JPS54144357A - Corticoidd177*alkylcarbonate* and its manufacture - Google Patents

Corticoidd177*alkylcarbonate* and its manufacture

Info

Publication number
JPS54144357A
JPS54144357A JP5198879A JP5198879A JPS54144357A JP S54144357 A JPS54144357 A JP S54144357A JP 5198879 A JP5198879 A JP 5198879A JP 5198879 A JP5198879 A JP 5198879A JP S54144357 A JPS54144357 A JP S54144357A
Authority
JP
Japan
Prior art keywords
alkylcarbonate
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5198879A
Other languages
English (en)
Other versions
JPS6252759B2 (ja
Inventor
Shiyutaahie Ururitsuhi
Furitsuchiyu Buerunaa
Georuku Aruperuman Hansu
Kuruto Zandou Yurugen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPS54144357A publication Critical patent/JPS54144357A/ja
Publication of JPS6252759B2 publication Critical patent/JPS6252759B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP5198879A 1978-04-25 1979-04-24 Corticoidd177*alkylcarbonate* and its manufacture Granted JPS54144357A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782817988 DE2817988A1 (de) 1978-04-25 1978-04-25 Corticoid 17-alkylcarbonate und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
JPS54144357A true JPS54144357A (en) 1979-11-10
JPS6252759B2 JPS6252759B2 (ja) 1987-11-06

Family

ID=6037909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5198879A Granted JPS54144357A (en) 1978-04-25 1979-04-24 Corticoidd177*alkylcarbonate* and its manufacture

Country Status (19)

Country Link
US (1) US4377575A (ja)
EP (1) EP0004975B1 (ja)
JP (1) JPS54144357A (ja)
AR (1) AR226157A1 (ja)
AT (1) AT372094B (ja)
AU (1) AU529172B2 (ja)
CA (1) CA1130276A (ja)
DE (2) DE2817988A1 (ja)
DK (1) DK157880C (ja)
ES (2) ES479709A1 (ja)
FI (1) FI791307A (ja)
GR (1) GR72886B (ja)
HU (1) HU180788B (ja)
IE (1) IE48328B1 (ja)
IL (1) IL57114A (ja)
NO (1) NO791365L (ja)
NZ (1) NZ190256A (ja)
PT (1) PT69544A (ja)
ZA (1) ZA791941B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835199A (ja) * 1981-08-26 1983-03-01 Mitsubishi Chem Ind Ltd モノヨ−ドステロイドおよびその製造法
JPS58103400A (ja) * 1981-12-11 1983-06-20 Ota Seiyaku Kk ６α−メチルプレドニゾロン誘導体

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
AU558725B2 (en) * 1983-09-07 1987-02-05 Mitsubishi Kasei Corporation Corticoid derivatives
JPS6056997A (ja) * 1983-09-07 1985-04-02 Mitsubishi Chem Ind Ltd 新規な６−酸素化コルチコイド／７α−カ−ボネ−ト誘導体およびその製法
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE4328819A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Corticosteroid-17-alkylcarbonat-21/0/-Carbonsäure- und Kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
WO2002012265A1 (en) * 2000-08-05 2002-02-14 Glaxo Group Limited 6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYL) OXY!-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
SI1383786T1 (sl) * 2001-04-30 2009-02-28 Glaxo Group Ltd Protivnetni 17.beta-karbotioatestrski derivati androstana s ciklično estrsko skupino na položaju 17.alfa
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20040138192A1 (en) * 2003-01-13 2004-07-15 Chemagis Ltd. Crystalline forms of halobetasol propionate
US7208485B2 (en) * 2003-01-13 2007-04-24 Chemagis Ltd. Crystalline forms of halobetasol propionate
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
NZ584160A (en) * 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
CN101945885A (zh) * 2007-12-20 2011-01-12 阿斯利康(瑞典)有限公司 用作糖皮质激素受体激动剂的甾类衍生物
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253831A (en) * 1968-01-19 1971-11-17 Glaxo Lab Ltd 9alpha,21-DIHALOPREGNANE COMPOUNDS
GB1281689A (en) * 1968-10-14 1972-07-12 Glaxo Lab Ltd Steroid 21-phosphates
US3558675A (en) * 1969-06-30 1971-01-26 Merck & Co Inc Steroid carbonates and process
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
US3832366A (en) * 1973-07-30 1974-08-27 Squibb & Sons Inc Process for preparing 21-chloro-17-acyloxy-20-ketosteroids
YU54476A (en) * 1975-03-31 1982-05-31 Taisho Pharmaceutical Co Ltd Process for obtaining 17-ester 21-halo-pregnane
US4021459A (en) * 1975-08-14 1977-05-03 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835199A (ja) * 1981-08-26 1983-03-01 Mitsubishi Chem Ind Ltd モノヨ−ドステロイドおよびその製造法
JPH0148917B2 (ja) * 1981-08-26 1989-10-20 Mitsubishi Chem Ind
JPS58103400A (ja) * 1981-12-11 1983-06-20 Ota Seiyaku Kk ６α−メチルプレドニゾロン誘導体

Also Published As

Publication number Publication date
AR226157A1 (es) 1982-06-15
ATA307479A (de) 1983-01-15
IE790831L (en) 1979-10-25
GR72886B (ja) 1984-01-02
DE2817988A1 (de) 1979-11-08
NO791365L (no) 1979-10-26
IE48328B1 (en) 1984-12-12
AT372094B (de) 1983-08-25
DK157880B (da) 1990-02-26
AU529172B2 (en) 1983-05-26
EP0004975A3 (en) 1979-11-14
NZ190256A (en) 1981-03-16
EP0004975A2 (de) 1979-10-31
ES488120A1 (es) 1980-09-16
US4377575A (en) 1983-03-22
JPS6252759B2 (ja) 1987-11-06
IL57114A0 (en) 1979-07-25
DE2962122D1 (en) 1982-03-25
HU180788B (en) 1983-04-29
ES479709A1 (es) 1980-08-16
DK157880C (da) 1990-07-30
IL57114A (en) 1983-11-30
EP0004975B1 (de) 1982-02-17
FI791307A (fi) 1979-10-26
ZA791941B (en) 1980-04-30
CA1130276A (en) 1982-08-24
DK168579A (da) 1979-10-26
PT69544A (de) 1979-05-01

Similar Documents

Publication Publication Date Title
JPS54144357A (en) Corticoidd177*alkylcarbonate* and its manufacture
GB2035310B (en) Indole-s-carbaxamides and this anologues
JPS54157576A (en) Cycloalkyltriazoles and manufacture
JPS5557597A (en) Phosfinylalkanoylprolines and their manufacture
JPS5566533A (en) 44position substituted benzaldehydedialkylacetal and its manufacture
JPS54122235A (en) 11aryloxyy33nitratoalkylaminoo22propanol and its manufacture
JPS54141943A (en) Adjustless vvbelt and its manufacture
JPS55384A (en) Novel 33aryloxy substituteddaminopyridine and its manufacture
JPS5551072A (en) 44phenyll1*33benzodiazepin and its manufacture
JPS54163546A (en) Aryllglyoxyloyloxyalkylacrylate*its manufacture and usage
JPS54125668A (en) Novel ureaa and amideecompound and manufacture
JPS54132564A (en) Phenoxyalkylamine and manufacture
JPS5527182A (en) Silylcarbonylether and its manufacture
JPS54145611A (en) Acyloxyy22butene and its manufacture
JPS54130554A (en) Dichloroazetidinone and its manufacture
JPS54163556A (en) Enterokilinic complex and its manufacture
JPS5553231A (en) 22propyllpentoo44enee11al* and its manufacture
JPS5540662A (en) Hydrocortisonee17*211diester and its manufacture
JPS54122292A (en) Novel betaalactam*its manufacture and use
JPS5549373A (en) 33chloroo33methyllbutanee or 33methyll22butenee1*44diaryllbisacetal and its manufacture
JPS54115379A (en) Novel nnazolylalkyllaniline and its manufacture
GB2022093B (en) Benzothalzocines and benzothiazonines
JPS54148724A (en) Nncyanoazomecins and their manufacture
JPS5517367A (en) Bisstetrahydroisoquinolinium compounds and their manufacture
JPS5585569A (en) Hexahydroo2*66methanoo33benzoazosine and its manufacture