JPS55113760A - Nnsubstituted aziridinee22carboxylic acid derivative and medicine containing it and having immunity stimulating activity - Google Patents

Nnsubstituted aziridinee22carboxylic acid derivative and medicine containing it and having immunity stimulating activity

Info

Publication number
JPS55113760A
JPS55113760A JP1977580A JP1977580A JPS55113760A JP S55113760 A JPS55113760 A JP S55113760A JP 1977580 A JP1977580 A JP 1977580A JP 1977580 A JP1977580 A JP 1977580A JP S55113760 A JPS55113760 A JP S55113760A
Authority
JP
Japan
Prior art keywords
nnsubstituted
acid derivative
stimulating activity
medicine containing
immunity stimulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1977580A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0150700B2 (en, 2012
Inventor
Bozuusu Erumaaru
Kamupe Buorufugangu
Teiiru Matsukusu
Bitsukaa Uubue
Beenaa Deiitomaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS55113760A publication Critical patent/JPS55113760A/ja
Publication of JPH0150700B2 publication Critical patent/JPH0150700B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP1977580A 1979-02-21 1980-02-21 Nnsubstituted aziridinee22carboxylic acid derivative and medicine containing it and having immunity stimulating activity Granted JPS55113760A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792906603 DE2906603A1 (de) 1979-02-21 1979-02-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
JPS55113760A true JPS55113760A (en) 1980-09-02
JPH0150700B2 JPH0150700B2 (en, 2012) 1989-10-31

Family

ID=6063481

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1977580A Granted JPS55113760A (en) 1979-02-21 1980-02-21 Nnsubstituted aziridinee22carboxylic acid derivative and medicine containing it and having immunity stimulating activity

Country Status (19)

Country Link
US (2) US4397848A (en, 2012)
EP (1) EP0014976B1 (en, 2012)
JP (1) JPS55113760A (en, 2012)
AR (1) AR223863A1 (en, 2012)
AT (1) ATE818T1 (en, 2012)
AU (1) AU529982B2 (en, 2012)
CA (1) CA1148962A (en, 2012)
CS (1) CS208798B2 (en, 2012)
DD (1) DD148772A5 (en, 2012)
DE (2) DE2906603A1 (en, 2012)
ES (1) ES488656A1 (en, 2012)
FI (1) FI70702C (en, 2012)
HU (1) HU182801B (en, 2012)
IE (1) IE49267B1 (en, 2012)
IL (1) IL59425A (en, 2012)
PL (1) PL129707B1 (en, 2012)
PT (1) PT70847A (en, 2012)
SU (1) SU1181541A3 (en, 2012)
ZA (1) ZA80902B (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
AU8171498A (en) * 1997-06-27 1999-01-19 Arizona Board Of Regents On Behalf Of The University Of Arizona, The Novel cyanoaziridines for treating cancer
WO2002041871A2 (en) * 2000-11-21 2002-05-30 Board Of Regents, The University Of Texas System Composition comprising an imexon or derivatives thereof and lipids
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
JP2005531495A (ja) * 2001-12-21 2005-10-20 シャイア ラボラトリーズ，インコーポレイテッド 高い物理的安定性を有する経口カプセル製剤
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
HRP20050696B1 (en) 2003-01-14 2008-10-31 Arena Pharmaceuticals Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
DK1606282T3 (da) * 2003-02-24 2009-03-16 Arena Pharm Inc Phenyl- og pyridylpipereidinye-derivater som modulatorer af glucosemetabolisme
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
EA011671B1 (ru) * 2004-06-04 2009-04-28 Арена Фармасьютикалз, Инк. Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
MY148521A (en) * 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
GEP20104966B (en) * 2005-09-16 2010-04-26 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
CA2786994C (en) 2010-01-27 2018-01-16 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
US10894787B2 (en) 2010-09-22 2021-01-19 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
EP4445956A3 (en) 2015-01-06 2024-12-04 Arena Pharmaceuticals, Inc. Compound for use in treating conditions related to the s1p1 receptor
PT3310760T (pt) 2015-06-22 2022-11-10 Arena Pharm Inc Sal cristalino de l-arginina de ácido (r)-2-(7-(4-ciclopentil-3-(trifluorometil)benziloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para utilização em distúrbios associados a recetores de s1p1
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
KR20210029190A (ko) 2018-06-06 2021-03-15 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
CN113816887A (zh) * 2021-08-31 2021-12-21 华中科技大学 一种氮杂环丙烷类化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644820A1 (de) * 1976-10-05 1978-04-06 Boehringer Mannheim Gmbh Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2731264A1 (de) 1977-07-11 1979-02-01 Boehringer Mannheim Gmbh Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETT=1972 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07301287A (ja) * 1995-03-23 1995-11-14 Sumitomo Heavy Ind Ltd 制御装置に用いられる内接噛合遊星歯車機構

Also Published As

Publication number Publication date
SU1181541A3 (ru) 1985-09-23
IE49267B1 (en) 1985-09-04
DE2906603A1 (de) 1980-09-04
IL59425A (en) 1984-05-31
HU182801B (en) 1984-03-28
ES488656A1 (es) 1980-09-16
ZA80902B (en) 1981-03-25
FI800510A7 (fi) 1980-08-22
EP0014976A1 (de) 1980-09-03
IL59425A0 (en) 1980-05-30
FI70702B (fi) 1986-06-26
DE3060268D1 (en) 1982-05-19
EP0014976B1 (de) 1982-04-07
PL222088A1 (en, 2012) 1980-12-01
US4517183A (en) 1985-05-14
CA1148962A (en) 1983-06-28
FI70702C (fi) 1986-10-06
PT70847A (de) 1980-03-01
AR223863A1 (es) 1981-09-30
AU5564980A (en) 1980-08-28
IE800327L (en) 1980-08-21
CS208798B2 (en) 1981-09-15
ATE818T1 (de) 1982-04-15
JPH0150700B2 (en, 2012) 1989-10-31
US4397848A (en) 1983-08-09
AU529982B2 (en) 1983-06-30
DD148772A5 (de) 1981-06-10
PL129707B1 (en) 1984-06-30

Similar Documents

Publication Publication Date Title
JPS55113760A (en) Nnsubstituted aziridinee22carboxylic acid derivative and medicine containing it and having immunity stimulating activity
JPS54145645A (en) *mmbenzoyllphenoxy**22propionic acid derivative and medicine
JPS57181043A (en) Arylcyclobutylamine derivative as medicine and manufacture
JPS567714A (en) Pharmaceutical medicine
JPS5618979A (en) Indolizine derivative* its manufacture and medicine containing it
JPS5481257A (en) Novel prostacycline derivative*its manufacture and medicine containing said derivative
GB2192129B (en) The preparation of pharmaceuticals for the stimulation of learning and improvement of memory
GB2060633B (en) Isocyanuric acid derivatives preparation and pharmaceutical use thereof
JPS53124238A (en) New prostan derivative * preparation thereof and medicine containing same
JPS568382A (en) 22substituted quinuclidine derivative and medicine therefrom
JPS5692255A (en) Benzamide derivative*its acid addition salt* its manufacture and medicine using it
JPS57169482A (en) Imidazopyrimidine derivative and application to medicine
JPS5646821A (en) Releaseecontrolled animal medicine and manufacture of same
JPS57131766A (en) Quinoline derivative and use as medicine
DE3064258D1 (en) Implantable cardioverter
JPS554365A (en) Cyclohexane derivative*its manufacture and medicine containing it
JPS5533467A (en) 11phenyll11propanol derivative*its manufacture and medicine containing it
JPS54128555A (en) Nnphenylalanine derivative*its manufacture and medicine
JPS57139016A (en) Burn patient medicine
JPS54109999A (en) Novel purine derivative*its manufacture and drug containing it and having antiallergic* antiiinflammatory and antiedematous activity
JPS56167636A (en) Use of 4-phenyl-4-oxy-2-hydroxybutanoic acid substitution derivative as drug
JPS54130586A (en) 55fluorouracil derivative*its manufacture and drug containing it
JPS5448799A (en) 33aminoo17aaazaaddhomooandrostane derivative*its manufacture and medicine containing it
JPS5643283A (en) Betaacarbolinee33carboxylic acid derivative* its manufacture and psychotic medicine containing it
JPS5622733A (en) Immunity creature therapeutic drug and its manufacture