JPH11500148A - 気道投与用製剤 - Google Patents
気道投与用製剤Info
- Publication number
- JPH11500148A JPH11500148A JP9519177A JP51917797A JPH11500148A JP H11500148 A JPH11500148 A JP H11500148A JP 9519177 A JP9519177 A JP 9519177A JP 51917797 A JP51917797 A JP 51917797A JP H11500148 A JPH11500148 A JP H11500148A
- Authority
- JP
- Japan
- Prior art keywords
- tramadol
- pharmaceutically acceptable
- dosage form
- administration
- analgesic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.鎮痛薬を温血動物へ気道投与するための剤形であって、製剤学上有効な量の トラマドールまたはその製剤学上許容しうる誘導体または塩と、気道投与に好適 な製剤学上許容しうる担体とを含有してなる前記剤形。 2.前記製剤学上許容しうる担体が鼻腔内または吸入投与に好適である、請求項 1記載の剤形。 3.前記製剤学上許容しうる担体が、液体、懸濁液、乳濁液、リポソーム、ペー スト、粉体、ガーゼパッキングおよびゲルからなる群から選ばれる、請求項2記 載の剤形。 4.等張食塩溶液または懸濁液を含む、請求項1記載の剤形。 5.前記製剤学上許容しうる担体が約4.0〜約9.0の範囲のpHを有する、請求項 1記載の剤形。 6.前記鎮痛薬が製剤学上有効な量の塩酸トラマドールを含有する、請求項1記 載の剤形。 7.前記トラマドールが約10〜約800mg/mlの範囲の量で存在する、請求項6記載 の剤形。 8.前記鎮痛薬が製剤学上有効な量のモノ-O-デスメチルトラマドールを含有す る、請求項1記載の剤形。 9.前記鎮痛薬がトラマドールHClとモノ-O-デスメチルトラマドールとの製 剤学上有効な組み合わせを含有する、請求項1記載の剤形。 10.温血動物において痛覚消失を引き起こすための方法であって、その痛覚消失 を必要とする温血動物の気道粘膜表面に、製剤学上許容しうる担体中に製剤学上 有効な量のトラマドールまたはその製剤学上許容しうる塩を含有する医薬製剤を 接触させることを含んでなる前記方法。 11.鼻腔内または吸入投与を含む、請求項10記載の方法。 12.前記製剤学上許容しうる担体が、液体、乳濁液、リポソーム、ペースト、粉 体およびゲルからなる群から選ばれる、請求項11記載の方法。 13.前記製剤学上許容しうる製剤が等張食塩液を含有する、請求項10記載の方 法。 14.前記製剤学上許容しうる担体が約4.0〜約9.0の範囲のpHを有する、請求項1 0記載の方法。 15.前記トラマドールが製剤学上有効な量の塩酸トラマドールを含有する、請求 項10記載の方法。 16.前記塩酸トラマドールが約10〜約800mg/mlの範囲の量で存在する、請求項15 記載の方法。 17.前記トラマドール誘導体が製剤学上有効な量のモノ-O-デスメチルトラマド ールを含有する、請求項10記載の方法。 18.前記製剤がトラマドールHClとモノ-O-デスメチルトラマドールとの製剤 学上有効な組み合わせを含有する、請求項10記載の方法。 19.製剤学上有効な量のトラマドールまたはその製剤学上許容しうる塩または誘 導体と吸入による投与のための製剤学上許容しうる担体とを含有する剤形を吸入 する工程を含んでなる、患者において痛覚消失をもたらすための方法。 20.製剤学上有効な量のトラマドールまたはその製剤学上許容しうる塩または誘 導体と鼻腔内投与のための製剤学上許容しうる担体とを含有する剤形を鼻腔内投 与する工程を含んでなる、患者において痛覚消失をもたらすための方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/557,279 US6017963A (en) | 1995-11-14 | 1995-11-14 | Formulation for intranasal administration |
US557,279 | 1995-11-14 | ||
US08/557,279 | 1995-11-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11500148A true JPH11500148A (ja) | 1999-01-06 |
JP3152437B2 JP3152437B2 (ja) | 2001-04-03 |
Family
ID=24224765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51917797A Expired - Fee Related JP3152437B2 (ja) | 1995-11-14 | 1996-11-14 | 気道投与用製剤 |
Country Status (8)
Country | Link |
---|---|
US (3) | US6017963A (ja) |
EP (1) | EP0877609B1 (ja) |
JP (1) | JP3152437B2 (ja) |
AT (1) | ATE247461T1 (ja) |
AU (1) | AU714303B2 (ja) |
CA (1) | CA2234847C (ja) |
DE (1) | DE69629591T2 (ja) |
WO (1) | WO1997017948A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009511571A (ja) * | 2005-10-11 | 2009-03-19 | イッサム リサーチ ディヴェロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 経鼻投与用組成物 |
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-
1995
- 1995-11-14 US US08/557,279 patent/US6017963A/en not_active Expired - Fee Related
-
1996
- 1996-11-14 EP EP96941475A patent/EP0877609B1/en not_active Expired - Lifetime
- 1996-11-14 AU AU10604/97A patent/AU714303B2/en not_active Ceased
- 1996-11-14 AT AT96941475T patent/ATE247461T1/de active
- 1996-11-14 DE DE69629591T patent/DE69629591T2/de not_active Expired - Lifetime
- 1996-11-14 WO PCT/US1996/018904 patent/WO1997017948A1/en active IP Right Grant
- 1996-11-14 JP JP51917797A patent/JP3152437B2/ja not_active Expired - Fee Related
- 1996-11-14 CA CA002234847A patent/CA2234847C/en not_active Expired - Fee Related
-
1999
- 1999-11-05 US US09/435,009 patent/US20010049391A1/en not_active Abandoned
-
2001
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009511571A (ja) * | 2005-10-11 | 2009-03-19 | イッサム リサーチ ディヴェロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 経鼻投与用組成物 |
Also Published As
Publication number | Publication date |
---|---|
AU714303B2 (en) | 1999-12-23 |
US20010049391A1 (en) | 2001-12-06 |
JP3152437B2 (ja) | 2001-04-03 |
DE69629591T2 (de) | 2004-07-01 |
WO1997017948A1 (en) | 1997-05-22 |
CA2234847A1 (en) | 1997-05-22 |
US20020022663A1 (en) | 2002-02-21 |
US6017963A (en) | 2000-01-25 |
EP0877609A1 (en) | 1998-11-18 |
AU1060497A (en) | 1997-06-05 |
EP0877609A4 (en) | 2000-06-07 |
ATE247461T1 (de) | 2003-09-15 |
US6642275B2 (en) | 2003-11-04 |
DE69629591D1 (de) | 2003-09-25 |
EP0877609B1 (en) | 2003-08-20 |
CA2234847C (en) | 2002-06-25 |
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