JPS55130911A - Analgesic - Google Patents
AnalgesicInfo
- Publication number
- JPS55130911A JPS55130911A JP3879279A JP3879279A JPS55130911A JP S55130911 A JPS55130911 A JP S55130911A JP 3879279 A JP3879279 A JP 3879279A JP 3879279 A JP3879279 A JP 3879279A JP S55130911 A JPS55130911 A JP S55130911A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- formula
- compound
- lower alkyl
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To provide an analgesic containing a biuret compound as an effective component.
CONSTITUTION: An analgesic containing a biuret compound of formula 1 (R1 is lower alkyl or phenyl; R2 is lower alkyl, phenyl, etc.; R1 and R2 may together form a single heterocyclic ring containing one or two hetero atoms with the adjacent N atom; R3 is H, lower alkyl, or phenyl; R4 is phenyl, benzyl, cyclohexyl, etc.), as an effective component. Dose: pref. 10W2,000mg/day of the compound 1. Two or three times per day. Administered in the form of an oral medicine, injection, suppository for rectal administration, external preparation, etc. The compound of formula 1 can be prepared by reacting a urea derivative of formula 2 with an isocyanate derivative of formula 3 in the absence or presence of a solvent (e.g. ether) at a temperature between room temp. and about the boiling point of the solvent. For example, 1-ethyl-1-methyl-5-phenylbiuret can be prepared at 65% yield.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3879279A JPS55130911A (en) | 1979-03-31 | 1979-03-31 | Analgesic |
US06/134,555 US4278672A (en) | 1979-03-31 | 1980-03-27 | Pharmaceutical composition and methods of use containing 1,1,3,5-substituted biuret compound |
FR8007037A FR2452926A1 (en) | 1979-03-31 | 1980-03-28 | PHARMACEUTICAL COMPOSITION CONTAINING A 1,1,3,5-SUBSTITUTED COMPOUND OF BIURET |
DE19803012123 DE3012123A1 (en) | 1979-03-31 | 1980-03-28 | PHARMACEUTICAL AGENT BASED ON 1,1,3,5-SUBSTITUTED BIURET COMPOUNDS |
GB8010753A GB2055042B (en) | 1979-03-31 | 1980-03-31 | Pharmaceutical compositions containing substituted biruets compound |
US06/257,418 US4371544A (en) | 1979-03-31 | 1981-04-24 | Pharmaceutical composition containing 1,1,3,5-substituted biuret compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3879279A JPS55130911A (en) | 1979-03-31 | 1979-03-31 | Analgesic |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55130911A true JPS55130911A (en) | 1980-10-11 |
JPS6323967B2 JPS6323967B2 (en) | 1988-05-18 |
Family
ID=12535148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3879279A Granted JPS55130911A (en) | 1979-03-31 | 1979-03-31 | Analgesic |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55130911A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58152859A (en) * | 1982-03-05 | 1983-09-10 | Taiho Yakuhin Kogyo Kk | Biuret derivative |
-
1979
- 1979-03-31 JP JP3879279A patent/JPS55130911A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58152859A (en) * | 1982-03-05 | 1983-09-10 | Taiho Yakuhin Kogyo Kk | Biuret derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS6323967B2 (en) | 1988-05-18 |
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