JP2002167334A - Composition with quinoa embryo bud - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition containing a quinoa embryo bud and/or its processed matter having cholesterol reducing effect such as foods containing quinoa embryo bud and/or its processed matter, preventive or treatment medicine for hypercholesterol related sickness containing quinoa embryo bud and/or its processed matter as an active ingredient. SOLUTION: This invention provides a composition having excellent cholesterol reducing or inhibitory effect. An active ingredient of this composition, quinoa embryo bud and/or its processed matter is extremely useful for foods or medicines, which is highly safe as a staple food in South and Central America, whose effective amount is orally ingestible easily without affecting taste or physical, chemical property.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a composition containing quinoa germ or a processed product thereof and capable of lowering blood cholesterol and hepatic cholesterol when taken orally, specifically, quinoa The present invention relates to a food containing a germ or a processed product thereof, or a preventive or therapeutic agent for a high cholesterol-related disease containing a quinoa germ or a processed product thereof as an active ingredient.

[0002]

2. Description of the Related Art In recent years, blood cholesterol and arteriosclerosis,
The relationship with various diseases such as myocardial infarction has been elucidated. Mortality due to lifestyle-related diseases such as diabetes and colorectal cancer including these diseases is increasing. It is said that this is a result of the shift to a high-fat, high-protein Western-style dietary pattern and an increase in preference for so-called refined and processed foods with the improvement of living standards. Under these circumstances and the growing trend toward health, the necessity of self-management has been advocated, and the development of foods having a cholesterol-suppressing / lowering effect has been desired. Various dietary fibers, pectin, saponin, chitosan, and the like are known to have a cholesterol lowering effect and can be used as foods. However, these influence the physical properties and taste of foods, and it is difficult to take them easily.

[0003] Quinopodium (Chinopodium quinoa) is a kind of cereal belonging to the family Acatheidae native to the southern Andes and is a staple food for people living in the Andes highlands, mainly in Peru. Quinoa is rich in dietary fiber, iron, minerals such as calcium, vitamins,
Since it contains all essential amino acids such as lysine, it has recently attracted attention as a complete food with excellent nutritional balance, and has been used as a processed food as well as a staple food.

It has been found that quinoa has a high saponin content and a highly bitter pericarp portion has a blood or liver cholesterol lowering effect (Japanese Patent Laid-Open No. 11-103801). On the other hand, although it is clear that the above-mentioned nutrients are contained in the cereal part of the seed normally used for food, the pharmacological actions including the cholesterol-lowering action are not considered in the endosperm and germ of the cereal part. Were individually analyzed and never studied.

[0005]

DISCLOSURE OF THE INVENTION The present invention provides a composition capable of ingesting an effective amount orally and having a cholesterol-suppressing / lowering effect, specifically, without affecting the taste and physical properties. An object of the present invention is to provide foods and pharmaceuticals that can exert the above-mentioned effects.

[0006]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have examined the cereal part of quinoa seeds by site, and as a result, have found that the germinal part which can be ingested can suppress or reduce cholesterol. And found that the present invention was completed. That is, the present invention provides the following (1) to
This is the invention of (4). (1) A composition comprising quinoa germ or a processed product thereof and having a cholesterol-lowering effect. (2) A food containing quinoa germ or a processed product thereof. (3) An agent for preventing a high cholesterol-related disease, comprising a quinoa germ or a processed product thereof as an active ingredient. (4) A therapeutic agent for high cholesterol-related diseases, comprising a quinoa germ or a processed product thereof as an active ingredient. Hereinafter, the present invention will be described in more detail.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The composition of the present invention contains quinoa germ or a processed product thereof as an active ingredient. Quinoa germ, which is an active ingredient of the composition of the present invention, is eaten as a part of quinoa, and its safety has been established.

The composition of the present invention is not particularly limited as long as it contains quinoa germ or a processed product thereof, and preferably includes food, medicine, feed and the like. In the present invention, the quinoa germ refers to a portion other than the endosperm obtained by threshing a quinoa cereal portion with a rice mill.

The treated quinoa germ refers to a quinoa germ obtained as described above, which is crushed and powdered, extracted with an appropriate solvent, and further purified by chromatography, dialysis, or the like. Say. The crushing for powdering the quinoa germ can be performed by a usual means such as a ball mill, a mortar, a blender, and a crusher.

For extraction of quinoa germ, water, alcohols such as ethanol, methanol, propanol and butanol, ethers such as ethyl ether and dioxane, ketones such as acetone and the like can be used as extraction solvents. When the extract is used once as a dried product after removing the solvent, any solvent can be used alone or as a mixture. On the other hand, when the extract is used in a state of being dissolved in a solvent, it is necessary to use a solvent that does not have a harmful effect on the human body. For example, it is desirable to use water, ethanol, or a mixture thereof. The extraction temperature is preferably within a range from room temperature to the boiling point of the solvent at normal pressure. The extraction time varies depending on the extraction temperature and the like, but is preferably within 48 hours.

The pulverized product or extract obtained as described above can be used as it is in the composition of the present invention. The extract can be further subjected to various methods such as ion exchange chromatography, gel filtration chromatography and dialysis. Those purified by a purification means may be used.

The above crushed quinoa germ, extract, and purified product of the extract (hereinafter referred to as quinoa germ or a processed product thereof) do not affect the taste and physical properties, and thus are added to food and processed. It is possible. The form of the food to which the quinoa germ or its processed product can be added and processed is not particularly limited and is selected as needed. Generally, processed foods such as various foods, bread, and confectionery, or syrups and drinks, etc. But beverages. In particular, quinoa germ or a processed product thereof has an excellent cholesterol-suppressing / lowering effect, so that a food containing them is suitable as a health food that can be easily taken.

Since the quinoa germ or the processed product has the above-mentioned action, it can be used as it is or by using a commonly used solid carrier, liquid carrier, emulsifier or the like, tablet, granule, powder, powder, powder, wettable powder, emulsion, capsule It can be formulated into a dosage form such as a preparation by a method known per se and used as a preparation for preventing or treating a disease associated with high cholesterol.

[0014] Formulation is carried out, for example, by mixing excipients, binders, coloring agents, fragrances and the like with quinoa germ or processed products, and granulating, warm-air drying, vacuum drying, spray drying, freeze-drying and the like. The drying can be performed by a method.

The excipients include, for example, starch, lactose, sucrose, mannitol, carboxymethylcellulose, corn starch, inorganic salts and the like. Examples of the binder include starch, corn starch, agar, thickening polysaccharides, and proteins such as casein.

[0016] The pharmaceutical preparation of the present invention can be used for various diseases associated with an increase in blood and liver cholesterol, such as hyperlipidemia, arteriosclerosis, angina, myocardial infarction, stroke, cerebral infarction, It is effective for the prevention or treatment of aortic aneurysm, obstructive arteriosclerosis, cerebrovascular dementia, renal vascular hypertension, renal atrophy, ischemic colitis, acute pancreatitis, xanthomas of the skin and tendons, and the like.

When the pharmaceutical preparation of the present invention is used for the prevention or treatment of the above-mentioned diseases, it can be safely orally administered to mammals such as humans, mice, rats, rabbits, dogs and cats. The dose of the present pharmaceutical preparation can be appropriately changed depending on the dosage form, age, body weight, blood or hepatic cholesterol level of the user, and the like. The upper limit is not particularly limited as long as the effect is obtained, but it is desirable to appropriately adjust the dose in consideration of the balance with other nutritional components. For example, as the quinoa germ or a processed product thereof, 0.5 g to 500 g per day of an adult is administered once or divided into several times.

[0018]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to these examples. In the examples, all percentages are based on weight unless otherwise specified. Example 1 Preparation of Quinoa Germ Quinoa seeds were threshed in 3 minutes using a rice mill. The cereal fraction obtained at this time was further threshed in 4 minutes, sieved, and the sieved was obtained as quinoa germ. Thereafter, the quinoa germ was powdered with a ball mill and subjected to the test described below.

Example 2 Preparation of Pharmaceutical Formulation The quinoa germ powder obtained in Example 1 was tableted according to a conventional method using crystalline cellulose as an excipient to obtain a pharmaceutical formulation of the present invention.

[Test Example 1] (Effect of Quinoa Germ Ingestion on Total Cholesterol Level in Blood) Twelve 5-week-old ICR male mice (about 35 g) were placed in a plastic breeding case with sawdust.
A control diet containing 1% cholesterol and a diet (QG diet) containing 20% of the quinoa germ powder obtained in Example 1 were freely fed to mice divided into two groups for 4 weeks. During that time, the total blood cholesterol level (plasma TC level) was measured every week. The results are shown in FIG. As shown in FIG. 1, the plasma TC value increased with the intake of the control diet, and remained at about 200 mg / dl. In contrast, the increase was suppressed in the QG diet, which was significantly lower than the control diet, and did not reach 200 mg / dl.

[Test Example 2] (Effect of Quinoa Germ Ingestion on Liver Weight and Liver Total Cholesterol Level) Twelve 5-week-old ICR male mice (about 35 g) were placed in a plastic breeding case with sawdust. Get in,
A control diet containing 1% cholesterol and a diet (QG diet) containing 20% of the quinoa germ powder obtained in Example 1 were freely fed to mice divided into two groups for 4 weeks. Four weeks later, liver weight and liver total cholesterol (liver TC value) were measured.
The results are shown in FIGS. The liver weight was about 4 g in the control diet, whereas the liver weight was 2.
5 g was significantly lower than the control diet (FIG. 2). Liver TC value was about 190 mg /
g, whereas the QG diet was significantly lower at about 98 mg / g (FIG. 3).

[0022]

According to the present invention, there is provided a composition capable of exhibiting excellent cholesterol lowering / suppressing effects. The quinoa germ or its processed product, which is an active ingredient of the present composition, is a staple food in Latin America, so it is highly safe, an effective amount can be easily taken orally, and the taste is good. And does not affect physical properties. Therefore, the present composition is very useful, for example, as foods and pharmaceuticals.

[Brief description of the drawings]

FIG. 1 shows changes in cholesterol level in mouse blood by administration of quinoa germ.

FIG. 2 shows changes in mouse liver weight due to administration of quinoa embryos.

FIG. 3 shows changes in the amount of cholesterol in mouse liver by administration of quinoa embryos.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61P 9/10 A61P 9/10 101 101 9/12 9/12 13/12 13/12 17/00 17 / 00 21/00 21/00 25/28 25/28 35/00 35/00 (72) Inventor Tadashi Fujimoto 1-5-3, Nihonbashi, Chuo-ku, Tokyo Dainippon Meiji Sugar Manufacturing Co., Ltd. (72) Inventor Takao Tetsuya 1-5-3 Nihonbashi, Chuo-ku, Tokyo Dainippon Meiji Sugar Manufacturing Co., Ltd. (72) Inventor Nobuaki Nishimura 1-5-3 Nihonbashi, Chuo-ku, Tokyo Dainippon Meiji Sugar Manufacturing Co., Ltd. F-term (reference) 4B018 LE03 MD49 ME04 MF01 MF07 4C088 AB12 AC05 BA07 BA08 BA09 BA10 CA01 CA03 CA05 CA06 CA14 CA16 MA52 NA14 ZA15 ZA36 ZA40 ZA45 ZA66 ZA81 ZA89 ZA94 ZB26 ZC33

Claims (4)

[Claims] 1. A quinoa germ or a processed product thereof,
A composition having a cholesterol lowering effect. 2. A food comprising quinoa germ or a processed product thereof. 3. An agent for preventing a high cholesterol-related disease, comprising a quinoa germ or a processed product thereof as an active ingredient. 4. A therapeutic agent for high cholesterol-related diseases, comprising quinoa germ or a processed product thereof as an active ingredient.