JPH11103801A - Composition containing quinua skin and food - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition ingestable in the form as it is, by easily adding to food, etc., excellent in medicinal efficacy, useful for the prophylaxis and treatment of atheroscrelosis, etc., and reducing cholesterol by containing a quinua skin or a treated material thereof. SOLUTION: This composition containing a quinua skin contains 0.5-100 wt.% powdery or a skin-shaped quinua skin obtained as a bran portion by threshing the quinua seeds by a rice polisher, or a quinua treated material obtained by further crushing the quinua skin finely to form a powder, extracting the obtained powder with a solvent such as methanol, and purifying the obtained extract with a chromatography, a dialysis, etc. Further, it is preferable to prepare a food by formulating the quinua skin or a treated material thereof, and the amount of intake of the quinua skin or the treated material thereof is preferably in a range of 0.5-60 g for an adult daily.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition and food containing quinoa skin or a component contained in quinoa skin. Specifically, the present invention relates to a composition and a food capable of lowering blood cholesterol and hepatic cholesterol when taken orally.

[0002]

2. Description of the Related Art In recent years, the relationship between blood cholesterol and various diseases such as arteriosclerosis and myocardial infarction has been clarified.
Mortality due to lifestyle-related diseases such as diabetes and colorectal cancer including these diseases is increasing. This is said to be the result of a shift in dietary patterns to high-fat, high-protein Western foods and an increase in preference for so-called refined and processed foods along with improvements in living standards. Under such circumstances, the need for self-management of health has been advocated due to the growing health orientation and the like, and development of health foods and the like having a cholesterol-lowering effect has been desired. Various dietary fibers are known to have a cholesterol lowering effect and to be used as local foods. However, in order to expect the cholesterol lowering effect of these dietary fibers, it is necessary to add 5-10% by weight or more of dietary fiber to the food, which affects the physical properties and taste of the food. It was difficult.

[0003]

The object of the present invention is to provide a composition having a cholesterol-lowering effect which can be easily added to foods or the like and which can be taken orally as it is, and a food containing the composition. Aim. As a result of intensive studies, the present inventors have found that orally ingestible quinoa skin has a cholesterol-lowering effect, and have completed the invention. To date, there have been no reports that quinoa has been found to have any physiological activity such as lowering blood cholesterol or hepatic cholesterol.

[0004]

The present invention includes the following inventions. (1) A composition for lowering cholesterol containing quinoa skin or a processed product thereof. (2) A food containing quinoa skin or a processed product thereof.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Quinopodium ( Chinopodium Quinoa ) is a kind of cereal belonging to the family Acatheaceae, and its seeds are eaten in Central and South America, and are partially used as staple food or processed food. The present inventors have studied quinoa seeds by dividing them into bark and cereal portions, and as a result, have found that bark has an effect of lowering cholesterol.

[0006] The term "quinoa skin" as used herein refers to a powder or skin-like product obtained by threshing quinoa seeds with a rice mill and obtaining a bran portion. A product extracted with an appropriate solvent, and a product obtained by further purifying the above extract by chromatography, dialysis, or the like, are referred to as a treated quinoa skin. The pulverization of the quinoa skin can be performed by a usual pulverizing / pulverizing means such as a ball mill, a mortar, a blender, and a pulverizer.

In the case of extracting quinoa skin, water, alcohols such as methanol, ethanol, propanol and butanol, ethers such as ethyl ether and dioxane, and ketones such as acetone can be used as an extraction solvent. When the extract is used once as a dried product after removing the solvent, any of the above-mentioned solvents can be used alone or as a mixture. On the other hand, when the extract is used in a state of being dissolved in a solvent, it is necessary to use a solvent that does not show harmful effects on the human body, and in this case, it is preferable to use water, ethanol, or a mixture thereof. . The extraction temperature is preferably within the range of room temperature to the boiling point of the solvent under normal pressure. The extraction time varies depending on the extraction temperature and the like, but is preferably within 48 hours. The extract thus obtained can be used as it is in the composition and food of the present invention, and the extract is further purified by various purification means such as ion exchange chromatography, gel filtration chromatography, and dialysis. May be used.

[0008] The composition of the present invention contains quinoa skin or a processed product thereof in an amount of 0.5 to 100% by weight. The effective intake of the composition of the present invention depends on the age, weight, blood or hepatic cholesterol level of the user, and the upper limit of the intake is not particularly limited, but the balance with other nutrients is taken into consideration. It is desirable to select as appropriate. Normal,
0.5 to 6 per day for adults as quinoa skin or its processed product
It is 0 g and can be taken once or in several divided doses. The composition of the present invention is obtained by mixing an excipient, a binder, a coloring agent, a flavoring agent and the like with quinoa skin or a processed product thereof, and granulating the mixture, using a general method such as hot air drying, vacuum drying, spray drying, and freeze drying. It is obtained by drying by a suitable drying method.

As excipients, for example, starch, lactose,
Sucrose, mannitol, carboxymethylcellulose, corn starch, inorganic salts and the like. Examples of the binder include starch, corn starch, agar, a thickening polysaccharide, and proteins such as casein. The form of the composition is not particularly limited and may be appropriately selected as necessary, but generally includes powders, granules, capsules, tablets and the like.

[0010] Quinoa peel or its processed product is added to food.
Because it can be processed, ingestion can be made easier and simpler. The form of the food to which quinoa rind or its processed product can be added and processed is not particularly limited and may be appropriately selected as needed. In general, processed foods such as various health foods and breads and confectionery (cookies, snacks, etc.) And syrups and drinks. Quinoa skin, which is a raw material of the composition of the present invention, is edible as a part of quinoa seeds, and its safety has been established.

[0011]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but the scope of the present invention is not limited to these Examples. In this example, all percentages are based on weight unless otherwise specified. Reference Example 1 Preparation Example of Quinoa Peel Quinoa seeds were threshed in three minutes using a rice mill. The bran obtained at this time was obtained as quinoa skin.

Example 1 Blood cholesterol lowering test (1) Measurement of total blood cholesterol amount 31 ICR male mice (7 weeks old, weighing about 30 g) were placed one by one in a plastic case covered with sawdust, and solidified. Feed was given. Twelve days later, the blood total cholesterol level of 9 randomly selected animals was measured in advance, and 31 of these 9 mice were fed a control diet containing 1% cholesterol. One week later (this day is defined as day 0), the total blood cholesterol level was measured again, and after confirming that the total blood cholesterol level had risen in one week, the average value of these total blood cholesterol levels was calculated. Divided into 4 groups so as to be almost the same, a control diet, a diet containing 1% soybean saponin (1% SS diet), a diet containing 1.5% quinoa skin obtained in Reference Example 1 (1.5% QSF diet), Similarly, they were fed a diet containing 3% quinoa skin (3% QSF diet) and raised for 5 weeks. Water was given ad libitum. During that time, the total blood cholesterol level was measured weekly. Since quinoa skin contains saponin, soybean saponin was used as a control substance for quinoa skin.

FIG. 1 shows the results. Preliminary feeding on solid feed (-
After 1 week to 0), when a control diet containing 1% cholesterol was given, the total blood cholesterol level increased about 1.5 times. After feeding on each diet, the values in the control group and the 1% SS group further increased in the first week, whereas the values in the control group and the 1% SS group increased by 1.5%.
The values of the% QSF group and the 3% QSF group decreased (p <0.05 for the 3% QSF group). After that, all 4 groups descended, 3% Q in the 5th week
In the SF group, the value was almost the same as the value of the mice receiving the solid feed. The QSF group was significantly lower than the control group (1.5% QSF group at weeks 1, 2, and 5;
P <0.05 for weekly 3% QSF group, p for week 1 to 3% QSF group
<0.01). The QSF group was significantly lower than the 1% SS group (p <0.01 for the 1.5% and 3% QSF
1.5% and 3% QSF groups weekly p <0.05). From these results, it was revealed that quinoa skin has a function of suppressing an increase in the total blood cholesterol level in mice on a high cholesterol diet.

(2) Measurement of Blood HDL Cholesterol Amount 31 ICR male mice (7 weeks old, weighing about 30 g) were placed one by one in a plastic case covered with sawdust and fed a solid feed. Twelve days later, the blood total cholesterol level was previously measured for nine randomly selected animals from among them, and 31 animals including these nine were fed a control diet. One week later (this day is defined as day 0), the total cholesterol level was measured again, and after confirming that the total blood cholesterol level had increased in one week, the average values of these total blood cholesterol levels were almost the same. Divided into 4 groups to become control food, 1% SS food, 1.5% QSF food, 3% QS respectively
They were fed F diet and raised for 5 weeks. Water was given ad libitum. At week 5, the total blood cholesterol level and the blood HDL cholesterol level were measured. HDL removes cholesterol accumulated in the blood vessel wall and transports cholesterol to the blood vessel wall.
It is said to antagonize DL and therefore HDL in blood
It is believed that the higher the proportion of cholesterol, the lower the risk for lifestyle-related diseases such as arteriosclerosis.

FIG. 2 shows the blood total cholesterol level and blood HDL cholesterol level of the four groups at week 5, and FIG. 3 shows the ratio of blood HDL cholesterol to blood total cholesterol level. The absolute amount of blood HDL cholesterol was not particularly different between the groups, but the ratio of blood HDL cholesterol to the total blood cholesterol was higher in the other three groups than in the control group. In particular, the 3% QSF group was significantly higher (p <0.05).
From these results, it was found that quinoa skin contained H in total blood cholesterol in mice on a high cholesterol diet.
It has been found that DL cholesterol has a function of increasing the ratio.

Example 2 Liver cholesterol lowering test 31 ICR male mice (7 weeks old, weighing about 30 g) were placed one by one in a plastic case covered with sawdust and fed a solid feed. Twelve days later, the blood total cholesterol level was previously measured for nine randomly selected animals from among them, and 31 animals including these nine were fed a control diet. One week later (this day is defined as day 0), the blood total cholesterol level was measured again, and after confirming that the blood total cholesterol level had risen in one week, the average value of these blood total cholesterol levels was almost unchanged. Divide into 4 groups to be the same, control food, 1% SS food, 1.5% QSF food, 3% Q respectively
They were fed an SF diet and raised for 5 weeks. Water was given ad libitum. Liver total cholesterol was measured at 5 weeks of breeding

Table 1 shows the liver weight and the total liver cholesterol level of the mice at week 5 of breeding. When the livers of each group were compared, the livers of the control group and the 1% SS group were whitish like fatty liver, but the livers of the 1.5% QSF group and the 3% Q
The liver color of the SF group was red as in the normal mice. The total liver cholesterol level was significantly lower in the QSF group than in the control group.

[0018]

[Table 1] From these results, it was revealed that quinoa skin has a function of suppressing an increase in the total liver cholesterol level in mice on a high cholesterol diet.

Example 3 Preparation Example of Composition Containing Quinoa Skin Quinoa skin obtained in Reference Example 1 was mixed with an excipient (maltodextrin base) so that the content was 1.5% by weight. After mixing, the mixture was granulated by an extrusion granulator and dried by hot-air drying at 80 ° C. to obtain a granular composition.

Example 4 Preparation Example of Food Containing Quinoa Skin (1) Healthy Food The quinoa skin obtained in Reference Example 1 was mixed with reduced lactose, a sweetener, vitamin C, and an emulsifier so as to be 6.0% by weight. . After mixing, the mixture was granulated by an extrusion granulator and dried by hot air drying at 80 ° C. to obtain a granule. 0.5 g of the granule was tableted to obtain a tablet-like food.

(2) Cookies The quinoa skin obtained in Reference Example 1 is mixed with flour, butter, sugar, and eggs so as to have a concentration of 3.0%, prepared into a cylindrical shape of 4 to 5 cm, and maintained at 4 ° C. for 1 hour. And cookie dough. The cookie dough was cut into a thickness of about 5 mm, and heated in an oven preheated to 180 ° C. for 12 minutes to produce a cookie.

[0022]

According to the present invention, there is provided a composition having a cholesterol-lowering effect which can be orally ingested as it is and which can be easily added to foods and the like, and a food containing the composition.

[Brief description of the drawings]

FIG. 1 is a graph showing changes in the total blood cholesterol level in mice due to ingestion of quinoa skin.

FIG. 2 is a graph showing total cholesterol and HDL cholesterol levels in blood.

FIG. 3 is a view showing the ratio of the amount of HDL cholesterol in the total amount of cholesterol in blood.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 35/78 ADN A61K 35/78 ADNC (72) Inventor Gosho Kensei 1-5-3 Nihonbashi, Chuo-ku, Tokyo Dainippon Meiji Sugar Co., Ltd. Inside

Claims (2)

[Claims] 1. A composition for lowering cholesterol, comprising quinoa skin or a processed product thereof. 2. A food containing quinoa skin or a processed product thereof.