JPH11180813A - Antimicrobial and antiseptic agent containing extract of seaweed - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a safe, antimicrobial and antiseptic agent having antimicrobial and antiseptic activities, and effective for prevention and treatment of surface disease of the skin such as eczema, itching, roughened skin and dry and rough state of the skin, and further to obtain a bathing agent, a food and drink and a fiber-treating agent. SOLUTION: The antimicrobial and antiseptic agent, the preparation for external use for skin, and the bathing agent, the food and drink or the fiber treating agent contains singly en extract of seaweed, or the extract of the seaweed, and a chitosan derivative obtained by reacting a chitosan with saccharides having reduced terminals. The seaweeds to be extracted are selected from them belonging to the genus Enteromorpha such as E.linza J. Agardh, the genus Laminaria such as L.japonika Areschoug, the family Undarial such as U.pinnatifida Suringar, the family Lessoniaceae such as Macrocystis pyrifera C.Ag., the genus Hizikia such as H.fusiforme Okamura, the genus Cyrtymenia such as C.sparsa Okamura, the genus Geridium such as G.amansii Lamouroux, the genus Meristotheca such as M.papulosa J.Ag., the genus Eucheuma such as E.serra J.Ag., the genus Gigartina such as G.tenella Harvey, the genus Grateloupia such as G.elliptica Holmes, the genus Eisenia E.bicyclis Setchell, the genus Dictyota such as D.dichotoma Lamouroux, the genus Ishige such as Ishige okamurai Yendo, the genus Gymnogonrus such as G.flabelliformis Harvey and the genus Callophyllis such as C.japonical Okamura.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a green seaweed, a kelp, a seaweed, a giant kelp, a pheasant, a seaweed, a seaweed, a seaweed, a giant squirrel, a squirrel, a tambanori, an almond, a sea squirrel, a seaweed,
An antibacterial and preservative containing one or more seaweed extracts selected from red sprouts and skin external preparations or baths, foods and beverages and fiber treatments comprising these, and further having chitosan and a reducing terminal By combining one or more chitosan derivatives obtained by reacting with saccharides,
The preservative effect is synergistically enhanced. Therefore, a new and safe antibacterial and preservative, skin external preparation or bath agent and food and drink,
A fiber treatment agent is provided.

[0002] The field of application is generally applicable to various internal and external preparations (including preparations used for animals), and specifically, ampules, capsules, pills, tablets, and powders. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Foods, 4) Topical or systemic skin cosmetics, 5) Scalp / hair Pharmaceutical and / or cosmetic preparations (eg, shampoos, rinses, treatments, permanent solutions, hair dyes,
Hairdressing agents, hair tonics, hair growth / hair restoration, etc.), 6) bath agents used in bath water, 7) other deodorants / deodorants, sanitary goods, sanitary cotton, wet tissues, etc.

[0003] Further, as foods and drinks, oral compositions (gum, candy, etc.), processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, and yudenmen Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy, mizuame, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce, Processed vegetables and fruits such as sprinkles and canned and bottled vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drinks, soft drinks, alcoholic beverages, etc. Use in general foods and drinks such as health foods.

Examples of the fiber treatment agent include general clothing (pajamas, shirts, pants, socks, bras, panties, tights, slips, blouses, pants, skirts, etc.), diapers, diaper covers, sanitary pants, In addition, sheets (duvet cover, cushion cover, pillow cover, cushion cover, etc.), blankets, mattresses, carpets, carpets, towels, towels, handkerchiefs, gloves, cloth bags, furoshiki, obi (ropes), sanitary cotton, filters It can be used for textile products such as non-woven fabrics such as and wet tissue.
Other applications include plastics, paints,
Adhesive, antibacterial for various products such as plumbing and air conditioning ducts of various factories, toilet and bath tiles, refrigerators, holding fruits and vegetables
Applicable as a preservative.

[0005]

2. Description of the Related Art In general, in order to suppress the growth of microorganisms, which cause decay and contamination, in vivo, invasion of microorganisms is performed by physical or chemical methods such as distribution of bactericidal substances and mucus on skin and mucous membranes. In addition, against microorganisms that have entered the living body,
Phagocytosis by phagocytes, lysing by lysozyme, etc.
It develops resistance through innate and nonspecific infection resistance and immune response to specific pathogens.

[0006] However, if the infectivity of bacteria exceeds the resistance in the living body, infection symptoms appear in the living body, such as dermatitis, conjunctivitis, food poisoning, diarrhea,
In addition, there is a risk of causing various symptoms such as ringworm (eg, a syrup), acne, dandruff, and kaumi associated with dandruff.

[0007] In view of the current usage of antibacterial and preservatives, foods, pharmaceuticals, quasi-drugs, cosmetics, and the like, except for items containing high levels of antiseptic substances such as alcohol, contain The use of various antibacterial and preservatives is essential.

Recently, sorbic acid, dehydroacetic acid and salts thereof, and paraoxybenzoic acid derivatives have been frequently used as antibacterial and preservatives for foods, pharmaceuticals, cosmetics, etc. due to putrefaction and contamination. There are restrictions in terms of sex, and the amount added and the target foods are restricted (for example, the upper limit of sorbic acid and its salts in food is 0.3%, and dehydroacetic acid and its salts are used in cheese, butter and margarine). It can be used only, and the upper limit of the blending ratio of methyl sodium paraoxybenzoate in cosmetics is 1.0%). It is a safe and natural antibacterial and preservative that does not irritate the skin. Development was desired.

Further, various drugs have been used for the prevention and treatment of infectious diseases inside and outside the body.
Antibiotics and synthetic antibacterials and preservatives, which occupy the majority, are certainly effective, but are regulated in terms of safety. Was sought.

[0010]

Therefore, the present inventors have studied various natural extracts which have an antibacterial and antiseptic effect and are safe for use in various fields, and have developed a novel extract. We have been studying substances and their actions.

[0011]

In view of these circumstances, the present inventors have developed various seaweeds which are useful as antibacterial and preservatives as the theme of development, and as a result, Aonori, Kombu, Wakame, Giant Kelp, Hijiki , Hirimen, Tengusa, Tosakanori, Giraffe, Suginori, Tambanori, Alame, Amijigusa, Ishige, Okitsunori, Red seaweed extract confirmed that the seaweed extract has an antibacterial and antiseptic effect, further using chitosan or low molecular weight chitosan,
It was confirmed that when used in combination with one or more chitosan derivatives obtained by reacting with a saccharide having a reducing terminal, a stronger synergistic antibacterial and antiseptic effect was obtained. And it is found that it is extremely effective to apply to novel antibacterial and preservatives that are safe for humans or animals, and further to skin external preparations and bath preparations, foods and drinks, and fiber treatment agents. completed. Hereinafter, the process leading to the present invention will be described.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The seaweed “Aonori” used in the present invention refers to a phylum Chlorophyta, a class of green algae (Chloa).
rophyceae), Ulva (Ulvales), Ulva (Ulvacea)
e), a hollow tubular body classified into the genus Aonori (Enteromorpha), the wall of which refers to an algal body consisting of a single layer of cells, for example,
Uzba Aonori (E.linza J. Agardh), Suzi Aonori (Ep
rolifera J. Ag.), Hira Aonori (E.compressa Grevill)
e), Bow Aonori (E. intestinalisLink), Hosoeda Aonori (E. crinita J. Ag.) and the like can be used.

[0013] "Kombu" refers to a brown algal plant phylum (Phaeophyt).
a), Heterogeneratae, Laminaria (Laminari
ales), Laminariaceae (Laminariaceae), Laminaria (Laminari
a), a leaf with no hair plexus, a mucous cavity, a single leaf without a middle rib, a fibrous root, an unbranched alga body, such as macomb (L. japonika Areschoug),
(L. japonica Areschoug var.ochotensis Okamura), Hosome kelp (L.
gustata Kjellman) can be used.

"Wakame" refers to a brown algal plant phylum (Phaeophyt).
a), Heterogeneratae, Laminaria (Laminari
ales) and alga bodies that have hair plexuses and mucous glands in the leaves and fold at the lower part of the body, such as wakame (U. pinnatifida Suringar),
ioides Okamura), Blue Wakame (U. peterseniana Okamur)
a) can be used.

"Giant kelp" refers to a brown algal plant phylum
(Phaeophyta), atypical generation class (Heterogeneratae), Laminariales (Laminariales), classified into Lessoniaceae (Lessoniaceae), refers to alga bodies that form a vast marine forest, for example,
Macrocystis pyrifera
C.Ag.), Macrocystis integrifolia (M.int
egrifolia Bory), Neocitys Luetokeana (Nere
ocystis luetkeana Post. et Rupr.) can be used.

"Hijiki" refers to the brown algal plant phylum (Phaeophyt).
a), Meridian rope (Cyclosporeae), Hibamata (Fucales), Hondara (Sargassaceae), genus Hizikia (Hizikia). Forests, roots, stems, leaves, and those having spindle-shaped or club-shaped bubbles with expanded columnar twigs can be used.

"Hilimen" means Rhodophyta (Rhodoph
yta), Florideae, Crachtone (Cryptone)
miales);
parsa Okamura), tetrasporangia scattered throughout the cortex,
Those having a crepe-like wrinkle on the body surface can be used.

"Tengsa" means Rhodophytium (Rhodophyt)
a), the genus Red Algae (Florideae),
s), there are three generations of male and female gametes, parasitized sporophytes, and tetraploids that are exactly the same in shape as gametes, classified into the family Gelidiaceae. It refers to the algae that grow asexually and produce asexual branches,
In the genus Tengsa (Geridium), for example,
(G. amansii Lamouroux), Nettle (G. subcostatum Okam)
ura), linseed (G. japonicum Okamura), and the like in the genus Pterocladia (Pterocladia), for example,
mera), cataobakusa (P. densa Okamera), and the like, in the genus Yatabella (Yatabella), for example, Y.
Okamura) and the like, in the genus (Acanthopeltis), e.g., Ai japonica (A. japonica Okamura), etc., in the genus Genus (Gelidiella), e.g., G. acerosa
(Forsskl) Feldmann et Hamel) can be used.

"Tosakanori" refers to Rhodophyta (Rhodoph
yta), Florideae, Giginartidae (Gigartinal
es), Myrinaceae (Solieriaceae),
heca), which is classified as Tosakanori (M.papulosa J.Ag.).
A material of about 40 cm or the like can be used.

"Kirinsai" refers to Rhodophyta (Rhodoph
yta), Florideae, Giginartidae (Gigartinal
es), Myrinaceae (Solieriaceae), Giraffe (Eucheum)
Classified into a), the body is cylindrical or oblate, the narrow base of the branch is light, and refers to algal bodies densely forming short conical or spiny projections, such as E. serra J. .Ag.), E.amakusaensis Okamura, Giraffe
(Ryukyu Tsunomata) (E.denticulata (Burman) Coll
ins et Hervey) and E.cupressoide
um WvBosse) can be used.

"Suginori" means Rhodophytium (Rhodophyt)
a), genus Red Algae (Florideae),
s), Giardinaceae (Gigartinaceae),
Classified in (a), the capsule refers to the alga body that usually emerges from the surface of the body, and the body usually branches in a pinnate form.
la Harvey), Shikinori (G.teedii (Roth) Lmx.), Kainori (G.intermedia Sur.), Ibotsunomata (G.mikamii Yo
shida (= G.verrucosa (Mikami) Kim, non (Ktzing) Setc
hell et Gardner]).

"Tambanori" means Rhodophyta (Rhodoph
yta), Florideae, Crachtone (Cryptone)
miales), Grateloupiaceae (or sometimes referred to as Cryptonemiaceae), or genus Grateloupia, tambanori (G. elliptica Holmes). , Leaves are divided into several pieces, length 20-30cm, width 5-15cm
About one can be used.

"Alame" refers to a brown algal plant phylum (Phaeophyt).
a), Heterogeneratae, Laminaria (Laminari
ales), Laminariaceae (Laminariaceae), Alame (Eisenia)
It refers to Alame (E. bicyclis Setchell), which has a cylindrical stem, 1.5 m or more if the habitat is deep, and a leaf with a dragon-like wrinkle.

"Amidigsa" refers to a brown algal plant phylum (Phaeoph
yta), the isomorphous class (Isogeneratae), the order Amis.
ctyotales), one meristem cell (Dictyotaceae), one meristem cell (Dictyota),
Both the inner layer and the cortex indicate an algal body composed of a single layer of cells, and for example, Amidigsa (D. dichotoma Lamouroux), Sakibiroamiji (D. dilatata) and the like can be used.

"Ishige" refers to a brown algal plant phylum (Phaeophyt).
a), atypical generation class (Heterogeneratae),
rdariales), Ishigeaceae, Ishige (Is
hige) refers to an algal body branched in the shape of a fork of about 10 cm, for example, Ishioka (I. okamurai Yendo), Irolo (I. foliacea Okamura) and the like can be used.

"Otsunori" means Rhodophyta (Rhodoph.
yta), Florideae, Giginartidae (Gigartinal
es), G.flabel, which is classified into the family Phyllophoraceae and the genus Gymnogongrus
liformis Harvey), the body is linear, oblate pressure crowding, correctly and bifurcated, and a height of about 7 cm and a width of about 1.5 to 2 mm can be used.

[0027] "Akaminoshinori" refers to a red algal plant phylum (Rho
dophyta), Red Algae (Florideae),
tonemiales), Callymeniaceae, and Callophyllis, C. japonica Okamura, C. crispata Okamura, C. palmatama Yamada , Black crab (C. adhaeren)
s Yamada) and C. adnata Okamur
a) can be used.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas sp., Akayukimo, Dunaliella spp .: Dunaliella spp., Chlorococcus spp .: Chlorococcus, Kwanomimo spp .: Kwanomimo spp., Volvox spp. Spirogyra: Hizaori, Spirogyra, Turugimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Species of the genus Mizudzumo, Genus genus, Colecaetus, Genus genus genus, Species of the genus Rosa: Rosa spp. Genus (Suizenjinori: Suizeninori, Aokko, Nostoc: Kawatake, Ishikurage, Hassai, Yuremo, Racenmo (Spirulina): Spirulina,
Genus trichodesmium (Aiakashio)), brown algae (Piraella spp .: Pyraella spp., Shiomidoro spp .: Nagamioshidoro, Isogrape spp .: Isogrape, Isogawara spp .: Isogawara, Krogashira spp .: Gunsenkurogashira, Kasilaki spp .: Kashirazaki, Muchimo spp .: Muchimo, Hiramchimo, Kebelligsa, and Sanadagusa: Sanadagusa, Fukurinamiji,
Common genus: Common rush, Common spider genus: Ezoyahazu, Yahuzugusa, Uraboshiahazu, Jigamigasa: Jigamigusa, Umiuchiwa: Umiuchiwa, Konaumiuchiwa,
Red-bellied prunus, Namimakura: Hirunamimakura, Somewagekusa: Somemebukesa, Nabarimo: Nabarimo,
Genus genus: genus moth, genus genus: matsumo, genus genus: agamatsu, genus okinawa: okinawa mozuku, niseftomozuku: niseftomozuku, futomozuku: futomozuku, ishimozuku: ishimozuku,
Chromo spp .: Chromo, Nisemozuku spp .: Nisemozuku spp., Mozuku spp .: Mozuku sp., Ichimegasa spp .: Ichimegasa, Quercus spp .: Keyari, Umibos spp .: Umiboss, Ulsiguca spp .: Ulsigusa, Keulsigsa, Tobacco spp.
Genus Lactobacillus, Genus Habanomodoki: Genus Habanomiki, Genus Habanori: Habanori, Genus Habanori: Genus Habanori, Common Bukuro: Common Bukuro, Genus Ezobukuro: Genus Ezobukuro, Fukuronori: Genus Fukuronori, Watamo, Genus Genus L. ： Genus bursa, shark sparrows genus: sharks horn, genus genus: iwahige, scorpion genus: scorpion genus, scorpion genus: scorpion genus, genus genus: fennel, turmo genus: turmo, genus: genus serrata, genus genus Kombu, Kombu genus: Hemlock,
Persimmon kelp, Oni kelp, Gohei kelp, Naga kelp, Pea kelp, Ochimitsu kelp, Toro kelp genus: Toro kelp, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Krome, Kikusembo genus:
Betula serrata, Nesirecomb: Nesirecomb, Kuroshiome: Kuroshiome, Necosicum genus: Necosicum, Ainuwakame: Ainuwakame, Tigaiso, S. , Hiemoku, Hondawara genus: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mamewarara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizumimoku, Genus,
Genus genus: genus oleum, genus bulumium: genus bulumium, genus cyperaceae: cyperaceae, etc., and red algae (the genus bovine genus: bovine kenori, funorinoshike, amanori genus: asakusanori, susabinori, upuruinori, oniamanori,
Genus: mirunoveni, akebonomozuku: akebonomozuku, konahada: haikonahada, yogorekonahada, aokonahada, umizomen, genus: umizomen, tsukumonori, kamogasunimozu, genus moss : Fusanori, Nisefusanori: Nisefusanori, Sodegarami: Sodegarami, Rattles: Rattles, Hiragratara, Hirohatamataki: Hirohatamatadaki, Tamatadaki: Tamaitadaki, Kaginaten , Kohira, Yohira, Kinukusa, Hibiroudo: Hibiroudo, Himehibiroudo, Isomumedoki: Isomumedoki, Michigaesou: Mi Gaesou, Ryuumonsou genera: Ryuumonsou, Heraryuumon, Nisekarekigusa genera: Nisekarekigusa, Okitsubara genera: Oba Okitsu rose, Aqaba genera: Aqaba, Marubaakaba, Naminohana genera:
Hosobaminanohana, Naminohana, Coralthus: Garagamodoki, Shiogosagoromo: Shiogosagoromo, Iwanoka: Etsukiiwanokawa, Kainokawa: Kainokawa, Kaninote: Kaninote, Coralum: Coralum, Mukadenori, Mukadenori, Mukadenori , Nikumukade, Tsurutsuru, Isonohana, genus: Nurakusa, Kronulakusa, Omokadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Hitotsumatsu, Katokurato Genus Itofunori, Nagaobane: Nagaobane, Funori: Hanafunori, Fukurofunori, Makuhnori, Kalexigusa: Kalexigusa, Kinuhada: Kinuhada, Genus Ezotosaka, Echinacea spp. ： Mirin, Hosobamilin, Tosakanori genus:
Genus genus: Ezonameshi: Ezonameshi, Isomocca: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiibaranori, Kizinoo: Kizinoo, Isotanthus: Isantano, Atsubanori, Atsubanori, Atsubanori Tsurushiramo, Shiramo, Oogonori,
Species of the genus Mizoonoki, birch and proboscis genus: Hachijoengu genus, Fushikrenori genus: Fushikrenori, Namiiwatake genus: Namiiwatake, Sponge genus: Scorpion sprouts, Simigen: Itanigusa, Simi,
Lycopodium, Lotus sp.
Genus Sperm, Hanasakura, Scrophulariaceae: Scrophular spp. , Species of the genus: Snapdragons, Snapdragons, Species of the Species: Species: igis, Keigis, Hariigis, Haneigis, Amixa, genus of Egonori: genus Egonori, Futoigis, Saeda:
Saeda, Chrysanthemum spp .: Chrysanthemum spp., Scrophulariaceae: Habutaenori, Konohanori, Suzushironori, Usubeni:
Usveni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Genus Sujiginu, Atubasujiginu, Hyusbanori Genus: Kagiusbanori, Yaleusbanori, Suziusbanori, Hyusbanori, Usubanoriomonia, Genus Genus, Genus Genus, Genus: Enashidadia,
The genus Simadadia: Isophea, Simadadia, Dazimodoki:
Genus: Dalmomodoki, Itogusa: Moletogusa, Futoigusa, Macri: Macri, Yanaginori: Hanayanagi, Yuna, Yanaginori, Motsureyuna, Benyanagicoly, Mosayanagi, Sasabayanaginori, Sozogenus: Krosozoz, Kobusozone, and Hizognah Genus: Kozanemo, Isomurasaki, Hosokozanemo, Himegoke Genus: Himegoke, Kurohimegoke, Hyodosig Genus: Chrysanthemum, Hyodosigusa, Usubahiodoshi, Isomegusa Genus: Isomegusa, Suzinasugusa:
Suginasugusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsu, Sawweed: Hakesakinokohikiba, Kawamozuku: Kawamozuku, Aokawamozuku,
Species of the genus Oysterfish, Genus Idekogome: Genus Ideyugogomi, Genus Okitamozuku: Genus Okitamozuku, Genus Oleaceae, Genus Chinolimo:
Chinorimo, Chisinori: Chisinori, etc., axle algae (Shajikumo, Shirasamamo, Hoshitsurimo: Hoshitsuurimo, Lichnotamnus, Flaskmo: Himegrassimo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo etc.) The same antibacterial
Preservative action can be expected.

It should be noted that Aonori, Kombu,
Extracts of seaweed, giant kelp, hijiki, hijirimen, tengusa, sasakanori, giraffe, cypress, tambanori, alame, amidigusa, ishige, okitsunori, red peach sardine are various parts of each seaweed body (whole plant, leaf, root, etc.) Crushed and then squeezed.
Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol, and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile, and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform can be used alone or in any combination of two or more kinds, and each solvent can be extracted. It can be used even when the objects are combined.

The chitosan derivative of the present invention is obtained by activating a sugar chain having a reducing terminal at an amino group or a hydroxyl group of chitosan, or by binding via a coupling agent. Representative methods are described below, but the method is not limited thereto.

The chitosan used in the present invention is usually crab,
It is obtained by deacetylating chitin obtained from the shell of shrimp or the like by alkali treatment, enzyme treatment, or the like. The degree of deacetylation is not particularly limited, but usually, the degree of deacetylation is preferably 50% or more.

The low molecular weight chitosan can be obtained, for example, by treating chitosan with concentrated hydrochloric acid or chlorine gas, sodium perborate, or hydrogen peroxide, or by treating chitin with an acid or alkali and deacetylating the glycoside at the same time. It may be obtained by a method of decomposing or a method of hydrolyzing with an enzyme such as chitinase.

Examples of the saccharide having a reducing end include aldoses, ketoses, such as glucose, galactose, and the like.
Monosaccharides include mannose, arabinose, xylose, erythrose and glyceraldehyde, heptulose, hexulose, pentulose, and amino sugars such as glucosamine, N-acetylglucosamine and galactosamine, deoxy sugars and branched sugars. In addition, natural sugars such as disaccharides to polysaccharides containing these monosaccharides as components, such as maltose, isomaltose, maltotriose, lactose or various oligosaccharides, pullulan, inulin, amylose, amylopectin, dextran, dextrin, and starch. And their decomposed products, isomerized products,
Derivatives (such as induction of COOH grouping) are mentioned, and one or more of these saccharides can be used in the reaction.

As a method for obtaining chitosan derived from these saccharides, a Schiff base is formed between the amino group at the 2-position of glucoseamine, which is a constituent sugar of chitosan, and a saccharide having a reducing terminal, and cyano hydrogen is formed. It is obtained by reductive alkylation using sodium borohydride (NaCNBH3) or an amine borane-based reducing agent such as ammonia borane (NH3BH3) or monomethylamine borane "CH3 (NH2BH3)".

In addition, as a method for deriving a saccharide into chitosan, a method utilizing a free carboxyl group of a saccharide or a carboxyl group of an oxidatively derived saccharide is convenient.
For example, a carboxyl group can be efficiently induced by oxidation of a free hydroxyl group at the C1-position of aldohexose of a saccharide using iodine or bromine.

The carboxyl group is activated by allowing SOCl2 to act on the free carboxyl group terminal of the saccharide or the carboxyl terminal derived from the reducing terminal, esterifying with p-nitrophenol, or acid chloride with phosphorus pentoxide or the like. Then, a chitosan derivative can be obtained by reacting with the amino group at the 2-position of glucoseamine, which is a constituent sugar of chitosan. Further, an amide bond can be formed between the carboxyl group of the saccharide and the amino group of chitosan using a carbodiimide-based coupling agent to obtain a chitosan derivative. Depending on the reaction solvent, general-purpose carbodiimide-based coupling agents such as N, N-dicyclohexylcarbodiimide (DCC) and 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) Condensation coupling agents can be used.
Since the reaction using the coupling agent progresses slowly, it is convenient for controlling the reaction system and is more preferably used.

Further, hydroxyl groups and amino groups still released from the chitosan compound having a sugar side chain introduced thereinto were subjected to, for example, oxyethylene, oxypropylene addition, carboxymethylation, phosphorylation, sulfate, dihydropropylation and the like. Derivatives may be used.

The chitosan derivative obtained as described above can be further purified by washing with a solvent, forming a precipitate, or purifying by gel filtration, ion exchange column chromatography, activated carbon exchange column chromatography, cellulose dialysis membrane or the like. it can.

The amino group substitution rate of the chitosan derivative of the present invention is preferably used in the range of 0.1 to 100%, but in order to obtain higher antibacterial activity, the substitution rate of 0.5 to 50% is required. More preferably used.

[0041] The Aonori, Kombu, Wakame,
Giant kelp, Hijiki, Himen, Tengusa,
Tosakanori, Giraffe, Suginori, Tambanori, Alame, Ami-jigusa, Ishige, Okitsunori, Extract of Akaminominori and chitosan derivatives are applied antibacterial and preservatives,
Furthermore, drying, concentration, dilution, etc. may be optionally performed and adjusted depending on the dosage form and form of the external preparation for skin, bath preparation, food and drink, and fiber treatment agent.

Although the production method is not particularly limited, it is usually sufficient if it is in the range of the boiling point of the solvent at normal temperature to normal pressure, and after extraction, filtration or ion exchange resin is used.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added to the extent that the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

Aonori, Kombu, Wakame, Giant Kelp, Hijiki, Hirimen, Tengusa, Tosakanori, Giraffe, Suginori, Tambanori, Alame of the present invention
The extract of Ami Jigusa, Ishige, Okitsunori, Akamomininori can be used as it is as an antibacterial and preservative, and it can be further incorporated into skin external preparations and bath preparations, foods and drinks, and fiber treatment agents. No,
Antibacterial and preservatives, skin external preparations and bath preparations, foods and drinks, fiber treatment agents, slightly different depending on the type, quality and expected degree of action, usually 0.01% by weight or more (hereinafter, weight%
It is preferably 0.5 to 60%. If the amount is less than 0.01%, the effect cannot be expected sufficiently.

The chitosan derivative of the present invention can be used as it is as an antibacterial and antiseptic in combination with one or more seaweed extracts, and is further incorporated into an external preparation for skin and bath, food and drink, and a fiber treatment agent. Although it is not particularly specified as the compounding amount, it slightly varies depending on the type and quality of antibacterial and antiseptic agents, skin external preparations and bath agents, food and drink, fiber treatment agents, expected degree of action, , 0.1% by weight or more (hereinafter, expressed by weight%), preferably 0.3%.
If the amount is less than 0.1%, the effect cannot be expected sufficiently.

The antimicrobial / preservative, skin external preparation and bath preparation, food / drink, and fiber treatment agent of the present invention may be used in addition to the above-mentioned essential components, if necessary, as long as the effects of the present invention are not impaired. , Quasi-drugs, cosmetics, foods and beverages, and the like, and can be produced by arbitrarily selecting and using components and additives in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.) and the like.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax, squalene, squalane, pristane, and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salts, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, Vinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, pressing, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) is used. ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

In addition, in the case of edible products, health and cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and the like, improvement of taste, provision of color tone, aroma and gloss, stabilization, It can be used for thickening and preservation. Furthermore, in addition to this, various cosmetic and pharmaceutical effects of each known raw material are expected, and by combining them, the intended effect is enhanced or multi-functional. It is also possible to make a product that expects an effect.

Specific plants (crude drugs) as raw materials include:
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Wisteria), Aotsujirafuji (Kibo), Aono Ryukyuran, Fukurin Ryuetsuran, Acacia, Akasugi Fruit, Akavine, Akamegashiwa (Red Bud), Akane (Akane Grassroot), Akayajiou Jio (Jihuang), Agi (Awei), Akinire (Royu bark), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Toshibushi), Ashitaba (Asuka), Azuki (Red azuki), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit , Avocado, flax, amateur (sweet tea),
Amachaworu, Amadokoro (Jade bamboo), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Ikakozolina (Biliary head), Itadori
(Tiger cane root), strawberry, fig (fructose) or its leaves, strawberry (winter aoiko), ichiyakuso, ginkgo (ginko leaf, ginkgo),
Itohimehagi (Enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (sanryou), gull-kasukagra fruit, Hime-uikyo, turmeric (Utsukin), Usubasaishin-keirinsaishin (spicy), Usveniaoi,
Usenitachioi, Echinacea purpurea (summer hay), Udo or Shishiudo (Qang, Independent, Tang Independent), Ume (Umei) or its flesh, Vladigashi, Oolong tea, Uwaurushi, Unshurikan (Chen skin), Estragon, Ezocogi (Yezo five) , Echinashi (Hymenoptera), Enoki, Ebisugusa (Keiko), Elderberry fruit, Elemi, Enju (Gossip, Gossip rice), Ogi / Kibanaogi
(Radix astragalus), spinach (yellow), giant crow squirrel (caronine),
Ootsu-la-fuji (self-defense), psyllium (carnage, carnival grass), toucan (Haruko), Oobanokera okera (white jujube), Obanayashabushi fruit, Omisanashi hawthorn (Yamako), Oohisasanoyuki, Sasanoyuki, oats (Turnover), okra fruit, panax ginseng
Ginseng (carrot), St. John's wort, St. John's wort Yoyu), Ominaeshi (defeated), Dutch strawberry, Dutch mustard (Watercress), Dutch jelly,
Dutch honeybee, olive, oregano, orange fruit or pericarp, silkworm (ripened yellow), cacao seeds, oyster or its leaves (persimmon), kagi kazura (chotou hook), cassia, casino citrus fruit (kozomi), gajutsu ), Kashiwa (Shaki, Shaba),
Cascarilla, Kanixa (Kin Sato), Kanokiso (Yoshikone),
Birch or weeping birch (white birch), pumpkin, capoknoki seeds, kahokku-sansho (shopper), cattail (bamboo), chamomile roman chamomile, chamiyatsude (weed plant), karasuri
(Our melon), crow squirrel (midsummer), oats, guarana seeds, karaya, karin (mouse), garcinia, river willow,
Kawatake mushroom, kawagomugi (inchinko), kansui (sweet), licorice (licorice), kanaraasa, candelilla, cantou, canna, raspberry, kiwi fruit, kikarasuuri
(Kuroro root), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum flower), Chrysanthemum (Azumitsu), Rigid grass (Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachi mentha, Kina, Chinese linden (Shincona, Red linden) , Yellowfin (Green), Gymnema
Sylvesta, cabbage, immature cabbage, cucumber, Kiraja saponaria, Kiraya, kumquat fruit, betel,
Agrimony (Sesangaku), Guava Fruit, Guayule, Quercus Infectoria (Gallery), Kukui Nuts, Kuko (Gugi, Gyugia, Gygi Leaf, Skeletal Bark), Kusagi Kazura
(Tenmen winter), Kuzu (Kakkon), Camphor tree, Gooseberry fruit,
Gardenia, gardenia, black clover, kumazasa, black pine, horseradish, clara, bitter cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, buckthorn, black crocodile (rescue),
Cloves (cloves, cloves), scallops (crops, sprouts), celosia (cow flowers, roosters), bay laurel (laurel), kenashisarutoribara (Tokubukuryo, mountain return), gentiana, gennoshoko (old vines), kousinbara ( Lunar flower), sui mint, kouzo fruit, kocha (tea), kohone (river bone), kouhon (straw and kara straw), koulyang, cilantro fruit, koganebana (yellow gon), lingonberry (koshibachi), coconut fruit, goshyu (Goshuyu), gosho strawberry (covered bonko), pepper (pepper), copaiba balsam, coffee beans, kobushi magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame crab (gensan), Gomi (Gomiko), Sanekazura, Binankazura, Matsubusa, Wheat
(Wheat), rice, rice bran (red bran, white bran), rice oil, cola acuminata seed, cola vera seed, fenugreek fruit, colombo, kondurango, kelp, konjac, comfrey
(Finnari grass), sisal, sisal asa, saxima button pelt (weird sen), cherry leaves / flowers / fruit / bark (cherry bark), cherry, pomegranate, sasa, sasanqua, sajimodaka (sawatachi), sweet potato, sugar cane, sugar beet , Jujube jujube (acid jujube), saffron (red safflower, western safflower), pomelo fruit, sabonso, salmonberry fruit, sarashinauma (masuma), salvia (sage), sawagikyo (yamakobana), sawagurumi (yamawomo), san Ginseng (37 ginseng), Sanshuyu (Sanshuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyanoki fruit, Shiitake mushroom
(Shitake mushroom), Shion (Shizono), Dikitaris, Shikunshi (Kimiko), Perilla, Aodiso, Chirimenzo, Catamendiso (Shiso leaf, Shiso), Rosewood, Shinanoki, Chinese syrup (Forsythia), Shimakaniku (Chrysanthemum flower), Shimotsukeisou, Potato , Peony (Shakuyaku), Shajin (Shasan), Janohige
(Bakumon Winter), Juzudama, Palm Fruit, Ginger (Ginger),
Shobu (irises, iris roots), shrimp fruits, birch seeds, white butterfly butterflies, white bananas, white banana flowers, white minant (Nantami), cinchona cassula bra, cinnamon, watermelon (watermelon), honeysuckle (gold and silver flowers,
Shinobi winter), sorrel (acid model), swimberry fruit, stevia,
Strawberry fruit, Japanese horsetail (Thorn), Stevia, Plum fruit, Scots pine cone, European larch, European pine, European pine cone, European hawthorn, European dandelion, European horse chestnut (Marronnier), European pear fruit, European wildflower (Elder), Atlantic Shrike (Juniper and Tomatsu), Achillea millefolium (Mirfoil), Achillea var. , Celery, senkyu (river cucumber), sendan, senburi (drug), senna fruit or leaves, senninso (great tate), souka (grass), buckwheat seeds, soybean potato, rhubarb (daihuang), radish, soybean, daidai ( Orange peel , Kikomi), takatodai (daigeki), takawarabi (inu), dark sweet cherry fruit, hollyhock, lycopodium thyme (thyme, momoka), tybana (tachibana skin), tyrannagi, tamarind seeds,
Onion, tamashiba (hot spring), arachis or its root bark, tanjin (dansin), dandelion (gakkohide) or shirobana dandelion, moko dandelion, dammar, cherry fruit, tigaya or its root (chinese root), chikusetsujin (bamboo ginseng), Chicory, Korean gourd (Gomiko), Korean radish
(Ohta), Korean ginseng (Wuyi), Korean ginseng
(Ginseng), Artemisia (Aiba), Choreimaitake
(Irei), Japanese Ginseng, Japanese chestnut (mushroom),
Camellia, camellia, clover (lacquer lacustrine), communis (duckweed), vines (red azuki), vines (red bean), vines (vegetables), vines (four-leaf ginseng), vines, deiko, teuchigurumi, duberry fruit, tengusa , Tendai yak (crowd medicine), Pepper (winter gourd), Pepper (bansho),
Touki (Toki), Calendula (marigold), Corn or corn hair (Nanban hair)
(Sadako), Toudondou (Ryubile), Dokudami (Jyukuyaku), Tokon (Sperm Root), Toshishi Mamedaoshi Nennashikazura, Tochu (Tonaka, Tonakaha), Tomato, Traganto, Triacanthus Seed, Tormentilla, Doronoki, Troroaoi, Niseria berry fruit, Chinese yam (Yamanoimo), Naked ramen (Butcher bloom), Naginata koju, Nazuna, Rape seed, Natsumikan, Jujube (daijujutsu), Naniwaibara
(Kanesakurako), Nameko, Narco lily (Yellow), Peanut
(Peanut), Nanten (Minami Tenmi), Nigaki (Maki), Nyagamogi (Grass), Nikuzuku, Kay Nikkei (Caesar) / Keishi (Keeshi), Chive (Nirako), Elderberry (Grasswood)・ Flowers or foliage, garlic (garlic), nurde (fivefold), leek, thistle (daiji), wild rose (fruit), yarrow, sawdust
(Mae Hu), Novara, Nomomo, Palm, Pineapple Fruit,
Hibiscus (Bussouge, Furin-Bussouge, Roselle), Hakamauraboshi (Bone Crushing Supplement), Hachsen (Ringworm Skin),
Huckleberry fruit, chickweed (red), hazel (haruko), hasidoro (roth root), basil, lotus (lotus, lotus root), parsley (holland jelly), hamadamugi, batata, hachiku madake (bamboo-boiled), patchouli, mint (Light load, light load leaf), barley (yokuinin), hanasuge (chimbo), banana, hanahacka, vanilla bins, papaya, hakogusa (mouse asparagus), hub grass, paprika, hamago and honeysuckle (crop)
Hamasuge (Kazuki), Hamabishi (Sitsuriko), Hamanas (Maikai flower), Hamaboufu (Hamaboshi), Hamamelis, Rose
(Roses), Parietaria, Harunire (Yellow, Yu white skin, Yuba), Breadfruit, Hiogi (sun dried), Lycopodium carrot
(Party ginseng), pecan nuts, amaryllidaceae (silver, vinegar sprout), hikikoshi (extended life grass), Hishi (hishomi), pistachio,
Beet, Hitotsuba (stone reed), Hinata no Kozuchi (cow knee), Hinoki, Hiba, Castor, Sunflower, Bell pepper, Higama
(Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta fruit, Juniper, Bjakuyu, Hiyu fruit, Belodo oyster, Hiroha okinagusa (Shiratoo), Loquat
(Loquat, loquat leaf), betel nut (large clothing skin, betel palm), sugar beetle (southern rattan), butterflies, coltsfoot (flowers and winter leaves),
Fujibakamama (Ranbusa), Fujimame (tonboshi), grape berries or pericarp, seeds and leaves, beech, Fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, black currant fruit, blackberry, plum fruit, furcellaria, blueberry (Acacia catechu) ), Prune, blond psyllium, bundo (green bean), luffa, safflower (safflower), henneken, belladonna, berry fruit, boysenberry fruit, boufu (windbreak), spinach, physalis (Torone), honoki (kopoku, sumatsu) Park), Bokeh (Gourd melon), Hosovanaokera (Sojutsu), Hosobabarengiku, Bodaiju (Bodaiju), Button
(Peony, peony skin), hops, jojoba, white berry fruits, hon-shimeji, mysurutennanshaw (Tenan star), ephedra (maoh), macadamia nuts, macri (marine grass), maguwa (mulberry white skin, mulberry leaf), Matabi (Mokuten Tate), Matsukasa, Matsuba, Matsuhodo (Bukuryo), Mayorum (Hanahakka), Malvanozadine (Bitterfruit), Mulberry Fruit, Quince, Mango, Mangosteen, Mansugurumi, Mandarin Fruit, Mannentake (Reishi), Citrus Plant fruit (Kikomi), Mishimasaiko (Saiko), Mizokukushi (Hanabe lotus), Misohagi (Chisatsuna), Mitsugashiwa, Mitsuba, Midorihakka, Mimosa,
Ginger, miracle fruit fruits, myrrh, myrobaran, mugwort (woody geese), mukunoki, mukuroji, murasaki (purple root), murasaki maize, mehajiki (benefit mother grass), mebogi, melaleuca, melissa, melilot, melon fruit, makoyoko tree, moso-kook Incense), Maple blossoms, Peach leaves (peach leaves), fruits and seeds (peach seeds), bean sprouts, morello cherry fruits, moloheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflowers (cornflowers), cornflowers , Yashabushi (arrow wheel), willow willow, yatsude (octagonal gilded), mistletoe (parasitic willow), willow leaf, yabugarashi, yabukouji (purple gold beef), pokeweed
(Land), alder (Yamaharu), bayberry (peeling bark), mugwort, eucalyptus, snowy citrus (tiger ear grass), yucca flebifolia, yuzu fruit, lily, yorigusa, mugwort
(Aiba leaf), lime fruit, rye, lacanca fruit, raspberry leaf / fruit, lavender, longan (longan meat), ryocha (green tea), apple fruit, gentian, lubas suavisimus (tenryu), lettuce, red currant fruit, lemon Fruits, lemongrass, forsythia, astragalus,
Wax palm, loganberry fruit, logwood, rosemary (mannen wax), rose hip (nobara), wasabi,
Waremokou (Jiyu) etc. are raised.

Materials derived from animal raw materials include cockscomb extract, bovine / human placenta extract, swine / cattle stomach, duodenum or intestinal extract or its decomposed product, and swine / cattle spleen extract. Products or their decomposed products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.), milk , Casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg ingredients Such as fish meat decomposition products.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation product of skim milk powder, trehalose or a derivative thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placental extract, silk peptide, plant extract (mulberry, corn, waremoko,
Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, artea, keihi, mankeishi, hamamelis, yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, kyorai, mao, (Senkyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ohgon, Peony, Peony, Genoshoko, Kakkon, Licorice, Fivefold, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku)

(20) Reduction / decomposition of melanin pigment Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, etc.

(21) Acceleration of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.)

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) SOX, catalase, glutathione peroxidase, etc.

(24) Antioxidants Ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured cells of sesame, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo, green tea, etc.)

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts and the like.

(27) Disinfectant / Disinfectant Acrynol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof.

(28) Humidifiers Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, sodium lactate and the like.

(29) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(31) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(32) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(33) Dyes and coloring agents Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(34) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(35) Nutrition enhancer Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(36) Dairy products Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk and the like.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, anti-redeposition agents such as carboxymethyl cellulose, rinse improvers such as soap, anti-caking agents,
Examples include a fluorescent whitening agent, a softener, a bleaching agent, a sizing agent, a stain removal aid and the like, and when used in combination therewith, various additive and synergistic effects can be expected.

In the present invention, Aonori, Kombu, Wakame,
Giant kelp, Hijiki, Himen, Tengusa,
Antibacterial and antiseptic agents containing extracts or / and chitosan derivatives of extracts of Tosakanori, Giraffe, Suginori, Tambanori, Alame, Ajigisa, Ishige, Okitsunori, and further, a skin external preparation and bath preparation, food and drink, and fiber treatment agents Are optional, ampules, capsules, pills,
Tablets, powders, granules, solids, liquids, gels, foams, emulsions, creams, ointments, sheets, etc., pharmaceuticals, quasi-drugs, skin and hair cosmetics, and bath agents , Foods and drinks, and textiles.

Specifically, for example, pharmaceutical preparations for internal and external use, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, shampoos, rinses, and hair treatments , Hair styling products, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc. , Toothpaste, mouth freshener
Gargle, deodorant / deodorant, sanitary cotton, wet tissue,
It can be applied to various products such as plastics, paints, adhesives, plumbing and air-conditioning ducts in various factories, tiles for toilets and baths, refrigerators, fruits and vegetables.

The foods and drinks include oral compositions (gum, candy, etc.), processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese sweets, raw noodles, Chinese noodles, and boiled foods. Noodles such as noodles, buckwheat, sauces, soy sauce, sauce, sugar, honey, powdered syrup, water syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce , Sprinkles, processed vegetables and fruits such as canned and bottled vegetables and fruits, dairy products such as cheese, butter, yogurt, fruit juices, vegetable juices, whey drinks, soft drinks, beverages such as alcoholic beverages, etc.
Use in general foods and drinks such as health foods is raised.

Examples of the fiber products treated with the fiber treatment agent include natural fibers such as cotton and hemp, regenerated cellulose fibers such as rayon and polynosic, and fiber products composed of blended fibers thereof, for example, yarns and knits. , Non-woven fabrics, non-woven webs, etc., as well as various synthetic fibers (eg, polyester, polyamide, vinyl, benzoate-based synthetic fibers, etc.), animal fibers (eg, wool, silk, etc.),
Alternatively, blended articles, cross-woven or cross-knitted articles, non-woven webs and the like using these fiber products in combination can be raised.

The specific field of application of the fiber treating agent of the present invention is as a softening agent, a bleaching agent, a sizing agent, a stain removal aid or the like in the form of a general textile product such as clothing (pajama, Shirts, pants, socks, bras, panties, tights, slips, blouses, pants, skirts, etc.), diapers, diaper covers, sanitary pants, and other sheets (duvet covers, cushion covers, pillowcases)
Cushion covers, etc.), blankets, mattresses, carpets, carpets, towels, towels, handkerchiefs, gloves and other nonwoven fabrics such as sanitary cotton, filters and wet tissues, and washing with commonly used detergents It can be used for textile products after it has been made.

The method of adding the antibacterial and preservative of the present invention to the skin external preparation and bath preparation, food and drink, and fiber treatment agent may be added in advance or during the production. It may be appropriately selected in consideration of workability.

[0094]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Aonori, Kombu, Wakame,
Giant kelp, Hijiki, Himen, Tengusa,
100 g of Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Aigigusa, Ishige, Okitsunori, Akamomininori were each heated and extracted with purified water (about 80 ° C) for about 1 hour, extracted at room temperature for 24 hours, filtered and extracted. About 1.0 kg of liquid (dry solids: about 0.4-1.5% by weight) is obtained.

(Production Example 2)
Giant kelp, Hijiki, Himen, Tengusa,
100 g of Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Aigigusa, Ishige, Okitsunori, Akamomininori in 50% ethanol solution or 30% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified water (about 30 ° C) After extraction at room temperature for 2 days and nights, the mixture is filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.4 to 1.5% by weight).

(Production Example 3) 5.0 g of D-galactopyranosyl-gluconic acid was dissolved in 30 ml of TEMED buffer (50 mM tetramethylenediamine, PH4.7), and 5.0 g of carbodiimide hydrochloride (EDC) was added. Stir for a minute. Next, 10 g of a chitosan (manufactured by Yaizu Suisan Kagaku Kogyo KK, 33% deacetylation degree) was dissolved in 10 g of TEMED buffer solution 12 in this EDC solution.
Add 0 ml and stir for 3 days. During this time, 3.3 g of EDC is added in several portions. Thereafter, the low molecular components are removed by dialysis, washed and dried, and the chitosan derivative of the present invention (chitosan-lactose derivative: lactose induction rate: about 31.5%, 13C-NMR)
About 12.5 g).

(Test 1) Evaluation of antibacterial and antiseptic activity The antiseptic activity was determined by an antibacterial test. The strain is not limited to a specific species, and the antibacterial activity against airborne bacteria and normal skin skin bacteria was used as an index. (Test method) a. Samples Various seaweed extracts and chitosan derivatives obtained in Production Examples 1 to 3 of the present invention were used for a test. The amount of the chitosan derivative added was 2% with respect to various seaweed extracts.
(w / v). b. Medium Difco Nutrient Broth Agar Medium (NB)
And Nissui Pharmaceutical potato dextrose agar (PA)
Was used. c. Measurement of Antibacterial Activity A medium prepared according to a standard method was kept at 50 ° C., and a sample was added to a final concentration of 5%, after which an agar plate was prepared.
After the medium has been sufficiently cooled, fingertips of a healthy person (approx.
2 hours later) were pressed at five locations on the surface of the medium. The medium
After leaving it open for 24 hours in a well-ventilated room, 48 hours at 30 ° C
And the growth state of the bacteria was observed. d. Judgment Criteria The antibacterial and antiseptic activities were evaluated on a 5-point scale for both filamentous and non-filamentous fungi. -... No growth of bacteria. + ... The number of colonies is 3 or less, and the colonies of filamentous fungi are slightly small. ++ ... 15 colonies or less, colonies of filamentous fungi are small. +++ ... 30 or less colonies, and colonies of filamentous fungi are slightly large. ++++ ... Bacteria grow on one side, filamentous fungi form huge colonies.

[0099]

[Table 1]

(Test Results) As shown in Table 1, Aonori, Kombu, Wakame, Giant Kelp, Hijiki,
It was confirmed that the extract of Hirimen, Tengusa, Tosakanori, Giraffe, Suginori, Tambanori, Alame, Ajigisa, Ishige, Okitsunori and Akamomininori had antibacterial and antiseptic effects.

[0101]

[Table 2]

(Test Results) As shown in Tables 1 and 2, Aonori, Kombu, Wakame, Giant Kelp, Hijiki, Hirimen, Tengusa, Tosakanori, Kirinsai,
Sugino, tambanori, alame, amijigusa, ishige,
It was confirmed that the combined use of the seaweed extract and the chitosan derivative resulted in a synergistically strong antibacterial and antiseptic action, compared to the case where the extract of the red sea cucumber and the red peach shrimp were used alone.

(Test 2) Safety test (1) Primary skin irritation test Japanese white rabbits (female, 3 per group) whose backs were shaved with various seaweed extracts or chitosan derivatives obtained in Production Examples 1 to 3 ,
(Approximately 2.3 kg body weight). The judgment is 24,
Erythema and edema were used as indices at 48 and 72 hours by primary irritation scoring. The result, in all animals,
No erythema and edema were observed, and it was judged negative.

(Test 3) Safety test (2) Skin cumulative irritation test Similarly, various seaweed extracts or chitosan derivatives obtained in Production Examples 1 to 3 were shaved on the flank of a Hartley-type guinea pig (female, group 1) Once a day on the skin of 3 animals, weighing around 320g)
0.5 ml / animal was applied 5 times a week. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indexes. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 4) Safety test (3) Acute toxicity test Similarly, various seaweed extract solutions or chitosan derivatives obtained in Production Examples 1 to 3 were concentrated and dried under reduced pressure. Ddy mice (male and female, 1
2,000 mg / kg was orally administered to a group of 5 animals, 5 weeks old), and the appearance and degree of toxicity symptoms were observed over time. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD50 is 2,000mg / k
It was judged to be g or more.

(Prescription examples) Production of antibacterial / preservatives, skin external preparation and bath preparation, food / drink, fiber treatment agent The following formulation examples are shown below according to the above evaluation results. And only the compounding amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Aonori 30% ethanol extract B: Kombu 50% 1,3-butylene glycol extract C: Wakame 50% Ethanol extract D: Giant kelp 50% 1,3-butylene glycol extract E: Hijiki 50% phyllogenecoll recall extract F: Polymen 60% 1,3-butylene recall extract G: Tengusa 50% 1,3-butylene recall Extract H: Tosakanori 40% ethanol extract I: Kirinsai 40% 1,3-butylene glycol extract J: Suginori 50% 1,3-゛ ゛ ゛ ゛ 抽出 Extract K: Tambanori 30% ethanol extract L: Alame 50% ethanol extract M: Amidixa 50% ア ミ グ ゛ ゜ ゜ 抽出 抽出 N: Ishige 50% 1,3- ゛ ゛Liquid P: Red flea 50% 1,3-butylene glycol extract * Extract of any one of A to P 3.0 11. 3% aqueous solution of chitosan derivative in Production Example 3 1.0 12. Appropriate perfume and preservative 13. Purified water 100 and the rest

(Formulation Example 2) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Aonori 30% ethanol extract 1.0 7. Akamomininori 30 % 1,3-butylene glycol extract 1.0 8. Appropriate amount of flavoring and preservatives 9. Purified water 100 residue

(Formulation Example 3) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Almond oil 15.0 5. Borax 0.5 6. 50% kelp 1,3-butylene glycol extract 2.0 7. 3% aqueous solution of chitosan derivative in Production Example 3 2.0 8. Appropriate amount of fragrance and preservative 9. Residue to 100 purified water

(Formulation Example 4) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6.Wakame 50% ethanol extract 1.0 7.Arame 50% ethanol extract 1.0 8.Oktonori 50% ethanol extract 1.0 9.Perfume, preservatives qs 10.Purified water 100

(Formulation Example 5) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Kirinsai 50% ethanol extract 0.5 5. Tambanori 30% ethanol extract 0.5 6. Amidixa 50% propylene glycol extract 0.5 7. Shige 50% 1,3-butylene glycol extract 0.5 8. pH adjuster qs 9. Preservative qs 10. Purified water 100

(Formulation Example 6) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Aonori 50% ethanol extract 1.0 6. Giant kelp 60% ethanol extract 1.0 7. Tosakanori 40% ethanol extract 1.0 8. pH adjuster qs 9. Preservative qs 10. Purified water 100 residue

(Formulation Example 7) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. A: Hydiki 50% phenolic alcohol extract B: 70% 1,3-butylene glycol extract from polyester C: 50% 1,3-butylene glycol extract from Tengusa ※ Extract from any one of A to C 3.0 6. Preservatives appropriate amount 7. Purified water 100 Residue to do

(Formulation Example 8) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Aonori 30% ethanol extract B: Kombu 50% 1 , 3-Phthylene liqueur extract C: Wakame 50% ethanol extract D: Giant kelp 50% 1,3-butylene cholesterol extract E: Hijiki 50% chlorophyll liqueur extract F: Hymen 60% 1,3-butylene liqueur extract Liquid G: Tengusa 50% 1,3-butylene recall extract H: Tosakanori 40% ethanol extract I: Kirinsai 40% 1,3-butylene recall extract J: Suginori 50% 1,3-butylene recall extract K: Tambanori 30% Ethanol Extract L: Alame 50% Ethanol Extract M: Amidixa 50% Phloreneculicoll Extract N: Ishige 50% 1,3-butylene glycol extract O: Okinori 50% ethanol extract P: Akamominori 50% 1,3-butylene glycol extract ※ Any one of A to P extract 3.0 5. Production Aqueous solution of 3% chitosan derivative in Example 3 1.0

(Formulation Example 9) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 3.0 4. A: Aonori 30% ethanol extract B: Kombu 50% 1,3-butylene Glycolic extract C: Wakame 50% ethanol extract D: Giant kelp 50% 1,3-butylene glycol extract E: Hijiki 50% chlorophyllen glycol extract F: Polymen 60% 1,3-butylene recall extract G: Tengusa 50% 1,3-butylene recall extract H: Tosakanori 40% ethanol extract I: Kirinsai 40% 1,3-butylene recall extract J: Suginori 50% 1,3-butylene recall extract K: Tambanori 30% ethanol Extract L: Alame 50% ethanol extract M: Amidixa 50% phenolic recall extract N: Ishige 50% 1,3-phenol゛ レ ン ゛ コ ー ル コ ー ル 抽出 Ｏ Ｏ ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ： ：. 2.0

(Prescription example 10) Coating protective agent A gauze or liniment cloth is impregnated with a prescription liquid obtained by mixing an appropriate amount of a 30% ethanol extract, an antibiotic, an anti-inflammation, etc., and attached to the wound. Alternatively, a 30% ethanol extract of Kotoji no nomata may be directly applied locally and covered with gauze or the like.

(Prescription example 11) Mentsuyu liquid wt% 1. Soy sauce 80.0 2. Black vinegar 2.0 3. Glucose 15.0 4. Sodium glutamate 1.0 5. Aonori hot water extraction powder 1.0 6. Kombu hot water extraction powder 1.0

(Formulation Example 11) Udon or buckwheat wt% 1. Flour or buckwheat flour 95.0 2. Salt 2.0 3. Giant kelp hot water extraction powder 1.5 4. Hijiki hot water extraction powder 1.5

(Formulation Example 12) Bread wt% 1. Wheat flour 90.0 2. Salt 1.0 3. Glucose 7.0 4. A: Aonori hot water extract powder B: Kombu hot water extract powder C: Wakame hot water extract powder D: Giant kelp Hot water extraction powder E: Hijiki hot water extraction powder F: Hydrimen hot water extraction powder G: Tengusa hot water extraction powder H: Tosakanori hot water extraction powder I: Kirinsai hot water extraction powder J: Suginori hot water extraction powder K: Tambanori Hot Water Extraction Powder L: Alame Hot Water Extraction Powder M: Amidixa Hot Water Extraction Powder N: Ishige Hot Water Extraction Powder O: Okitsunori Hot Water Extraction Powder P: Red Stormfish Hot Water Extraction Powder * Extraction of any one of AP Powder 1.0 5. Chitosan derivative powder of Production Example 3 1.0

(Formulation Example 13) Cookie weight% 1. Milk 65.0 2. Whole egg 14.0 3. Sugar 15.0 4. Constarch 4.1 5. Salt 0.4 6. Powdered hot water extract 1.5 7. Perfume appropriate amount

(Formulation Example 14) Sausage weight% 1. Ground meat 93.0 2. Chicken egg 5.0 3. Spices 0.5 4. Seasoning 0.5 5. Kirinsai 50% 1,3-butylen liqueur extracted powder 0.5 6. Suginori 50% 1,3 -Phthylene glycol extract powder 0.5

(Formulation Example 15) Beverage weight% 1. Glucose liquid sugar 33.0 2. Grapefruit juice 64.0 3. Tambanori hot water extract powder 1.5 4. Alame hot water extract powder 1.0 5. Flavor 0.5 6. Acidulant proper amount

(Formulation Example 16) Gum weight% 1. Menthol micron 31.0 2. Grapefruit flavor 63.0 3. Chlorella water extract 2.0 4. Amidigsa hot water extract powder 2.0 5. Ishige hot water extract powder 2.0

(Formulation Example 17) Miso soup weight% 1. Tofu 45.0 2. Deep fried 2.5 3. Carrot 5.0 4. Burdock 5.0 5. Red miso 15.0 6. A: Aonori hot water extract powder B: Kombu hot water extract powder C: Red sprouts hot water extracted powder * Extracted powder of any one of A to C 5.0 7. 3% chitosan derivative powder of Production Example 0.5 0.5 8. Residue for bonito dashi 100

(Formulation Example 18) Kamaboko weight% 1. Surimi 82.0 2. Starch 10.0 3. Mirin 3.0 4. Sodium glutamate 2.0 5. Salt 1.5 6. Seasonings (amino acids, etc.) 1.0 7. Wakame hot water extract powder 0.3 8. Chitosan derivative powder of Production Example 3 0.2

(Test 5) Use effect test The effect of the skin external preparation and bath preparation of the present invention actually used was examined. The test used was a panel of 10 people aged 5 to 50 years old who suffered from skin diseases such as dry skin, rough skin, eczema, and atopic dermatitis. This was done by applying an appropriate amount to the face for 3 months. Also, for 10 people (5 to 50 years old) who have the same skin disease on the scalp and hairline, apply the appropriate amount of the hair tonic of Formulation Example 8 to the scalp for 3 months after daily hair washing. A use test was conducted by

Further, the bath preparation of Formulation Example 9 was also applied to 10 people aged 1 to 65 years old who suffer from skin diseases such as dry skin, rough skin, eczema, and atopic dermatitis.
For three months, they were always bathed once a day in a bath water in which an appropriate amount of bath agent was dissolved, and a use test was conducted. In contrast,
Emulsions, hair tonics, and bath preparations prepared by removing various seaweed extracts and chitosan derivatives of the present invention from the same formulation were used in the same manner. The evaluation was performed according to the following criteria. The results are as shown in Table 3 and the numerical values in the table represent the number of persons.
No one complained of abnormalities on the skin or scalp during the use period.

"Effect of improving skin (scalp) disease" Efficacy: Redness, itching, dry skin and rough skin due to inflammation such as eczema were improved. Somewhat effective: Redness and itching, dry skin, and rough skin due to inflammation such as eczema were slightly improved. Ineffective: No change from before use.

(Test Results) As shown in Table 3, Aonori, Kombu, Wakame, Giant Kelp, Hijiki,
Hyperimen, Tengusa, Tosakanori, Giraffe, Suginori, Tambanori, Alame, Ajigisa, Ishige, Okitsunori, Akamomininori extract, and further use of skin external preparations and bath preparations in combination with chitosan derivatives may cause inflammation, itching and drying due to eczema Good effects were confirmed for the improvement of skin diseases such as skin and rough skin.

[0130]

[Table 3]

(Test 6) Use Effect Test The effect of the food of the present invention actually used was examined. The use test was conducted using the bread of Formulation Example 12 at room temperature (about 1
0 to 25 ° C., humidity 55 to 65%) and a thermo-hygrostat (temperature: 30 ° C., humidity 80%) to observe changes. A control prepared by removing the various seaweed extracts and the chitosan derivative of the present invention from bread in the same manner was used as a control.

(Test Results) A food containing the seaweed extract of the present invention or a food further containing a chitosan derivative in addition to the seaweed extract of the present invention was obtained at room temperature (about 10 to 25 ° C., humidity 55 to 65 ° C.).
%) Storage for 10 days or more, or a thermo-hygrostat (temperature: 30%)
(C, 80% humidity) storage did not show any change for more than 7 days.
Molds proliferated on the 7th day of storage under a humidity of 55 to 65%) and on the 5th day of storage under a thermo-hygrostat (temperature: 30 ° C., humidity: 80%), resulting in discoloration and decay.

(Test 7) Use effect test The effect when the fiber treating agent of the present invention was actually used was examined. The use test is Shake F, which is adopted when certifying the SEK mark of antibacterial and deodorized textile products
The examination was performed according to the lask method (processing technology VOL. 31, NO. 7, P477-480). The test method was as follows. To a cloth (2.0 g), 3.0 ml of various seaweed extracts of the present invention (Production Example 2) and a chitosan derivative 0.1% aqueous solution of chitosan derivative (Production Example 3) were added, and air-dried. 0.05 g of the sterilization rate of Staphylococcus aureus (Staphylococcus aureus: ATCC6538P) and Klebsiella pneumoniae (Klebsiella pneumoniae) were determined based on the Shake Flash method. The results are shown in Table 4.

[0134]

[Table 4]

(Test Results) A fiber product containing the seaweed extract of the present invention, or a fiber product further containing a chitosan derivative in addition to the seaweed extract of the present invention can be used as a common indicator for Staphylococcus aureus and Klebsiella pneumoniae. A very effective sterilization effect was confirmed.

[0136]

[Effects of the Invention] The present invention relates to the following:
Giant kelp, Hijiki, Himen, Tengusa,
One or more seaweed extracts selected from Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Amidixa, Ishige, Okitsunori, Akamomininori have an antibacterial and antiseptic effect, and can be used internally or externally for humans or animals. It is safe. Therefore, when used as an antibacterial and preservative, it is possible to prevent spoilage and contamination of various forms of preparations and products. In addition, its antibacterial effect is effective for the prevention and treatment of skin diseases such as eczema, itching, rough skin, and swelling of the skin. Agents, bleaching agents, sizing agents, stain removal aids, and the like, and textile processing agents, etc.). Further, the antibacterial and antiseptic effects are synergistically enhanced by using a seaweed extract in combination with one or more chitosan derivatives obtained by reacting chitosan and a saccharide having a reducing end. .

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification code FI A23L 3/3562 A23L 3/3562 A61K 7/00 A61K 7/00 K J U 7/06 7/06 7/50 7/50 31 / 73 31/73 35/80 ADB 35/80 ADBA D06M 14/22 D06M 14/22 14/24 14/24 (72) Inventor Takehito Naito 153, 380 Iwai, Gifu City, Gifu Prefecture 153 (72) Inventor ▲ Ko ▼ Yan 1-32 Kurono Corp., 32, Furu Market, Gifu City, Gifu Prefecture (72) Inventor Yoshiharu Matahira 1510-2 Higashicho, Shimada-shi, Shizuoka Prefecture (72) Inventor Hirofumi Yura 5-9-1 Shonandai, Fujisawa-shi, Kanagawa Prefecture Room No.601, No.1 Court Court

Claims (8)

[Claims] 1. Aonori, Kombu, Wakame, Giant Kelp, Hijiki, Hirimen, Tengusa, Tosakanori,
An antibacterial and antiseptic agent containing at least one seaweed extract selected from giraffe, suginori, tambanori, alame, amidixa, ishige, okitsunori, and red sardine. 2. An external preparation for skin and a bath preparation, which comprises the antibacterial and preservative according to claim 1. 3. A food or drink comprising the antibacterial and preservative according to claim 1. 4. A fiber treating agent comprising the antibacterial and preservative according to claim 1. 5. An antibacterial / preservative comprising the following essential components (1) and (2): (1) Aonori, kelp, seaweed, giant kelp,
At least one seaweed extract selected from the group consisting of Hijiki, Hirimen, Tengusa, Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Amijigusa, Ishige, Okitsunori, and Akamominori. (2) One or more chitosan derivatives obtained by reacting chitosan with a saccharide having a reducing end. 6. An external preparation for skin and a bath preparation comprising the following essential components (1) and (2): (1) Aonori, kelp, seaweed, giant kelp,
At least one seaweed extract selected from the group consisting of Hijiki, Hirimen, Tengusa, Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Amijigusa, Ishige, Okitsunori, and Akamominori. (2) One or more chitosan derivatives obtained by reacting chitosan with a saccharide having a reducing end. 7. A food or drink comprising the following (1) and (2) as essential components. (1) Aonori, kelp, seaweed, giant kelp,
At least one seaweed extract selected from the group consisting of Hijiki, Hirimen, Tengusa, Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Amijigusa, Ishige, Okitsunori, and Akamominori. (2) One or more chitosan derivatives obtained by reacting chitosan with a saccharide having a reducing end. 8. A fiber treating agent comprising the following (1) and (2) as essential components. (1) Aonori, kelp, seaweed, giant kelp,
At least one seaweed extract selected from the group consisting of Hijiki, Hirimen, Tengusa, Tosakanori, Kirinsai, Suginori, Tambanori, Alame, Amijigusa, Ishige, Okitsunori, and Akamominori. (2) One or more chitosan derivatives obtained by reacting chitosan with a saccharide having a reducing end.