JPH11514862A5 - - Google Patents

Info

Publication number
JPH11514862A5
JPH11514862A5 JP1997513707A JP51370797A JPH11514862A5 JP H11514862 A5 JPH11514862 A5 JP H11514862A5 JP 1997513707 A JP1997513707 A JP 1997513707A JP 51370797 A JP51370797 A JP 51370797A JP H11514862 A5 JPH11514862 A5 JP H11514862A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997513707A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11514862A (ja
JP4191797B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1996/015571 external-priority patent/WO1997012033A1/en
Publication of JPH11514862A publication Critical patent/JPH11514862A/ja
Publication of JPH11514862A5 publication Critical patent/JPH11514862A5/ja
Application granted granted Critical
Publication of JP4191797B2 publication Critical patent/JP4191797B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP51370797A 1995-09-27 1996-09-27 組み換えc型肝炎ウイルスrnaレプリカーゼ Expired - Fee Related JP4191797B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US438395P 1995-09-27 1995-09-27
US60/004,383 1995-09-27
PCT/US1996/015571 WO1997012033A1 (en) 1995-09-27 1996-09-27 Recombinant hepatitis c virus rna replicase

Publications (3)

Publication Number Publication Date
JPH11514862A JPH11514862A (ja) 1999-12-21
JPH11514862A5 true JPH11514862A5 (enExample) 2004-09-30
JP4191797B2 JP4191797B2 (ja) 2008-12-03

Family

ID=21710540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51370797A Expired - Fee Related JP4191797B2 (ja) 1995-09-27 1996-09-27 組み換えc型肝炎ウイルスrnaレプリカーゼ

Country Status (8)

Country Link
US (2) US5981247A (enExample)
EP (1) EP0859833B1 (enExample)
JP (1) JP4191797B2 (enExample)
AT (1) ATE318896T1 (enExample)
AU (1) AU719122B2 (enExample)
CA (1) CA2233309A1 (enExample)
DE (1) DE69635864T2 (enExample)
WO (1) WO1997012033A1 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1278077B1 (it) 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
FR2761695B1 (fr) * 1997-04-04 1999-09-24 Bio Merieux Arn polymerase fonctionnant preferentiellement sur matrice d'arn, sa preparation et son utilisation
JP2001526028A (ja) 1997-12-11 2001-12-18 スミスクライン・ビーチャム・コーポレイション C型肝炎ウイルスns5b末端切断タンパク質およびその抗ウイルス化合物同定方法
EA200700564A1 (ru) 1998-02-25 2007-08-31 Эмори Юниверсити 2`-фторнуклеозиды
JP2002510509A (ja) * 1998-04-02 2002-04-09 バイロファーマ・インコーポレイテッド C型肝炎ウイルスns5b組成物およびその使用方法
WO1999067396A1 (en) * 1998-06-24 1999-12-29 International Reagents Corporation Hcv-derived rna polymerase gene
AU2181800A (en) * 1998-12-10 2000-06-26 Eli Lilly And Company Primer-independent rna synthesis catalyzed by hcv polymerase
EP1634888A3 (en) 1999-11-12 2007-11-21 Pharmasset, Inc. Synthesis of 2'-deoxy-L-nucleosides
CA2389691A1 (en) * 2000-04-07 2001-10-18 Shionogi & Co., Ltd. A pre-incubation method for an assay of an inhibitor to an hcv rna-dependent rna polymerase
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
YU92202A (sh) 2000-05-26 2006-01-16 Idenix (Cayman) Limited Metode i smeše za lečenje flavi virusa i pesti virusa
GB0029539D0 (en) * 2000-12-04 2001-01-17 Isis Innovation Method for identifying modulatorss of transcription
IL156457A0 (en) * 2001-01-31 2004-01-04 Bristol Myers Squibb Pharma Co An in-vitro method for genomic replication
US7452705B2 (en) * 2001-05-22 2008-11-18 The University Of Chicago N4 virion single-stranded DNA dependent RNA polymerase
WO2003025156A2 (en) * 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
US20030104445A1 (en) * 2001-09-25 2003-06-05 Hayes Robert J. RNA dependent RNA polymerase mediated protein evolution
JP2005504087A (ja) 2001-09-28 2005-02-10 イデニクス(ケイマン)リミテツド 4’が修飾されたヌクレオシドを使用するc型肝炎ウイルス治療のための方法および組成物
KR100447578B1 (ko) * 2001-11-01 2004-09-07 주식회사 이매진 Hcv 자가 복제 효소 활성의 세포내 측정용 키트 및측정 방법
US20030114409A1 (en) * 2001-11-16 2003-06-19 Mello Craig C. Facilitation of RNA interference
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
PT1523489E (pt) 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
PT1576138T (pt) 2002-11-15 2017-05-03 Idenix Pharmaceuticals Llc 2'-metil-nucleósidos em combinação com interferão e mutação de flaviviridae
SI2604620T2 (sl) 2003-05-30 2024-10-30 Gilead Pharmasset Llc Modificirani fluorirani nukleozidni analogi
US20050075309A1 (en) 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
US7329732B2 (en) * 2004-01-09 2008-02-12 Merck & Co., Inc. HCV RNA-dependent RNA polymerase
WO2006121468A1 (en) 2004-11-22 2006-11-16 Genelabs Technologies, Inc. 5-nitro-nucleoside compounds for treating viral infections
CN101142226A (zh) 2005-02-28 2008-03-12 健亚生物科技公司 用于治疗病毒感染的三环核苷化合物
TW200720285A (en) 2005-04-25 2007-06-01 Genelabs Tech Inc Nucleoside compounds for treating viral infections
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
EP2307434B1 (en) 2008-07-02 2014-02-12 IDENIX Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
EP2166016A1 (en) 2008-09-18 2010-03-24 Centocor Ortho Biotech Products L.P. Phosphoramidate Derivatives of Nucleosides
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
WO2011023801A1 (en) 2009-08-31 2011-03-03 F. Hoffmann-La Roche Ag Hcv ns3/4a replicon shuttle vectors
AU2010317996A1 (en) 2009-11-14 2012-05-10 F. Hoffmann-La Roche Ag Biomarkers for predicting rapid response to HCV treatment
MX2012005703A (es) 2009-12-02 2012-06-12 Hoffmann La Roche Biomarcadores para pronosticar una respuesta prolongada al tratamiento contra el vhc.
WO2011123668A2 (en) 2010-03-31 2011-10-06 Pharmasset, Inc. Stereoselective synthesis of phosphorus containing actives
US20110245328A1 (en) 2010-03-31 2011-10-06 Hyunsoon Kang HCV NS5A Replicon Shuttle Vectors
JP5872539B2 (ja) 2010-03-31 2016-03-01 ギリアド ファーマセット エルエルシー プリンヌクレオシドホスホルアミダート
WO2011123586A1 (en) 2010-04-01 2011-10-06 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
AR082453A1 (es) 2010-04-21 2012-12-12 Novartis Ag Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos
AU2011281546B2 (en) 2010-07-22 2014-07-10 Novartis Ag 2,3,5-trisubstituted thiophene compounds and uses thereof
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
US9351989B2 (en) 2010-12-29 2016-05-31 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
EP2691409B1 (en) 2011-03-31 2018-02-21 Idenix Pharmaceuticals LLC. Compounds and pharmaceutical compositions for the treatment of viral infections
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
AU2012308900A1 (en) 2011-09-12 2013-05-09 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
EP2768838A1 (en) 2011-10-14 2014-08-27 IDENIX Pharmaceuticals, Inc. Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
PL3038601T3 (pl) 2013-08-27 2020-08-24 Gilead Pharmasset Llc Formulacja złożona dwóch związków przeciwwirusowych

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5726155A (en) * 1993-08-02 1998-03-10 The Scripps Research Institute Regulation of oxidative burst using LMWG-derived peptides and analogs
IT1278077B1 (it) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal

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