JPS60172926A - Healthy food - Google Patents

Abstract

PURPOSE:A healthy food for eliminating fatness, containing a saponin, dregs of unrefined rice vinegar, and a diuretic as active ingredients. CONSTITUTION:A healthy food containing a saponin (saponin obtained from a leguminous plant such as soybean, etc., cucurbitaceous plant such as Gynostemma pentaphyllum Makino, etc.), dregs of unrefined rice vinegar (preferably less of rice vinegar obtained by fermenting rice to give rice vinegar, drying pressed extraction residue, grinding it), and a diuretic (e.g., defatted Coicis Semen, Catalpa, Pounella Spica, etc.) in a blending ratio of 1:5:2-1:100:20. Preferably a dose of saponin is 2-20mg/kg day, dose of dregs of unrefined rice vinegar 10- 250mg/kg, and dose of diuretic 5-50mg/kg, respectively. The healthy food may be blended with other components for various purposes. Addition of ISAGORU (edible fiber) is especially preferable because it provides a person who eats it with a feeling of fullness with its small amount and prevents excess intake of calorie. A biscuit, tablet, powder, etc. may be used as the dosage form.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to health foods, more particularly to health foods that make it possible to prevent or eliminate obesity, especially biscuits.

Conventionally, various health foods have been commercially available for purposes such as weight loss, but many of them are designed to reduce the amount of calories contained in sweeteners, etc., to prevent people from consuming too many calories, and to help people lose weight. be. However, in reality, even if the calorie content of snack foods such as biscuits is reduced, many calories are ingested from other foods, and this is often not useful for alleviating obesity.

In addition, attempts have been made to actively prevent obesity by adding substances that promote fat breakdown, such as soybean saponin, but obesity is caused by various factors, and adding only a single ingredient is not enough. Generally, the effect is not sufficiently increased.

The inventors of the present invention have examined various causes of obesity and researched health foods that can suppress all of the factors. As a result, a health food containing saponin, rice vinegar moromi, and diuretics as active ingredients effectively alleviates obesity. I found out what to do.

The present invention (saponins used are soybean and azuki bean).

Plants of the legume family such as Aspergillus, paubra, and kapocha.

Cucurbitaceae plants such as Jiaogulan, other plants, and Korean ginseng.

It may be obtained from plants such as salsa root, bellflower root, and licorice root. Preferred is soybean saponin. Saponin has the effect of promoting the decomposition of fat, suppressing the synthesis and absorption of excess fat, and preventing the formation of lipid peroxide in the body.

Saponin may be obtained by any commonly known manufacturing method. For example, the raw material is dry-pulverized, degreased using a fat-soluble solvent such as 11-hexane, then heated and extracted with a lower aliphatic alcohol, treated with a mixture of n-butanol and water (1:1), and the solvent is removed under reduced pressure. The residue was distilled off at the bottom and dissolved by adding a small amount of methanol. This solution was added to a large amount of ether to form a precipitate and treated with water-saturated n-butanol,
The soluble part was distilled under reduced pressure, the solvent was removed, and the residue was distributed with a mixture of n-butanol and water (1:1).The water-transferred part was subjected to silica gel column chromatography (elution solvent:
A powder obtained by a method such as fractionation with (loform-methanol-water) is used.

The dosage of saponin for humans is 2 to 2 times a day per 1 body weight.
It is 20■. If it is less than 1■, there will be no weight loss effect,
It has low toxicity orally, but when administered in large quantities, side effects such as promotion of alcohol metabolism occur.

Rice vinegar moromi suppresses lipid synthesis and absorption and has the effect of improving bowel movements. It also has the effect of improving blood circulation.

Rice vinegar moromi is preferably rice vinegar lees, which is generally produced by fermenting rice to produce rice vinegar, then drying and pulverizing the pressed extraction residue.

The dosage of rice vinegar moromi is preferably in the range of 10 to 250'Q/9. If it is less than 5m9, there will be no weight loss effect, and
The effect decreases as the distance exceeds 00m7.

Examples of diuretics include defatted yokuinin, kasapagekagosou, goshitsu, ``nouhakuhi'', japanese radish, and caffeine. Preferably it is defatted Yokuinin. Those having a fat synthesis inhibiting effect are preferred. The general method for producing defatted Yokuinin is to remove the seed coat of No. 1 tome, grind it into about 20 mesh pieces, defatte it using a fat-soluble solvent such as 11-hexane, and dry and grind the residue. Ru.

The dosage m of the diuretic is preferably in the range of 5 to 50 μ/KIi. If it is less than 9/2, no weight loss effect will be seen.

The blending ratio of saponin: rice vinegar moromi: defatted Yokuinin is 1:
A range of 5:2 to 1:100-20 is preferred.

The health food of the present invention may contain other ingredients for various purposes. For example, high amylose starch is a type of indigestible polysaccharide, isacol is a type of dietary fiber that causes a feeling of fullness due to water content, and other low-calorie sweet bulking agents (reduced maltose powder, reduced maltose starch syrup, xylose, polydextrose, etc.) ) is exemplified.

In particular, it is particularly preferable to incorporate isagol into the health food of the present invention because it gives the recipient a feeling of fullness with a small amount and prevents them from consuming too many calories from snack foods.

The health food of the present invention also contains vitamins and other nutrients,
Alternatively, it is preferable to incorporate microcapsules containing perfume or the like. In particular, if flavorings or vitamins are directly added to foods that require baking in an oven, such as biscuits, etc., there is a risk of decomposition due to thermal decomposition, etc.
Preference is given to formulation in microcapsules.

Although any conventionally known method may be used for manufacturing the microcapsules, the method described in JP-A-56-49154 is particularly suitable.

Examples of the health food of the present invention include biscuits, tablets, powders 1, granules, chips, and the like.

When the health food of the present invention is ingested, the weight of adipose tissue in various regions is reduced, obesity is eliminated, and cholesterol is also reduced.

Additionally, if you incorporate dietary fiber that expands with water (such as isagol), you can feel full with just 13 biscuits, and eating just one biscuit a day can easily eliminate obesity. , and there's little chance of getting too many calories from other foods.

The present invention will be explained in more detail with reference to Examples.

Example 1 Mouse) Gold thioglucose (C, old tb)
Obese mice were created by administering rice vinegar lees alone to the additive of the present invention (i-oglucose) to create obese mice.
Effects of soybean saponin, rice vinegar lees and Yokuinino (hereinafter referred to as a combination) and Yokuinin alone, and rat K 5tr
Eptozotocin (insulin-secreting B cell destruction) was administered to create diabetic rats, and experiments were conducted to examine the effects of rice vinegar lees, the combination drug, and Yokuinin on diabetic rats.

A, Experimental material: The animal is a tcit female mouse, weighing 25 g, wis
Male tar rats weighing 200 g were purchased from the Shizuoka Laboratory for Experimental Animals and preliminarily bred for about 5 days before being used in experiments.

Gold thioglucose is Sl, manufactured by GUMA, rice vinegar lees.

The combination drug and Yokuinin are manufactured by Hitoshi Morishita Co., Ltd.! 8! There was.

The blended feed for raising mice has the following proportions.

Weighted casein 15 Corn starch 55 Corn oil 25 Salto mixture 4 Vitamin mixture 1 Vitamin A 3000 lU 30% choline chloride 200''? The above-mentioned compounded feed was mixed with the test drug and administered to mice.

In addition, the test drug was mixed with powdered rat feed manufactured by Oriental Yeast Co., Ltd. and administered to the rats.

B. Experimental method 1) Effects of rice vinegar lees, combination drug, and Yokuinin on obese mice due to Gold Lhioglucose administration: ICR female mice were preliminarily bred for 5 days, and experiments were conducted using healthy and well-colored mice. I did it.

That is, mice were treated with Gold Lhioglucose O.
, 6/Ky (body weight) was administered intraperitoneally to the rats, and after being fed a mixed diet for 7 weeks, they were sacrificed, and blood, parahepatic uterine adipose tissue, and intestinal tract were immediately collected.

The experimental groups were as follows.

a) Normal group -=・-・Gold Llliogluco
The mice were fed normal food (solid food) without administering se.

b) Obesity group --- Gold thioglucose
were administered, and the compound feed alone was administered.

C) Rice vinegar lees administration group---Gold tbiogl
Administer ucose and add 5 rice vinegar lees to the mixed feed! /ni'!
and 1! /KV intake.

d) Combined drug (Crude 5oyasaponin) administration group-----Golclrbic+glucose was administered, and compound feed a was administered to the mixed drug (Crude 5oyasaponin).
ponin IQ□n1gA! /) E, 1: Hypoallergenic agent (
C, S 50 my/Ky) were mixed and raised for intake.

e) Yokuinin administration group --- Gold t, bio
Administer glucose and add 1g/yokuinin to the mixed feed? , 0.5 f/KIJ: Hi 0.1! /to?
The animals were fed with additional intake.

Mice in each of the above groups were kept for 7 weeks.

During the rearing period, food and water were provided ad libitum, and food intake and body weight were measured once a week.

The mice were kept in a fed state for the experiment, blood was collected from the carotid artery, and the liver, parauterine adipose tissue, and intestinal tract were removed immediately after laparotomy. In addition, the weights of liver and parauterine adipose tissue were measured.

2) Streptozotoc
in) Effects of rice vinegar lees 9 mixture and Yokuinin on diabetic rats after administration 3: WisLar male rats were preliminarily bred for one week, and experiments were conducted using healthy rats with good fur.

That is, rats were fasted for 14 hours but allowed access to water ad libitum), and 5trepLozoLoc-i was administered via the tail vein.
N was administered to rats per gram at 651n97, fed on chow for 5 days, and a urine test was performed. The rats were diabetic and administered the drug. The drug was administered for 5 weeks,
Blood and liver were collected. However, the animals were kept in a fasted state for 14 hours before slaughter (water was freely available).

The administration groups were as follows.

a) Normal group----5trcptozotocin
The animals were raised on solid feed without being administered.

b) Diabetic group----5treptozotoci
n and fed powdered feed.

C) Rice vinegar axis group----5Lreptozotoci
Administer n and add 5f of rice vinegar powder to powdered feed! / to 9 and 1! /9<intake amount) and administered.

d) Combination drug group----5treptozotocin
7, and a mixture (Crude 5 oyas) was added to powdered feed.
aponin100 wtg/KV) O, 1: Hi (C
, S 50'''W/?) were reared with mixed intakes.

e) Yokuinin group -=-3treptozotocin
was administered, and the powdered feed had a Yokuinin IQ/Kp of 0.5!
/ 9 and 0.1 g/Kl intake) and reared.

J Measurement of blood glucose, insulin, transaminases and lipids, or liver lipids: 0 Neutral fat ("I'riglyceride)" ---
--"ll'riglycride B-test
(Wako) 0 Lipoperoxide
-・・-Lipoperoxide-test (Wako) Total Cholesf
erol )-Cholesterol B-tes
tO blood sugar (Glucose) -------Gluco
se B-test (Wako) 0 transaminase (
GO"I', GPT)...S・TA-test
(Wako) O Insulin...EIA
Method (manufactured by MBL) oNEFA...-NEFA-test (Wako) O phospholipid (PIIO! IPIIOI 1pid)...
・PIIO8L) 11011pids-test (Wako) 4) Morphological changes in the small intestine: Immediately after sacrificing the mouse, the small intestine was divided into the duodenum and the corner of the gyrus and removed, and intestinal harmful substances were removed with 0.9% NaCj'. The intestine was washed twice, and a site 4 to 6c+++ from the pylorus was used as observation material for each intestinal tract. The excised intestinal tract was fixed in ice with 2.5% geltaraldehyde, conductive staining was performed, critical point drying (Hitachi [Ict'-1), platinum deposition (Hitachi IB
-5) It was then observed using a Hitachi S-50OA scanning electron microscope.

5) Measurement of intestinal mucosal enzyme activity: Divide the small intestine into the duodenum and the jejunum and preliminarily add 0.9% N.
After washing twice with aC/, the membrane was inverted and the mucosal part was scraped off according to Fujita's method, and a 10% homogenate solution was prepared with 0.9% NaCj7, which was used as a sample for enzyme activity measurement. Malto
se and 5ucrase activities were determined by Dahlguist.
It was measured using the method of

The above results are shown in Table-1.

As is clear from Table 1, although Yokuinin and rice vinegar lees alone have an anti-obesity effect, they do not have the well-balanced anti-obesity effect like a combination drug.

Example 2 Biscuits were prepared by the method shown below.

Ingredients A unsalted margarine 100 shyotoning 50 powdered mulch 275 cm licked rice 25 eggs (all eggs) 135 ingredients B soy saponin 1 Rice vinegar 20 oakinin 20 isagor, 120 degreasing pour milk 125 salt 5 baking powder 10 crab coaton 10 ingredients c Skill flour 250 High amylose starch 250 Total 1396 Knead the unsalted margarine and shortening in ingredient A into a cream, add powdered mulch to make it homogeneous, then add beaten eggs,
Add vanilla essence and mix. Next, a sieved mixture of the above component B was added and kneaded, and component C was added and kneaded.

While dusting with flour, it was rolled out to a thickness of 5 mm, cut out with a mold, and baked in an oven at 150°C for 15 minutes.

As a result of administering the obtained biscuits to five monitors for two months, all monitors showed changes in body weight, chest circumference, waist circumference,
A decrease in hip and thigh circumference was observed. Monitor reduction rate = (value at measurement - value at start) / value at start (X
100) are shown in Figures 1-5. The dosage was lunch, specifically the three biscuits mentioned above. There was no feeling of hunger on all monitors.

Example 3 A biscuit containing flavor capsules was prepared using the materials shown below.

Materials (approx. 110 sheets) Weight (grams) Ingredient A Unsalted margarine 100 Shyotoning 50 Powdered mulch 275 Egg (whole egg) 135 Fragrance capsule (microcapsule) 56 Ingredient B Soybean saponin 1 Rice vinegar moromi 20 Defatted Yokuinin 20 Isagol 120 Defatted Milk powder 125 Salt 5 Baking powder 10 Component C soft flour 250 High amylose starch 250 Total 1417 The manufacturing method was the same as in Example 2.

[Brief explanation of the drawing]

1 to 5 are diagrams showing the results of monitor tests. Figure 1 is a graph showing the rate of decrease in body weight, Figure 2 is the rate of decrease in chest circumference, Figure 3 is the rate of decrease in waist, Figure 4 is the rate of decrease in hips, and Figure 5 is a graph showing the rate of decrease in thighs. . Patent applicant Osaka Pharmaceutical Research Institute Co., Ltd.

Claims (1)

[Claims] 1. A health food containing saponin, rice vinegar moromi, and a diuretic as active ingredients. 2. The health food according to item 1, wherein the saponin is soybean saponin. 3. The health food according to item 1, wherein the diuretic is defatted Yokuinin. 4. The health food according to item 1, wherein the health food is a biscuit. 5. Health food containing saponin, rice vinegar moromi, diuretic and dietary fiber. 6. The health food according to item 5, wherein the saponin is soybean saponin. 7. The health food according to item 5, wherein the diuretic is defatted Yokuinin. 8. The health food according to item 5, wherein the dietary fiber is isagol. 9. The health food according to item 5, wherein the health food is a biscuit. 10. A health food containing microcapsules containing saponin, rice vinegar moromi, diuretics, dietary fiber, and vitamins or nutrients. 11. The health food according to item 10, wherein the saponin is soybean saponin. 12. The health food according to item 10, wherein the diuretic is defatted Yokuinin. 13. The health food according to item 10, wherein the dietary fiber is isagol. 14. The health food according to item 10, wherein the health food is a biscuit.