JPS55100390A - Preparation of beta-lactam compound - Google Patents

Preparation of beta-lactam compound

Info

Publication number
JPS55100390A
JPS55100390A JP845579A JP845579A JPS55100390A JP S55100390 A JPS55100390 A JP S55100390A JP 845579 A JP845579 A JP 845579A JP 845579 A JP845579 A JP 845579A JP S55100390 A JPS55100390 A JP S55100390A
Authority
JP
Japan
Prior art keywords
beta
compound
7alpha
formula
alkali metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP845579A
Other languages
Japanese (ja)
Inventor
Koshiro Aida
Seiichi Masai
Hirotada Yamada
Masataka Fukumura
Hisao Tohiki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP845579A priority Critical patent/JPS55100390A/en
Publication of JPS55100390A publication Critical patent/JPS55100390A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE:To obtain a 7alpha-methoxy-beta-lactam compound, an antibacterial, in high purity and yield simply, by reacting a specific beta-lactam compound with methanol, its alkali metal salt, and a halogenating agent. CONSTITUTION:A compound of formula I (R<1> is aromatic group; R<2> is COOH, alkoxycarbonyl group, etc.; R<3> is H, halogen, heterocyclic thio group, etc.; X is S or O; M is H, alkali metal cation, etc.) is reacted with methanol and its alkali metal salt at -95--15 deg.C, and then reacted with a halogenating agent, e.g. tert-butyl hypochlorite, at the same temperature to form a 7alpha-methoxycephalosporin or 7alpha- methoxy-1-oxacephalosporin of formula II. The compound of formula II is stable to beta-lactamase and an excellent antibacterial having a wide antibacterial spectrum.
JP845579A 1979-01-26 1979-01-26 Preparation of beta-lactam compound Pending JPS55100390A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP845579A JPS55100390A (en) 1979-01-26 1979-01-26 Preparation of beta-lactam compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP845579A JPS55100390A (en) 1979-01-26 1979-01-26 Preparation of beta-lactam compound

Publications (1)

Publication Number Publication Date
JPS55100390A true JPS55100390A (en) 1980-07-31

Family

ID=11693592

Family Applications (1)

Application Number Title Priority Date Filing Date
JP845579A Pending JPS55100390A (en) 1979-01-26 1979-01-26 Preparation of beta-lactam compound

Country Status (1)

Country Link
JP (1) JPS55100390A (en)

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