active Pending
-
1979
- 1979-07-16 GB GB7924710A patent/GB2028655B/en not_active Expired
- 1979-07-18 CA CA332,022A patent/CA1123738A/en not_active Expired
- 1979-07-18 NZ NZ191053A patent/NZ191053A/en unknown
- 1979-07-20 IL IL57846A patent/IL57846A/en unknown
- 1979-07-20 ZA ZA00793734A patent/ZA793734B/en unknown
- 1979-07-20 IN IN747/CAL/79A patent/IN151264B/en unknown
- 1979-07-21 EG EG439/79A patent/EG15790A/en active
- 1979-07-23 GR GR59674A patent/GR69652B/el unknown
- 1979-07-23 DK DK310079A patent/DK159136C/en not_active IP Right Cessation
- 1979-07-23 HU HU79TO1112A patent/HU180965B/en unknown
- 1979-07-23 FI FI792303A patent/FI792303A/en not_active Application Discontinuation
- 1979-07-23 FR FR7918926A patent/FR2433945A1/en active Granted
- 1979-07-23 CH CH680379A patent/CH641351A5/en not_active IP Right Cessation
- 1979-07-23 DE DE19792929840 patent/DE2929840A1/en active Granted
- 1979-07-24 NL NL7905708A patent/NL7905708A/en active Search and Examination
- 1979-07-24 PT PT69969A patent/PT69969A/en unknown
- 1979-07-24 LU LU81546A patent/LU81546A1/en unknown
- 1979-07-24 IT IT49844/79A patent/IT1118900B/en active
- 1979-07-24 NO NO792443A patent/NO792443L/en unknown
- 1979-07-24 ES ES482818A patent/ES482818A1/en not_active Expired
- 1979-07-24 PH PH22810A patent/PH16496A/en unknown
- 1979-07-24 CS CS795161A patent/CS268651B2/en unknown
- 1979-07-24 SE SE7906340A patent/SE7906340L/en not_active Application Discontinuation
- 1979-07-24 AU AU49191/79A patent/AU529031B2/en not_active Expired
- 1979-07-27 BE BE0/196403A patent/BE877831A/en not_active IP Right Cessation
- 1979-08-08 IE IE1411/79A patent/IE48602B1/en not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5082221A (en) * | 1973-11-08 | 1975-07-03 | ||
JPS5244222A (en) * | 1975-09-30 | 1977-04-07 | Yamanouchi Pharmaceut Co Ltd | Method of making insulin preparations for rectal application |
JPS5272812A (en) * | 1975-12-12 | 1977-06-17 | Banyu Pharmaceut Co Ltd | Preparation of cephatridin pharmaceuticals for rectal infusion |
JPS52105220A (en) * | 1976-02-28 | 1977-09-03 | Toyama Chem Co Ltd | Composition for rectal administration comprising beta-lactam ring containing substance and method of making same |
JPS5619847A (en) * | 1979-07-25 | 1981-02-24 | Hitachi Ltd | Manufacturing process for discharge lamp |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100739830B1 (en) * | 2001-03-23 | 2007-07-13 | 주식회사 하원제약 | Process for preparing Cephalosporin derivative |
Also Published As
Publication number | Publication date |
---|---|
FR2433945B1 (en) | 1984-12-14 |
CH641351A5 (en) | 1984-02-29 |
GR69652B (en) | 1982-07-07 |
FR2433945A1 (en) | 1980-03-21 |
PH16496A (en) | 1983-10-28 |
IE791411L (en) | 1980-01-25 |
GB2028655B (en) | 1982-12-22 |
DK310079A (en) | 1980-01-26 |
AU529031B2 (en) | 1983-05-26 |
BE877831A (en) | 1980-01-23 |
DE2929840C2 (en) | 1989-01-12 |
IE48602B1 (en) | 1985-03-20 |
FI792303A (en) | 1980-01-26 |
SE7906340L (en) | 1980-01-27 |
ZA793734B (en) | 1980-07-30 |
AU4919179A (en) | 1980-01-31 |
LU81546A1 (en) | 1980-01-24 |
CS268651B2 (en) | 1990-04-11 |
CS516179A2 (en) | 1989-09-12 |
GB2028655A (en) | 1980-03-12 |
PT69969A (en) | 1979-08-01 |
NZ191053A (en) | 1982-02-23 |
NL7905708A (en) | 1980-01-29 |
IL57846A (en) | 1983-09-30 |
DE2929840A1 (en) | 1980-02-14 |
CA1123738A (en) | 1982-05-18 |
NO792443L (en) | 1980-01-28 |
HU180965B (en) | 1983-05-30 |
IT1118900B (en) | 1986-03-03 |
IN151264B (en) | 1983-03-19 |
DK159136C (en) | 1991-03-11 |
EG15790A (en) | 1986-09-30 |
ES482818A1 (en) | 1980-09-01 |
DK159136B (en) | 1990-09-10 |
IT7949844A0 (en) | 1979-07-24 |
IL57846A0 (en) | 1979-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5334794A (en) | Cephalosporin derivatives and their preparation | |
JPS5262213A (en) | Polypluenyl derivatives | |
HUT39175A (en) | Process for producing 7-/3-aryl-1-piperazinyl/- and 7-/3-cyclohexyl-1-piperazinyl/-3-quinoline-carboxylic acids and pharmaceutical compositions containing them as active agents | |
JPS5517342A (en) | Cephalosporin composition for rectal administaration | |
JPS5495589A (en) | Production of cephalosporin derivative | |
JPS5732290A (en) | Novel penicillin derivative and its preparation | |
JPS54138590A (en) | 7-methoxycephalosporin compound, its preparation, and anti-bacterial agent containing the same | |
KR840004121A (en) | Stabilization Method of Azrene Derivatives | |
JPS57158719A (en) | Rectal administration pharmaceutical | |
JPS56142286A (en) | Preparation of penicillin 1-oxide | |
JPS5436286A (en) | Novel cephalosporanic acid derivative, its optically active isomer, and its preparation | |
JPS5246067A (en) | Reduction of optically active 5-oxo-2-pyrrolidinacetic acid esters | |
JPS5283684A (en) | Penicillin and cephalosporin derivatives | |
JPS5217447A (en) | Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester | |
JPS5564589A (en) | Penicillin ester compound | |
JPS5373566A (en) | 7,8,9,10,-tetrahydrophenanthridone-3-acetic acids | |
JPS54135791A (en) | 7-methoxycephalosporin compound, its preparation, and antibacterial agent containing the compound as main component | |
JPS5512922A (en) | Thermo developed light-sensitive material | |
JPS5536404A (en) | New penicillanic acid derivative, its optically active isomer, its salt, and its preparation | |
JPS53112891A (en) | Production of 7-aminocephalosporanic acid derivative | |
JPS5448784A (en) | N,n-dimethylacetamide adduct of cephalosporin and its preparation | |
JPS5280310A (en) | Cleanser composition | |
JPS52122391A (en) | Novel penicillins | |
JPS5439017A (en) | Novel organic sulfonic acid esters and their preparation | |
JPS5297993A (en) | Novel penicillin and cephalosporin derivatives |