JPS54144376A - Preparation of fusaric acid and its calcium salt - Google Patents

Preparation of fusaric acid and its calcium salt

Info

Publication number
JPS54144376A
JPS54144376A JP5064478A JP5064478A JPS54144376A JP S54144376 A JPS54144376 A JP S54144376A JP 5064478 A JP5064478 A JP 5064478A JP 5064478 A JP5064478 A JP 5064478A JP S54144376 A JPS54144376 A JP S54144376A
Authority
JP
Japan
Prior art keywords
pref
aniline
sulfur
methyl
calcium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5064478A
Other languages
Japanese (ja)
Inventor
Masao Kawamura
Tadaaki Nishi
Kunioki Kato
Akira Onoe
Shinichi Takemori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Seika Chemicals Co Ltd
Original Assignee
Seitetsu Kagaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seitetsu Kagaku Co Ltd filed Critical Seitetsu Kagaku Co Ltd
Priority to JP5064478A priority Critical patent/JPS54144376A/en
Publication of JPS54144376A publication Critical patent/JPS54144376A/en
Pending legal-status Critical Current

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  • Pyridine Compounds (AREA)

Abstract

PURPOSE: To prepare fusaric acid and its calcium salt useful as a hypotensive and an antibiotic substance, safely, economically, in high yield, from 2-methyl-5-n- butylpyridine, aniline and sulfur, through a novel specific compound.
CONSTITUTION: 2-Methyl-5-n-butyl pridine is made to react with aniline and sulfur at 100W200°C to afford a novel compound, 5-n-butyl-2-thiopicolinanilide, which is hydrolyzed to obtain the title compound. The hydrolysis is carried out in the presence of a hydrolyzing agent (pref. 30W90 wt%, more pref. 40W80 wt% aqueous solution of sulfuric acid) at 100W150°C, pref. 110W130°C. The preferable molar ratios of 2-methyl-5-n-butylpyridine to aniline and sulfur are 1 to 0.5W3.0, and 0.5W6.0, respectively.
COPYRIGHT: (C)1979,JPO&Japio
JP5064478A 1978-04-28 1978-04-28 Preparation of fusaric acid and its calcium salt Pending JPS54144376A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5064478A JPS54144376A (en) 1978-04-28 1978-04-28 Preparation of fusaric acid and its calcium salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5064478A JPS54144376A (en) 1978-04-28 1978-04-28 Preparation of fusaric acid and its calcium salt

Publications (1)

Publication Number Publication Date
JPS54144376A true JPS54144376A (en) 1979-11-10

Family

ID=12864647

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5064478A Pending JPS54144376A (en) 1978-04-28 1978-04-28 Preparation of fusaric acid and its calcium salt

Country Status (1)

Country Link
JP (1) JPS54144376A (en)

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