JPS54125669A - 1,2-dithiolane compound and its preparation - Google Patents
1,2-dithiolane compound and its preparationInfo
- Publication number
- JPS54125669A JPS54125669A JP3211878A JP3211878A JPS54125669A JP S54125669 A JPS54125669 A JP S54125669A JP 3211878 A JP3211878 A JP 3211878A JP 3211878 A JP3211878 A JP 3211878A JP S54125669 A JPS54125669 A JP S54125669A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dithiolane
- prepared
- preparation
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A 1,2-dithiolane compound of formula I (R is H, lower alkyl, aralkyl).
EXAMPLE: N-(1,2-Dithiolane-4-carbonyl)-L-proline.
USE: Inhibiting action to angiotensin conversion enzyme and bradikinin decomposition enzyme (kininase) of animals, especially mammals. For example, diagnosis, preventive, and remedy for hypertention.
PROCESS: The compound I is prepared by oxidizing the compound II with air, O2, halogen, peroxides, ferric compounds, sodium tetrathionate, sulfoxide compounds, oxidase, etc. The compound II can be prepared by reacting the compound III (R1,2 are H, acyl) or its reactive derivative at the carboxyl group, with a compound IV, and if necessary hydrolyzing the resulting compound V.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3211878A JPS54125669A (en) | 1978-03-20 | 1978-03-20 | 1,2-dithiolane compound and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3211878A JPS54125669A (en) | 1978-03-20 | 1978-03-20 | 1,2-dithiolane compound and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54125669A true JPS54125669A (en) | 1979-09-29 |
Family
ID=12349971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3211878A Pending JPS54125669A (en) | 1978-03-20 | 1978-03-20 | 1,2-dithiolane compound and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54125669A (en) |
-
1978
- 1978-03-20 JP JP3211878A patent/JPS54125669A/en active Pending
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