JPS5337656A - Azabicyclohexanes* their preparation and thier use - Google Patents

Azabicyclohexanes* their preparation and thier use

Info

Publication number
JPS5337656A
JPS5337656A JP11064777A JP11064777A JPS5337656A JP S5337656 A JPS5337656 A JP S5337656A JP 11064777 A JP11064777 A JP 11064777A JP 11064777 A JP11064777 A JP 11064777A JP S5337656 A JPS5337656 A JP S5337656A
Authority
JP
Japan
Prior art keywords
azabicyclohexanes
preparation
thier
thier use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11064777A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6129341B2 (es
Inventor
Jiyoojifu Fuanshiyou Uiriamu
Uiriamu Epusutain Jiyoojifu
Sutefuen Kurourii Rantsu
Meiberu Hotsufuman Korisu
Robaato Safuaa Shidonii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of JPS5337656A publication Critical patent/JPS5337656A/ja
Publication of JPS6129341B2 publication Critical patent/JPS6129341B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
JP11064777A 1976-09-15 1977-09-16 Azabicyclohexanes* their preparation and thier use Granted JPS5337656A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes

Publications (2)

Publication Number Publication Date
JPS5337656A true JPS5337656A (en) 1978-04-06
JPS6129341B2 JPS6129341B2 (es) 1986-07-05

Family

ID=27505564

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11064777A Granted JPS5337656A (en) 1976-09-15 1977-09-16 Azabicyclohexanes* their preparation and thier use

Country Status (16)

Country Link
JP (1) JPS5337656A (es)
AR (2) AR220684A1 (es)
AT (2) AT367036B (es)
AU (1) AU519620B2 (es)
BE (1) BE858683A (es)
CH (2) CH637929A5 (es)
DD (1) DD133943A5 (es)
DE (1) DE2740562A1 (es)
DK (3) DK146245C (es)
FR (1) FR2375212A1 (es)
GR (1) GR72713B (es)
HU (1) HU177531B (es)
NL (1) NL189041C (es)
PL (1) PL115869B1 (es)
SE (2) SE435384B (es)
YU (2) YU39499B (es)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5813568A (ja) * 1981-07-01 1983-01-26 アメリカン・サイアナミド・カンパニ− 置換３−アザビシクロ〔３・１・０〕ヘキサン類および薬としてのその用途
JPS6332100A (ja) * 1986-07-25 1988-02-10 東京電力株式会社 シ−ルド掘進機
JPH0390799A (ja) * 1989-09-01 1991-04-16 Nkk Corp シールド掘進装置
JP2008507550A (ja) * 2004-07-22 2008-03-13 ワイス 神経系障害及び状態の処置方法
JP2008507552A (ja) * 2004-07-22 2008-03-13 ワイス 神経系障害および状態の治療方法
JP2009502939A (ja) * 2005-07-27 2009-01-29 ディオーブイ ファーマシューティカル，インク． 新規１−アリール−３−アザビシクロ［３．１．０］ヘキサン：調製および神経精神障害の処理への使用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5813568A (ja) * 1981-07-01 1983-01-26 アメリカン・サイアナミド・カンパニ− 置換３−アザビシクロ〔３・１・０〕ヘキサン類および薬としてのその用途
JPS6332100A (ja) * 1986-07-25 1988-02-10 東京電力株式会社 シ−ルド掘進機
JPH0549800B2 (es) * 1986-07-25 1993-07-27 Tokyo Electric Power Co
JPH0390799A (ja) * 1989-09-01 1991-04-16 Nkk Corp シールド掘進装置
JP2008507550A (ja) * 2004-07-22 2008-03-13 ワイス 神経系障害及び状態の処置方法
JP2008507552A (ja) * 2004-07-22 2008-03-13 ワイス 神経系障害および状態の治療方法
JP2009502939A (ja) * 2005-07-27 2009-01-29 ディオーブイ ファーマシューティカル，インク． 新規１−アリール−３−アザビシクロ［３．１．０］ヘキサン：調製および神経精神障害の処理への使用
JP2013035842A (ja) * 2005-07-27 2013-02-21 Euthymics Bioscience Inc 新規１−アリール−３−アザビシクロ［３．１．０］ヘキサン：調製および神経精神障害の処理への使用
US8877798B2 (en) 2005-07-27 2014-11-04 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9205074B2 (en) 2005-07-27 2015-12-08 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9737506B2 (en) 2005-07-27 2017-08-22 Neurovance, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US10039746B2 (en) 2005-07-27 2018-08-07 Otsuka America Pharmaceutical, Inc. 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders

Also Published As

Publication number Publication date
HU177531B (en) 1981-11-28
CH637931A5 (en) 1983-08-31
ATA661577A (de) 1981-10-15
YU39499B (en) 1984-12-31
PL200831A1 (es) 1980-02-11
DE2740562C2 (es) 1989-05-03
FR2375212A1 (fr) 1978-07-21
JPS6129341B2 (es) 1986-07-05
AU2844177A (en) 1979-03-08
YU188582A (en) 1985-03-20
DK438580A (da) 1980-10-16
DK146245B (da) 1983-08-08
AR220684A1 (es) 1980-11-28
AR227507A1 (es) 1982-11-15
NL189041B (nl) 1992-07-16
SE7710367L (sv) 1978-03-16
DK407577A (da) 1978-03-16
SE8203437L (sv) 1982-06-03
AT367037B (de) 1982-05-25
YU217477A (en) 1983-01-21
SE435384B (sv) 1984-09-24
CH637929A5 (en) 1983-08-31
BE858683A (fr) 1978-03-14
AT367036B (de) 1982-05-25
NL189041C (nl) 1992-12-16
DK438480A (da) 1980-10-16
ATA288280A (de) 1981-10-15
DK146245C (da) 1984-01-16
YU43523B (en) 1989-08-31
DD133943A5 (de) 1979-01-31
PL115869B1 (en) 1981-05-30
AU519620B2 (en) 1981-12-17
FR2375212B1 (es) 1981-07-31
SE452610B (sv) 1987-12-07
NL7709691A (nl) 1978-03-17
GR72713B (es) 1983-12-01
DE2740562A1 (de) 1978-03-23

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