JPH11503163A - 低温溶融性薬物と制御放出のための添加物との均質混合物 - Google Patents
低温溶融性薬物と制御放出のための添加物との均質混合物Info
- Publication number
- JPH11503163A JPH11503163A JP8530428A JP53042896A JPH11503163A JP H11503163 A JPH11503163 A JP H11503163A JP 8530428 A JP8530428 A JP 8530428A JP 53042896 A JP53042896 A JP 53042896A JP H11503163 A JPH11503163 A JP H11503163A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- additive
- wax
- controlled release
- homogeneous mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 低温にて溶融する治療上有効量の薬物と、エチルセルロース、メチルセル ロース、ヒドロキシプロピルセルロース、ポリアクリルアミド、エチレン酢酸ビ ニルコポリマー、ポリメチルメタクリレート、ポリヒドロキシエチルメタクリレ ートおよびワックスなどから選択される添加物とを組合せて含有し、添加物と薬 物とが前記薬物を92〜97%重量/重量含む均質な薬物−添加物複合体を形成 することを特徴とする制御放出性処方物。 2. 前記薬物がナトリウム水素ジバルプロエクス、イブプロフェン、ラミプリ ル、ジベンジリン、硝酸エリトリチル、硝酸イソソルビド、メトスキシミド、ケ トプロフェン、ゲムフィブロジル、パロキセチン塩酸塩およびトリミプラミンマ レイン酸塩よりなる群から選択される請求の範囲第1項に記載の制御放出性処方 物。 3. 前記添加物がポリアルキレンワックスである請求の範囲第1項に記載の制 御放出性処方物。 4. 前記ポリアルキレンワックスがポリエチレンワックスで ある請求の範囲第3項に記載の制御放出性処方物。 5. 前記均質な薬物−添加物複合体がカプセル中にて形成される請求の範囲第 1項に記載の制御放出性処方物。 6. (a)薬物と添加物とを150℃未満の温度にて溶融させ、前記薬物と前 記添加物とを混合して均質混合物を生成させ、前記薬物が前記均質混合物の92 〜97%w/wを占め; (b)前記均質混合物を硬化させて薬物−添加物複合体を形成させる ことを特徴とする制御放出性処方物の製造方法。 7. 前記添加物をエチルセルロース、メチルセルロース、ヒドロキシプロピル セルロース、ポリアクリルアミド、エチレン酢酸ビニルコポリマー、ポリメチル メタクリレート、ポリヒドロキシエチルメタクリレートおよびワックスよりなる 群から選択する請求の範囲第6項に記載の方法。 8. 前記添加物がポリアルキレンワックスである請求の範囲第7項に記載の方 法。 9. 前記薬物と前記添加物とを別々に溶融させ、次いで液体状にて合し、前記 薬物と前記添加物とを混合して前記均質混合物を形成させる請求の範囲第6項に 記載の方法。 10. 前記薬物をナトリウム水素ジバルプロエクス、イブプロフェン、ラミプ リル、ジベンジリン、硝酸エリトリチル、硝酸イソソルビド、メトスキシミド、 ケトプロフェン、ゲムフィブロジル、パロキセチン塩酸塩およびトリミプラミン マレイン酸塩よりなる群から選択する請求の範囲第6項に記載の方法。 11.(a)薬物と添加物とを150℃未満の温度にて溶融させ、前記薬物と前 記添加物とを混合して均質混合物を生成させ、前記薬物が前記均質混合物の92 〜97%w/wを占め; (b)前記均質混合物をカプセルに添加し; (c)前記均質混合物を硬化させて薬物−添加物複合体を生成させ; (d)前記カプセルをキャッピングする ことを組合せてなる、制御放出性処方物の製造方法。 12. 前記添加物をエチルセルロース、メチルセルロース、ヒドロキシプロピ ルセルロース、ポリアクリルアミド、エチレン酢酸ビニルコポリマー、ポリメチ ルメタクリレート、ポリヒドロキシエチルメタクリレートおよびワックスよりな る群から選択する請求の範囲第11項に記載の方法。 13. 前記ワックスがポリアルキレンワックスである請求の 範囲第12項に記載の方法。 14. 前記ポリアルキレンワックスがポリエチレンワックスである請求の範囲 第13項に記載の方法。 15. 前記薬物をナトリウム水素ジバルプロエクス、イブプロフェン、ラミプ リル、ジベンジリン、硝酸エリトリチル、硝酸イソソルビド、メトスキシミド、 ケトプロフェン、ゲムフィブロジル、パロキセチン塩酸塩およびトリミプラミン マレイン酸塩よりなる群から選択する請求の範囲第11項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41540195A | 1995-04-03 | 1995-04-03 | |
US08/415,401 | 1995-04-03 | ||
PCT/US1996/004513 WO1996031197A1 (en) | 1995-04-03 | 1996-04-02 | Homogeneous mixtures of low temperature-melting drugs and additives for controlled release |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11503163A true JPH11503163A (ja) | 1999-03-23 |
JP3768536B2 JP3768536B2 (ja) | 2006-04-19 |
Family
ID=23645549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53042896A Expired - Lifetime JP3768536B2 (ja) | 1995-04-03 | 1996-04-02 | 低温溶融性薬物と制御放出のための添加物との均質混合物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US5807574A (ja) |
EP (1) | EP0818990A1 (ja) |
JP (1) | JP3768536B2 (ja) |
CA (1) | CA2216934A1 (ja) |
MX (1) | MX9707585A (ja) |
WO (1) | WO1996031197A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006265258A (ja) * | 1995-07-20 | 2006-10-05 | Smithkline Beecham Plc | パロキセチン制御放出組成物 |
JP2010523640A (ja) * | 2007-04-13 | 2010-07-15 | ザイスィス リミテッド | 医薬組成物 |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
TR199903025T2 (xx) | 1997-06-10 | 2000-07-21 | Synthon B.V. | 4-Fenilpiperidin bile�imleri. |
US5955475A (en) * | 1997-06-30 | 1999-09-21 | Endo Pharmaceuticals Inc. | Process for manufacturing paroxetine solid dispersions |
GB9724544D0 (en) * | 1997-11-21 | 1998-01-21 | Smithkline Beecham Plc | Novel Formulation |
GB9808052D0 (en) | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
GB9810180D0 (en) * | 1998-05-13 | 1998-07-08 | Smithkline Beecham Plc | Novel formulation |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
WO2000054775A1 (de) | 1999-03-12 | 2000-09-21 | Basf Ag | Stabile pharmazeutische anwendungsform für paroxetin-anhydrat |
US6482440B2 (en) * | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
US20020132010A1 (en) * | 2000-12-22 | 2002-09-19 | Yihong Qui | Divalproex sodium dosage forms and a process for their production |
US20040105886A1 (en) * | 2001-02-16 | 2004-06-03 | Chih-Ming Chen | Divalproex sodium tablets |
US6610326B2 (en) * | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
WO2003037301A2 (en) * | 2001-10-29 | 2003-05-08 | King Pharmaceuticals Research And Development, Inc | Oral dosage forms for improving the bioavailability of therapeutic agents |
ATE461681T1 (de) * | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
ITMI20032399A1 (it) * | 2003-12-09 | 2005-06-10 | Zambon Spa | Composizione farmaceutica contenente gabapentina. |
WO2005067887A2 (en) | 2004-03-24 | 2005-07-28 | Actavis Group | Formulations of ramipril |
US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
US20050276848A1 (en) * | 2004-06-15 | 2005-12-15 | Nilobon Podhipleux | Sustained release neutralized divalproex sodium |
US20050276849A1 (en) * | 2004-06-15 | 2005-12-15 | Nilobon Podhipleux | Sustained release dosage forms |
US7713550B2 (en) * | 2004-06-15 | 2010-05-11 | Andrx Corporation | Controlled release sodium valproate formulation |
WO2006023347A1 (en) * | 2004-08-20 | 2006-03-02 | Alpharma, Inc. | Paroxetine formulations |
DE102005037630A1 (de) | 2005-08-09 | 2007-02-15 | Glatt Gmbh | Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung |
US20070082046A1 (en) * | 2005-10-11 | 2007-04-12 | Banner Pharmacaps, Inc. | Enteric valproic acid |
EP2042165A1 (de) * | 2007-09-28 | 2009-04-01 | Swiss Caps Rechte und Lizenzen AG | Hot-Melt-Befüllte Weichkapseln |
CN105476951A (zh) * | 2009-05-04 | 2016-04-13 | 普西维达公司 | 多孔硅药物洗脱颗粒 |
JP6026424B2 (ja) | 2010-11-01 | 2016-11-16 | シヴィダ・ユーエス・インコーポレイテッドPsivida Us, Inc. | 治療薬送達のための生物浸食性ケイ素ベースのデバイス |
JP2016512839A (ja) | 2013-03-15 | 2016-05-09 | シヴィダ・ユーエス・インコーポレイテッドPsivida Us, Inc. | 治療物質の送達のための生体内分解性ケイ素系組成物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL108838C (ja) * | 1956-03-27 | |||
US3279998A (en) * | 1962-06-22 | 1966-10-18 | Smith Kline French Lab | Method of preparing sustained release tablets |
DE3024416C2 (de) * | 1980-06-28 | 1982-04-15 | Gödecke AG, 1000 Berlin | Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung |
IL72381A (en) * | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
FR2549371B1 (fr) * | 1983-07-20 | 1985-09-13 | Sanofi Sa | Nouvelle composition pharmaceutique contenant de l'acide valproique ou un de ses sels |
US4913906B1 (en) * | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
US5240712A (en) * | 1987-07-17 | 1993-08-31 | The Boots Company Plc | Therapeutic agents |
GB8716975D0 (en) * | 1987-07-17 | 1987-08-26 | Boots Co Plc | Therapeutic agents |
US4885175A (en) * | 1987-12-23 | 1989-12-05 | Wm. Wrigley Jr. Company | Method of making chewing gum with wax-coated delayed release ingredients |
FR2643556B1 (fr) * | 1989-02-27 | 1993-03-05 | Sanofi Sa | Composition pharmaceutique a liberation prolongee d'acide valproique |
WO1992001446A1 (en) * | 1990-07-20 | 1992-02-06 | Aps Research Limited | Sustained-release formulations |
JP2572673B2 (ja) * | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | 徐放性錠剤 |
AU8404891A (en) * | 1990-08-09 | 1992-03-02 | Warner-Lambert Company | Flavor delivery system with improved release and method of preparation |
DE4031881C2 (de) * | 1990-10-08 | 1994-02-24 | Sanol Arznei Schwarz Gmbh | Lösungsmittelfreie, oral zu verabreichende pharmazeutische Zubereitung mit verzögerter Wirkstoffreisetzung und Verfahren zu deren Herstellung |
FR2682677A1 (fr) * | 1991-10-17 | 1993-04-23 | Sanofi Elf | Complexe forme de l'acide propyl-2 pentene-2 ouique (e) et de son sel de sodium, sa preparation et compositions pharmaceutiques le contenant. |
US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
-
1996
- 1996-04-02 WO PCT/US1996/004513 patent/WO1996031197A1/en not_active Application Discontinuation
- 1996-04-02 MX MX9707585A patent/MX9707585A/es unknown
- 1996-04-02 CA CA002216934A patent/CA2216934A1/en not_active Abandoned
- 1996-04-02 EP EP96910705A patent/EP0818990A1/en not_active Withdrawn
- 1996-04-02 JP JP53042896A patent/JP3768536B2/ja not_active Expired - Lifetime
-
1997
- 1997-06-20 US US08/879,468 patent/US5807574A/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006265258A (ja) * | 1995-07-20 | 2006-10-05 | Smithkline Beecham Plc | パロキセチン制御放出組成物 |
JP2010523640A (ja) * | 2007-04-13 | 2010-07-15 | ザイスィス リミテッド | 医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
MX9707585A (es) | 1997-12-31 |
CA2216934A1 (en) | 1996-10-10 |
US5807574A (en) | 1998-09-15 |
JP3768536B2 (ja) | 2006-04-19 |
EP0818990A1 (en) | 1998-01-21 |
WO1996031197A1 (en) | 1996-10-10 |
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