JPH11514339A - 非−β−酸化可能脂肪酸類似体、治療用活性薬剤としてのその利用及びその調製方法 - Google Patents
非−β−酸化可能脂肪酸類似体、治療用活性薬剤としてのその利用及びその調製方法Info
- Publication number
- JPH11514339A JPH11514339A JP9506567A JP50656797A JPH11514339A JP H11514339 A JPH11514339 A JP H11514339A JP 9506567 A JP9506567 A JP 9506567A JP 50656797 A JP50656797 A JP 50656797A JP H11514339 A JPH11514339 A JP H11514339A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- fatty acid
- structural formula
- compound
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.アルキルが8〜26個の炭素原子を持つ飽和又は不飽和単価水素基を表わし 、Xがセレン原子を表わし、Rが水素又はC1−C4アルキルであるものとして、 アルキル−X−CH2COOR という一般構造式(I)の非−β−酸化可能脂肪酸類似体の、 a)哺乳動物の血中のコレステロール及びトリグリセリド濃度を低減させるため といったような、高脂血症及び抗了テローム発生条件の治療のため、 b)低密度リポタンパク質(LDL)の酸化的修飾を阻害するための及び、 c)ガン細胞の成長を低減させるため、 の薬剤の製造を目的とした利用。 2.アルキルが8〜26個の炭素原子を持つ飽和又は不飽和炭化水素基を表わし 、Xがイオウ原子を表わし、Rが水素又はC1−C4アルキルであるものとして、 アルキル−X−CH2COOR という一般構造式(I)の非−β−酸化可能脂肪酸類似体の、 a)低密度リポタンパク質(LDL)の酸化的修飾を阻害するための及び、 b)ガン細胞の成長を低減させるため、 の薬剤の製造を目的とした利用。 3.アルキルがテトラデシル基を表わしている、請求項1又は2のいずれか1項 に記載の利用。 4.構造式(I)の化合物がテトラデシルチオ酢酸である、請求項2に記載の利 用。 5.構造式(I)の化合物がテトラデシルセレン酢酸である、請求項1〜3のい ずれか1項に記載の利用。 6.a)低脂肪血条件の治療のため及び哺乳動物の血中コレステロール及びトリ グリセリドの濃度を減少させるため、b)低密度リポタンパク質(LDL)の酸 化的修飾を阻害するため、及びc)ガン細胞の成長を低減させるための薬剤の製 造方法において、 アルキルが8〜22個の炭素原子を持つ飽和又は不飽和単価水素基を表わし、 Xがセレン原子を表わし、Rが水素又はC1−C4アルキルであるものとして、 アルキル−X−CH2COOR という一般構造式(I)の非−β−酸化可能脂肪酸類似体を、薬学的に受容可能 な担体又は希釈剤と共に取込む段階を含んで成る製造方法。 7.低密度リポタンパク質(LDL)の酸化的修飾を阻害するため及びガン細胞 の成長を低減させるための薬剤の製造方法において、 アルキルが8〜22個の炭素原子を持つ飽和又は不飽和炭化水素基を表わし、 Xがイオウ原子を表わし、Rが水素又はC1-C4アルキルであるものとして、 アルキル−X−CH2COOR という一般構造式(I)の非−β−酸化可能脂肪酸類似体を、薬学的に受容可能 な担体又は希釈剤と共に取込む段階を含んで成る製造方法。 8.一般構造式(I)の化合物が、請求項3〜5のいずれか1項に記載のもので ある、請求項6又は7に記載の方法。 9.アルキルが8〜22個の炭素原子を持つ飽和又は不飽和単価水素基を表わし 、Xがセレン原子を表わし、Rが水素又はC1−C4アルキルであるものとして、 アルキル−X−CH2COOR という一般構造式(I)を有する脂肪酸類似体。 10.一般構造式(I)の化合物が請求項3〜5のいずれか1項に記載のもので ある、請求項9に記載の脂肪酸類似体。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO952796A NO952796D0 (no) | 1995-07-14 | 1995-07-14 | Fettsyre analoger med ikkeoksyderbart B-sete, fremstilling og anvendelse i krapeutiske preparater |
NO952796 | 1995-07-14 | ||
PCT/NO1995/000195 WO1997003663A1 (en) | 1995-07-14 | 1995-10-25 | NON-β-OXIDIZABLE FATTY ACID ANALOGUES, THEIR USES AS THERAPEUTIC ACTIVE MEDICAMENTS, AND PREPARATION THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11514339A true JPH11514339A (ja) | 1999-12-07 |
JP3553966B2 JP3553966B2 (ja) | 2004-08-11 |
Family
ID=19898394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50656797A Expired - Fee Related JP3553966B2 (ja) | 1995-07-14 | 1995-10-25 | 非−β−酸化可能脂肪酸類似体、治療用活性薬剤としてのその利用及びその調製方法 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6046237A (ja) |
EP (3) | EP0840604B1 (ja) |
JP (1) | JP3553966B2 (ja) |
KR (1) | KR100394986B1 (ja) |
AT (1) | ATE224188T1 (ja) |
AU (2) | AU4272696A (ja) |
CA (1) | CA2226871A1 (ja) |
DE (1) | DE69528291T2 (ja) |
DK (1) | DK0840604T3 (ja) |
ES (1) | ES2183889T3 (ja) |
NO (1) | NO952796D0 (ja) |
PT (1) | PT840604E (ja) |
WO (1) | WO1997003663A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003527364A (ja) * | 2000-03-03 | 2003-09-16 | ティア、メディカ、アクチスカベット | 新規脂肪酸類似体 |
JP2006517954A (ja) * | 2003-01-31 | 2006-08-03 | ジェンフィ | アシルグリセロール並びにその窒素−及び硫黄含有類似物の治療上の使用 |
JP2006518358A (ja) * | 2003-02-12 | 2006-08-10 | ジェンフィ | アシル化アミノプロパンジオール並びにその窒素及び硫黄含有類似物の使用 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999058120A1 (en) * | 1998-05-08 | 1999-11-18 | Rolf Berge | USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS |
AU784116B2 (en) * | 1999-09-17 | 2006-02-09 | Peplin Biolipids Pty Ltd | Anti-cancer nitro- and thia-fatty acids |
AUPQ291499A0 (en) * | 1999-09-17 | 1999-10-07 | Women's And Children's Hospital Adelaide | Novel nitro and sulphur containing compounds |
NO20003591L (no) * | 2000-07-13 | 2002-01-14 | Thia Medica As | Fettsyreanaloger for behandling av kreft |
NO20006008L (no) * | 2000-11-28 | 2002-05-29 | Thia Medica As | Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer |
US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
US7842727B2 (en) * | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
FR2828487B1 (fr) | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
AU2003243272A1 (en) * | 2002-05-22 | 2003-12-12 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
JP5008258B2 (ja) | 2002-06-20 | 2012-08-22 | アイシー・ベック・リミテッド | 含硫黄ホスホリピド誘導体 |
AU2003291097A1 (en) * | 2002-11-20 | 2004-06-15 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
CA2554735A1 (en) * | 2004-01-30 | 2005-08-11 | Peplin Biolipids Pty Ltd | Therapeutic and carrier molecules |
AU2005264781B2 (en) * | 2004-07-19 | 2011-07-28 | Life Science Nutrition As | Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities |
CA2587013A1 (en) * | 2004-11-08 | 2006-05-18 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
CA3052449C (en) | 2013-03-11 | 2021-10-19 | Jan Remmereit | Lipid compositions comprising 5, 11, 14-eicosatrienoic acid and conjugated linoleic acids |
WO2014140934A2 (en) | 2013-03-11 | 2014-09-18 | Life Science Nutrition As | Natural lipids containing non-oxidizable fatty acids |
CN105498622B (zh) * | 2015-12-10 | 2017-10-17 | 江南大学 | 一种含硒表面活性剂及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2208533A1 (de) * | 1972-02-23 | 1973-09-27 | Kolmar Laboratories | Neue alkylthioaether |
GB8813012D0 (en) * | 1988-06-02 | 1988-07-06 | Norsk Hydro As | Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals |
-
1995
- 1995-07-14 NO NO952796A patent/NO952796D0/no unknown
- 1995-10-25 DE DE69528291T patent/DE69528291T2/de not_active Expired - Fee Related
- 1995-10-25 EP EP95941241A patent/EP0840604B1/en not_active Expired - Lifetime
- 1995-10-25 JP JP50656797A patent/JP3553966B2/ja not_active Expired - Fee Related
- 1995-10-25 KR KR19980700295A patent/KR100394986B1/ko not_active IP Right Cessation
- 1995-10-25 WO PCT/NO1995/000195 patent/WO1997003663A1/en active IP Right Grant
- 1995-10-25 DK DK95941241T patent/DK0840604T3/da active
- 1995-10-25 AT AT95941241T patent/ATE224188T1/de not_active IP Right Cessation
- 1995-10-25 EP EP02075955A patent/EP1232750A1/en not_active Withdrawn
- 1995-10-25 US US08/981,956 patent/US6046237A/en not_active Expired - Lifetime
- 1995-10-25 EP EP02075954A patent/EP1232749A1/en not_active Ceased
- 1995-10-25 CA CA002226871A patent/CA2226871A1/en not_active Abandoned
- 1995-10-25 ES ES95941241T patent/ES2183889T3/es not_active Expired - Lifetime
- 1995-10-25 PT PT95941241T patent/PT840604E/pt unknown
- 1995-10-25 AU AU42726/96A patent/AU4272696A/en not_active Abandoned
-
2000
- 2000-09-21 AU AU61243/00A patent/AU734431B2/en not_active Ceased
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003527364A (ja) * | 2000-03-03 | 2003-09-16 | ティア、メディカ、アクチスカベット | 新規脂肪酸類似体 |
JP2006517954A (ja) * | 2003-01-31 | 2006-08-03 | ジェンフィ | アシルグリセロール並びにその窒素−及び硫黄含有類似物の治療上の使用 |
JP2006518358A (ja) * | 2003-02-12 | 2006-08-10 | ジェンフィ | アシル化アミノプロパンジオール並びにその窒素及び硫黄含有類似物の使用 |
Also Published As
Publication number | Publication date |
---|---|
US6046237A (en) | 2000-04-04 |
WO1997003663A1 (en) | 1997-02-06 |
DK0840604T3 (da) | 2002-12-30 |
KR19990028993A (ko) | 1999-04-15 |
KR100394986B1 (ko) | 2004-01-24 |
EP1232750A1 (en) | 2002-08-21 |
CA2226871A1 (en) | 1997-02-06 |
AU734431B2 (en) | 2001-06-14 |
DE69528291T2 (de) | 2003-05-08 |
DE69528291D1 (de) | 2002-10-24 |
EP1232749A1 (en) | 2002-08-21 |
NO952796D0 (no) | 1995-07-14 |
EP0840604A1 (en) | 1998-05-13 |
PT840604E (pt) | 2003-01-31 |
AU4272696A (en) | 1997-02-18 |
ES2183889T3 (es) | 2003-04-01 |
ATE224188T1 (de) | 2002-10-15 |
JP3553966B2 (ja) | 2004-08-11 |
EP0840604B1 (en) | 2002-09-18 |
AU6124300A (en) | 2000-11-30 |
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