JPH1149687A - Skin preparation containing extract of agave americana l. or agave sisalana perr. a. rigida mill. for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe lipase activity-stimulating agent, a moisturizing agent, beautifully whitening agent, contact dermatitis-inhibiting agent, skin external use agent, bath agent, drink or food by compounding a specific plant extract as an active ingredient. SOLUTION: This skin. preparation for external use contains the extract of one or more plants selected from Agave americana L., Agave sisalana Perr.; A. rigida Mill., etc. The extract has a lipase activity-stimulating action, a moisture-retaining action, a melamine production-inhibiting action, and a contact dermatitis-inhibiting action. The extract is preferably compounded in an amount of 0.1-60 wt.%. The medicine is effective for inhibiting the fat secretion of skin and scalp, for treating the diseases of fatty skin (e.g. acnes, dander), hand roughness, itching, dry skin, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a novel and safe lipase activity promoter, moisturizer, whitening agent or contact dermatitis inhibitor containing one or more plant extracts selected from agave and sisal; and The present invention relates to application to various skin external preparations, bath preparations, and foods and drinks in the fields of pharmaceuticals, quasi-drugs, and cosmetics.

[0002] The field of application is generally applicable to various internal and external preparations (including preparations used for animals), and specifically, ampules, capsules, pills, tablets, and powders. , Granular, solid, liquid, gel or foamy 1) pharmaceuticals, 2) quasi-drugs, 3) foods, 4) topical or systemic skin cosmetics, 5) scalp / hair Pharmaceutical or / and cosmetic preparations to be applied (eg, shampoos, rinses, treatments, permanent solutions, hair styling,
Hair tonics, hair growth and hair growth products), 6) bath agents used in bath water, 7) other liquid odor / odor control agents, sanitary articles, sanitary cotton, wet tissues, etc.

[0003] Further, as foods and drinks, oral compositions (gum, candy, etc.), processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, and yuden noodles , Buckwheat and other noodles, sauces, soy sauce, sauce, sugar, honey, powdered candy, water syrup, and other spices, curry powder, mustard powder, pepper powder and other spices, jam, marmalade, chocolate spread, pickles, soy sauce, Sprinkled or processed vegetables and fruits such as canned and bottled vegetables and fruits, cheese,
It is used for dairy products such as butter and yogurt, miso soup, soup, fruit juice, vegetable juice, beverages such as whey drinks, soft drinks, alcoholic beverages, and other general foods and drinks such as health foods.

[0004]

2. Description of the Related Art Body fat in the subcutaneous tissue plays an important role in protecting health. In particular, there are functions such as energy storage, protein saving, body temperature regulation, and onset / maintenance of menstruation. Causes various diseases when accumulated in
For example, the effects of excess body fat include hyperlipidemia and, consequently, a lot of fat deposits on the walls of the arteries, reducing the elasticity and stiffening of the arteries. Such a condition is called arteriosclerosis, which is said to lead to angina and myocardial infarction, and also causes hypertension, which causes a stroke and a heart attack. In addition, diabetes and osteoarticular disorders due to weight gain also occur.

[0005] Therefore, reducing fat is very important for health, and in order to reduce fat, lipase enzymes are used to break down triacylglycerol into fatty acids and glycerin. Lipase itself encapsulated in a base is used as a cosmetic (JP-A-62-220598).
In addition, the use of the yoquinin extract as a sebum secretagogue (JP-A-60-174723) and the orchid plant: Purple orchid extract are effective for oily skin acne (JP-A-57-102).
No. 809), and as a sebum suppressant, there is cyproterone acetate by oral administration, but it is not effective enough, or causes irritable symptoms such as rash and nausea,
There is a problem in terms of side effects, and at present, no safe lipase activity promoter has been found when administered orally or transdermally.

[0006] Incidentally, body fat can be reduced by dietary restriction, but the balance of daily energy intake and nutritional factors is lost, and consequently the body weight is drastically reduced, and thereafter, the weight return is increased. When used as an external preparation for skin or a bath agent, water necessary for the skin is removed, and there is a possibility that the skin may become rough and rough, which is problematic.

[0007]

In view of these circumstances,
The present inventors have developed a variety of plants that are useful as lipase activity promoters, moisturizers, whitening agents or contact dermatitis inhibitors, and as a result, agave and sisal extracts have lipase activity promoting effects, Action, melanin production inhibitory action, contact dermatitis inhibitory action,
Therefore, it can be usefully used as a lipase activity promoter, moisturizer, whitening agent, contact dermatitis inhibitor, and also suppresses skin or scalp fat, and skin diseases of oily skin (for example, acne, seborrheic eczema, It is effective for prevention and treatment of inflammatory skin diseases such as seborrheic alopecia and dandruff), rough hands and Kayumi, as well as dry skin. It also promotes the decomposition of fat, reduces excess fat in the body, moisturizes the skin, and can be used as a whitening agent to prevent sunburn, etc. The present invention has been completed by providing a product.

[0008]

The plant "Agave" used in the present invention is an agave family (Agavaceae)
ae), agave agave (Agave) plant Aono agave (Agave americana L.) whole plant, fruits, flowers, leaves, stems, bark, roots, etc. A.americana L.var margi
nata HORT.), Yuki Ohisasano (A.filifera Salm.cv.C
ompacta), Yuki Sasano (A. victoriae-reginae T. Moor
e), lysin (A. potatorum Zucc.) and the like can also be used. In addition, “Sisal” is
gave) plant Sisal Asa (Agave sisalana Perr .; A.rig
ida Mill.), whole plants, fruits, flowers, leaves, stems, bark, roots, etc., but other species of the same species, A. cantala Roxb., Heneken (A. fourcroydes Le)
m.) can also be used.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The agave and sisal extracts used in the present invention refer to various parts of each plant (whole plant, fruit, flower, leaf, stem, bark, root, etc.) as they are or after pulverization. Exploited. And / or as it is or after pulverization, extracted with a solvent.

Examples of the extraction solvent include water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform can be used alone or in any combination of two or more kinds. It can be used even when the objects are combined.

The agave or sisal extract may be dried, concentrated or concentrated depending on the lipase activity promoter, moisturizer, whitening agent or contact dermatitis inhibitor, skin external preparation or bath agent, food and drink dosage form and form. Dilution or the like may be arbitrarily performed and adjusted.

Although the production method is not particularly limited, it is usually sufficient if it is within the range of the boiling point of the solvent at normal temperature to normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added to the extent that the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The agave or sisal extract of the present invention can be used as it is as a lipase activity promoter, moisturizer, whitening agent or contact dermatitis inhibitor, and can be further incorporated into a skin external agent or bath agent, food or drink. The amount of the lipase is not particularly specified, but the lipase activity promoter, moisturizer, whitening agent or contact dermatitis inhibitor, skin external preparation or bath agent, type of food and drink, quality, expected effect Although slightly different depending on the degree, it is usually 0.05% by weight or more (hereinafter, represented by weight%), and preferably 0.1 to 60%. If the amount is less than 0.05%, the effect cannot be expected sufficiently.

The lipase activity promoter, moisturizing agent, whitening agent or contact dermatitis inhibitor, skin external preparation or bath agent, and food and drink of the present invention may be used in addition to the above-mentioned essential components, and if necessary, the effects of the present invention. Can be produced in combination with components and additives used in pharmaceuticals, quasi-drugs, cosmetics, foods and beverages, and the like, within a range that does not impair.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow, tallow fatty acid, kukuinut oil, safflower oil, shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, Turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mokuro, coconut oil, tallow, lard, hydrogenated products of these oils and fats (hardened oil, etc.) and the like.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane, and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C ₂ -C ₄ ) oxide to which ethylene oxide is added. _{2 to} C ₄ ) chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethyl cellulose , Methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin
A₁), Dehydroretinal (vitamin A_Two), Carochi
N, lycopene (provitamin A), vitamin B group: thia
Min hydrochloride, thiamine sulfate (vitamin B₁), Lvov
Rabin (vitamin B_Two ), Pyridoxine (vitamin
B₆), Cyanocobalamin (vitamin B₁₂), Folic acid,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid or its
Derivatives, vitamin D group: Ergocalciferol (bi
Tamin D_Two), Cholecalciferol (vitamin D_Three),
Dihydrotaxerol, Vitamin E group: Tocophero
Or its derivatives, ubiquinones, vitamin K group:
Tonadione (vitamin K₁), Menaquinone (vitamin
K_Two), Menadione (vitamin K_Three), Menadiol (bi
Tamin K_Four), Other essential fatty acids (vitamin F), mosquitoes
Lunitine, ferulic acid, γ-oryzanol, orot
Acids, vitamin Ps (rutin, eriocitrin, hesperi
Gin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. However, usually, water and a water-soluble organic solvent (for example, ethanol) are used. ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water, Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and / or improves rough skin, hair growth, hair growth, hair loss prevention In addition to cosmetic effects such as imparting gloss, cleaning effect, alleviating fatigue, promoting blood flow, and warm bath effect, it can also be expected to have effects such as fragrance, deodorization, thickening, preservation, and buffering.

In the case of edible products, health or cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging), etc., improvement of taste, provision of color tone, aroma and gloss, stabilization, It can be used for thickening and preservation. Furthermore, in addition to this, we expect various cosmetic and pharmacological effects of each raw material known so far, and aim to increase the intended effect by combining them,
Alternatively, a product that is expected to have a multifunctional effect can be provided.

Specific plants (crude drugs) as raw materials include:
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Fuji), Aotsuji Lafzi (Kibo), Acacia, Akasuri Fruit, Red Grape, Red Megawiwa (Red Bud), Akane
(Kanekane Akane), Ayajiou Jiou (Jihuang), Agi (Awei),
Akinire (Royu skin), Akebi (Kidori), Asa (John Asako), Maruba Asagao or Asagao (Toshiko), Ashitaba (Asuka),
Azuki (red azuki), acerola, ase yak (Asenyaku), anise, Abemaki fruit, avocado, ama, amacha (sweet tea),
Amachaworu, Amadokoro (Jade bamboo), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Ikakozolina (Biliary head), Itadori
(Tiger cane root), strawberry, fig (fructose) or its leaves, strawberry (winter aoiko), ichiyakuso, ginkgo (ginko leaf, ginkgo),
Itohimehagi (Enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (sanryou), gull-kasukagra fruit, Hime-uikyo, turmeric (Utsukin), Usubasaishin-keirinsaishin (spicy), Usveniaoi,
Pterodactyla mushroom, Nepenthes (summer hay), Udo or Shishudo (Qang, Independent, Tang Independent), Plum (Ume) or its pulp, Vladigashi, Uwaurushi, Unshuri mandarin (Chen skin), Estragon, Ezocogi (Ezo fivega), Enoki ,
Ebisugusa (Keiko), Elderberry fruit, Elemi, Enju (Gossip, Gossip rice), Ogi-kibana-ohgi (Koki),
Ouren (yellow), giant crow squirrel (karonin), giant skull (self-defense), psyllium (vegetative child, vegetative grass), toucan hazel (Haruko), obanokera okera (white jitsu), obayashishabushi fruit, o hawthorn hawthorn ), Barley (barley), oguruma (turning over), okra fruit, panax ginseng and ginseng (carrot), hypericum persicae, kogomebayotogirisou perforum, perforated periwinkle (branch cut grass), odorikosou (interrupted), onamimimi (small earlings) (Tianhe), Onyuri Sasayuri Hakatayuri (Yuri), Ononis, Halibut (Hihayu), Ominaeshi (Loose), Dutch strawberry, Dutch mustard (Cresson), Dutch jelly, Dutch honey, olive, oregano, orange fruit or Pericarp, lycaenium (ripe ground yellow), cacao seeds, oysters or their leaves (persimmon), Kagikazura (Hook Choto), Cassia, Kasinaki Fruit (Kozumi), Gajutsu (Shazajutsu), Kashiwa
(Kazuki, Kazaha), Cascarilla, Kanixa (Kinosato), Kanokosou (Kisakune), Birch or Weeping birch (White birch), Pumpkin, Kapokinoki seeds, Kahoku Sansho (shopper), Gama (Kaba yellow), Chamomile roma Chamomile, kamiyatsude (weeds), crow squirrel (flower meadow), crow squirrel (midsummer), oak wheat, guarana seeds, karaya, karin (gourd), kawayanagi, kawataketake, kawarayomogi (inchinko), kansui
(Sweet), liquorice (licorice), candelilla, cantou, canna, raspberry, kiwi fruit, kikarasuri (urorone), kikyo (bellflower, bellflower root), chrysanthemum (chrysanthemum flower), catalpa (azumi),
Rumex (Yotei), Pheasant (Kikomi), Kizuta, Kidachi Aloe, Kidachiha, Kinoki, Yellowfin (Huangbashi), Gymnema sylvestre, Cabbage, Cabbage immature, Cucumber,
Kiraja saponaria, Kiraya, kumquat fruit, betel, kinmizukiki (sensuru-kusa), guava fruit, guayule,
Quercus Infectoria (Gallery), Kukui Nuts, Kukui (Gugi, Gyugia, Gyugoli, Leaf Skin), Kusagi Kazura (Tenmen Fuyu), Kuzu (Kakuzu), Kusunoki, Gooseberry Fruit, Gardenia, Kunugi Saw), Kumazasa, Kumatsuzura (horse whipweed), Clara (Bittersweet), Cranberry fruit,
Chestnut or its astringent skin, Curculigo latifolia fruit, grapefruit fruit, buckthorn, Black stalk
(Rescue), cloves (cloves, cloves), kayga (crop, crocodile spikes), celosia (cow flowers, rooster), bay laurel (laurel), gentiana, gennoshoko (old crocodile), koushinbara (moon season flowers) , Kosui mint (Melissa), Kozo fruit, Kocha (tea), Kouhone (Raw bone), Kouhon (Straw and Kara straw), Koulyan, Koendro fruit, Koganebana (Yellow Gon), Cowberry (Koshibachi), Coconut fruit, Goshyu
(Goshuyu), goshoichigo (covered bonko), pepper (pepper), copaiba balsam, coffee beans, kobushi tamshiba magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame crab (gensin) ), Wheat (wheat), rice, rice bran (red bran, white bran), rice oil, cola acuminata seed, cola vera seed, fenugreek fruit, colombo, conzulango, kelp, konjac, comfrey (finnari grass), saxima Button ヅ (weird sen), cherry leaves, flowers, fruits, bark
(Cherry bark), cherry, pomegranate, sasa, lily
Sazanka, Sajiomodaka (Sawahka), Sweet potato, Sugarcane, Sugar beet, Sanebu jujube (Acid jujube), Saffron (Bamboo safflower, West safflower), Pomelo fruit, Sabonsou, Salmonberry fruit, Sarashinashoma (Masame), Salvia (Sage), Sawagikyo (Yamakona), Hawthorn (Yamazako), Panax ginseng (Seven carrots), Sanshuyu (Yasugoyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Kareite), Cyanoki fruit, Shiitake ( Shiitake mushrooms), Shion (Shien), Dikitaris, Shikunshi (Kimiko), Shiso, Aodiso, Chirimenjiso, Catamendiso (Shiso leaves, Shiso), Rosewood, Shinano,
Chinese Forsythia (Forsythia), Zinnia (Chrysanthemum), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Janohige (Bakumonyu), Juzudama, Palm Fruit,
Ginger (ginger), ginger (iris, iris root), shizuku fruit, birch oak seeds, white walnut butterflies, white blossoms, white blossoms, white blossoms, white blossoms, white cinnamon syllabus, cinnamon, watermelon, watermelon (Gold and silver flowers, Shinobi winter), sorrel (acid model), swimberry fruit, strawberry fruit, horsetail (Thorn), stevia, plum fruit, pine cone, cone larch,
Vines, walnuts, hawthorn,
Dandelion, horse chestnut (malonie), pear fruit, prunus japonicus, prunus japonicus, prunus edulis, prunus edulis, millefoil, balsam pears, pygmy root, pygmye pylon, ), Mallow, hirohasenega, senega, seri, celery, senkyu (river cucumber), sendan, senju (drug), senna fruit or leaves,
Senninsou (great tate), souka (grass), buckwheat seeds, soybean potato, rhubarb (daihuang), radish, soybean, daidai (orange peel, kikomi), takatodai (daigei), takawarabi (gull),
Dark sweet cherry fruit, hollyhock, hollyhock (thyme, Hyakurika), hollyhock (tachibana skin), hollyhock, tamarind seeds, onion, tamashiba (spicy), arachis or its root bark, tanjin (dansan), dandelion (gakko)
Or white dandelion, moko dandelion, dammar, cherry fruit, cypress or its root (chinese radish), ginseng carrot (bamboo ginseng), chicory, Korean ginseng (Gomiko), Korean ginseng (Ohuang), Korean ginseng (Buoy), Korean ginseng Carrots (carrots), artemisia (autumn leaves), choreimaitake (chorei), foliage, camellia, camellia,
Tsumekusa (lacquer lacustrine), Tsuyukusa (duckling grass), Tsuruazuki (red azuki bean), Tsurudukudami (what's a crow), Tsuruna (apricot), Carrot (four-leaf ginseng), Tsuwabuki, Deiko, Teuchigulumi, Duberry fruit, Tengusa, Tendaiyaku (crow) Medicine), red pepper, winter pepper, red pepper, pepper, touki, marigold, corn or corn hair (nanban hair), red horned mochi (female child), torindo (dragon gall), Dokudami (jujutsu), radish (root sprout), ginseng (bamboo carrot), eucommia (tochu, tochuha), tomato, tragacanth, triacanthus seed, tormentilla, dronoki, trollooi, nizeleria berry fruit, yam
Yamanoimo (Yakuyaku), Nagi-kida (Butcher Bloom),
Koji Naginata, Nazuna, Rape, Natsumikan, Jujube (daijutsu), Naniwaibara (Kanekurako), Narukoyuri (Yellow),
Peanut (peanut), Nanten (Minami Tenmi), Nigaki (Makinoki), Nigamogi (bitumen), Nikuzuku, Nikkei (Cinnamon bark),
Leek (Niriko), elderberry (bone-bearing tree) fruit / flower or foliage, garlic (garlic), nulde (fivefold), leeks, thistle (daiji), noybara (fruit), yarrow, sawdust (maehu),
Novara, Nomomo, Palm, Pineapple fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakata lily (Yuri), Hakayamauraboshi (Bone crushing), Hakusen
(Ringworm skin), huckleberry fruit, chickweed (red), hazel
(Haruko), Hasiridokoro (Roth root), Basil, Lotus (Russian meat, Lotus root), Parsley (Netherland jelly), Hadakamugi, Batata, Hachiku Madake (Bamboo-boiled), Patchouli, Mint (Light-weight, Light-weight leaf), Adlay ( Yokuinin), Hanasuge (grandmother), banana, hanamint, vanilla bins, papaya,
Butterweed (Rabbit malt grass), Habu grass, Paprika, Hamago and Mitsuba Hamago (vine thorn), Hamasuge (Kazukiko), Hamabishi
(Shikoriko), Hamanas (maikai flower), Hamabofu (beach storm), Hamamelis, rose (rose), Parietaria, Harunire (yellow, yu white skin, yuba), breadfruit, giant olive (sun dried), lycopodium carrot (party) , Pecan nuts, Amaryllidaceae (Shirubi, Suzuka Hana), Hikikoshi (Extended life grass), Hishi
(Hishimi), Pistachio, Beet, Hitotsuba (Ishire), Hinata Kozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower,
Bell pepper, Himegama (incense blossom), Himematsutake, Pimenta fruit, Juniperum, Hydrangea fruit, Biloba oyster, Hiroha okinagusa (Hakuto Okina), Loquat (Loquat, Loquat leaf), Betel nut (Large clothing skin, Betel palm), Houtou Kazura (Southern rattan), Butterbur, dandelion (winter flower, winter leaf), fujibakama (orchid grass), fuji bean
(Flat bean), grape fruit or pericarp / leaf, beech, sycamore (Cordyceps sinensis), Brazilian liquorice, black currant fruit, blackberry, plum fruit, furcellaria, blueberry (Prunus aegypti), prune, blonde psyllium, bundou (Mung beans), loofah, safflower
(Safflower), belladonna, berry fruit, boysenberry fruit, boufu (windbreak), spinach, physalis (Torone), honoki (kopoku, japan), bokeh (gourd), hosobananaokera (blue atrophy), hosobabarengiku, bodaiju ( Bodhi tree), button (peony, peony skin), hop, jojoba, white berry fruit, hon-shimeji, meisurutennanshaw
(Tiannan star), Ephedra (mao), Macadamia nut, Macri
(Sea-grass), maguwa (mulberry white skin, mulberry leaf), red snapper (kiten tate),
Matsukasa, Matsuba, Matsuhodo (Bukuryo), Mayorum (Hanaminka), Malvanozadin (Ginseng), Mulberry fruit, Quince, Malonie, Mango, Mansugurumi, Mandarin fruit, Mannentake (Lingzhi), Fruit of Citrus plant (Fruit), Mishimasaiko (Saiko), Mizokukushi (Hanabe Lotus), Misohagi (Chishuna), Mitsugashiwa, Mitsuba, Mitsuba Hamago
(Thorn horn), Green peppermint, Mimosa, Myoga, Miracle fruit fruit, Myrrh, Myrobaran, Mukuge (Mokuge), Mukunoki, Mukuroji, Murasaki (purple root), Murasaki maize, Mehajiki (Masugi), Mebogi, Melaleuca, Melissa, Melissa, Melon fruit, sagebrush, moso bamboo, mocktail (wood incense), maple blossom, peach leaf
(Peach leaves), fruits, seeds (peach kernels), bean sprouts, morello cherry fruits, moroheiya (burlap), yakawamurasakiimo, yakuchi
(Masutoshi), cornflower (cornflower), cornflower mint, yashabushi (arrow car), yachiyanagi, Japanese yamide (octagonal gold plate), mistletoe (willow parasitism), willow leaf, yabugarashi, yabukouji (purple gold cow), yamagobo (land) , Mountain alder (Yamaharu), bayberry (Yumebai), sagebrush, eucalyptus, yukinoshita (tiger eargrass), yucca flevifolia, yuz fruit, lily, yorugusa, mugwort (autumn leaf), lime fruit, rye, lacanca fruit, raspberry leaf・ Fruit, lavender, longan (longan meat), ryocha (green tea), apple fruit, gentian, rubus sabisimus (sweeten), lettuce, red currant fruit, lemon fruit, lemongrass, forsythia, forsythia, wax palm, Loganberry fruit, Logwood, Rosemary (Mannenrow), Rosehip (Nobara), Wakame, Wasa , It is raised, such as burnet (Chinire).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Usubaaonori, Sujiahonori, Hiraaonori, Bouuaonori, Hosoedaoonori], and seaweeds [Brown algae: Macombu, konsoubu, Hoshisobu] Honey kelp, wakame, hirome, blue seaweed, macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana, hijiki, hibamata], seaweed [red algae: red alga: jijirimen, maxa (tengusa), hirakusa, onyxa, obaxa, kataobaxa ,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsunomatata), Ezotunomata, Togetsunomata, Hirakotonogi, Kotoji, Kotoji , Hyus Banori] and the like.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas, Akayukimo, Dunaliella spp .: Dunaliella, Chlorococcus spp .: Chlorococcus, Kwanomimo spp .: Kwanomimo, Volvox spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Blue-green algae (Genus Papilio xylophila: L. spp., Phyllophyllum, Genus Noctuida: Kawatake, Ishikurage,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp.
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike, Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Kalexa: Kalexa, Tosakamaki: Hosobanotokamaki, Kurosakamaki,
Genus genus: genus genus: genus: kinuhada, genus: scorpion genus: ezotsaka, genus tsukasanori: enashikarimenia, otsukasanori, hanagatakarimenia, hohono: genus: lyca, genus genus: genus, genus, genus, genus, genus : Scarabaeni, Okamuragusa: Yamadagusa, Mirin: Mirin, Hosobamilin,
Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari,
Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibaranori, Kizinoo genus: Kizinoo, Isodantsuu genus: Isodanthu, Atsubanori genus: Atsubanori, Ogonori genus: Ogonori, Tsurushiramo, Shiramo, Omoganotenori, Mizonotogonen Genus mushrooms, genus fushikenori: fushikrenori, genus namimaki: namimiwa, sponge spp. Black and white genus: Red moss, Red moss Genus: Taoyagisou,
Hanasakura, sarcophaga: sarcophagid, sardonyx, scorpion genus: hanaeda, hirata goat: hiratagoat, dars genus: dars, masagoshibari, anadars, uebagsa genus: webagsa, safflower smelt, sarcophaga, sarcophaga, sarcophaga Genus: sunflowers, swelling flowers, squirrels: squirrels, squirrels, squirrels, squirrels, squirrels : Usveni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sudiginu, Atubasujinu, Hyusbanori: Kaguius Nori, Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanolimodoki, Ayanishiki genus: Ayanishiki, Ayaginu genus: Ayaginu, Dadia genus: Enashidazia, Simadadia genus: Isohagi, Simadazia, Dazimodogutoid, Dazimodogoida , Genus macri: genus macri, genus sanaginori: hanayanagi, yuna, yamaginori, motsureyuna, venyanagicoli, mosanayanagi, sasabayanaginori, genus sozo: closozo, cobusoso, hannesozo, sozonohana, hanegusa, kenegusa
Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo,
Physcomitrella: Physcombe:
Kikuhiodori, Hodosigusa, Usubahiodoshi, Isomegusa genus: Isomegusa, Suzinagusa: Suzinasugusa, Isobashou: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed, Meadowweed, Genus genus (Ochium spp .: Ochium spp., Ochium spp., Chinorimo spp .: Chinorimo, Tiszinori: Tiszinori etc.).

The axle algae (genera spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

[0038] Materials derived from animal raw materials include a cockscomb extract, a cow / human placenta extract, a pig / cattle stomach, a duodenum or an intestinal extract or a decomposition product thereof, and a pig / cattle spleen extract. Product or its degradation product, extract of pig / cattle brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin or its decomposition product Or a derivative thereof, a silk protein or a degradation product thereof or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin,
Heme, protohem, heme iron, etc.), milk, casein or its decomposition products or their derivatives, skim milk powder or its decomposition products or their derivatives, lactoferrin or its decomposition products,
Egg ingredients, fish meat decomposition products, etc.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, rice ferment extract, rice bran extract, euglena extract, lactic acid fermentation product of skim milk powder, trehalose or a derivative thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) Ultraviolet absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B ₆ derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B ₆ derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid or a derivative thereof, hydroquinone or a glycoside thereof, kojic acid or a derivative thereof, placental extract, silk peptide, plant extract (mulberry, corn, waremokou,
Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, artea, keihi, mankeishi, hamamelis, yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, hemp yellow, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genenoshoko, Kakkon, Licorice, Gopiko, Aloe, Shouma, Safflower, Green Tea, Tea, Asenyaku).

(20) Reduction / decomposition of melanin pigment Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, etc.

(21) Promoting action of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid ester, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo, green tea, etc.).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or a salt thereof, polyethylene glycol, chondroitin sulfate or a salt thereof, a water-soluble chitin or chitosan derivative, sodium lactate and the like.

(29) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(31) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, Nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -1-methylphenol, N-phenylparaphenylenediamine, metaaminophenol , Metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(32) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(33) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(34) Sweeteners sugar, sweet tea, fructose, arabinose, galactose, xylose, mannose, maltose, honey, glucose, miraculin, monelin, etc.

(35) Nutrition enhancer Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron, etc.

(36) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizers, emulsifiers, animal / plant proteins or their decomposed products, animal / Vegetable polysaccharide or its degradation product, animal or vegetable glycoprotein or its degradation product, blood flow promoter, anti-inflammatory agent / antiallergic agent, cell activator, keratolytic agent, wound treatment agent, foaming agent, thickening Agents, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, etc., are known to date with the lipase activity promoter, moisturizer, whitening agent or contact dermatitis inhibitor of the present invention. Additive or synergistic lipase activity accelerating action, moisturizing action, whitening action or anti-inflammatory action can be expected depending on the combination with the lipase activity promoter, moisturizer, whitening agent or ingredient having a contact dermatitis inhibitor. .

The lipase activity promoter, moisturizing agent, whitening agent or contact dermatitis inhibitor of the present invention, the external preparation for skin or bath, and the food and drink can be in any form, such as ampule, capsule or powder. Drugs, quasi-drugs, cosmetics for skin and hair, such as pills, granules, pills, tablets, solids, liquids, gels, foams, emulsions, creams, ointments and sheets, or It can be used by blending in bath preparations and foods and drinks.

Specifically, for example, pharmaceutical preparations for internal and external use, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, shampoos, rinses, and hair treatments , Hair creams, pomades, hair sprays, hair styling products, perm agents, hair tonics, hair dyes, hair growth and hair growth products, and other hair cosmetics
Makeup cosmetics such as foundation, white powder, whitening, lipstick, blusher, eyeshadow, eyeliner, mascara, eyebrows, eyelashes, etc.
Includes perfumes, bath agents, other toothpastes, mouth fresheners / gargles, liquid odor / deodorant inhibitors, sanitary products, sanitary cotton, wet tissues, etc., and also used in general foods and drinks It is possible.

The method for adding to the agave or sisal extract-containing lipase activity promoter, moisturizer, whitening agent or contact dermatitis inhibitor, skin external preparation or bath agent, or food or drink of the present invention is added in advance. However, it may be added during the production, and may be appropriately selected in consideration of workability.

[0066]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Agave, sisal,
100 g of each was warmed and extracted with purified water (about 80 ° C.) for about 6 hours, extracted at room temperature for one day and then filtered, and the extract (dry solids: about 0.4 to 1.6% by weight) was filtered out to about Get 1.0kg.

(Production Example 2) Agave, sisal,
100 g of each was immersed in a 50% ethanol solution, a 50% 1,3-butylene glycol solution, or a 60% propylene glycol solution, or purified water (about 30 ° C.), extracted at room temperature for 4 days and nights, and then filtered and extracted. About 1.0 kg of liquid (dry solids: about 0.4-1.6% by weight) is obtained.

(Test 1) Evaluation of lipase activity promoting action In the lipolysis process, triacylglycerol is decomposed into fatty acids and glycerin, and this decomposition reaction is carried out by lipase. It is an index of. It is also believed that lipase activation involves c-AMP-mediated multi-step reactions in adipocytes. In this test, Production Examples 1 to
The extract obtained in 2 was examined by measuring the lipase activity value using the quantitative reaction of lipase in human blood as an index. (Test method) a. Samples The extracts obtained in Production Examples 1 and 2 of the present invention were prepared to a concentration of 50% and subjected to a test. b. Skin extract 10 ml of physiological saline was added to 1 g of the skin of the guinea pig back, extraction was performed by ultrasonic waves, and the supernatant obtained by centrifugation (12,000 rpm, 15 minutes) was used as a skin extract. c. Enzyme lipase Enzyme lipase (porcine pancreas-derived / Sigma) contains 0.2 units
It was adjusted to become. d. Measurement of lipase activity A mixture of 30% sample, 20% skin extract and 50% 0.2units lipase was used as a sample, and the test was performed according to the test method of Lipase Kit S (Dainippon Pharmaceutical Co., Ltd.). As a control, purified water and various extraction solvent concentrations were used instead of the samples, and the control was set to 100% for each sample and control, based on the difference in color development from the blind test in which the substrate was added after the reaction was stopped. , The following equation (Equation 1)
Lipase activity promotion rate (= lipase activity promotion action)
I asked.

[0070]

(Equation 1)

[0071]

[Table 1]

(Test Results) As shown in Table 1, it was confirmed that the agave and sisal extracts of the present invention had a lipase activity promoting action.

(Test 2) Moisturizing test (Test method and evaluation method) 1) Epidermis stratum corneum moisture content measuring device (high frequency IMPERDANCE METE
R model IB 335, manufactured by IBS Co., Ltd.), and the electrical conductivity of the skin was measured with an electrode having an outer diameter of 6 mm and a center diameter of 1 mm. The measurement site is the inside of the forearm flexion side, and the electrical conductivity of the measurement site is measured in advance. Next, about 1 ml of each sample was applied to the measurement site, and after 30 seconds, the excess sample was removed.
Immediately after that, the electric conductivity was measured every 30 seconds for 19 minutes, and a moisture retention test was performed. In addition, the sample of the moisturizing test was manufactured in Production Examples 1 to 2
The extract obtained in the above was prepared to a concentration of 50% and used for the test.
The test conditions are as follows: temperature: 22 to 24 ° C, relative humidity: 50 to 52
% And the results are shown in FIG.

[0074]

FIG.

(Test Results) As shown in FIG. 1, it was confirmed that the agave and sisal extracts of the present invention had a moisturizing effect as compared with purified water.

(Test 3) Moisturizing test (Test method and evaluation method) 1) Transepidermal water loss measuring device (TEWAMETER TM210 COUR)
Using AGE + KHAKA Elctonic GmbH, Germany), apply 1 ml of each sample to the flexion side of the left forearm of a person, and wipe off after 30 seconds.
After wiping, the measurement was started about 10 minutes later using a transepidermal water loss measuring apparatus, and the measurement was performed at intervals of 2 seconds for 1 minute and 30 seconds, and the average value of all the values was obtained. Each blank was measured under the same conditions before sample application, and the difference between before and after application was defined as the amount of water change. The results are shown in FIG. The test conditions were as follows:
22-24 ° C., relative humidity: adjusted to 50-52%.

[0077]

FIG. 2

(Test Results) As shown in FIG. 2, it was confirmed that the agave and sisal extracts of the present invention had a reduced amount of water evaporation compared to purified water and had a moisturizing effect.

(Test 4) Melanin production inhibition test (Test method and evaluation method) a. Cells and culture conditions B16 mouse melanoma cells were used. 1 for culture
MEM medium (GIBCO B containing 0% fetal bovine serum (GIBCO BRL))
RL) and cultured at 5% CO2 at 37 ° C. b. Sample In addition, the sample of the moisture retention test was used for the test using the extract (solid content concentration 0.5%) obtained in Production Examples 1 and 2 of the present invention.
In addition, arbutin (Sigma) and ascorbic acid (Kishida Chemical) were prepared under the same conditions as comparative samples and used for the test. C. Measurement 1 × 105 B16 melanoma cells were inoculated in a 60 mm plastic Petri dish and pre-cultured for 24 hours. afterwards,
Replace with fresh medium and add sample. After culturing the cells for 3 days, they were collected by trypsinization. The recovered cells were removed from non-melanin substances with 5% TCA, a mixed solution of ether / ethanol and anhydrous ether, and then 1NNaOH, 10% DM
It was dissolved in SO solution, and the absorbance at 420 nm was measured to determine the melanin content (melanin production inhibitory action). The results are shown in FIG.

[0080]

FIG. 3

(Test Results) As shown in FIG. 3, the agave and sisal extracts of the present invention were confirmed to have an equal or higher inhibitory effect on melanin production than arbutin and ascorbic acid. Available as

(Test 5) Contact dermatitis suppression test In the contact dermatitis reaction, T
Lymphocytes, upon contacting the same antigen again, release various lymphokines that activate macrophages and lymphocytes, causing an inflammatory response. Therefore, a substance that suppresses a series of inflammatory reactions that occur again against the same antigen can be expected to be used as a delayed allergic agent. In this test, a hydrophilic petrolatum ointment containing the extract obtained in Production Examples 1 and 2 was formulated, and the method of Nakamura et al. (Nihon Pharmacological Journal, 76,595 (1)
980)), its effect on paraphenylenediamine-induced contact dermatitis reaction was examined.

(Test Method) a. The sample extract was concentrated under reduced pressure by evaporating the solvent under reduced pressure, and a hydrophilic petrolatum ointment containing 10% by weight in terms of solid content was produced and used by a conventional method. b. Measurement of edema swelling rate First, 0.1 ml of 2.5% paraphenylenediamine / acetone: olive oil = 4: 1 (hereinafter, PPD) was continuously applied to shaved abdominal skin of a mouse (BALB / c female mouse: about 8 weeks old) for 3 days. After application, sensitization was performed, and after 5 days, 20 mg of the test drug was applied to the unilateral auricle three times at hourly intervals. One hour after the final application, the test drug was sufficiently wiped off, and 20 μl of PPD was applied to the auricle to raise it. 17 hours after the inoculation, the test drug was applied again to the auricle which had been evoked twice at 1 hour intervals, and then, 19 hours after the insult, the test drug was thoroughly wiped out. 5.0 mm) and weighed.
In addition, the swelling rate was measured from the difference in the weight of the untreated one-sided pinna, and the dermatitis inhibition rate was determined in comparison with the control group, and a contact dermatitis inhibition test was performed. In the test, 8 to 9 mice were used.

[0084]

[Table 2]

(Test Results) As shown in Table 2, it was confirmed that the agave and sisal extract of the present invention had a contact dermatitis inhibitory action.

(Test 6) Safety test (1) Skin primary irritation test The agave and sisal extracts obtained in Production Examples 1 and 2 were purified water so that the dry solid concentration was about 1.0 ^W / _V %. And applied to the skin of Japanese white rabbits (female, 3 per group, weighing about 2.3 kg) whose back was shaved. The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 7) Safety test (2) Skin cumulative irritation test Agave similarly obtained in Production Examples 1 and 2,
A sisal extract was prepared with purified water so as to have a dry solid concentration of about 1.0 ^W / _V %, and was applied to the skin of a Hartley-type guinea pig (female, three per group, about 320 g in weight) whose flanks were shaved. 0.5 ml / animal was applied once a day, 5 times a week. Apply 2
Weekly and shaving was done on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indexes. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 8) Safety Test (3) Acute Toxicity Test Agave similarly obtained in Production Examples 1 and 2,
The powder obtained by concentrating and drying the sisal extract under reduced pressure (dry solid content: about 1.0 ^W / _V %) was ddy fasted for 4 hours before the test.
2,000m in mice (male and female, 5 mice per group, 5 weeks old)
g / kg was orally administered, and the appearance and degree of toxicity symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, the LD ₅₀ was determined to be 2,000 mg / kg or more.

(Prescription Examples) Production of various lipase activity promoters, moisturizers, whitening agents, contact dermatitis inhibitors, skin external preparations or bath agents, foods and drinks According to the above evaluation results, the following formulation examples are shown. The formulation examples may be those manufactured by a conventional method in the manufacture of each product, and only the compounding amounts are shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7.1 Polyoxy Ethylene (20) soorbitan monooleate 2.0 8., 3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Agave hot water extract B: Sisal hot water extract * A or B extract 5.0 11. Suitable amount of fragrance and preservatives

(Formulation Example 2) Peel-off pack weight% 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Agave hot water extract 5.0 7. Perfume, preservative Adequate amount 8.Purified water 100 residue

(Prescription Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. Agave 50% 1,3-butylene glycol extract 10.0 7. Appropriate amount of fragrance and preservative

(Formulation Example 4) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Sisal 50% 1,3-butylen glycol extract 10.0 7. Appropriate amount of fragrance and preservative 8. Purified water 100

(Formulation Example 5) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. 50% sisal ethanol extract 5.0 5. Agave 50% phenolic alcohol extract 5.0 6. pH adjuster qs 7.preservative qs 8.purified water 100

(Formulation Example 6) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Agave 50% 1,3-butylene glycol extract 3.0 6.pH adjuster qs 7.preservative qs 8.purified water 100

(Formulation Example 7) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphate 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. A: Agave 50% ethanol extract B : Sisal 50% ethanol extract * Extract of either A or B 3.0 6. Preservative appropriate amount 7. Purified water 100 residue

(Formulation Example 8) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Agave 50% ethanol extract B: Sisal 50% ethanol Extract * Any one of A and B extract 5.0 5. Residue with purified water 100

(Formulation Example 9) Granule bath agent weight% 1. Sodium bicarbonate 60.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. A: Aonori 50% 1,3-butylene glycol extract B: Sisal hot water Extract * Either A or B extract 7.0

(Prescription example 10) Coating protective agent A gauze or liniment cloth is impregnated with a prescription liquid prepared by mixing an appropriate amount of agave 30% ethanol extract, antibiotics, anti-inflammation, etc., and attached to the wound. Alternatively, the agave 30% ethanol extract may be directly applied locally and covered with gauze or the like.

(Formulation Example 11) Mentsuyu liquid weight% 1. Soy sauce 80.0 2. Black vinegar 2.0 3. Glucose 15.0 4. Sodium glutamate 2.0 5. Sisal hot water extraction powder 1.0

(Formulation Example 11) Udon or buckwheat weight% 1. Flour or buckwheat flour 96.0 2. Salt 1.0 3. Sisal hot water extraction powder 3.0

(Formulation Example 12) Bread wt% 1. Wheat flour 91.0 2. Salt 0.7 3. Glucose 6.8 4. A: Agave hot water extracted powder B: Sisal hot water extracted powder * A or B any one of the extracted powders 1.5

(Formulation Example 13) Cookie weight% 1. Milk 65.0 2. Whole eggs 14.0 3. Sugar 15.0 4. Constarch 4.1 5. Salt 0.4 6. Sisal hot water extraction powder 1.5 7. Perfume

(Formulation Example 14) Sausage weight% 1. Ground meat 94.0 2. Chicken eggs 5.0 3. Spices 0.3 4. Seasonings 0.5 5. Agave hot water extract powder 0.2

(Formulation Example 15) Beverage weight% 1. Glucose liquid sugar 33.0 2. Grapefruit juice 62.0 3. Agave hot water extracted powder 2.5 4. Sisal hot water extracted powder 2.0 5. Flavor 0.5 6. Acidulant proper amount

(Formulation Example 16) Gum weight% 1. Menthol micron 31.0 2. Grapefruit flavor 65.0 3. Agave hot water extract 2.0 4. Sisal hot water extract 2.0

(Formulation Example 17) Miso soup weight% 1. Tofu 45.0 2. Deep fried 2.5 3. Carrot 5.0 4. Burdock 5.0 5. Red miso 15.0 6. A: Agave hot water extract powder B: Sisal hot water extract powder * A , B Extracted powder of any one type 5.0 7.Resistance to make bonito dashi 100

(Test 9) Use effect test The effect when the external preparation for skin or bath preparation of the present invention was actually used was examined. Use test: 20 panelists, 15-30 years old suffering from oily skin, acne and eczema, and apply the appropriate amount of the emulsion of Formulation 1 to the face every day, twice a day, in the morning and at night after washing the face for 3 months. It was done by doing.
Also, similar skin diseases are seen on the scalp and hairline.
For each name (15-30 years old), a usage test was conducted by applying an appropriate amount of the hair tonic of Formulation Example 8 to the scalp for 2 months after daily hair washing.

Further, as for the bath preparation of Formulation Example 9, an appropriate amount of bath preparation was dissolved once a day for 20 months for 20 to 15-year-olds suffering from greasy skin, acne and eczema. We had you take a bath in hot water and performed use test. As controls, those prepared by removing the plant extract of the present invention from milky lotions, hair tonics, and bath preparations by the same method were used. The evaluation was performed according to the following criteria.
The numbers in the table represent the number of people as shown in FIG. No one complained of abnormalities on the skin or scalp during the use period.

"Skin (scalp) disease improving effect" Effective. Oily skin, acne and eczema were improved. Slightly effective. Oily skin, acne and eczema slightly improved. Ineffective. No change from before use.

(Test Results) From the results of Tables 3 to 5, the use of the agave or sisal extract-containing skin external preparation or bath agent of the present invention is effective in improving skin diseases such as oily skin and acne and eczema. , Good effect was confirmed.

[0112]

[Table 3]

[0113]

[Table 4]

[0114]

[Table 5]

(Test 10) Use Effect Test The effect of the food containing the plant extract of the present invention actually used was examined. The usage test was for 10 persons aged 15 to 30 years old who are suffering from oily skin, acne and eczema as panelists. I got it.

A control prepared by removing the plant extract of the present invention from miso soup in the same manner was used as a control.
The evaluation was performed according to the following criteria. The results are as shown in Table 6 and the numbers in the table represent the number of persons. No one complained of abnormalities on the skin or scalp during the use period.

"Skin disease improving effect" Effective. Oily skin, acne and eczema were improved. Slightly effective. Oily skin, acne and eczema slightly improved. Ineffective. No change from before use.

(Test Results) From the results in Table 6, it was confirmed that the use of the food containing the agave and the sisal extract of the present invention showed a favorable effect on the improvement of oily skin and skin diseases such as eczema and acne. Was.

[0119]

[Table 6]

(Test 11) Use effect test The effect of the skin external preparation or bath preparation of the present invention actually used was examined. The test was conducted with 20 panelists aged 5 to 50 years old who suffer from irritable skin diseases such as rough hands, Kayumi and redness or dry and Kasatsuki skin. Was applied to the face for 3 months. In addition, 20 people (3-45 years old) who have the same skin disease on the scalp and hairline
After the hair was washed every day, a usage test was conducted by applying an appropriate amount of the hair tonic of Formulation Example 9 to the scalp for 3 months.

Further, the bath preparation of Prescription Example 9 was also administered to 20 persons aged 1 to 65 years old suffering from inflammatory skin diseases such as rough hands, Kayumi and redness, or dry and Kasatsu skin for 3 months. Once a day, they were bathed in bath water in which an appropriate amount of bath agent was dissolved, and a use test was conducted. Controls include latex,
Hair tonics and bath preparations prepared by removing the various plant extracts of the present invention from the bath preparation were used in the same manner.
The evaluation was performed according to the following criteria. The results are shown in Tables 7 to 9, and the numerical values in the table represent the number of persons. No one complained of abnormalities on the skin or scalp during the use period.

"Skin (scalp) disease improving effect" or "moisturizing effect" Efficacy: Inflammatory skin diseases such as rough hands, Kayumi, and redness, or dry and Kasatsuki skin were improved. Slightly effective: Inflammatory skin diseases such as rough hands, Kayumi, and redness, and dry and Kasatsuki skin were slightly improved. Ineffective: No change from before use.

(Test results) From the results of Tables 7 to 9, the use of the agave or sisal extract-containing skin external preparation or bath agent of the present invention improves the inflammatory skin diseases such as rough hands, Kayumi and redness, or dryness. -A good effect of giving a moisturizing effect to Kasatsuki skin was confirmed.

[0124]

[Table 7]

[0125]

[Table 8]

[0126]

[Table 9]

(Test 12) Use Effect Test The effect of the food of the present invention actually used was examined. The test used was a panel of 10 people aged 5 to 50 years old who suffer from inflammatory skin diseases such as rough hands, Kayumi and redness, or dry skin and Kasatsuki skin. (About 50g each time) for 3 months.

As a control, a mixture prepared by removing the plant extract of the present invention from bread in the same manner was used.
The evaluation was performed according to the following criteria. The results are as shown in Table 10, and the numerical values in the table represent the number of persons. No one complained of abnormalities during the use period.

"Skin (scalp) disease improving effect" or "moisturizing effect" Efficacy: Inflammatory skin diseases such as rough hands, Kayumi, and redness, or dry and Kasatsuki skin were improved. Slightly effective: Inflammatory skin diseases such as rough hands, Kayumi, and redness, and dry and Kasatsuki skin were slightly improved. Ineffective: No change from before use.

(Test Results) From the results shown in Table 10, it can be seen that the use of the agave or sisal extract-containing skin external preparation or bath agent of the present invention improves inflammatory skin diseases such as rough hands, Kayumi and redness, or dryness and Kasatsuki. A good effect of providing a moisturizing effect on the skin was confirmed.

[0131]

[Table 10]

[0132]

Industrial Applicability According to the present invention, a plant extract of at least one of agave and sisal has a lipase activity accelerating action, a moisturizing action, a melanin production inhibitory action, and a contact dermatitis inhibitory action. It is safe for internal or external use. Therefore, it can be usefully used as a lipase activity promoter, humectant, whitening agent, contact dermatitis inhibitor or anti-inflammatory agent, and further into various forms of preparations (medicines, quasi-drugs, cosmetics, foods). Application of is also possible. It also suppresses fat on the skin or scalp, skin diseases of oily skin (eg, acne, seborrheic eczema, seborrheic alopecia, dandruff, etc.), inflammatory skin diseases such as rough hands and Kayumi, and dry skin. It is effective for prevention and treatment of It can also be used as a whitening agent that promotes the decomposition of fat, reduces excess fat in the body, moisturizes the skin by moisturizing, and prevents sunburn.

[Brief description of the drawings]

FIG. 1 is a diagram showing the water content of the stratum corneum of the agave and sisal extract of the present invention.

FIG. 2 is a diagram showing a change in water content of the agave and sisal extract of the present invention using a transepidermal water loss measuring apparatus.

FIG. 3 is a diagram showing the amount of melanin in the agave and sisal extracts of the present invention.

────────────────────────────────────────────────── ─── Continued on front page (51) Int.Cl. ⁶ Identification code FI A61K 7/48 A61K 7/48 7/50 7/50 // A23L 1/06 A23L 1/06 1/076 1/076 1 / 09 1/09 1/16 1/16 A 1/221 1/221 C 2/52 2/38 C 2/38 A61K 7/06 A61K 7/06 7/075 7/075 7/08 7/08 A23L 2 / 00 F

Claims (6)

[Claims] 1. An agave selected from agave and sisal
A lipase activity promoter comprising at least one plant extract. 2. One selected from agave and sisal
A humectant comprising at least one plant extract. 3. An item selected from agave and sisal
A whitening agent comprising at least one plant extract. 4. One selected from agave and sisal
A contact dermatitis inhibitor comprising at least one plant extract. 5. A lipase activity promoter, a humectant, a whitening agent or a contact dermatitis inhibitor according to any one of claims 1 to 4.
An external preparation for skin or a bath preparation, which comprises at least one kind. 6. A lipase activity promoter, a humectant, a whitening agent or a contact dermatitis inhibitor according to any one of claims 1 to 4.
A food or drink characterized by containing at least seeds.