JPS54144385A - Purification of 5-fluorouracil - Google Patents

Purification of 5-fluorouracil

Info

Publication number
JPS54144385A
JPS54144385A JP4989478A JP4989478A JPS54144385A JP S54144385 A JPS54144385 A JP S54144385A JP 4989478 A JP4989478 A JP 4989478A JP 4989478 A JP4989478 A JP 4989478A JP S54144385 A JPS54144385 A JP S54144385A
Authority
JP
Japan
Prior art keywords
fluorouracil
crude
exchange resin
orotic acid
activated alumina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4989478A
Other languages
Japanese (ja)
Other versions
JPS6134427B2 (en
Inventor
Yoshio Oda
Keiichi Uchida
Shinsuke Morikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Priority to JP4989478A priority Critical patent/JPS54144385A/en
Publication of JPS54144385A publication Critical patent/JPS54144385A/en
Publication of JPS6134427B2 publication Critical patent/JPS6134427B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare high purity 5-fluororacil useful as an antiulcer agent and its raw material, in high yield, by the adsorption treatment of crude 5-fluorouracil with an adsorbent comprising activated alumina and a cationic ion exchange resin.
CONSTITUTION: A solution of crude 5-fluorouracil (formula I) is treated sucessively with (1) an activated alumina or activated charcoal, (2) a cation exchange resin, and if necessary, (3) a porous polymer bead, to obtain a purified 5-fluorouracil free from colored impurities. The crude 5-fluorouracil is pref. prepared by the de-carbonation of 5-fluoro-orotic acid III obtained by the fluorination of orotic acid II.
COPYRIGHT: (C)1979,JPO&Japio
JP4989478A 1978-04-28 1978-04-28 Purification of 5-fluorouracil Granted JPS54144385A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4989478A JPS54144385A (en) 1978-04-28 1978-04-28 Purification of 5-fluorouracil

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4989478A JPS54144385A (en) 1978-04-28 1978-04-28 Purification of 5-fluorouracil

Publications (2)

Publication Number Publication Date
JPS54144385A true JPS54144385A (en) 1979-11-10
JPS6134427B2 JPS6134427B2 (en) 1986-08-07

Family

ID=12843726

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4989478A Granted JPS54144385A (en) 1978-04-28 1978-04-28 Purification of 5-fluorouracil

Country Status (1)

Country Link
JP (1) JPS54144385A (en)

Also Published As

Publication number Publication date
JPS6134427B2 (en) 1986-08-07

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