JPH11193290A - ピロールスルホンアミド系化合物 - Google Patents

ピロールスルホンアミド系化合物

Info

Publication number
JPH11193290A
JPH11193290A JP9366757A JP36675797A JPH11193290A JP H11193290 A JPH11193290 A JP H11193290A JP 9366757 A JP9366757 A JP 9366757A JP 36675797 A JP36675797 A JP 36675797A JP H11193290 A JPH11193290 A JP H11193290A
Authority
JP
Japan
Prior art keywords
group
compound
general formula
formula
pyrrole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9366757A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11193290A5 (enExample
Inventor
Akira Mizuno
章 水野
Makoto Shibata
誠 柴田
Chie Iwamori
智恵 岩森
Jiichi Fukami
治一 深見
Norio Inomata
則夫 猪俣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Priority to JP9366757A priority Critical patent/JPH11193290A/ja
Priority to HU0001183A priority patent/HUP0001183A3/hu
Priority to CA002282815A priority patent/CA2282815A1/en
Priority to CN988028867A priority patent/CN1131870C/zh
Priority to CNB031328490A priority patent/CN1193014C/zh
Priority to PCT/JP1998/005955 priority patent/WO1999033841A2/en
Priority to US09/367,842 priority patent/US6331623B1/en
Priority to EP98961599A priority patent/EP0970089A2/en
Priority to AU16907/99A priority patent/AU752510B2/en
Priority to KR1019997007707A priority patent/KR20000075642A/ko
Publication of JPH11193290A publication Critical patent/JPH11193290A/ja
Priority to US09/939,829 priority patent/US6583296B2/en
Priority to US10/421,929 priority patent/US6743913B2/en
Publication of JPH11193290A5 publication Critical patent/JPH11193290A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP9366757A 1997-12-26 1997-12-26 ピロールスルホンアミド系化合物 Pending JPH11193290A (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP9366757A JPH11193290A (ja) 1997-12-26 1997-12-26 ピロールスルホンアミド系化合物
EP98961599A EP0970089A2 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
AU16907/99A AU752510B2 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
CN988028867A CN1131870C (zh) 1997-12-26 1998-12-25 新的吡咯磺酰胺化合物
CNB031328490A CN1193014C (zh) 1997-12-26 1998-12-25 新的吡咯磺酰胺化合物
PCT/JP1998/005955 WO1999033841A2 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
US09/367,842 US6331623B1 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
HU0001183A HUP0001183A3 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine derivatives, process for their preparation and pharmaceutical compositions containing them
CA002282815A CA2282815A1 (en) 1997-12-26 1998-12-25 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
KR1019997007707A KR20000075642A (ko) 1997-12-26 1998-12-25 세로토닌-2 수용체 길항작용 및 알파 1-저해 작용을 갖는 피롤로티아진 및 피롤로티아제핀 화합물
US09/939,829 US6583296B2 (en) 1997-12-26 2001-08-28 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and α-1-blocking action
US10/421,929 US6743913B2 (en) 1997-12-26 2003-04-24 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and α-1-blocking action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9366757A JPH11193290A (ja) 1997-12-26 1997-12-26 ピロールスルホンアミド系化合物

Publications (2)

Publication Number Publication Date
JPH11193290A true JPH11193290A (ja) 1999-07-21
JPH11193290A5 JPH11193290A5 (enExample) 2005-07-28

Family

ID=18487596

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9366757A Pending JPH11193290A (ja) 1997-12-26 1997-12-26 ピロールスルホンアミド系化合物

Country Status (9)

Country Link
US (3) US6331623B1 (enExample)
EP (1) EP0970089A2 (enExample)
JP (1) JPH11193290A (enExample)
KR (1) KR20000075642A (enExample)
CN (2) CN1131870C (enExample)
AU (1) AU752510B2 (enExample)
CA (1) CA2282815A1 (enExample)
HU (1) HUP0001183A3 (enExample)
WO (1) WO1999033841A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11193289A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
ES2919779T3 (es) 2017-06-20 2022-07-28 Imbria Pharmaceuticals Inc Derivado de 1-[(2,3,4-trimetoxifenil)metil]-piperazina, composiciones del mismo y métodos para aumentar la eficiencia del metabolismo cardíaco
US12318382B2 (en) 2018-10-17 2025-06-03 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3198117B2 (ja) 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体
FR2675802B1 (fr) * 1991-04-26 1993-12-24 Rhone Poulenc Rorer Sa Antiserotonines, leur preparation et les medicaments les contenant.
US5399557A (en) 1991-08-07 1995-03-21 Suntory Limited Pyrroloazepine compound
ATE236162T1 (de) 1991-08-07 2003-04-15 Suntory Ltd Pyrroloazepinderivate
WO1995018117A1 (en) * 1993-12-24 1995-07-06 Suntory Limited Benzothiazine derivative
CA2189297C (en) 1995-11-02 2004-09-21 Masahiro Imoto Process for preparing 1-substituted pyrrole-3-carboxylic acid derivatives
ATE216388T1 (de) * 1995-12-01 2002-05-15 Suntory Ltd Pyrroloazepin-derivate
JPH10251258A (ja) 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
IL139064A0 (en) 1999-02-17 2001-11-25 Suntory Ltd Intermittent claudication therapeutic drugs comprising pyrroloazepines

Also Published As

Publication number Publication date
EP0970089A2 (en) 2000-01-12
AU1690799A (en) 1999-07-19
HUP0001183A2 (hu) 2000-10-28
WO1999033841B1 (en) 2001-05-25
US20030229070A1 (en) 2003-12-11
CA2282815A1 (en) 1999-07-08
CN1261366A (zh) 2000-07-26
AU752510B2 (en) 2002-09-19
WO1999033841A3 (en) 1999-09-02
WO1999033841A2 (en) 1999-07-08
US20020137928A1 (en) 2002-09-26
US6331623B1 (en) 2001-12-18
HUP0001183A3 (en) 2002-12-28
CN1495163A (zh) 2004-05-12
KR20000075642A (ko) 2000-12-26
CN1193014C (zh) 2005-03-16
US6743913B2 (en) 2004-06-01
US6583296B2 (en) 2003-06-24
CN1131870C (zh) 2003-12-24

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