JPH11511172A - 新生血管形成の予防及びヒト悪性疾患の処置のためのキナゾリノン含有薬理組成物 - Google Patents
新生血管形成の予防及びヒト悪性疾患の処置のためのキナゾリノン含有薬理組成物Info
- Publication number
- JPH11511172A JPH11511172A JP9509466A JP50946697A JPH11511172A JP H11511172 A JPH11511172 A JP H11511172A JP 9509466 A JP9509466 A JP 9509466A JP 50946697 A JP50946697 A JP 50946697A JP H11511172 A JPH11511172 A JP H11511172A
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- hydrogen
- halofuginone
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.新生血管形成を減退させる及びヒト悪性疾患を処置するための組成物であ って、薬理学的有効量の次式Iの化合物: (式中: R1は水素、ハロゲン、ニトロ、ベンゾ、低級アルキル、フェニル及び低級ア ルコキシより成る群の構成員である; R2はヒドロキシ、アセトキシ及び低級アルコキシより成る群の構成員である ;そして R3は水素及び低級アルケノキシ−カルボニルより成る群の構成員である) を活性成分として、薬理学的に許容される担体と組合さって含んで成る、前記 組成物。 2.前記化合物がハロフギノンである、請求項1記載の組成物。 3.本明細書に記載の、新生血管減退活性を有する医薬品の製造における、請 求項1記載の式Iの化合物の利用。 4.本明細書に記載の、ヒト腫瘍細胞に対して抗増殖作用を有する医薬品の製 造における、請求項1記載の式Iの化合物の利用。 5.長期脈管形成に苦しむヒト患者の処置のための方法であって、新生血管形 成を減退するのに有効な薬理学的有効量の次式Iの化合物: (式中: R1は水素、ハロゲン、ニトロ、ベンゾ、低級アルキル、フェニル及び低級ア ルコキシより成る群の構成員である; R2はヒドロキシ、アセトキシ及び低級アルコキシより成る群の構成員である ;そして R3は水素及び低級アルケノキシ−カルボニルより成る群の構成員である) を投与することを含んで成る方法。 6.悪性疾患に苦しむヒト患者の処置のための方法であって、悪性ヒト腫瘍細 胞の増殖を阻害するのに有効な薬理学的有効量の次式Iの化合物: (式中: R1は水素、ハロゲン、ニトロ、ベンゾ、低級アルキル、フェニル及び低級ア ルコキシより成る群の構成員である; R2はヒドロキシ、アセトキシ及び低級アルコキシより成る群の構成員である ;そして R3は水素及び低級アルケノキシ−カルボニルより成る群の構成 員である) を投与することを含んで成る方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL114951 | 1995-08-15 | ||
IL11495195A IL114951A (en) | 1995-08-15 | 1995-08-15 | Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization |
PCT/US1996/013210 WO1997006805A1 (en) | 1995-08-15 | 1996-08-12 | Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization and for treating human malignancies |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11511172A true JPH11511172A (ja) | 1999-09-28 |
JP4101875B2 JP4101875B2 (ja) | 2008-06-18 |
Family
ID=11067877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50946697A Expired - Fee Related JP4101875B2 (ja) | 1995-08-15 | 1996-08-12 | 新生血管形成の予防及びヒト悪性疾患の処置のためのキナゾリノン含有薬理組成物 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0850062B1 (ja) |
JP (1) | JP4101875B2 (ja) |
CN (1) | CN1113652C (ja) |
AT (1) | ATE279925T1 (ja) |
AU (1) | AU705955B2 (ja) |
CA (1) | CA2228524C (ja) |
DE (1) | DE69633673T2 (ja) |
DK (1) | DK0850062T3 (ja) |
ES (1) | ES2231824T3 (ja) |
IL (1) | IL114951A (ja) |
WO (1) | WO1997006805A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003523460A (ja) * | 2000-01-25 | 2003-08-05 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 抗脈管形成活性を有し、かつ、抗凝固作用がない、部分脱硫酸グリコサミノグリカンの誘導体 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4808997A (en) | 1996-09-30 | 1998-04-24 | Brigham And Women's Hospital | Methods and compounds for treatment of abnormal uterine bleeding |
US6028075A (en) * | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
IL147416A (en) * | 2001-12-31 | 2008-11-26 | Israel State | Combined modalities for improved cancer treatment |
CN100434425C (zh) * | 2005-03-09 | 2008-11-19 | 首都师范大学 | 4-喹唑啉酮衍生物及其在抗肿瘤药物中的应用 |
CN102653521B (zh) * | 2012-04-27 | 2014-08-06 | 首都师范大学 | 吲哚-2-酮的哌嗪硫代甲酰肼衍生物及其制备方法和用途 |
AR110963A1 (es) | 2017-02-07 | 2019-05-22 | Dae Woong Pharma | Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3320124A (en) * | 1964-07-20 | 1967-05-16 | American Cyanamid Co | Method for treating coccidiosis with quinazolinones |
DE2934069A1 (de) * | 1979-08-23 | 1981-03-12 | Hoechst Ag, 6000 Frankfurt | Mittel gegen theileriosen und seine verwendung. |
DE3638446A1 (de) * | 1986-11-11 | 1988-05-26 | Hoechst Ag | Coccidiozide mittel |
CA2113229C (en) * | 1994-01-11 | 1999-04-20 | Mark Pines | Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof |
IL110831A (en) * | 1994-08-31 | 1998-12-27 | Hadasit Med Res Service | Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis |
IL112125A (en) * | 1994-12-22 | 1998-02-08 | Hadasit Med Res Service | Quinazolinone-containing pharmaceutical compositions |
-
1995
- 1995-08-15 IL IL11495195A patent/IL114951A/xx not_active IP Right Cessation
-
1996
- 1996-08-12 DK DK96928874T patent/DK0850062T3/da active
- 1996-08-12 CA CA002228524A patent/CA2228524C/en not_active Expired - Fee Related
- 1996-08-12 CN CN96196609A patent/CN1113652C/zh not_active Expired - Fee Related
- 1996-08-12 ES ES96928874T patent/ES2231824T3/es not_active Expired - Lifetime
- 1996-08-12 JP JP50946697A patent/JP4101875B2/ja not_active Expired - Fee Related
- 1996-08-12 EP EP96928874A patent/EP0850062B1/en not_active Expired - Lifetime
- 1996-08-12 WO PCT/US1996/013210 patent/WO1997006805A1/en active IP Right Grant
- 1996-08-12 AT AT96928874T patent/ATE279925T1/de not_active IP Right Cessation
- 1996-08-12 AU AU68469/96A patent/AU705955B2/en not_active Ceased
- 1996-08-12 DE DE69633673T patent/DE69633673T2/de not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003523460A (ja) * | 2000-01-25 | 2003-08-05 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 抗脈管形成活性を有し、かつ、抗凝固作用がない、部分脱硫酸グリコサミノグリカンの誘導体 |
US8222231B2 (en) | 2000-01-25 | 2012-07-17 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect |
Also Published As
Publication number | Publication date |
---|---|
AU6846996A (en) | 1997-03-12 |
DK0850062T3 (da) | 2005-02-07 |
EP0850062B1 (en) | 2004-10-20 |
DE69633673D1 (de) | 2004-11-25 |
WO1997006805A1 (en) | 1997-02-27 |
CA2228524C (en) | 2003-01-07 |
ATE279925T1 (de) | 2004-11-15 |
DE69633673T2 (de) | 2006-02-09 |
CN1113652C (zh) | 2003-07-09 |
JP4101875B2 (ja) | 2008-06-18 |
CA2228524A1 (en) | 1997-02-27 |
ES2231824T3 (es) | 2005-05-16 |
AU705955B2 (en) | 1999-06-03 |
IL114951A0 (en) | 1995-12-08 |
EP0850062A4 (en) | 2000-03-15 |
CN1194583A (zh) | 1998-09-30 |
IL114951A (en) | 1999-08-17 |
EP0850062A1 (en) | 1998-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6028075A (en) | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies | |
JP2001278789A (ja) | サリドマイドを有効成分とする医薬品製剤 | |
JP2000515523A (ja) | 創傷および線維性障害の治療における性ステロイド機能モジュレーターの使用 | |
RO117996B1 (ro) | Metoda de tratament pentru inhibarea migratiei celulelor musculare netede, vasculare | |
JPH11511172A (ja) | 新生血管形成の予防及びヒト悪性疾患の処置のためのキナゾリノン含有薬理組成物 | |
US6090814A (en) | Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization | |
KR20010006485A (ko) | 망막 색소상피세포의 과잉증식에 관한 질환의 예방 또는 치료제 | |
JP2005537282A (ja) | セファロタキシンアルカロイドによる血管新生抑制、並びにその誘導体、組成物、および使用方法 | |
CZ127999A3 (cs) | Inhibitor sekundárního zákalu | |
JP2001511177A (ja) | 皮膚障害の治療 | |
Neil et al. | Investigation of the role of signal transduction in attachment of ocular melanoma cells to matrix proteins: inhibition of attachment by calmodulin antagonists including tamoxifen | |
EP0794780B1 (en) | Quinazolinone-containing pharmaceutical compositions and methods for the use thereof | |
US5998422A (en) | Quinazolinone-containing pharmaceutical compositions and methods for the use thereof | |
ITMI970309A1 (it) | Analoghi delle purine atti all'inibizione dell'angiogenesi | |
MXPA97009189A (en) | Methods to inhibit the migration of cells of the smooth muscle vascu | |
WO2005009461A1 (en) | Factor vii activating protease (fsap) polypeptides for the treatment of angiogenesis-related disorders |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060829 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20061128 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070122 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070228 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20070417 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070628 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20071108 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080219 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080321 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110328 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120328 Year of fee payment: 4 |
|
LAPS | Cancellation because of no payment of annual fees |