JPS5441387A - Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin - Google Patents

Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin

Info

Publication number
JPS5441387A
JPS5441387A JP9899777A JP9899777A JPS5441387A JP S5441387 A JPS5441387 A JP S5441387A JP 9899777 A JP9899777 A JP 9899777A JP 9899777 A JP9899777 A JP 9899777A JP S5441387 A JPS5441387 A JP S5441387A
Authority
JP
Japan
Prior art keywords
bleomycin
medium
diaminopropane
phenylethyl
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9899777A
Other languages
Japanese (ja)
Other versions
JPS5739752B2 (en
Inventor
Aoi Kunishima
Tadao Yamazaki
Hiroyuki Hayashi
Ichiro Takahashi
Mitsuo Nozaki
Koichi Shintani
Katsuhisa Tomita
Kunio Takada
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP9899777A priority Critical patent/JPS5441387A/en
Priority to DK267478A priority patent/DK148808C/en
Priority to CS784304A priority patent/CS210673B2/en
Priority to ES471297A priority patent/ES471297A1/en
Priority to HU78NI217A priority patent/HU179556B/en
Publication of JPS5441387A publication Critical patent/JPS5441387A/en
Publication of JPS5739752B2 publication Critical patent/JPS5739752B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare a carcinostatic bleomycin derivative (NK 631) by culturing bleomycin-producing fungi belonging to Streptomyces genus in a medium containing N-[(S)-1'-phenylethyl)-1,3-diaminopropane.
CONSTITUTION: Bleomycin-producing fungi belonging to Streptomyces genus, e.g. Streptomyces verticillus NK-68-144 (FERM-P No.4108) is cultured in a nutrient medium contaning N-[(S)-1'-phenylethyl]-1,3-diaminopropane, which is a precursor of the title compound, under aerobic condition, and the title conpound (NK 631) is separated from the medium. The concentration of the precursor in the medium is usually 0.2W2mg/ml, and pref. 1mg/ml. The NK-631 has remarkably low tendency of lung fibrosis compared with conventional bleomycins, while keeping high carcinostatic activity.
COPYRIGHT: (C)1979,JPO&Japio
JP9899777A 1977-08-18 1977-08-18 Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin Granted JPS5441387A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP9899777A JPS5441387A (en) 1977-08-18 1977-08-18 Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin
DK267478A DK148808C (en) 1977-08-18 1978-06-14 METHOD FOR PREPARING 3 - ((S) -1'-PHENYLETHYLAMINO) PROPYLAMINOBLEOMYCINE
CS784304A CS210673B2 (en) 1977-08-18 1978-06-29 Manufacturing process of 3-(ls)p-1 - phenylethylamino prropylaminobleomycine
ES471297A ES471297A1 (en) 1977-08-18 1978-06-30 Preparation of 33*s**1*phenylethylaminooproplyaminoobleomycin
HU78NI217A HU179556B (en) 1977-08-18 1978-07-03 Process for producing 3-square bracket-bracket-s-bracket closed 1-comma above-phenyl-ethyl-amino-square bracket closed-propyl-amino-bleomycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9899777A JPS5441387A (en) 1977-08-18 1977-08-18 Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin

Publications (2)

Publication Number Publication Date
JPS5441387A true JPS5441387A (en) 1979-04-02
JPS5739752B2 JPS5739752B2 (en) 1982-08-23

Family

ID=14234606

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9899777A Granted JPS5441387A (en) 1977-08-18 1977-08-18 Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin

Country Status (5)

Country Link
JP (1) JPS5441387A (en)
CS (1) CS210673B2 (en)
DK (1) DK148808C (en)
ES (1) ES471297A1 (en)
HU (1) HU179556B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54124692U (en) * 1978-02-20 1979-08-31
CN107434821A (en) * 2016-05-25 2017-12-05 国科戎安生物科技（北京）有限公司 It is a kind of111The chelate of indium bleomycin derivative and application
CN107434822A (en) * 2016-05-25 2017-12-05 国科戎安生物科技（北京）有限公司 Bleomycin derivative and preparation method and application

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62129960U (en) * 1986-02-13 1987-08-17
JPS62129961U (en) * 1986-02-13 1987-08-17

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54124692U (en) * 1978-02-20 1979-08-31
CN107434821A (en) * 2016-05-25 2017-12-05 国科戎安生物科技（北京）有限公司 It is a kind of111The chelate of indium bleomycin derivative and application
CN107434822A (en) * 2016-05-25 2017-12-05 国科戎安生物科技（北京）有限公司 Bleomycin derivative and preparation method and application

Also Published As

Publication number Publication date
CS210673B2 (en) 1982-01-29
DK148808B (en) 1985-10-07
ES471297A1 (en) 1979-01-16
HU179556B (en) 1982-11-29
DK267478A (en) 1979-02-19
DK148808C (en) 1986-04-14
JPS5739752B2 (en) 1982-08-23

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