JPS54138566A - Mevalonolactone derivative - Google Patents
Mevalonolactone derivativeInfo
- Publication number
- JPS54138566A JPS54138566A JP4301378A JP4301378A JPS54138566A JP S54138566 A JPS54138566 A JP S54138566A JP 4301378 A JP4301378 A JP 4301378A JP 4301378 A JP4301378 A JP 4301378A JP S54138566 A JPS54138566 A JP S54138566A
- Authority
- JP
- Japan
- Prior art keywords
- halogen
- compound
- substituted
- alkyl
- mevalonolactone derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JYVXNLLUYHCIIH-ZCFIWIBFSA-N R-mevalonolactone, (-)- Chemical class C[C@@]1(O)CCOC(=O)C1 JYVXNLLUYHCIIH-ZCFIWIBFSA-N 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000881 depressing effect Effects 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- -1 trimethylene, vinylene Chemical group 0.000 abstract 1
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4301378A JPS54138566A (en) | 1978-04-12 | 1978-04-12 | Mevalonolactone derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4301378A JPS54138566A (en) | 1978-04-12 | 1978-04-12 | Mevalonolactone derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54138566A true JPS54138566A (en) | 1979-10-27 |
| JPS6136518B2 JPS6136518B2 (enExample) | 1986-08-19 |
Family
ID=12652092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4301378A Granted JPS54138566A (en) | 1978-04-12 | 1978-04-12 | Mevalonolactone derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54138566A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009023975A (ja) * | 2007-07-23 | 2009-02-05 | Nagoya Industrial Science Research Inst | ペルオキシゾーム増殖剤応答性受容体（ＰＰＡＲ）αリガンド剤 |
-
1978
- 1978-04-12 JP JP4301378A patent/JPS54138566A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009023975A (ja) * | 2007-07-23 | 2009-02-05 | Nagoya Industrial Science Research Inst | ペルオキシゾーム増殖剤応答性受容体（ＰＰＡＲ）αリガンド剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6136518B2 (enExample) | 1986-08-19 |
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