JPS54144385A - Purification of 5-fluorouracil - Google Patents
Purification of 5-fluorouracilInfo
- Publication number
- JPS54144385A JPS54144385A JP4989478A JP4989478A JPS54144385A JP S54144385 A JPS54144385 A JP S54144385A JP 4989478 A JP4989478 A JP 4989478A JP 4989478 A JP4989478 A JP 4989478A JP S54144385 A JPS54144385 A JP S54144385A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouracil
- crude
- exchange resin
- orotic acid
- activated alumina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare high purity 5-fluororacil useful as an antiulcer agent and its raw material, in high yield, by the adsorption treatment of crude 5-fluorouracil with an adsorbent comprising activated alumina and a cationic ion exchange resin.
CONSTITUTION: A solution of crude 5-fluorouracil (formula I) is treated sucessively with (1) an activated alumina or activated charcoal, (2) a cation exchange resin, and if necessary, (3) a porous polymer bead, to obtain a purified 5-fluorouracil free from colored impurities. The crude 5-fluorouracil is pref. prepared by the de-carbonation of 5-fluoro-orotic acid III obtained by the fluorination of orotic acid II.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4989478A JPS54144385A (en) | 1978-04-28 | 1978-04-28 | Purification of 5-fluorouracil |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4989478A JPS54144385A (en) | 1978-04-28 | 1978-04-28 | Purification of 5-fluorouracil |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54144385A true JPS54144385A (en) | 1979-11-10 |
JPS6134427B2 JPS6134427B2 (en) | 1986-08-07 |
Family
ID=12843726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4989478A Granted JPS54144385A (en) | 1978-04-28 | 1978-04-28 | Purification of 5-fluorouracil |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54144385A (en) |
-
1978
- 1978-04-28 JP JP4989478A patent/JPS54144385A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6134427B2 (en) | 1986-08-07 |
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