JPS54125669A - 1,2-dithiolane compound and its preparation - Google Patents

1,2-dithiolane compound and its preparation

Info

Publication number
JPS54125669A
JPS54125669A JP3211878A JP3211878A JPS54125669A JP S54125669 A JPS54125669 A JP S54125669A JP 3211878 A JP3211878 A JP 3211878A JP 3211878 A JP3211878 A JP 3211878A JP S54125669 A JPS54125669 A JP S54125669A
Authority
JP
Japan
Prior art keywords
compound
dithiolane
prepared
preparation
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3211878A
Other languages
Japanese (ja)
Inventor
Yoshikazu Oka
Tetsuya Aono
Haru Omura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP3211878A priority Critical patent/JPS54125669A/en
Publication of JPS54125669A publication Critical patent/JPS54125669A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 1,2-dithiolane compound of formula I (R is H, lower alkyl, aralkyl).
EXAMPLE: N-(1,2-Dithiolane-4-carbonyl)-L-proline.
USE: Inhibiting action to angiotensin conversion enzyme and bradikinin decomposition enzyme (kininase) of animals, especially mammals. For example, diagnosis, preventive, and remedy for hypertention.
PROCESS: The compound I is prepared by oxidizing the compound II with air, O2, halogen, peroxides, ferric compounds, sodium tetrathionate, sulfoxide compounds, oxidase, etc. The compound II can be prepared by reacting the compound III (R1,2 are H, acyl) or its reactive derivative at the carboxyl group, with a compound IV, and if necessary hydrolyzing the resulting compound V.
COPYRIGHT: (C)1979,JPO&Japio
JP3211878A 1978-03-20 1978-03-20 1,2-dithiolane compound and its preparation Pending JPS54125669A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3211878A JPS54125669A (en) 1978-03-20 1978-03-20 1,2-dithiolane compound and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3211878A JPS54125669A (en) 1978-03-20 1978-03-20 1,2-dithiolane compound and its preparation

Publications (1)

Publication Number Publication Date
JPS54125669A true JPS54125669A (en) 1979-09-29

Family

ID=12349971

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3211878A Pending JPS54125669A (en) 1978-03-20 1978-03-20 1,2-dithiolane compound and its preparation

Country Status (1)

Country Link
JP (1) JPS54125669A (en)

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