JPS55130911A - Analgesic - Google Patents

Analgesic

Info

Publication number
JPS55130911A
JPS55130911A JP3879279A JP3879279A JPS55130911A JP S55130911 A JPS55130911 A JP S55130911A JP 3879279 A JP3879279 A JP 3879279A JP 3879279 A JP3879279 A JP 3879279A JP S55130911 A JPS55130911 A JP S55130911A
Authority
JP
Japan
Prior art keywords
phenyl
formula
compound
lower alkyl
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3879279A
Other languages
Japanese (ja)
Other versions
JPS6323967B2 (en
Inventor
Hajime Fujimura
Yasuzo Hiramatsu
Takahiro Yabuuchi
Masakatsu Kuki
Katsuo Takigawa
Takatsugu Honna
Hidekazu Miyake
Akira Kajitani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Original Assignee
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Production Development, Zaidan Hojin Seisan Kaihatsu Kenkyusho filed Critical Research Institute for Production Development
Priority to JP3879279A priority Critical patent/JPS55130911A/en
Priority to US06/134,555 priority patent/US4278672A/en
Priority to FR8007037A priority patent/FR2452926A1/en
Priority to DE19803012123 priority patent/DE3012123A1/en
Priority to GB8010753A priority patent/GB2055042B/en
Publication of JPS55130911A publication Critical patent/JPS55130911A/en
Priority to US06/257,418 priority patent/US4371544A/en
Publication of JPS6323967B2 publication Critical patent/JPS6323967B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To provide an analgesic containing a biuret compound as an effective component.
CONSTITUTION: An analgesic containing a biuret compound of formula 1 (R1 is lower alkyl or phenyl; R2 is lower alkyl, phenyl, etc.; R1 and R2 may together form a single heterocyclic ring containing one or two hetero atoms with the adjacent N atom; R3 is H, lower alkyl, or phenyl; R4 is phenyl, benzyl, cyclohexyl, etc.), as an effective component. Dose: pref. 10W2,000mg/day of the compound 1. Two or three times per day. Administered in the form of an oral medicine, injection, suppository for rectal administration, external preparation, etc. The compound of formula 1 can be prepared by reacting a urea derivative of formula 2 with an isocyanate derivative of formula 3 in the absence or presence of a solvent (e.g. ether) at a temperature between room temp. and about the boiling point of the solvent. For example, 1-ethyl-1-methyl-5-phenylbiuret can be prepared at 65% yield.
COPYRIGHT: (C)1980,JPO&Japio
JP3879279A 1979-03-31 1979-03-31 Analgesic Granted JPS55130911A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP3879279A JPS55130911A (en) 1979-03-31 1979-03-31 Analgesic
US06/134,555 US4278672A (en) 1979-03-31 1980-03-27 Pharmaceutical composition and methods of use containing 1,1,3,5-substituted biuret compound
FR8007037A FR2452926A1 (en) 1979-03-31 1980-03-28 PHARMACEUTICAL COMPOSITION CONTAINING A 1,1,3,5-SUBSTITUTED COMPOUND OF BIURET
DE19803012123 DE3012123A1 (en) 1979-03-31 1980-03-28 PHARMACEUTICAL AGENT BASED ON 1,1,3,5-SUBSTITUTED BIURET COMPOUNDS
GB8010753A GB2055042B (en) 1979-03-31 1980-03-31 Pharmaceutical compositions containing substituted biruets compound
US06/257,418 US4371544A (en) 1979-03-31 1981-04-24 Pharmaceutical composition containing 1,1,3,5-substituted biuret compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3879279A JPS55130911A (en) 1979-03-31 1979-03-31 Analgesic

Publications (2)

Publication Number Publication Date
JPS55130911A true JPS55130911A (en) 1980-10-11
JPS6323967B2 JPS6323967B2 (en) 1988-05-18

Family

ID=12535148

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3879279A Granted JPS55130911A (en) 1979-03-31 1979-03-31 Analgesic

Country Status (1)

Country Link
JP (1) JPS55130911A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152859A (en) * 1982-03-05 1983-09-10 Taiho Yakuhin Kogyo Kk Biuret derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152859A (en) * 1982-03-05 1983-09-10 Taiho Yakuhin Kogyo Kk Biuret derivative

Also Published As

Publication number Publication date
JPS6323967B2 (en) 1988-05-18

Similar Documents

Publication Publication Date Title
JPS5671073A (en) Imidazole derivative
JPS568352A (en) Aminoalkylvenzene derivative
PT76614B (en) THIOMETHYLPYRIDINE DERIVATIVES PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS
JPS55130911A (en) Analgesic
JPS55130913A (en) Antiphlogistic agent
JPS5583749A (en) Quinolone derivative
JPS55130912A (en) Antiphlogistic agent
JPS55130910A (en) Analgesic
GB1008849A (en) Basically substituted triazolidines, processes for their manufacture and pharmaceutical preparations containing them
ES8105330A1 (en) Thiazolo (2,3-b) benzo (and azabenzo) thiazole derivatives, process for their preparation and pharmaceutical compositions containing them.
DE3067553D1 (en) Nitrosourea derivatives, process for preparing them, and pharmaceutical compositions containing them
JPS55104274A (en) Isoxazolin-3-one derivative and its preparation
JPS5610174A (en) Analgesic and antiphlogistic agent
JPS57149277A (en) Heterocyclic compound
JPS55111470A (en) Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient
JPS5536454A (en) Novel immunosuppressive agent
JPS5690067A (en) Novel heterocyclic ring substituted phenylacetic acid derivative
JPS5283818A (en) Novel cyclohexane derivatives
JPS57212188A (en) Imidazobenzoxazine derivative and its preparation
JPS5569512A (en) Antispasmodic agent
JPS5620577A (en) 4- n-alkylanilino quinazoline derivative and its preparation
JPS55129268A (en) Carbostyril derivative
JPS5528919A (en) Medicine comprising 5-(3'-pyridyl)-2-mercaptoimidazole derivative as active constituent
JPS5610179A (en) Synthesis of benzoxazole
JPS5663977A (en) Secoprostaglandin i2 derivative and its preparation