JPS55120526A - Preparation of optical active alcohol - Google Patents

Preparation of optical active alcohol

Info

Publication number
JPS55120526A
JPS55120526A JP2819379A JP2819379A JPS55120526A JP S55120526 A JPS55120526 A JP S55120526A JP 2819379 A JP2819379 A JP 2819379A JP 2819379 A JP2819379 A JP 2819379A JP S55120526 A JPS55120526 A JP S55120526A
Authority
JP
Japan
Prior art keywords
sugar
metallic
compound
active alcohol
monosaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2819379A
Other languages
Japanese (ja)
Other versions
JPS5935367B2 (en
Inventor
Sho Yamazaki
Seiichi Nakahama
Akira Hirao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP54028193A priority Critical patent/JPS5935367B2/en
Publication of JPS55120526A publication Critical patent/JPS55120526A/en
Publication of JPS5935367B2 publication Critical patent/JPS5935367B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PURPOSE: To obtain an optical active alcohol in high optical yields useful as a preparative intermediate for a drug, spice, etc., by reducing a ketone compound with a metallic boron hydride compound in the presence of a specific sugar in an inert organic solvent.
CONSTITUTION: A ketone compound shown by the formula I (R is alkyl; R2 is aryl) is reduced with a metallic foron hydride (e.g., sodium boron hydride) in the presence of a sugar in an inert organic solvent to give the desired compound shown by the formula II (asterisk is asymmetric carbon atom) A monosaccharide and a polysaccharide may be used as the sugar, preferably the monosaccharide, e.g., 1,4:3,6-dianhydro-D-sorbital. The amount of the sugar to be used is double the molar quantity of the compound of I when the sugar has one OH and equimolar quantity when it has two OH. The use of a carboxylic acid, a metallic halide (e.g., aluminum halide) together with the sugar raises the yields.
COPYRIGHT: (C)1980,JPO&Japio
JP54028193A 1979-03-13 1979-03-13 Method for producing optically active alcohols Expired JPS5935367B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP54028193A JPS5935367B2 (en) 1979-03-13 1979-03-13 Method for producing optically active alcohols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54028193A JPS5935367B2 (en) 1979-03-13 1979-03-13 Method for producing optically active alcohols

Publications (2)

Publication Number Publication Date
JPS55120526A true JPS55120526A (en) 1980-09-17
JPS5935367B2 JPS5935367B2 (en) 1984-08-28

Family

ID=12241836

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54028193A Expired JPS5935367B2 (en) 1979-03-13 1979-03-13 Method for producing optically active alcohols

Country Status (1)

Country Link
JP (1) JPS5935367B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100436412C (en) * 2004-07-06 2008-11-26 厦门大学 Method for preparing relative amino alcohol by borohydride-acid reduction system reducing amino ketone derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100436412C (en) * 2004-07-06 2008-11-26 厦门大学 Method for preparing relative amino alcohol by borohydride-acid reduction system reducing amino ketone derivative

Also Published As

Publication number Publication date
JPS5935367B2 (en) 1984-08-28

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