JPS54145609A - Preparation of acylaminoacetal - Google Patents

Preparation of acylaminoacetal

Info

Publication number
JPS54145609A
JPS54145609A JP5426278A JP5426278A JPS54145609A JP S54145609 A JPS54145609 A JP S54145609A JP 5426278 A JP5426278 A JP 5426278A JP 5426278 A JP5426278 A JP 5426278A JP S54145609 A JPS54145609 A JP S54145609A
Authority
JP
Japan
Prior art keywords
compound
formula
reducing
pederin
acylaminoacetal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5426278A
Other languages
Japanese (ja)
Inventor
Takeshi Matsumoto
Mitsutoshi Yanagiya
Kazuo Tsuzuki
Takahiro Watanabe
Yasuyuki Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP5426278A priority Critical patent/JPS54145609A/en
Publication of JPS54145609A publication Critical patent/JPS54145609A/en
Pending legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound which is a raw material for synthesis of pederin, toxin of an insect Paederus fuscipes, having an inhibitory action to ribosome protein synthesis, and as such has physiological activity, by reducing a specific compound.
CONSTITUTION: Acylaminoacetal of formula II is obtained by reducing a compound of formula I (R1WR3 are hydrocarbon) with a borohydride compound such as NaBH4. the reaction is carried out in a solvent at a temperature of 0W50°C. Reducing agent is used in an amount of 1-1.5 equivalent based on a starting material. The compound of formula I is prepared by reacting a nitrile of formula R1CN with a compound of formula R2OH in the presence of an acid, converting the reaction product into a compound III, and acylating the compound III.
USE: A compound having partial structure of pederin of formula IV, which has a strong eruption action, and has useful pharmacological effect.
COPYRIGHT: (C)1979,JPO&Japio
JP5426278A 1978-05-08 1978-05-08 Preparation of acylaminoacetal Pending JPS54145609A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5426278A JPS54145609A (en) 1978-05-08 1978-05-08 Preparation of acylaminoacetal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5426278A JPS54145609A (en) 1978-05-08 1978-05-08 Preparation of acylaminoacetal

Publications (1)

Publication Number Publication Date
JPS54145609A true JPS54145609A (en) 1979-11-14

Family

ID=12965642

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5426278A Pending JPS54145609A (en) 1978-05-08 1978-05-08 Preparation of acylaminoacetal

Country Status (1)

Country Link
JP (1) JPS54145609A (en)

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