JPS54145609A - Preparation of acylaminoacetal - Google Patents
Preparation of acylaminoacetalInfo
- Publication number
- JPS54145609A JPS54145609A JP5426278A JP5426278A JPS54145609A JP S54145609 A JPS54145609 A JP S54145609A JP 5426278 A JP5426278 A JP 5426278A JP 5426278 A JP5426278 A JP 5426278A JP S54145609 A JPS54145609 A JP S54145609A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reducing
- pederin
- acylaminoacetal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound which is a raw material for synthesis of pederin, toxin of an insect Paederus fuscipes, having an inhibitory action to ribosome protein synthesis, and as such has physiological activity, by reducing a specific compound.
CONSTITUTION: Acylaminoacetal of formula II is obtained by reducing a compound of formula I (R1WR3 are hydrocarbon) with a borohydride compound such as NaBH4. the reaction is carried out in a solvent at a temperature of 0W50°C. Reducing agent is used in an amount of 1-1.5 equivalent based on a starting material. The compound of formula I is prepared by reacting a nitrile of formula R1CN with a compound of formula R2OH in the presence of an acid, converting the reaction product into a compound III, and acylating the compound III.
USE: A compound having partial structure of pederin of formula IV, which has a strong eruption action, and has useful pharmacological effect.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5426278A JPS54145609A (en) | 1978-05-08 | 1978-05-08 | Preparation of acylaminoacetal |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5426278A JPS54145609A (en) | 1978-05-08 | 1978-05-08 | Preparation of acylaminoacetal |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54145609A true JPS54145609A (en) | 1979-11-14 |
Family
ID=12965642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5426278A Pending JPS54145609A (en) | 1978-05-08 | 1978-05-08 | Preparation of acylaminoacetal |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54145609A (en) |
-
1978
- 1978-05-08 JP JP5426278A patent/JPS54145609A/en active Pending
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